JP2015500827A5

JP2015500827A5 -

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Publication number: JP2015500827A5
Authority: JP; Japan
Prior art keywords: antigen; toxa; seq; toxb; immunogenic composition
Prior art date: 2012-12-07
Legal status : Granted

Application number

JP2014545387A

Other languages

English (en)

Japanese (ja)

Other versions

JP2015500827A (ja

JP6084631B2 (ja

Filing date

2012-12-07

Publication date

2016-01-14

2011-12-08 Priority claimed from GB201121149A external-priority patent/GB201121149D0/en

2012-09-27 Priority claimed from GBGB1217321.7A external-priority patent/GB201217321D0/en

2012-12-07 Application filed filed Critical

2012-12-07 Priority claimed from PCT/IB2012/002955 external-priority patent/WO2013084071A2/en

2015-01-08 Publication of JP2015500827A publication Critical patent/JP2015500827A/ja

2016-01-14 Publication of JP2015500827A5 publication Critical patent/JP2015500827A5/ja

2017-02-22 Application granted granted Critical

2017-02-22 Publication of JP6084631B2 publication Critical patent/JP6084631B2/ja

Status Active legal-status Critical Current

2032-12-07 Anticipated expiration legal-status Critical

Links

239000000427 antigen Substances 0.000 claims description 168
102000036639 antigens Human genes 0.000 claims description 168
108091007433 antigens Proteins 0.000 claims description 168
239000000203 mixture Substances 0.000 claims description 67
230000002163 immunogen Effects 0.000 claims description 48
108090000765 processed proteins & peptides Proteins 0.000 claims description 19
229920001184 polypeptide Polymers 0.000 claims description 17
102000004196 processed proteins & peptides Human genes 0.000 claims description 17
229960005486 vaccine Drugs 0.000 claims description 14
125000003275 alpha amino acid group Chemical group 0.000 claims description 13
150000001413 amino acids Chemical class 0.000 claims description 11
241000193163 Clostridioides difficile Species 0.000 claims description 10
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 9
230000000890 antigenic effect Effects 0.000 claims description 8
239000013256 coordination polymer Substances 0.000 claims description 8
239000012634 fragment Substances 0.000 claims description 8
241000124008 Mammalia Species 0.000 claims description 7
230000002708 enhancing effect Effects 0.000 claims description 4
230000028993 immune response Effects 0.000 claims description 4
101710084578 Short neurotoxin 1 Proteins 0.000 claims description 2
101710182223 Toxin B Proteins 0.000 claims description 2
101710182532 Toxin a Proteins 0.000 claims description 2
239000002671 adjuvant Substances 0.000 claims description 2
150000001720 carbohydrates Chemical class 0.000 claims description 2
230000006806 disease prevention Effects 0.000 claims description 2
238000006386 neutralization reaction Methods 0.000 claims 1
239000002253 acid Substances 0.000 description 2
238000010845 search algorithm Methods 0.000 description 2
PXFBZOLANLWPMH-UHFFFAOYSA-N 16-Epiaffinine Natural products C1C(C2=CC=CC=C2N2)=C2C(=O)CC2C(=CC)CN(C)C1C2CO PXFBZOLANLWPMH-UHFFFAOYSA-N 0.000 description 1
239000011159 matrix material Substances 0.000 description 1
238000000034 method Methods 0.000 description 1
230000003472 neutralizing effect Effects 0.000 description 1

JP2014545387A 2011-12-08 2012-12-07 Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ毒素ベースのワクチン Active JP6084631B2 (ja)