JP6412131B2 - ＭＥＲＳ‐ＣｏＶワクチン - Google Patents

ＭＥＲＳ‐ＣｏＶワクチン Download PDF

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Publication number
JP6412131B2
JP6412131B2 JP2016534936A JP2016534936A JP6412131B2 JP 6412131 B2 JP6412131 B2 JP 6412131B2 JP 2016534936 A JP2016534936 A JP 2016534936A JP 2016534936 A JP2016534936 A JP 2016534936A JP 6412131 B2 JP6412131 B2 JP 6412131B2
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Prior art keywords
mers
spike
acid sequence
seq
immunogenic composition
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Expired - Fee Related
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JP2016534936A
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Japanese (ja)
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JP2016539946A5 (enExample
JP2016539946A (ja
Inventor
ビー．ウェイナー デイビッド
ビー．ウェイナー デイビッド
ムスマニ カルッピアー
ムスマニ カルッピアー
ワイ．サーデサイ ニランジャン
ワイ．サーデサイ ニランジャン
Original Assignee
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア
イノビオ ファーマシューティカルズ，インコーポレイティド
イノビオ ファーマシューティカルズ，インコーポレイティド
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Publication of JP2016539946A publication Critical patent/JP2016539946A/ja
Publication of JP2016539946A5 publication Critical patent/JP2016539946A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/20011—Coronaviridae
    • C12N2770/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2016534936A 2013-11-29 2014-11-26 ＭＥＲＳ‐ＣｏＶワクチン Expired - Fee Related JP6412131B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361910153P 2013-11-29 2013-11-29
US61/910,153 2013-11-29
PCT/US2014/067537 WO2015081155A1 (en) 2013-11-29 2014-11-26 Mers-cov vaccine

Publications (3)

Publication Number Publication Date
JP2016539946A JP2016539946A (ja) 2016-12-22
JP2016539946A5 JP2016539946A5 (enExample) 2017-12-28
JP6412131B2 true JP6412131B2 (ja) 2018-10-24

Family

ID=53199622

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016534936A Expired - Fee Related JP6412131B2 (ja) 2013-11-29 2014-11-26 ＭＥＲＳ‐ＣｏＶワクチン

Country Status (10)

Country Link
US (5) US10016497B2 (enExample)
EP (1) EP3074051A4 (enExample)
JP (1) JP6412131B2 (enExample)
KR (2) KR20160091350A (enExample)
CN (2) CN112057613A (enExample)
AU (1) AU2014354797C1 (enExample)
CA (1) CA2932055A1 (enExample)
IL (3) IL305392A (enExample)
SA (1) SA516371223B1 (enExample)
WO (1) WO2015081155A1 (enExample)

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US11103575B2 (en) 2014-02-28 2021-08-31 The New York Blood Center, Inc. Immunogenic composition for MERS coronavirus infection
EP3045181B1 (en) * 2015-01-19 2018-11-14 Ludwig-Maximilians-Universität München A novel vaccine against the middle east respiratory syndrome coronavirus (MERS-CoV)
US11058779B2 (en) 2015-09-08 2021-07-13 Sirnaomics, Inc. Sirna/nanoparticle formulations for treatment of middle-east respiratory syndrome coronaviral infection
DE20164728T1 (de) 2015-10-22 2021-09-30 Modernatx, Inc. Impfstoffe gegen atemwegsvirus
CN106397549B (zh) * 2016-10-11 2019-08-06 中国疾病预防控制中心病毒病预防控制所 MERS-CoV特异性多肽及其应用
WO2018089306A1 (en) 2016-11-10 2018-05-17 Oyagen, Inc. Methods of treating and inhibiting ebola virus infection
KR20180058206A (ko) * 2016-11-23 2018-05-31 에스케이케미칼 주식회사 중동호흡기증후군 코로나바이러스 s 단백질 면역원 조성물 및 이의 제작 방법
WO2018170347A1 (en) 2017-03-17 2018-09-20 Modernatx, Inc. Zoonotic disease rna vaccines
KR102017217B1 (ko) * 2017-10-19 2019-09-02 주식회사 엔케이맥스 중동호흡기증후군 코로나바이러스에 대한 항체 및 이를 이용한 항체역가 측정방법
WO2021158248A1 (en) 2020-02-04 2021-08-12 Oyagen, Inc. Method for treating coronavirus infections
JP2023511780A (ja) 2020-02-25 2023-03-22 イノビオ ファーマシューティカルズ，インコーポレイティド コロナウイルスに対するワクチンおよび使用方法
CN111378785A (zh) * 2020-03-12 2020-07-07 仁宽(上海)生物科技有限公司 用于核酸诊断新型冠状病毒2019-nCov的假病毒标准品及其应用
US11559577B2 (en) 2020-03-31 2023-01-24 Engimata, Inc. Immunogenic composition forming a vaccine, and a method for its manufacture
US20230181681A1 (en) * 2020-05-08 2023-06-15 Industry Academic Cooperation Foundation, Hallym University Peptide for suppressing coronavirus and use thereof
US20230226170A1 (en) * 2020-05-12 2023-07-20 Greffex, Inc. Engineering coronavirus spike proteins as vaccine antigens, their design and uses
WO2021252604A1 (en) * 2020-06-09 2021-12-16 The Wistar Institute Of Anatomy And Biology Coronavirus disease 2019 (covid-19) combination vaccine
WO2022011332A2 (en) * 2020-07-10 2022-01-13 Engimata, Inc Immunogenic composition forming a vaccine, and a method for its manufacture
WO2022020604A1 (en) * 2020-07-22 2022-01-27 Greffex, Inc. Multivalent beta-coronavirus vaccines, their design and uses
US20230279361A1 (en) * 2020-07-27 2023-09-07 National University Corporation Shiga University Of Medical Science Method for in vitro proliferating virus belonging to family coronaviridae, method for producing neutralizing antibody to virus belonging to family coronaviridae, and method for producing infection model of severe acute respiratory syndrome coronavirus 2
UY39378A (es) * 2020-08-14 2022-01-31 Univ Wuerzburg J Maximilians Vacuna de salmonella para el tratamiento de coronavirus
US20240016919A1 (en) * 2020-08-25 2024-01-18 The Wistar Institute Of Anatomy And Biology INTRADERMAL MERS-CoV VACCINE
US20230349889A1 (en) * 2020-09-10 2023-11-02 The Council Of The Queensland Institute Of Medical Research Methods of Determining Immune Response
AU2021340715A1 (en) * 2020-09-11 2023-04-27 Mark J. Cantwell Enhancing immunity using chimeric cd40 ligand and coronavirus vaccine
US20220370598A1 (en) * 2021-05-05 2022-11-24 Inovio Pharmaceuticals, Inc. Vaccines Against Coronavirus and Methods of Use

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Also Published As

Publication number Publication date
WO2015081155A1 (en) 2015-06-04
CA2932055A1 (en) 2015-06-04
AU2014354797B2 (en) 2017-10-26
US20200222527A1 (en) 2020-07-16
AU2014354797A1 (en) 2016-07-07
CN105939730A (zh) 2016-09-14
SA516371223B1 (ar) 2023-01-31
IL245903A0 (en) 2016-07-31
JP2016539946A (ja) 2016-12-22
US20210401972A1 (en) 2021-12-30
IL305392A (en) 2023-10-01
CN112057613A (zh) 2020-12-11
CN105939730B (zh) 2020-09-11
US20190022213A1 (en) 2019-01-24
US11135284B2 (en) 2021-10-05
US10016497B2 (en) 2018-07-10
EP3074051A4 (en) 2017-04-12
US20170258893A1 (en) 2017-09-14
US20240123056A1 (en) 2024-04-18
KR20160091350A (ko) 2016-08-02
IL276210A (en) 2020-09-30
IL276210B2 (en) 2024-01-01
KR20230122181A (ko) 2023-08-22
AU2014354797C1 (en) 2018-02-01
IL276210B1 (en) 2023-09-01
IL245903B (en) 2020-08-31
US11801298B2 (en) 2023-10-31
EP3074051A1 (en) 2016-10-05
US10548971B2 (en) 2020-02-04

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