EA030381B1 - Иммунотерапевтическая композиция, ее применения и способы лечения или профилактики инфекции, вызванной вирусом гепатита дельта - Google Patents
Иммунотерапевтическая композиция, ее применения и способы лечения или профилактики инфекции, вызванной вирусом гепатита дельта Download PDFInfo
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| JP5745102B2 (ja) | 2011-02-12 | 2015-07-08 | グローブイミューン，インコーポレイテッド | 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物 |
| SG193396A1 (en) | 2011-03-17 | 2013-10-30 | Globeimmune Inc | Yeast-brachyury immunotherapeutic compositions |
| WO2012174220A1 (en) | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| RU2642300C2 (ru) | 2011-08-17 | 2018-01-24 | Глоубиммьюн, Инк. | Иммунотерапевтические композиции на основе дрожжей-muc1 и способы их применения |
| SG11201408652SA (en) | 2012-06-26 | 2015-01-29 | Biodesix Inc | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| KR20150132867A (ko) | 2013-03-19 | 2015-11-26 | 글로브이뮨 | 척색종에 대한 효모-기반의 면역치료 |
| TWI626948B (zh) | 2013-03-26 | 2018-06-21 | 環球免疫公司 | 治療或預防人類免疫缺乏病毒感染之組合物及方法 |
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| US10799567B2 (en) * | 2014-04-11 | 2020-10-13 | Globeimmune, Inc. | Yeast-based immunotherapy and type I interferon sensitivity |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| EP3226973A4 (en) * | 2014-12-04 | 2018-05-30 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| KR20170102002A (ko) | 2015-01-09 | 2017-09-06 | 이투빅스 코포레이션 | 에볼라 바이러스 백신접종을 위한 방법 및 조성물 |
| US10835496B2 (en) | 2015-04-21 | 2020-11-17 | Eiger Biopharmaceuticals, Inc. | Pharmaceutical compositions comprising lonafarnib and ritonavir |
| JP6789283B2 (ja) | 2015-08-03 | 2020-11-25 | グローブイミューン，インコーポレイテッド | 改変酵母−ブラキュリー免疫療法組成物 |
| LT3416675T (lt) * | 2016-02-19 | 2021-06-25 | Eiger Biopharmaceuticals, Inc. | Hepatito delta viruso infekcijos gydymas interferonu lambda |
| CN107641661A (zh) * | 2016-12-28 | 2018-01-30 | 成都百泰赛维生物科技有限公司 | 一种用于检测汉族人hdv病毒的试剂盒 |
| CN107653342A (zh) * | 2016-12-28 | 2018-02-02 | 成都百泰赛维生物科技有限公司 | 一种pcr法检测汉族人hdv病毒的方法 |
| CN112543640B (zh) | 2018-05-15 | 2025-02-14 | 全球免疫公司 | 用于诱导细胞免疫应答的重组酵母裂解物 |
| US20230131808A1 (en) * | 2020-04-22 | 2023-04-27 | Southlake Pharmaceuticals, Inc. | Pegylated interferon tau and compositions and methods thereof |
| WO2024123891A1 (en) * | 2022-12-07 | 2024-06-13 | The University Of North Carolina At Chapel Hill Office Of Technology Commercialization | Engineered microorganism compositions and applications thereof |
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| WO1998028004A1 (en) * | 1996-12-24 | 1998-07-02 | The Crown In The Right Of The Queensland Department Of Health (Sir Albert Sakzewski Virus Research Centre) | Hepatitis delta particle containing a fusion protein immunogen |
| WO2010033841A1 (en) * | 2008-09-19 | 2010-03-25 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis c virus infection |
| WO2010121180A1 (en) * | 2009-04-17 | 2010-10-21 | Globeimmune, Inc. | Combination immunotherapy compositions against cancer and methods |
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|---|---|---|---|---|
| FR2486400B1 (fr) | 1980-07-09 | 1986-05-30 | Univablot | Medicaments a base de levures ou de leurs extraits insolubles |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US4775622A (en) | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| US5310654A (en) | 1985-07-31 | 1994-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining virulence of Yersinia |
| US5234830A (en) | 1988-02-03 | 1993-08-10 | Suntory Limited | DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region |
| IL95019A0 (en) | 1989-08-09 | 1991-06-10 | Mycogen Corp | Process for encapsulation of biologicals |
| US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| US5413914A (en) | 1993-07-07 | 1995-05-09 | The Regents Of The University Of Colorado | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
| AU4270196A (en) * | 1994-10-07 | 1996-05-02 | Lutz Gissmann | Papilloma virus-like particles, fusion proteins and process for producing the same |
| US5858378A (en) | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
| US6844171B1 (en) | 1998-07-02 | 2005-01-18 | President And Fellows Of Harvard College | Oligomerization of hepatitis delta antigen |
| US20020044948A1 (en) | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| EP1272213B1 (en) | 2000-04-06 | 2006-03-08 | SEER Pharmaceuticals, LLC. | Microbial delivery system |
| AU2002225681A1 (en) | 2000-11-15 | 2002-05-27 | Globe Immune, Inc. | Yeast-dentritic cell vaccines and uses thereof |
| FR2830019B1 (fr) * | 2001-09-24 | 2005-01-07 | Assist Publ Hopitaux De Paris | Molecules d'acides nucleiques d'hdv, leurs fragments et leurs apllications |
| CN1622828A (zh) | 2001-12-18 | 2005-06-01 | 基因创新有限公司 | 用于诊断和治疗用途的纯化的丙型肝炎病毒外被蛋白 |
| KR101241272B1 (ko) | 2002-12-16 | 2013-03-15 | 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 | 면역 요법으로서의 효모계 백신 |
| US7439042B2 (en) | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| EP2460533A3 (en) * | 2004-10-18 | 2014-01-08 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| AU2006253891B2 (en) * | 2005-02-25 | 2011-12-01 | Zoetis P Llc | N Protein Mutants of Porcine reproductive and respiratory syndrome virus |
| US20100034840A1 (en) | 2005-07-11 | 2010-02-11 | David Apelian | Compositions and methods for eliciting an immune response to escape mutants of targeted therapies |
| US20070172503A1 (en) | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
| KR20140029551A (ko) | 2006-02-02 | 2014-03-10 | 글로브이뮨 | 면역 반응 유도를 위한 효모-기반 백신 |
| EP2004666B1 (en) | 2006-03-27 | 2014-09-03 | Globeimmune, Inc. | Ras mutation and compositions and methods related thereto |
| US20080138354A1 (en) * | 2006-07-21 | 2008-06-12 | City Of Hope | Cytomegalovirus vaccine |
| EP2121013B1 (en) | 2007-02-02 | 2014-10-15 | Globeimmune, Inc. | Methods for producing yeast-based vaccines |
| CA2681246A1 (en) | 2007-03-19 | 2008-09-25 | Globeimmune, Inc. | Compositions and methods for targeted ablation of mutational escape of targeted therapies for cancer |
| WO2010065626A1 (en) | 2008-12-02 | 2010-06-10 | Globeimmune, Inc. | Genotyping tools, methods and kits |
| ITTO20080964A1 (it) * | 2008-12-22 | 2010-06-23 | Natimab Therapeutics S R L | Anticorpo monoclonale anti-hcv come medicamento per il trattamento terapeutico e la prevenzione di infezioni da hcv |
| BR112012002628B1 (pt) * | 2009-08-07 | 2021-09-08 | Transgene Sa | Composição imunogênica, molécula de ácido nucleico, vetor, partícula viral infecciosa, micro-organismo transgênico, composição, usos da composição imunogênica e kit de partes |
| AU2010291985B2 (en) * | 2009-09-14 | 2016-05-05 | The Regents Of The University Of Colorado | Modulation of yeast-based immunotherapy products and responses |
| WO2011115914A1 (en) | 2010-03-14 | 2011-09-22 | Globeimmune, Inc. | Pharmacogenomic and response-guided treatment of infectious disease using yeast-based immunotherapy |
| WO2012019127A2 (en) | 2010-08-05 | 2012-02-09 | The Regents Of The University Of Colorado | Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases |
| EP2651439B1 (en) | 2010-12-17 | 2018-09-19 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| JP5745102B2 (ja) | 2011-02-12 | 2015-07-08 | グローブイミューン，インコーポレイテッド | 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物 |
| SG193396A1 (en) | 2011-03-17 | 2013-10-30 | Globeimmune Inc | Yeast-brachyury immunotherapeutic compositions |
| WO2012174220A1 (en) | 2011-06-14 | 2012-12-20 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| RU2642300C2 (ru) | 2011-08-17 | 2018-01-24 | Глоубиммьюн, Инк. | Иммунотерапевтические композиции на основе дрожжей-muc1 и способы их применения |
-
2012
- 2012-06-14 WO PCT/US2012/042426 patent/WO2012174220A1/en not_active Ceased
- 2012-06-14 EA EA201490015A patent/EA030381B1/ru not_active IP Right Cessation
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-
2013
- 2013-12-10 IL IL229902A patent/IL229902B/en active IP Right Grant
-
2017
- 2017-01-17 US US15/408,087 patent/US9987352B2/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998028004A1 (en) * | 1996-12-24 | 1998-07-02 | The Crown In The Right Of The Queensland Department Of Health (Sir Albert Sakzewski Virus Research Centre) | Hepatitis delta particle containing a fusion protein immunogen |
| WO2010033841A1 (en) * | 2008-09-19 | 2010-03-25 | Globeimmune, Inc. | Immunotherapy for chronic hepatitis c virus infection |
| WO2010121180A1 (en) * | 2009-04-17 | 2010-10-21 | Globeimmune, Inc. | Combination immunotherapy compositions against cancer and methods |
Non-Patent Citations (1)
| Title |
|---|
| HUANG, Y.-H. et al.: "Varied Immunity Generated in Mice by DNA Vaccines with Large and Small Hepatitis Delta Antigens". Journal of Virology. 2003. 77(24): 12980-12985, page 12981 * |
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| EP2720716A1 (en) | 2014-04-23 |
| CN103732250A (zh) | 2014-04-16 |
| US9987352B2 (en) | 2018-06-05 |
| US20140193362A1 (en) | 2014-07-10 |
| EP2720716A4 (en) | 2015-03-11 |
| EA201490015A1 (ru) | 2014-12-30 |
| AU2012271625B2 (en) | 2017-05-18 |
| IL229902B (en) | 2019-07-31 |
| ES2671381T3 (es) | 2018-06-06 |
| SG10201605265TA (en) | 2016-08-30 |
| AU2012271625A1 (en) | 2014-01-30 |
| CA2838950C (en) | 2020-10-27 |
| EP2720716B1 (en) | 2018-03-21 |
| BR112013032381B1 (pt) | 2021-01-12 |
| WO2012174220A1 (en) | 2012-12-20 |
| US9579377B2 (en) | 2017-02-28 |
| SG195383A1 (en) | 2013-12-30 |
| HK1197026A1 (en) | 2015-01-02 |
| US20170182153A1 (en) | 2017-06-29 |
| JP2014523878A (ja) | 2014-09-18 |
| CA2838950A1 (en) | 2012-12-20 |
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