JP2012501959A5 - - Google Patents
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- Publication number
- JP2012501959A5 JP2012501959A5 JP2010523608A JP2010523608A JP2012501959A5 JP 2012501959 A5 JP2012501959 A5 JP 2012501959A5 JP 2010523608 A JP2010523608 A JP 2010523608A JP 2010523608 A JP2010523608 A JP 2010523608A JP 2012501959 A5 JP2012501959 A5 JP 2012501959A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- seq
- immunogenic composition
- antigens
- ypo0499
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 631
- 102000036639 antigens Human genes 0.000 claims description 631
- 108091007433 antigens Proteins 0.000 claims description 631
- 230000002163 immunogen Effects 0.000 claims description 75
- 239000000203 mixture Substances 0.000 claims description 75
- 230000028993 immune response Effects 0.000 claims description 29
- 241000124008 Mammalia Species 0.000 claims description 27
- 239000003814 drug Substances 0.000 claims description 24
- 238000004519 manufacturing process Methods 0.000 claims description 24
- 238000002560 therapeutic procedure Methods 0.000 claims description 13
- 101100294224 Yersinia pestis nlpI gene Proteins 0.000 claims description 9
- 101100493693 Yersinia pestis bamC gene Proteins 0.000 claims description 6
- 101100116909 Yersinia pestis djlA gene Proteins 0.000 claims description 6
- 101100421109 Yersinia pestis secM gene Proteins 0.000 claims description 6
- 101100381447 Yersinia pestis bamA gene Proteins 0.000 claims description 4
- 101100440427 Yersinia pestis coaE gene Proteins 0.000 claims description 4
- 101100064180 Yersinia pestis dsbA gene Proteins 0.000 claims description 4
- 101100281900 Yersinia pestis fyuA gene Proteins 0.000 claims description 4
- 101100220525 Yersinia pestis groEL gene Proteins 0.000 claims description 4
- 101100126385 Yersinia pestis ispD gene Proteins 0.000 claims description 4
- 101100188657 Yersinia pestis ompA gene Proteins 0.000 claims description 4
- 101100060882 Yersinia pestis pla gene Proteins 0.000 claims description 4
- 101100475179 Yersinia pestis rpsC gene Proteins 0.000 claims description 4
- 101100093726 Yersinia pestis rpsD gene Proteins 0.000 claims description 4
- 101100365859 Yersinia pestis skp gene Proteins 0.000 claims description 4
- 101100478915 Yersinia pestis surA gene Proteins 0.000 claims description 4
- 101100118435 Yersinia pestis tufA gene Proteins 0.000 claims description 4
- 241000607479 Yersinia pestis Species 0.000 claims description 3
- 101100170819 Yersinia pestis dnaK gene Proteins 0.000 claims description 3
- 101100472136 Yersinia pestis rplI gene Proteins 0.000 claims description 3
- 101100207359 Yersinia pestis tpx gene Proteins 0.000 claims description 3
- 229920001184 polypeptide Polymers 0.000 claims description 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 239000002955 immunomodulating agent Substances 0.000 claims description 2
- 229940121354 immunomodulator Drugs 0.000 claims description 2
- 150000001413 amino acids Chemical class 0.000 claims 16
- 238000003491 array Methods 0.000 claims 1
- 101100393774 Yersinia pestis hemL gene Proteins 0.000 description 3
- 101100256513 Yersinia pestis secB gene Proteins 0.000 description 3
- 230000005847 immunogenicity Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0717187.9A GB0717187D0 (en) | 2007-09-04 | 2007-09-04 | Compositions comprising yersinia pestis antigens |
| PCT/IB2008/003081 WO2009031043A2 (en) | 2007-09-04 | 2008-09-04 | Compositions comprising yersinia pestis antigens |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012501959A JP2012501959A (ja) | 2012-01-26 |
| JP2012501959A5 true JP2012501959A5 (enExample) | 2012-10-11 |
Family
ID=38640215
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523608A Pending JP2012501959A (ja) | 2007-09-04 | 2008-09-04 | Ｙｅｒｓｉｎｉａｐｅｓｔｉｓ抗原を含む組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100183674A1 (enExample) |
| EP (1) | EP2205274A2 (enExample) |
| JP (1) | JP2012501959A (enExample) |
| AU (1) | AU2008294413A1 (enExample) |
| CA (1) | CA2698360A1 (enExample) |
| GB (1) | GB0717187D0 (enExample) |
| WO (1) | WO2009031043A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7082569B2 (en) | 2001-01-17 | 2006-07-25 | Outlooksoft Corporation | Systems and methods providing dynamic spreadsheet functionality |
| EP2590676B1 (en) | 2010-07-06 | 2016-08-17 | GlaxoSmithKline Biologicals SA | Virion-like delivery particles for self-replicating rna molecules |
| HUE026646T2 (en) | 2010-07-06 | 2016-07-28 | Glaxosmithkline Biologicals Sa | Preferred liposomes containing lipids of PKA value for delivery of RNA |
| SI3243526T1 (sl) | 2010-07-06 | 2020-02-28 | Glaxosmithkline Biologicals S.A. | Dostava RNA za sprožitev večih imunskih poti |
| US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
| PL2591114T3 (pl) | 2010-07-06 | 2017-08-31 | Glaxosmithkline Biologicals Sa | Immunizacja dużych ssaków małymi dawkami rna |
| RS63329B1 (sr) | 2010-08-31 | 2022-07-29 | Glaxosmithkline Biologicals Sa | Pegilovani lipozomi za isporuku rnk koja kodira imunogen |
| AU2011295938B2 (en) | 2010-08-31 | 2016-01-14 | Glaxosmithkline Biologicals S.A. | Lipids suitable for liposomal delivery of protein-coding RNA |
| CN103269713B (zh) | 2010-10-11 | 2016-01-20 | 诺华有限公司 | 抗原递送平台 |
| EP2667852B1 (en) | 2011-01-27 | 2016-11-09 | GlaxoSmithKline Biologicals SA | Adjuvant nanoemulsions with crystallisation inhibitors |
| EP2688590B1 (en) | 2011-03-24 | 2020-02-12 | GlaxoSmithKline Biologicals SA | Adjuvant nanoemulsions with phospholipids |
| JP2014520806A (ja) | 2011-07-06 | 2014-08-25 | ノバルティス アーゲー | Ｒｎａ分子の送達のための有用なｎ：ｐ比を有するリポソーム |
| EP3332802A1 (en) | 2011-07-06 | 2018-06-13 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
| HUE041800T2 (hu) | 2011-08-31 | 2019-05-28 | Glaxosmithkline Biologicals Sa | Pegilált liposzómák immunogént kódoló RNS bejuttatására |
| CN104602702B (zh) | 2012-09-18 | 2021-08-27 | 葛兰素史密丝克莱恩生物有限公司 | 外膜囊泡 |
| MX377255B (es) | 2013-03-08 | 2025-03-07 | Novartis Ag | Lipidos y composiciones de lipidos para el suministro de agentes activos. |
| EP3083556B1 (en) | 2013-12-19 | 2019-12-25 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| WO2015095346A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| JP6778175B2 (ja) | 2014-07-16 | 2020-10-28 | ノバルティス アーゲー | 脂質ナノ粒子ホスト中に核酸を封入する方法 |
| CN107072946B (zh) | 2014-09-05 | 2022-01-11 | 诺华股份有限公司 | 用于递送活性剂的脂质和脂质组合物 |
| EP3061826A1 (en) | 2015-02-27 | 2016-08-31 | Novartis AG | Flavivirus replicons |
| TW202229228A (zh) | 2020-10-14 | 2022-08-01 | 喬治梅森研究基金會 | 可離子化脂質及其製造和使用方法 |
| US20240350410A1 (en) | 2021-08-16 | 2024-10-24 | Glaxosmithkline Biologicals Sa | Freeze-drying of lipid nanoparticles (lnps) encapsulating rna and formulations thereof |
| US20250134824A1 (en) | 2021-08-16 | 2025-05-01 | Glaxosmithkline Biologicals Sa | Low-dose lyophilized rna vaccines and methods for preparing and using the same |
| GB202303019D0 (en) | 2023-03-01 | 2023-04-12 | Glaxosmithkline Biologicals Sa | Method of lyophilisation |
| GB202311382D0 (en) | 2023-07-25 | 2023-09-06 | Glaxosmithkline Biologicals Sa | Lyophilised compostion |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE231184T1 (de) * | 1995-03-13 | 2003-02-15 | Secr Defence | Impfstoffe gegen die pest |
| US7776336B2 (en) * | 2005-10-25 | 2010-08-17 | Novartis Vaccines And Diagnostics Srl | Compositions comprising Yersinia pestis antigens |
-
2007
- 2007-09-04 GB GBGB0717187.9A patent/GB0717187D0/en not_active Ceased
-
2008
- 2008-09-04 AU AU2008294413A patent/AU2008294413A1/en not_active Abandoned
- 2008-09-04 EP EP08829437A patent/EP2205274A2/en not_active Withdrawn
- 2008-09-04 CA CA2698360A patent/CA2698360A1/en not_active Abandoned
- 2008-09-04 US US12/733,488 patent/US20100183674A1/en not_active Abandoned
- 2008-09-04 JP JP2010523608A patent/JP2012501959A/ja active Pending
- 2008-09-04 WO PCT/IB2008/003081 patent/WO2009031043A2/en not_active Ceased
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