JP2018064580A5 - - Google Patents
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- JP2018064580A5 JP2018064580A5 JP2017239124A JP2017239124A JP2018064580A5 JP 2018064580 A5 JP2018064580 A5 JP 2018064580A5 JP 2017239124 A JP2017239124 A JP 2017239124A JP 2017239124 A JP2017239124 A JP 2017239124A JP 2018064580 A5 JP2018064580 A5 JP 2018064580A5
- Authority
- JP
- Japan
- Prior art keywords
- subtype
- seq
- amino acid
- acid sequence
- polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 241000712461 unidentified influenza virus Species 0.000 claims 55
- 125000003275 alpha amino acid group Chemical group 0.000 claims 54
- 101710154606 Hemagglutinin Proteins 0.000 claims 48
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 48
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 48
- 101710176177 Protein A56 Proteins 0.000 claims 48
- 239000000185 hemagglutinin Substances 0.000 claims 47
- 229920001184 polypeptide Polymers 0.000 claims 44
- 102000004196 processed proteins & peptides Human genes 0.000 claims 44
- 108090000765 processed proteins & peptides Proteins 0.000 claims 43
- 239000000203 mixture Substances 0.000 claims 26
- 239000012634 fragment Substances 0.000 claims 13
- 238000000034 method Methods 0.000 claims 11
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 230000002238 attenuated effect Effects 0.000 claims 10
- 230000002163 immunogen Effects 0.000 claims 10
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 6
- 241000712431 Influenza A virus Species 0.000 claims 5
- 238000001415 gene therapy Methods 0.000 claims 4
- 210000004408 hybridoma Anatomy 0.000 claims 4
- 241000700605 Viruses Species 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000036039 immunity Effects 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 241000700199 Cavia porcellus Species 0.000 claims 1
- 241000282693 Cercopithecidae Species 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241000282577 Pan troglodytes Species 0.000 claims 1
- 241000845082 Panama Species 0.000 claims 1
- 241000700159 Rattus Species 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18126309P | 2009-05-26 | 2009-05-26 | |
| US61/181,263 | 2009-05-26 | ||
| US22430209P | 2009-07-09 | 2009-07-09 | |
| US61/224,302 | 2009-07-09 | ||
| US30589810P | 2010-02-18 | 2010-02-18 | |
| US61/305,898 | 2010-02-18 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016014445A Division JP2016127846A (ja) | 2009-05-26 | 2016-01-28 | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018064580A JP2018064580A (ja) | 2018-04-26 |
| JP2018064580A5 true JP2018064580A5 (enExample) | 2018-08-30 |
Family
ID=42352512
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513195A Expired - Fee Related JP5941841B2 (ja) | 2009-05-26 | 2010-05-26 | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
| JP2016014445A Pending JP2016127846A (ja) | 2009-05-26 | 2016-01-28 | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
| JP2017239124A Pending JP2018064580A (ja) | 2009-05-26 | 2017-12-14 | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012513195A Expired - Fee Related JP5941841B2 (ja) | 2009-05-26 | 2010-05-26 | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
| JP2016014445A Pending JP2016127846A (ja) | 2009-05-26 | 2016-01-28 | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8673314B2 (enExample) |
| EP (1) | EP2435475B1 (enExample) |
| JP (3) | JP5941841B2 (enExample) |
| AU (1) | AU2010254136B2 (enExample) |
| CA (1) | CA2800182A1 (enExample) |
| WO (1) | WO2010138564A1 (enExample) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
| JP5941841B2 (ja) | 2009-05-26 | 2016-06-29 | アイカーン スクール オブ メディシン アット マウント サイナイ | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
| US9849192B2 (en) | 2009-11-18 | 2017-12-26 | Rutgers, The State University Of New Jersey | Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies |
| CA2818237C (en) | 2009-11-18 | 2021-05-18 | University Of Medicine And Dentistry Of New Jersey | Targeting tumor cells with chemotherapeutic agents conjugated to matriptase antibodies |
| AU2011217903B2 (en) * | 2010-02-18 | 2017-03-02 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
| CA2831974C (en) * | 2011-04-21 | 2021-04-06 | Baxter International Inc. | A method for isolating and quantifying antigens in the absence of detergents and alkylating agents |
| AR087364A1 (es) * | 2011-07-29 | 2014-03-19 | Pf Medicament | Anticuerpo anti-cxcr4 y su uso para la deteccion y dianostico de canceres |
| GB201115214D0 (en) * | 2011-09-02 | 2011-10-19 | Health Prot Agency | Influenza virus antibody compositions |
| WO2013043729A1 (en) | 2011-09-20 | 2013-03-28 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| WO2013081463A2 (en) | 2011-12-02 | 2013-06-06 | Aimm Therapeutics B.V. | Influenza a virus specific antibodies |
| EP2822968B1 (en) * | 2012-03-08 | 2018-01-10 | Janssen Vaccines & Prevention B.V. | Human binding molecules capable of binding to and neutralizing influenza b viruses and uses thereof |
| CN102621320B (zh) * | 2012-03-20 | 2014-07-02 | 中国检验检疫科学研究院 | 一种用于快速检测人禽流感病毒的非诊断性双抗体夹心法 |
| EP2904015A4 (en) * | 2012-10-02 | 2016-10-05 | Univ Rutgers | TARGETED RELEASE OF ANTIBODIES TO ACTIVATED MATRIPTASE-CONJUGATED TOXINS |
| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| CN105209071A (zh) | 2013-03-14 | 2015-12-30 | 抗非特公司 | 用于提高疗效的基于鼻内递送中和抗体的组合物和方法 |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| US9695245B2 (en) | 2013-03-15 | 2017-07-04 | Edimer Pharmaceuticals, Inc | Anti-ectodysplasin antibodies |
| WO2015025900A1 (ja) * | 2013-08-23 | 2015-02-26 | 学校法人藤田学園 | 抗インフルエンザウイルス中和抗体 |
| SG11201602522VA (en) * | 2013-10-02 | 2016-04-28 | Medimmune Llc | Neutralizing anti-influenza a antibodies and uses thereof |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| KR102344390B1 (ko) | 2014-02-04 | 2021-12-28 | 콘트라펙트 코포레이션 | 수동 인플루엔자 면역화에 유용한 항체, 및 이의 사용을 위한 조성물, 조합 및 방법 |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| WO2016118937A1 (en) | 2015-01-23 | 2016-07-28 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| JP2018518151A (ja) * | 2015-03-27 | 2018-07-12 | ユニバーシティ オブ サザン カリフォルニア | Ｂ７−ｈ４発現充実性腫瘍を処置するためのｃａｒ ｔ細胞 |
| AU2016243124A1 (en) | 2015-03-27 | 2017-11-02 | University Of Southern California | CAR T-cell therapy directed to LHR for the treatment of solid tumors |
| CN108778274A (zh) | 2016-03-18 | 2018-11-09 | 新泽西鲁特格斯州立大学 | 用通过可体内裂解的连接部分与抗蛋白裂解酶抗体缀合的化学治疗剂靶向肿瘤细胞 |
| US11185582B2 (en) | 2016-05-09 | 2021-11-30 | Icahn School Of Medicine At Mount Sinai | Broadly neutralizing anti-human cytomegalovirus (HCMV) antibodies and methods of use thereof |
| US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
| CA3078465A1 (en) * | 2017-08-23 | 2019-02-28 | Brown University | Methods and compositions relating to anti-chi3l1 antibody reagents |
| US10766968B2 (en) | 2017-08-23 | 2020-09-08 | Brown University | Methods and compositions relating to anti-CHI3L1 antibody reagents to treat cancer |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| EP4536709A2 (en) * | 2022-06-09 | 2025-04-16 | Santa Ana Bio, Inc. | Antibodies targeting c-kit and/or siglec and uses thereof |
Family Cites Families (65)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA836080B (en) | 1982-08-23 | 1984-04-25 | Scripps Clinic Res | Broad spectrum influenza antisera |
| US5182192A (en) * | 1987-03-27 | 1993-01-26 | The Wistar Institute | Monoclonal antibodies against glycolipid antigens, methods of producing these antibodies, and use therefor |
| US5413923A (en) | 1989-07-25 | 1995-05-09 | Cell Genesys, Inc. | Homologous recombination for universal donor cells and chimeric mammalian hosts |
| US5854037A (en) | 1989-08-28 | 1998-12-29 | The Mount Sinai School Of Medicine Of The City University Of New York | Recombinant negative strand RNA virus expression systems and vaccines |
| US6001634A (en) | 1989-08-28 | 1999-12-14 | Palese; Peter | Recombinant negative strand RNA viruses |
| US6887699B1 (en) | 1990-05-22 | 2005-05-03 | Medimmune Vaccines, Inc. | Recombinant negative strand RNA virus expression systems and vaccines |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| FR2664905B1 (fr) | 1990-07-18 | 1994-08-12 | Agronomique Inst Nat Rech | Baculovirus modifie, son procede d'obtention, et vecteurs d'expression obtenus a partir dudit baculovirus. |
| DE69127627T2 (de) | 1990-08-29 | 1998-02-19 | Genpharm Int | Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
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| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
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| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| JP3037554B2 (ja) | 1993-04-20 | 2000-04-24 | 寳酒造株式会社 | 免疫原性人工ポリペプチド |
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| WO1994016109A1 (en) | 1993-01-15 | 1994-07-21 | Whitehead Institute For Biomedical Research | Membrane fusion events and means for altering same |
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| WO2006104615A2 (en) | 2005-02-24 | 2006-10-05 | University Of Massachusetts | Influenza nucleic acids, polypeptides, and uses thereof |
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| JP4758148B2 (ja) * | 2005-06-14 | 2011-08-24 | 泰三 宇田 | インフルエンザウイルスのヘマグルチニンに対する抗体酵素 |
| PL1951299T3 (pl) | 2005-11-04 | 2012-07-31 | Novartis Ag | Szczepionki przeciw grypie zawierające kombinacje adiuwantów cząsteczkowych i czynników wzmacniających immunogenność |
| HUE037464T2 (hu) | 2005-12-02 | 2018-08-28 | Icahn School Med Mount Sinai | Nem-natív felületi fehérjéket prezentáló kiméra Newcastle disease vírusok és alkalmazásuk |
| US7914797B2 (en) | 2005-12-06 | 2011-03-29 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Influenza vaccine |
| US10183986B2 (en) | 2005-12-15 | 2019-01-22 | Industrial Technology Research Institute | Trimeric collagen scaffold antibodies |
| CA2652452C (en) * | 2006-05-15 | 2018-07-31 | Sea Lane Biotechnologies, Llc | Neutralizing antibodies to influenza viruses |
| US8148085B2 (en) * | 2006-05-15 | 2012-04-03 | Sea Lane Biotechnologies, Llc | Donor specific antibody libraries |
| US9511134B2 (en) * | 2006-05-18 | 2016-12-06 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
| BRPI0714495B8 (pt) | 2006-07-21 | 2021-05-25 | California Inst Of Techn | lentivírus deficiente para replicação recombinante pseudotipado |
| US8192927B2 (en) | 2006-09-07 | 2012-06-05 | Crucell Holland B.V. | Human bind molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| ES2536401T3 (es) | 2006-09-11 | 2015-05-25 | Novartis Ag | Fabricación de vacunas contra virus de la gripe sin usar huevos |
| US8603467B2 (en) | 2007-06-15 | 2013-12-10 | Xiamen University | Monoclonal antibodies binding to avian influenza virus subtype H5 haemagglutinin and uses thereof |
| EP2014279A1 (en) | 2007-06-22 | 2009-01-14 | Pevion Biotech AG | Virosomes comprising hemagglutinin derived from an influenza virus produced in a cell line, compositions, methods of manufacturing, use thereof |
| JP5187883B2 (ja) * | 2007-07-18 | 2013-04-24 | 独立行政法人科学技術振興機構 | 抗原ペプチドおよびその利用 |
| US20090092635A1 (en) | 2007-08-17 | 2009-04-09 | Wyeth | Heterologous prime-boost immunization regimen |
| FR2921387B1 (fr) | 2007-09-26 | 2012-04-20 | Sanofi Pasteur | Procede de production du virus de la grippe |
| GB0810305D0 (en) * | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| CN101970483A (zh) | 2007-12-06 | 2011-02-09 | 达纳-法伯癌症研究公司 | 抗流感病毒抗体及其使用方法 |
| CN102046656A (zh) | 2008-03-28 | 2011-05-04 | 航道生物技术有限责任公司 | 针对病毒抗原的中和性分子 |
| GB0905570D0 (en) | 2009-03-31 | 2009-05-13 | Novartis Ag | Combined vaccines |
| WO2010117786A1 (en) | 2009-03-30 | 2010-10-14 | Mount Sinai School Of Medicine Of New York University | Influenza virus vaccines and uses thereof |
| MY183517A (en) | 2009-05-11 | 2021-02-24 | Janssen Vaccines & Prevention Bv | Human binding molecules capable of neutralizing influenza virus h3n2 and uses thereof |
| JP5941841B2 (ja) | 2009-05-26 | 2016-06-29 | アイカーン スクール オブ メディシン アット マウント サイナイ | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
| EP3228627A1 (en) | 2009-06-24 | 2017-10-11 | Medicago Inc. | Chimeric influenza virus- like particles comprising hemagglutinin |
| US8828406B2 (en) | 2009-07-30 | 2014-09-09 | Icahn School Of Medicine At Mount Sinai | Influenza viruses and uses thereof |
| AU2011217903B2 (en) | 2010-02-18 | 2017-03-02 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
| WO2012009790A1 (en) | 2010-07-22 | 2012-01-26 | Schrader John W | Cross-protective pathogen protection, methods and compositions thereof |
| WO2013043729A1 (en) | 2011-09-20 | 2013-03-28 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
-
2010
- 2010-05-26 JP JP2012513195A patent/JP5941841B2/ja not_active Expired - Fee Related
- 2010-05-26 US US12/788,103 patent/US8673314B2/en active Active
- 2010-05-26 CA CA2800182A patent/CA2800182A1/en not_active Abandoned
- 2010-05-26 EP EP10720978.5A patent/EP2435475B1/en active Active
- 2010-05-26 WO PCT/US2010/036170 patent/WO2010138564A1/en not_active Ceased
- 2010-05-26 AU AU2010254136A patent/AU2010254136B2/en not_active Ceased
-
2014
- 2014-01-23 US US14/162,354 patent/US9175069B2/en active Active
-
2015
- 2015-04-29 US US14/699,273 patent/US20150239960A1/en not_active Abandoned
-
2016
- 2016-01-28 JP JP2016014445A patent/JP2016127846A/ja active Pending
-
2017
- 2017-12-14 JP JP2017239124A patent/JP2018064580A/ja active Pending
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