JP2014523878A5 - - Google Patents
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- Publication number
- JP2014523878A5 JP2014523878A5 JP2014515985A JP2014515985A JP2014523878A5 JP 2014523878 A5 JP2014523878 A5 JP 2014523878A5 JP 2014515985 A JP2014515985 A JP 2014515985A JP 2014515985 A JP2014515985 A JP 2014515985A JP 2014523878 A5 JP2014523878 A5 JP 2014523878A5
- Authority
- JP
- Japan
- Prior art keywords
- hdv
- immunotherapeutic composition
- seq
- antigen
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000037262 Hepatitis delta Diseases 0.000 claims 30
- 241000724709 Hepatitis delta virus Species 0.000 claims 30
- 230000001024 immunotherapeutic effect Effects 0.000 claims 19
- 239000000427 antigen Substances 0.000 claims 14
- 102000036639 antigens Human genes 0.000 claims 14
- 108091007433 antigens Proteins 0.000 claims 14
- 125000003275 alpha amino acid group Chemical group 0.000 claims 10
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 8
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 8
- 108020001507 fusion proteins Proteins 0.000 claims 5
- 102000037865 fusion proteins Human genes 0.000 claims 5
- 208000015181 infectious disease Diseases 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 2
- 230000003053 immunization Effects 0.000 claims 2
- 230000002163 immunogen Effects 0.000 claims 2
- 230000030648 nucleus localization Effects 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 229910002699 Ag–S Inorganic materials 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 230000004083 survival effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161497039P | 2011-06-14 | 2011-06-14 | |
| US61/497,039 | 2011-06-14 | ||
| PCT/US2012/042426 WO2012174220A1 (en) | 2011-06-14 | 2012-06-14 | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014523878A JP2014523878A (ja) | 2014-09-18 |
| JP2014523878A5 true JP2014523878A5 (enExample) | 2015-07-23 |
Family
ID=47357462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014515985A Pending JP2014523878A (ja) | 2011-06-14 | 2012-06-14 | Ｄ型肝炎ウイルス感染の治療又は予防のための酵母ベースの組成物及び方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9579377B2 (enExample) |
| EP (1) | EP2720716B1 (enExample) |
| JP (1) | JP2014523878A (enExample) |
| CN (1) | CN103732250A (enExample) |
| AU (1) | AU2012271625B2 (enExample) |
| BR (1) | BR112013032381B1 (enExample) |
| CA (1) | CA2838950C (enExample) |
| EA (1) | EA030381B1 (enExample) |
| ES (1) | ES2671381T3 (enExample) |
| IL (1) | IL229902B (enExample) |
| SG (2) | SG10201605265TA (enExample) |
| WO (1) | WO2012174220A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2651439B1 (en) | 2010-12-17 | 2018-09-19 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| AU2012214394B2 (en) | 2011-02-12 | 2016-08-11 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis B infection |
| EP3238731B1 (en) | 2011-03-17 | 2021-02-17 | Globeimmune, Inc. | Yeast-brachyury immunotherapeutic compositions |
| WO2012174220A1 (en) | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| KR102049928B1 (ko) | 2011-08-17 | 2019-11-28 | 글로브이뮨 | 효모-muc1 면역요법 조성물 및 그 용도 |
| AU2013281221B2 (en) | 2012-06-26 | 2018-05-17 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| SG10201707608QA (en) | 2013-03-19 | 2017-10-30 | Globeimmune Inc | Yeast-based immunotherapy for chordoma |
| TWI626948B (zh) | 2013-03-26 | 2018-06-21 | 環球免疫公司 | 治療或預防人類免疫缺乏病毒感染之組合物及方法 |
| US10226522B2 (en) | 2013-08-30 | 2019-03-12 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of tuberculosis |
| WO2015157639A1 (en) * | 2014-04-11 | 2015-10-15 | Globeimmune, Inc. | Yeast-based immunotherapy and type i interferon sensitivity |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| JP2017536403A (ja) * | 2014-12-04 | 2017-12-07 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドＥｉｇｅｒ Ｂｉｏｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | デルタ肝炎ウイルス感染の治療 |
| JP2018502922A (ja) | 2015-01-09 | 2018-02-01 | イーチュービクス コーポレイション | エボラウイルスワクチン接種のための方法および組成物 |
| WO2016172342A1 (en) | 2015-04-21 | 2016-10-27 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| AU2016303525B2 (en) | 2015-08-03 | 2021-01-21 | Globeimmune, Inc. | Modified yeast-Brachyury immunotherapeutic compositions |
| PT3416675T (pt) * | 2016-02-19 | 2021-06-14 | Eiger Biopharmaceuticals Inc | Tratamento de infeção pelo vírus da hepatite delta com interferão lambda |
| CN107653342A (zh) * | 2016-12-28 | 2018-02-02 | 成都百泰赛维生物科技有限公司 | 一种pcr法检测汉族人hdv病毒的方法 |
| CN107641661A (zh) * | 2016-12-28 | 2018-01-30 | 成都百泰赛维生物科技有限公司 | 一种用于检测汉族人hdv病毒的试剂盒 |
| CN112543640B (zh) | 2018-05-15 | 2025-02-14 | 全球免疫公司 | 用于诱导细胞免疫应答的重组酵母裂解物 |
| WO2021216801A1 (en) * | 2020-04-22 | 2021-10-28 | Southlake Pharmaceuticals, Inc. | Pegylated interferon tau and compositions and methods thereof |
| WO2024123891A1 (en) * | 2022-12-07 | 2024-06-13 | The University Of North Carolina At Chapel Hill Office Of Technology Commercialization | Engineered microorganism compositions and applications thereof |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2486400B1 (fr) | 1980-07-09 | 1986-05-30 | Univablot | Medicaments a base de levures ou de leurs extraits insolubles |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US4775622A (en) | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| US5310654A (en) | 1985-07-31 | 1994-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining virulence of Yersinia |
| US5234830A (en) | 1988-02-03 | 1993-08-10 | Suntory Limited | DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region |
| IL95019A0 (en) | 1989-08-09 | 1991-06-10 | Mycogen Corp | Process for encapsulation of biologicals |
| US5413914A (en) | 1993-07-07 | 1995-05-09 | The Regents Of The University Of Colorado | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
| US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| DE122007000092I1 (de) * | 1994-10-07 | 2008-03-27 | Univ Loyola Chicago | Papillomavirusähnliche partikel, fusionsproteine sowie verfahren zu deren herstellung |
| US5858378A (en) | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
| AUPO434196A0 (en) | 1996-12-24 | 1997-01-23 | Crown In The Right Of The Queensland Department Of Health, The | An improved therapeutic |
| US6844171B1 (en) | 1998-07-02 | 2005-01-18 | President And Fellows Of Harvard College | Oligomerization of hepatitis delta antigen |
| US20020044948A1 (en) | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| US8153414B2 (en) | 2000-04-06 | 2012-04-10 | Allertein Therapeutics, Llc | Microbial delivery system |
| AU2002225681A1 (en) | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| FR2830019B1 (fr) * | 2001-09-24 | 2005-01-07 | Assist Publ Hopitaux De Paris | Molecules d'acides nucleiques d'hdv, leurs fragments et leurs apllications |
| CN1622828A (zh) | 2001-12-18 | 2005-06-01 | 基因创新有限公司 | 用于诊断和治疗用途的纯化的丙型肝炎病毒外被蛋白 |
| CN102370974B (zh) | 2002-12-16 | 2014-09-17 | 全球免疫股份有限公司 | 用于免疫治疗的基于酵母的疫苗 |
| US7439042B2 (en) | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| KR20070068460A (ko) * | 2004-10-18 | 2007-06-29 | 글로브이뮨 | 만성 ｃ형 간염에 대한 효모계 치료 |
| JP4320357B2 (ja) * | 2005-02-25 | 2009-08-26 | ファイザー・プロダクツ・インク | ブタ生殖器呼吸器症候群ウイルスのｎタンパク質変異体 |
| EP2371381A3 (en) | 2005-07-11 | 2012-07-18 | Globeimmune, Inc. | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
| US20070172503A1 (en) | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
| MX2008009929A (es) | 2006-02-02 | 2008-10-01 | Globeimmune Inc | Vacuna a base de levadura para inducir una respuesta inmune. |
| KR20090008290A (ko) | 2006-03-27 | 2009-01-21 | 글로브이뮨 | Ｒａｓ 돌연변이와 그에 관련된 조성물 및 방법 |
| US20080138354A1 (en) * | 2006-07-21 | 2008-06-12 | City Of Hope | Cytomegalovirus vaccine |
| CN101687030B (zh) | 2007-02-02 | 2014-07-02 | 环球免疫公司 | 用于生产基于酵母的疫苗的方法 |
| CN101730542A (zh) | 2007-03-19 | 2010-06-09 | 环球免疫公司 | 用于靶向消除癌症靶向疗法的突变逃逸的组合物和方法 |
| EP2331125A4 (en) | 2008-09-19 | 2013-03-27 | Globeimmune Inc | IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS |
| WO2010065626A1 (en) | 2008-12-02 | 2010-06-10 | Globeimmune, Inc. | Genotyping tools, methods and kits |
| ITTO20080964A1 (it) | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| AU2010236206B2 (en) * | 2009-04-17 | 2016-10-20 | Globeimmune, Inc. | Combination immunotherapy compositions against cancer and methods |
| CA2770075C (en) * | 2009-08-07 | 2021-08-24 | Perrine Martin | Composition for treating hbv infection |
| CA2774326C (en) | 2009-09-14 | 2023-11-07 | Donald Bellgrau | Modulation of yeast-based immunotherapy products and responses |
| JP2013522302A (ja) | 2010-03-14 | 2013-06-13 | グローブイミューン，インコーポレイテッド | 酵母系免疫療法を使用した感染症の薬理ゲノミクス及び治療反応性ガイド治療 |
| WO2012019127A2 (en) | 2010-08-05 | 2012-02-09 | The Regents Of The University Of Colorado | Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases |
| EP2651439B1 (en) | 2010-12-17 | 2018-09-19 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| AU2012214394B2 (en) | 2011-02-12 | 2016-08-11 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis B infection |
| EP3238731B1 (en) | 2011-03-17 | 2021-02-17 | Globeimmune, Inc. | Yeast-brachyury immunotherapeutic compositions |
| WO2012174220A1 (en) | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| KR102049928B1 (ko) | 2011-08-17 | 2019-11-28 | 글로브이뮨 | 효모-muc1 면역요법 조성물 및 그 용도 |
-
2012
- 2012-06-14 WO PCT/US2012/042426 patent/WO2012174220A1/en not_active Ceased
- 2012-06-14 EA EA201490015A patent/EA030381B1/ru not_active IP Right Cessation
- 2012-06-14 ES ES12800096.5T patent/ES2671381T3/es active Active
- 2012-06-14 CN CN201280039821.5A patent/CN103732250A/zh active Pending
- 2012-06-14 BR BR112013032381-7A patent/BR112013032381B1/pt active IP Right Grant
- 2012-06-14 SG SG10201605265TA patent/SG10201605265TA/en unknown
- 2012-06-14 SG SG2013091632A patent/SG195383A1/en unknown
- 2012-06-14 JP JP2014515985A patent/JP2014523878A/ja active Pending
- 2012-06-14 CA CA2838950A patent/CA2838950C/en active Active
- 2012-06-14 AU AU2012271625A patent/AU2012271625B2/en active Active
- 2012-06-14 US US14/125,779 patent/US9579377B2/en active Active
- 2012-06-14 EP EP12800096.5A patent/EP2720716B1/en active Active
-
2013
- 2013-12-10 IL IL229902A patent/IL229902B/en active IP Right Grant
-
2017
- 2017-01-17 US US15/408,087 patent/US9987352B2/en active Active
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