JP2015096557A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015096557A5 JP2015096557A5 JP2015025534A JP2015025534A JP2015096557A5 JP 2015096557 A5 JP2015096557 A5 JP 2015096557A5 JP 2015025534 A JP2015025534 A JP 2015025534A JP 2015025534 A JP2015025534 A JP 2015025534A JP 2015096557 A5 JP2015096557 A5 JP 2015096557A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- hbv
- seq
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161442204P | 2011-02-12 | 2011-02-12 | |
| US61/442,204 | 2011-02-12 | ||
| US201161496945P | 2011-06-14 | 2011-06-14 | |
| US61/496,945 | 2011-06-14 | ||
| US201161507361P | 2011-07-13 | 2011-07-13 | |
| US61/507,361 | 2011-07-13 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553534A Division JP5745102B2 (ja) | 2011-02-12 | 2012-02-09 | 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016068623A Division JP6109989B2 (ja) | 2011-02-12 | 2016-03-30 | 慢性ｂ型肝炎感染症のための酵母系治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015096557A JP2015096557A (ja) | 2015-05-21 |
| JP2015096557A5 true JP2015096557A5 (enExample) | 2016-01-21 |
| JP5911983B2 JP5911983B2 (ja) | 2016-04-27 |
Family
ID=46638950
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553534A Active JP5745102B2 (ja) | 2011-02-12 | 2012-02-09 | 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物 |
| JP2015025534A Active JP5911983B2 (ja) | 2011-02-12 | 2015-02-12 | 慢性ｂ型肝炎感染症のための酵母系治療薬 |
| JP2016068623A Active JP6109989B2 (ja) | 2011-02-12 | 2016-03-30 | 慢性ｂ型肝炎感染症のための酵母系治療薬 |
| JP2017043689A Pending JP2017105834A (ja) | 2011-02-12 | 2017-03-08 | 慢性ｂ型肝炎感染症のための酵母系治療薬 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553534A Active JP5745102B2 (ja) | 2011-02-12 | 2012-02-09 | 慢性ｂ型肝炎感染症のための酵母系免疫療法組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016068623A Active JP6109989B2 (ja) | 2011-02-12 | 2016-03-30 | 慢性ｂ型肝炎感染症のための酵母系治療薬 |
| JP2017043689A Pending JP2017105834A (ja) | 2011-02-12 | 2017-03-08 | 慢性ｂ型肝炎感染症のための酵母系治療薬 |
Country Status (25)
| Country | Link |
|---|---|
| US (7) | US8877205B2 (enExample) |
| EP (2) | EP3266464A3 (enExample) |
| JP (4) | JP5745102B2 (enExample) |
| KR (1) | KR102026840B1 (enExample) |
| CN (1) | CN103476426B (enExample) |
| AP (1) | AP2013007110A0 (enExample) |
| AU (2) | AU2012214394B2 (enExample) |
| BR (1) | BR112013020425A2 (enExample) |
| CA (1) | CA2827150C (enExample) |
| CL (1) | CL2013002334A1 (enExample) |
| CO (1) | CO6791572A2 (enExample) |
| CR (1) | CR20130424A (enExample) |
| EA (1) | EA028659B1 (enExample) |
| EC (1) | ECSP13012862A (enExample) |
| ES (1) | ES2643389T3 (enExample) |
| HK (1) | HK1248120A1 (enExample) |
| IL (1) | IL227900B (enExample) |
| MA (1) | MA34956B1 (enExample) |
| PE (1) | PE20140844A1 (enExample) |
| PH (1) | PH12013501683A1 (enExample) |
| SG (1) | SG192285A1 (enExample) |
| TW (1) | TWI504608B (enExample) |
| UA (1) | UA112859C2 (enExample) |
| WO (1) | WO2012109404A1 (enExample) |
| ZA (1) | ZA201306481B (enExample) |
Families Citing this family (92)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012083302A2 (en) | 2010-12-17 | 2012-06-21 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| US9238679B2 (en) * | 2011-02-11 | 2016-01-19 | The Trustees Of The University Of Pennslyvania | Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same |
| AU2012214141B2 (en) | 2011-02-11 | 2016-01-28 | The Trustees Of The University Of Pennsylvania | Nucleic acid molecule encoding hepatitis B virus core protein and vaccine comprising the same |
| CN103476426B (zh) * | 2011-02-12 | 2021-08-10 | 全球免疫股份有限公司 | 用于慢性乙型肝炎病毒感染的基于酵母的治疗剂 |
| HUE033491T2 (en) | 2011-03-17 | 2017-12-28 | Globeimmune Inc | Yeast-brachyury immunotherapeutic compositions |
| US9579377B2 (en) | 2011-06-14 | 2017-02-28 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| KR102049928B1 (ko) | 2011-08-17 | 2019-11-28 | 글로브이뮨 | 효모-muc1 면역요법 조성물 및 그 용도 |
| US9653272B2 (en) | 2012-06-26 | 2017-05-16 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| EP2917231B1 (en) | 2012-11-12 | 2019-03-06 | Ruprecht-Karls-Universität Heidelberg | Lipopeptides for use in treating liver diseases and cardiovascular diseases |
| US10507235B2 (en) | 2013-03-19 | 2019-12-17 | Globeimmune, Inc. | Yeast-based immunotherapy for Chordoma |
| US9782473B2 (en) | 2013-03-26 | 2017-10-10 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human immunodeficiency virus infection |
| TWI654200B (zh) | 2013-08-30 | 2019-03-21 | 環球免疫公司 | 治療或預防結核病的組合物及方法 |
| CN106456677B (zh) * | 2014-04-11 | 2025-06-03 | 全球免疫股份有限公司 | 基于酵母的免疫疗法和i型干扰素敏感性 |
| CN107001429B (zh) * | 2014-11-28 | 2022-01-04 | 赛特瑞恩股份有限公司 | 乙型肝炎病毒表面抗原的表位及与其特异性结合以中和乙型肝炎病毒的结合分子 |
| KR20170102002A (ko) | 2015-01-09 | 2017-09-06 | 이투빅스 코포레이션 | 에볼라 바이러스 백신접종을 위한 방법 및 조성물 |
| EP3722297A1 (en) | 2015-03-04 | 2020-10-14 | Gilead Sciences, Inc. | Toll-like receptor modulating 4,6-diamino-pyrido[3,2-d]pyrimidine compounds |
| AU2016303525B2 (en) | 2015-08-03 | 2021-01-21 | Globeimmune, Inc. | Modified yeast-Brachyury immunotherapeutic compositions |
| CA2995004A1 (en) | 2015-08-26 | 2017-03-02 | Gilead Sciences, Inc. | Deuterated toll-like receptor modulators |
| SG11201803474UA (en) * | 2015-11-04 | 2018-05-30 | Hookipa Biotech Ag | Vaccines against hepatitis b virus |
| ES2834698T3 (es) * | 2016-01-12 | 2021-06-18 | Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh | Medios y métodos para tratar el HBV |
| BR102017010009A2 (pt) | 2016-05-27 | 2017-12-12 | Gilead Sciences, Inc. | Compounds for the treatment of hepatitis b virus infection |
| EP3276006A1 (en) * | 2016-07-27 | 2018-01-31 | Theravectys | Lentiviral vectors for expression of hepatitis b virus (hbv) antigens |
| US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| ES2906581T3 (es) | 2016-09-02 | 2022-04-19 | Gilead Sciences Inc | Compuestos moduladores de los receptores tipo Toll |
| CN106421774B (zh) * | 2016-09-08 | 2019-05-28 | 中国科学院生物物理研究所 | PreS1用于制备乙肝疫苗以及治疗慢性乙型肝炎的用途 |
| BR112019007450A2 (pt) | 2016-10-14 | 2020-07-07 | Precision Biosciences, Inc. | meganucleases modificadas específicas para sequências de reconhecimento no genoma do vírus da hepatite b |
| TWI714820B (zh) | 2017-01-31 | 2021-01-01 | 美商基利科學股份有限公司 | 替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型 |
| JOP20180008A1 (ar) | 2017-02-02 | 2019-01-30 | Gilead Sciences Inc | مركبات لعلاج إصابة بعدوى فيروس الالتهاب الكبدي b |
| GB201705765D0 (en) * | 2017-04-10 | 2017-05-24 | Univ Oxford Innovation Ltd | HBV vaccine |
| JOP20180040A1 (ar) | 2017-04-20 | 2019-01-30 | Gilead Sciences Inc | مثبطات pd-1/pd-l1 |
| EP3607968A4 (en) * | 2017-06-05 | 2021-03-31 | Beacle Inc. | VIRAL-TYPE PARTICLES INTENDED FOR USE TO INDUCE AN IMMUNE RESPONSE AGAINST HBV |
| AU2018319538B9 (en) | 2017-08-22 | 2021-05-27 | Gilead Sciences, Inc. | Therapeutic heterocyclic compounds |
| US11389531B2 (en) | 2017-12-19 | 2022-07-19 | Janssen Sciences Ireland Unlimited Company | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
| EA202091513A1 (ru) | 2017-12-19 | 2020-09-09 | Янссен Сайенсиз Айрлэнд Анлимитед Компани | Вакцины против вируса гепатита b (hbv) и их применение |
| AU2018390825A1 (en) * | 2017-12-19 | 2020-06-18 | Ichor Medical Systems, Inc. | Methods and apparatus for the delivery of hepatitis B virus (HBV) vaccines |
| KR20200101416A (ko) * | 2017-12-19 | 2020-08-27 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | B형 간염 바이러스(hbv) 백신 및 그 용도 |
| US11020476B2 (en) | 2017-12-19 | 2021-06-01 | Janssen Sciences Ireland Unlimited Company | Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV) |
| EP3728282B1 (en) | 2017-12-20 | 2023-11-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3' cyclic dinucleotides with phosphonate bond activating the sting adaptor protein |
| CN111566120B (zh) | 2017-12-20 | 2023-09-29 | 捷克共和国有机化学与生物化学研究所 | 活化sting转接蛋白的具有膦酸酯键的3’3’环状二核苷酸 |
| CN111712494A (zh) | 2018-02-13 | 2020-09-25 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| CA3091142C (en) | 2018-02-26 | 2023-04-11 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| KR20250136930A (ko) | 2018-03-06 | 2025-09-16 | 프레시전 인코포레이티드 | 사람 파필로마바이러스 백신 및 이의 용도 |
| JP2021514666A (ja) | 2018-03-06 | 2021-06-17 | プレシゲン，インコーポレイテッド | Ｂ型肝炎ワクチンおよびその使用 |
| WO2019195181A1 (en) | 2018-04-05 | 2019-10-10 | Gilead Sciences, Inc. | Antibodies and fragments thereof that bind hepatitis b virus protein x |
| TWI833744B (zh) | 2018-04-06 | 2024-03-01 | 捷克科學院有機化學與生物化學研究所 | 3'3'-環二核苷酸 |
| TW202005654A (zh) | 2018-04-06 | 2020-02-01 | 捷克科學院有機化學與生物化學研究所 | ２，２，─環二核苷酸 |
| TWI818007B (zh) | 2018-04-06 | 2023-10-11 | 捷克科學院有機化學與生物化學研究所 | 2'3'-環二核苷酸 |
| US11142750B2 (en) | 2018-04-12 | 2021-10-12 | Precision Biosciences, Inc. | Optimized engineered meganucleases having specificity for a recognition sequence in the Hepatitis B virus genome |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2019211799A1 (en) | 2018-05-03 | 2019-11-07 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 2'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide |
| CN112543640B (zh) | 2018-05-15 | 2025-02-14 | 全球免疫公司 | 用于诱导细胞免疫应答的重组酵母裂解物 |
| CN112384283B (zh) | 2018-07-06 | 2023-08-15 | 吉利德科学公司 | 治疗性的杂环化合物 |
| KR102651420B1 (ko) | 2018-07-06 | 2024-03-28 | 길리애드 사이언시즈, 인코포레이티드 | 치료 헤테로시클릭 화합물 |
| KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2020028097A1 (en) | 2018-08-01 | 2020-02-06 | Gilead Sciences, Inc. | Solid forms of (r)-11-(methoxymethyl)-12-(3-methoxypropoxy)-3,3-dimethyl-8-0x0-2,3,8,13b-tetrahydro-1h-pyrido[2,1-a]pyrrolo[1,2-c] phthalazine-7-c arboxylic acid |
| AU2019366355B2 (en) | 2018-10-24 | 2022-10-13 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| CN117105933A (zh) | 2018-10-31 | 2023-11-24 | 吉利德科学公司 | 具有hpk1抑制活性的取代的6-氮杂苯并咪唑化合物 |
| CN113227089B (zh) | 2018-10-31 | 2024-07-05 | 吉利德科学公司 | 作为hpk1抑制剂的取代的6-氮杂苯并咪唑化合物 |
| EP3934757B1 (en) | 2019-03-07 | 2023-02-22 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 2'3'-cyclic dinucleotides and prodrugs thereof |
| US20220143061A1 (en) | 2019-03-07 | 2022-05-12 | Institute Of Organic Chemistry And Biochemistry Ascr, V.V.I. | 3'3'-cyclic dinucleotides and prodrugs thereof |
| EP3935065A1 (en) | 2019-03-07 | 2022-01-12 | Institute of Organic Chemistry and Biochemistry ASCR, V.V.I. | 3'3'-cyclic dinucleotide analogue comprising a cyclopentanyl modified nucleotide as sting modulator |
| TWI751517B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| TWI751516B (zh) | 2019-04-17 | 2022-01-01 | 美商基利科學股份有限公司 | 類鐸受體調節劑之固體形式 |
| EP3972695A1 (en) | 2019-05-23 | 2022-03-30 | Gilead Sciences, Inc. | Substituted exo-methylene-oxindoles which are hpk1/map4k1 inhibitors |
| WO2020254876A1 (en) * | 2019-06-18 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Virus-like particle delivery of hepatitis b virus (hbv) vaccines |
| CA3140708A1 (en) | 2019-06-18 | 2020-12-24 | Helen Horton | Combination of hepatitis b virus (hbv) vaccines and pyridopyrimidine derivatives |
| JP7295283B2 (ja) | 2019-06-25 | 2023-06-20 | ギリアード サイエンシーズ， インコーポレイテッド | Ｆｌｔ３ｌ－ｆｃ融合タンパク質及び使用方法 |
| WO2021011891A1 (en) | 2019-07-18 | 2021-01-21 | Gilead Sciences, Inc. | Long-acting formulations of tenofovir alafenamide |
| EP4017476A1 (en) | 2019-08-19 | 2022-06-29 | Gilead Sciences, Inc. | Pharmaceutical formulations of tenofovir alafenamide |
| EP4021923A1 (en) | 2019-08-29 | 2022-07-06 | VIR Biotechnology, Inc. | Hepatitis b virus vaccines |
| CN114514427A (zh) * | 2019-09-27 | 2022-05-17 | 富士瑞必欧株式会社 | 乙型肝炎病毒核心相关抗原的免疫测定和用于其的试剂盒 |
| HRP20241379T1 (hr) | 2019-09-30 | 2024-12-20 | Gilead Sciences, Inc. | Cjepiva za hbv i postupci za liječenje hbv |
| ES3022990T3 (en) | 2019-12-06 | 2025-05-29 | Prec Biosciences Inc | Optimized engineered meganucleases having specificity for a recognition sequence in the hepatitis b virus genome |
| MX2022008572A (es) | 2020-01-09 | 2022-09-23 | Virion Therapeutics Llc | Vectores adenoviricos que codifican antigenos viricos de la hepatitis b fusionados con la glucoproteina d del virus del herpes y metodos de uso de los mismos. |
| US12285480B2 (en) | 2020-03-11 | 2025-04-29 | Nantcell, Inc. | Method of inducing immunity against SARS-CoV-2 using spike and nucleocapsid-ETSD immunogens delivered by RNA and replication-defective adenoviruses |
| US11857620B2 (en) | 2020-03-11 | 2024-01-02 | Immunitybio, Inc. | Method of inducing immunity against SARS-CoV-2 using spike (s) and nucleocapsid (N)-ETSD immunogens delivered by a replication-defective adenovirus |
| US20210284716A1 (en) | 2020-03-11 | 2021-09-16 | Immunitybio, Inc. | ACE2-Fc Trap |
| TWI845826B (zh) | 2020-03-20 | 2024-06-21 | 美商基利科學股份有限公司 | 4'-c-經取代-2-鹵基-2'-去氧腺苷核苷之前藥及其製造與使用方法 |
| WO2022006146A1 (en) * | 2020-06-29 | 2022-01-06 | The Trustees Of Columbia University In The City Of New York | Yeast-based vaccines |
| MX2023001507A (es) | 2020-08-07 | 2023-03-06 | Gilead Sciences Inc | Profarmacos de analogos de nucleotidos de fosfonamida y su uso farmaceutico. |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| TW202348237A (zh) | 2021-05-13 | 2023-12-16 | 美商基利科學股份有限公司 | TLR8調節化合物及抗HBV siRNA療法之組合 |
| CN117480155A (zh) | 2021-06-23 | 2024-01-30 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| JP7686091B2 (ja) | 2021-06-23 | 2025-05-30 | ギリアード サイエンシーズ， インコーポレイテッド | ジアシルグリセロールキナーゼ調節化合物 |
| CN117377671A (zh) | 2021-06-23 | 2024-01-09 | 吉利德科学公司 | 二酰基甘油激酶调节化合物 |
| EP4359415A1 (en) | 2021-06-23 | 2024-05-01 | Gilead Sciences, Inc. | Diacylglyercol kinase modulating compounds |
| WO2023085956A1 (en) * | 2021-11-09 | 2023-05-19 | Avalia Immunotherapies Limited | Novel therapeutic vaccines |
| WO2024220982A1 (en) * | 2023-04-21 | 2024-10-24 | The Wistar Institute Of Anatomy And Biology | Compositions comprising aptamers and methods of modulating the immune response using the same |
| US20250345389A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| US20250345390A1 (en) | 2024-05-13 | 2025-11-13 | Gilead Sciences, Inc. | Combination therapies |
| WO2025240246A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
| WO2025240242A1 (en) | 2024-05-13 | 2025-11-20 | Gilead Sciences, Inc. | Combination therapies with ribavirin |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2486400B1 (fr) | 1980-07-09 | 1986-05-30 | Univablot | Medicaments a base de levures ou de leurs extraits insolubles |
| NZ199722A (en) | 1981-02-25 | 1985-12-13 | Genentech Inc | Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain |
| US4775622A (en) | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| US5310654A (en) | 1985-07-31 | 1994-05-10 | The Board Of Trustees Of The Leland Stanford Junior University | Method for determining virulence of Yersinia |
| US5164485A (en) * | 1985-08-20 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Modified hepatitis B virus surface antigen P31 and production thereof |
| US5234830A (en) | 1988-02-03 | 1993-08-10 | Suntory Limited | DNA encoding a KEX2 endoprotease without a C-terminal hydrophobic region |
| US6306625B1 (en) * | 1988-12-30 | 2001-10-23 | Smithkline Beecham Biologicals, Sa | Method for obtaining expression of mixed polypeptide particles in yeast |
| IL95019A0 (en) | 1989-08-09 | 1991-06-10 | Mycogen Corp | Process for encapsulation of biologicals |
| US6607727B1 (en) | 1991-08-26 | 2003-08-19 | The Scripps Research Institute | Peptides for inducing cytotoxic T lymphocyte responses to hepatitus B virus |
| AU5679394A (en) * | 1992-11-25 | 1994-06-22 | International Biotechnology Laboratories, Inc. | Hepatitis b virus vaccines |
| US5830463A (en) | 1993-07-07 | 1998-11-03 | University Technology Corporation | Yeast-based delivery vehicles |
| US5413914A (en) | 1993-07-07 | 1995-05-09 | The Regents Of The University Of Colorado | Yeast assay to identify inhibitors of dibasic amino acid processing endoproteases |
| US5858378A (en) | 1996-05-02 | 1999-01-12 | Galagen, Inc. | Pharmaceutical composition comprising cryptosporidium parvum oocysts antigen and whole cell candida species antigen |
| JP3713900B2 (ja) | 1996-07-19 | 2005-11-09 | ソニー株式会社 | 負極材料及びこれを用いた非水電解液二次電池 |
| CA2320488C (en) * | 1998-02-12 | 2007-03-06 | Immune Complex, Corporation | Strategically modified hepatitis b core proteins and their derivatives |
| AU2358201A (en) * | 1999-12-03 | 2001-06-12 | Innogenetics N.V. | New hbv sequences |
| GB0216074D0 (en) * | 2002-07-11 | 2002-08-21 | Weatherford Lamb | Improving collapse resistance of tubing |
| US20020044948A1 (en) | 2000-03-15 | 2002-04-18 | Samir Khleif | Methods and compositions for co-stimulation of immunological responses to peptide antigens |
| EP1272213B1 (en) | 2000-04-06 | 2006-03-08 | SEER Pharmaceuticals, LLC. | Microbial delivery system |
| US7083787B2 (en) | 2000-11-15 | 2006-08-01 | Globeimmune, Inc. | Yeast-dendritic cell vaccines and uses thereof |
| CN1171636C (zh) * | 2001-06-06 | 2004-10-20 | 中国人民解放军第二军医大学 | 一种乙型肝炎dna疫苗 |
| US8029803B2 (en) * | 2002-06-20 | 2011-10-04 | Paladin Labs, Inc. | Chimeric antigens for eliciting an immune response |
| US8343502B2 (en) | 2002-12-16 | 2013-01-01 | Globeimmune, Inc. | Yeast-based vaccines as immunotherapy |
| US7439042B2 (en) | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| CN104147597A (zh) | 2002-12-16 | 2014-11-19 | 全球免疫股份有限公司 | 用于免疫治疗的基于酵母的疫苗 |
| CA2520768A1 (en) * | 2003-03-28 | 2005-02-10 | Idm Pharma, Inc. | Methods of identifying optimal variants of peptide epitopes |
| DE10339927A1 (de) * | 2003-08-29 | 2005-03-24 | Rhein Biotech Gesellschaft für neue Biotechnologische Prozesse und Produkte mbH | Zusammensetzung zur Prophylaxe/Therapie von HBV-Infektionen und HBV-vermittelten Erkrankungen |
| AU2005295317B2 (en) | 2004-10-18 | 2011-10-13 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| BRPI0613025A2 (pt) | 2005-07-11 | 2010-12-14 | Globeimmune Inc | composiÇço para reduzir a resistÊncia a um agente, mÉtodo para a preparaÇço de um veÍculo de levedura e uso da composiÇço |
| US20070172503A1 (en) | 2005-12-13 | 2007-07-26 | Mycologics,Inc. | Compositions and Methods to Elicit Immune Responses Against Pathogenic Organisms Using Yeast Based Vaccines |
| JP5198290B2 (ja) | 2006-02-02 | 2013-05-15 | グローブイミューン，インコーポレイテッド | 免疫反応を誘発する酵母ベースワクチン |
| KR20090008290A (ko) | 2006-03-27 | 2009-01-21 | 글로브이뮨 | Ｒａｓ 돌연변이와 그에 관련된 조성물 및 방법 |
| KR100836745B1 (ko) * | 2007-01-31 | 2008-06-10 | (주)두비엘 | Ｈｂｖ 백신 및 그의 제조 방법 |
| KR20150006022A (ko) | 2007-02-02 | 2015-01-15 | 글로브이뮨 | 효모계 백신의 제조방법 |
| CN101036784B (zh) * | 2007-03-09 | 2010-11-10 | 中国人民解放军第二军医大学 | 一种乙型肝炎治疗性细胞毒性t细胞表位疫苗及其制备方法 |
| JP5579451B2 (ja) | 2007-03-19 | 2014-08-27 | グローブイミューン，インコーポレイテッド | ガンのための標的化治療の変異性回避の標的化アブレーションのための組成物 |
| EP2331125A4 (en) | 2008-09-19 | 2013-03-27 | Globeimmune Inc | IMMUNOTHERAPY FOR CHRONIC HEPATITIS C-VIRUS INFECTIONS |
| WO2010065626A1 (en) | 2008-12-02 | 2010-06-10 | Globeimmune, Inc. | Genotyping tools, methods and kits |
| KR101781966B1 (ko) | 2009-04-17 | 2017-09-27 | 글로브이뮨 | 암에 대한 병용 면역요법 조성물 및 방법 |
| AU2010291985B2 (en) | 2009-09-14 | 2016-05-05 | The Regents Of The University Of Colorado | Modulation of yeast-based immunotherapy products and responses |
| WO2011115914A1 (en) | 2010-03-14 | 2011-09-22 | Globeimmune, Inc. | Pharmacogenomic and response-guided treatment of infectious disease using yeast-based immunotherapy |
| WO2012019127A2 (en) | 2010-08-05 | 2012-02-09 | The Regents Of The University Of Colorado | Combination yeast-based immunotherapy and arginine therapy for the treatment of myeloid-derived supressor cell-associated diseases |
| WO2012083302A2 (en) | 2010-12-17 | 2012-06-21 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| CN103476426B (zh) | 2011-02-12 | 2021-08-10 | 全球免疫股份有限公司 | 用于慢性乙型肝炎病毒感染的基于酵母的治疗剂 |
| HUE033491T2 (en) | 2011-03-17 | 2017-12-28 | Globeimmune Inc | Yeast-brachyury immunotherapeutic compositions |
| US9579377B2 (en) | 2011-06-14 | 2017-02-28 | Globeimmune, Inc. | Yeast-based compositions and methods for the treatment or prevention of hepatitis delta virus infection |
| KR102049928B1 (ko) | 2011-08-17 | 2019-11-28 | 글로브이뮨 | 효모-muc1 면역요법 조성물 및 그 용도 |
-
2012
- 2012-02-09 CN CN201280018222.5A patent/CN103476426B/zh active Active
- 2012-02-09 JP JP2013553534A patent/JP5745102B2/ja active Active
- 2012-02-09 PE PE2013001865A patent/PE20140844A1/es not_active Application Discontinuation
- 2012-02-09 PH PH1/2013/501683A patent/PH12013501683A1/en unknown
- 2012-02-09 ES ES12744328.1T patent/ES2643389T3/es active Active
- 2012-02-09 AU AU2012214394A patent/AU2012214394B2/en active Active
- 2012-02-09 SG SG2013060777A patent/SG192285A1/en unknown
- 2012-02-09 WO PCT/US2012/024409 patent/WO2012109404A1/en not_active Ceased
- 2012-02-09 MA MA36222A patent/MA34956B1/fr unknown
- 2012-02-09 AP AP2013007110A patent/AP2013007110A0/xx unknown
- 2012-02-09 EP EP17175311.4A patent/EP3266464A3/en not_active Withdrawn
- 2012-02-09 US US13/984,888 patent/US8877205B2/en active Active
- 2012-02-09 EP EP12744328.1A patent/EP2672991B1/en active Active
- 2012-02-09 KR KR1020137024018A patent/KR102026840B1/ko active Active
- 2012-02-09 CA CA2827150A patent/CA2827150C/en active Active
- 2012-02-09 EA EA201391170A patent/EA028659B1/ru not_active IP Right Cessation
- 2012-02-09 BR BR112013020425A patent/BR112013020425A2/pt not_active IP Right Cessation
- 2012-02-10 TW TW101104436A patent/TWI504608B/zh active
- 2012-09-02 UA UAA201310911A patent/UA112859C2/uk unknown
-
2013
- 2013-03-13 US US13/798,837 patent/US8722054B2/en active Active
- 2013-08-12 CL CL2013002334A patent/CL2013002334A1/es unknown
- 2013-08-28 ZA ZA2013/06481A patent/ZA201306481B/en unknown
- 2013-08-30 EC ECSP13012862 patent/ECSP13012862A/es unknown
- 2013-08-31 CR CR20130424A patent/CR20130424A/es unknown
- 2013-09-12 CO CO13216900A patent/CO6791572A2/es unknown
- 2013-09-29 IL IL227900A patent/IL227900B/en active IP Right Grant
-
2014
- 2014-02-19 US US14/184,481 patent/US8961988B2/en active Active
- 2014-09-23 US US14/494,235 patent/US9290547B2/en active Active
-
2015
- 2015-01-07 US US14/591,592 patent/US9428556B2/en active Active
- 2015-02-12 JP JP2015025534A patent/JP5911983B2/ja active Active
-
2016
- 2016-03-30 JP JP2016068623A patent/JP6109989B2/ja active Active
- 2016-07-18 US US15/212,930 patent/US9943591B2/en active Active
- 2016-11-10 AU AU2016256751A patent/AU2016256751B2/en active Active
-
2017
- 2017-03-08 JP JP2017043689A patent/JP2017105834A/ja active Pending
-
2018
- 2018-03-01 US US15/909,112 patent/US10441650B2/en active Active
- 2018-06-13 HK HK18107680.0A patent/HK1248120A1/en unknown