CA2884859C - Hiv-1 antibody evolution immunogens - Google Patents

Hiv-1 antibody evolution immunogens Download PDF

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Publication number
CA2884859C
CA2884859C CA2884859A CA2884859A CA2884859C CA 2884859 C CA2884859 C CA 2884859C CA 2884859 A CA2884859 A CA 2884859A CA 2884859 A CA2884859 A CA 2884859A CA 2884859 C CA2884859 C CA 2884859C
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CA
Canada
Prior art keywords
hiv
seq
sequence defined
envelope protein
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2884859A
Other languages
English (en)
French (fr)
Other versions
CA2884859A1 (en
Inventor
Barton F. Haynes
Hua-Xin Liao
Rebecca M. Lynch
Tongqing Zhou
Feng Gao
Scott Boyd
George M. Shaw
Beatrice H. Hahn
Thomas B. Kepler
Bette T. Korber
Peter Kwong
John Mascola
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston University
University of Pennsylvania
Los Alamos National Security LLC
Duke University
Leland Stanford Junior University
United States Department of Health and Human Services
Original Assignee
Boston University
University of Pennsylvania
Los Alamos National Security LLC
Duke University
Leland Stanford Junior University
United States Department of Health and Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Boston University, University of Pennsylvania, Los Alamos National Security LLC, Duke University, Leland Stanford Junior University, United States Department of Health and Human Services filed Critical Boston University
Publication of CA2884859A1 publication Critical patent/CA2884859A1/en
Application granted granted Critical
Publication of CA2884859C publication Critical patent/CA2884859C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/21—Retroviridae, e.g. equine infectious anemia virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2884859A 2012-09-12 2013-09-12 Hiv-1 antibody evolution immunogens Active CA2884859C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201261700252P 2012-09-12 2012-09-12
US61/700,252 2012-09-12
US201261708466P 2012-10-01 2012-10-01
US61/708,466 2012-10-01
US201361764421P 2013-02-13 2013-02-13
US61/764,421 2013-02-13
PCT/US2013/000210 WO2014042669A1 (en) 2012-09-12 2013-09-12 Antibody evolution immunogens

Publications (2)

Publication Number Publication Date
CA2884859A1 CA2884859A1 (en) 2014-03-20
CA2884859C true CA2884859C (en) 2024-06-18

Family

ID=50278581

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2884859A Active CA2884859C (en) 2012-09-12 2013-09-12 Hiv-1 antibody evolution immunogens

Country Status (7)

Country Link
US (2) US10004800B2 (enExample)
EP (1) EP2895500B1 (enExample)
JP (1) JP6491095B2 (enExample)
CN (1) CN104968671B (enExample)
AU (3) AU2013316100B8 (enExample)
CA (1) CA2884859C (enExample)
WO (1) WO2014042669A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6491095B2 (ja) 2012-09-12 2019-04-03 デューク ユニバーシティ 抗体進化免疫原
US10149902B2 (en) 2014-03-19 2018-12-11 Duke University Swarm immunization with envelopes from CH505
CA2944068A1 (en) * 2014-03-31 2015-10-08 Duke University Compositions comprising ch848 envelopes and uses thereof
CA2962938A1 (en) * 2014-09-28 2016-03-31 Duke University Compositions comprising ch505 envelopes, and trimers
WO2016049633A1 (en) * 2014-09-28 2016-03-31 Duke University Compositions and methods for transient immune response modulation during vaccination
EP3240559A1 (en) * 2014-12-24 2017-11-08 Duke University Compositions comprising ch505 envelopes, and trimers (eight valent hiv-1 composition and methods)
WO2016172070A1 (en) * 2015-04-20 2016-10-27 Duke University Swarm immunization with envelopes from ch505
EP3423472A4 (en) 2016-03-01 2019-12-25 Duke University COMPOSITIONS WITH HIV COVERS FOR INDUCING CH235 CELL LINE ANTIBODIES
CA3016352A1 (en) 2016-03-03 2017-09-08 Duke University Compositions and methods for inducing hiv-1 antibodies
US11318197B2 (en) 2016-03-03 2022-05-03 Duke University Compositions and methods for inducing HIV-1 antibodies
EP3519428A4 (en) 2016-10-03 2020-07-08 Duke University METHODS OF IDENTIFYING IMMUNOGENS BY TARGETING IMPROBABLE MUTATIONS
WO2018218225A1 (en) 2017-05-25 2018-11-29 Duke University Compositions comprising modified hiv envelopes
US12138304B2 (en) 2018-10-01 2024-11-12 Duke University HIV-1 envelope stabilizing mutations
AU2020315598B2 (en) 2019-07-16 2024-12-12 Gilead Sciences, Inc. HIV vaccines and methods of making and using
WO2021081437A2 (en) 2019-10-23 2021-04-29 Duke University Compositions comprising v2 opt hiv envelopes
CA3202466A1 (en) 2021-01-14 2022-07-21 Jiani LI Hiv vaccines and methods of using
CA3206343A1 (en) 2021-01-28 2022-08-04 Rory HENDERSON Compositions comprising hiv envelopes to induce hiv-1 antibodies
EP4333614A4 (en) * 2021-05-05 2025-04-09 Leveragen, Inc. MANIPULATED NON-HUMAN ANIMALS TO PRODUCE ANTIBODIES
CN117651486A (zh) * 2021-05-05 2024-03-05 利威瑞健股份有限公司 用于生产抗体的工程改造的非人动物
EP4415751A4 (en) * 2021-10-11 2025-10-08 Univ Duke Compositions containing HIV envelopes for the induction of HIV-1 antibodies
CA3234955A1 (en) * 2021-10-12 2023-04-20 Barton F. Haynes Compositions comprising v2 opt hiv envelopes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0218817D0 (en) 2002-08-13 2002-09-18 San Raffaele Centro Fond Pharmaceutical compounds
AU2005280004B2 (en) * 2004-08-27 2012-02-23 Institute Of Tropical Medicine Modified HIV-1 envelope proteins
EP1802332A4 (en) * 2004-09-09 2010-08-18 Henry M Jackson Foundation MODIFIED HIV-1 CREAM PROTEINS
JP2006149234A (ja) 2004-11-25 2006-06-15 Japan Science & Technology Agency プライム−ブーストワクチン接種法
CA2704059A1 (en) * 2007-10-30 2009-05-07 International Aids Vaccine Initiative Antigen-antibody complexes as hiv-1 vaccines
US8628782B2 (en) * 2009-02-26 2014-01-14 The United States Of America, As Represented By The Department Of Health And Human Services Deletion of the beta 20-21 loop in HIV gp120 exposes the CD4 binding site for improved antibody binding and antibody induction
EP2477651A1 (en) 2009-09-17 2012-07-25 Sanofi Pasteur Inc. Immunological compositions for hiv
WO2011046623A2 (en) 2009-10-16 2011-04-21 Duke University Hiv-1 antibodies
EP2763699A4 (en) 2011-10-03 2015-05-20 Univ Duke VACCINE
JP6491095B2 (ja) 2012-09-12 2019-04-03 デューク ユニバーシティ 抗体進化免疫原

Also Published As

Publication number Publication date
EP2895500A1 (en) 2015-07-22
JP2015529678A (ja) 2015-10-08
US10004800B2 (en) 2018-06-26
EP2895500B1 (en) 2019-11-27
WO2014042669A1 (en) 2014-03-20
US20180360948A1 (en) 2018-12-20
AU2020200453A1 (en) 2020-02-13
CA2884859A1 (en) 2014-03-20
AU2013316100B2 (en) 2018-03-01
US20150366961A1 (en) 2015-12-24
US10849970B2 (en) 2020-12-01
CN104968671A (zh) 2015-10-07
JP6491095B2 (ja) 2019-04-03
CN104968671B (zh) 2020-07-03
AU2013316100B8 (en) 2018-03-08
EP2895500A4 (en) 2016-04-13
AU2018203805A1 (en) 2018-06-21

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