JP2014237714A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014237714A5 JP2014237714A5 JP2014174221A JP2014174221A JP2014237714A5 JP 2014237714 A5 JP2014237714 A5 JP 2014237714A5 JP 2014174221 A JP2014174221 A JP 2014174221A JP 2014174221 A JP2014174221 A JP 2014174221A JP 2014237714 A5 JP2014237714 A5 JP 2014237714A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- binding fragment
- antibody
- influenza
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 208000037797 influenza A Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8383808P | 2008-07-25 | 2008-07-25 | |
| US61/083,838 | 2008-07-25 | ||
| US18158209P | 2009-05-27 | 2009-05-27 | |
| US61/181,582 | 2009-05-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519252A Division JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014237714A JP2014237714A (ja) | 2014-12-18 |
| JP2014237714A5 true JP2014237714A5 (enExample) | 2015-05-14 |
| JP6022515B2 JP6022515B2 (ja) | 2016-11-09 |
Family
ID=41570664
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2011519253A Pending JP2011528902A (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2014174221A Active JP6022515B2 (ja) | 2008-07-25 | 2014-08-28 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011519252A Active JP5607620B2 (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
| JP2011519253A Pending JP2011528902A (ja) | 2008-07-25 | 2009-07-27 | 抗ａ型インフルエンザウイルス中和抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US8685402B2 (enExample) |
| EP (2) | EP2313433A2 (enExample) |
| JP (3) | JP5607620B2 (enExample) |
| KR (2) | KR20110049802A (enExample) |
| CN (2) | CN102216327A (enExample) |
| AU (2) | AU2009275226B2 (enExample) |
| BR (1) | BRPI0911699B8 (enExample) |
| CA (2) | CA2731686C (enExample) |
| CO (1) | CO6341572A2 (enExample) |
| CR (2) | CR20110079A (enExample) |
| EC (1) | ECSP11010823A (enExample) |
| ES (1) | ES2662519T3 (enExample) |
| GT (1) | GT201100023A (enExample) |
| IL (2) | IL210772A0 (enExample) |
| MA (1) | MA32577B1 (enExample) |
| MX (2) | MX2011000767A (enExample) |
| NZ (2) | NZ590891A (enExample) |
| RU (1) | RU2553325C2 (enExample) |
| WO (2) | WO2010010467A2 (enExample) |
| ZA (2) | ZA201101113B (enExample) |
Families Citing this family (78)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3524619A1 (en) | 2007-12-06 | 2019-08-14 | Dana-Farber Cancer Institute, Inc. | Antibodies against influenza virus and methods of use thereof |
| RU2553325C2 (ru) * | 2008-07-25 | 2015-06-10 | Институт Фо Ресёч Ин Биомедицин | Нейтрализующие антитела против вируса гриппа а и их использование |
| US8871207B2 (en) | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| EP2545074A4 (en) * | 2010-03-08 | 2014-01-08 | Celltrion Inc | HUMAN MONOCLONAL ANTIBODIES MADE FROM HUMAN B-CELLS WITH NEUTRALIZING EFFECT AGAINST INFLUENZA A-VIRUS |
| CN106397584A (zh) * | 2010-06-17 | 2017-02-15 | 特瑞利斯生物科学有限责任公司 | 可用于被动流感免疫的抗体 |
| US9534042B2 (en) * | 2010-09-03 | 2017-01-03 | Fujita Health University | Influenza virus-neutralizing antibody and screening method therefor |
| WO2012045001A2 (en) * | 2010-09-30 | 2012-04-05 | Vanderbilt University | Influenza virus antibodies and immunogens and uses therefor |
| WO2012145572A1 (en) | 2011-04-20 | 2012-10-26 | The Trustees Of The University Of Pennsylvania | Regimens and compositions for aav-mediated passive immunization of airborne pathogens |
| US8961978B2 (en) | 2011-07-14 | 2015-02-24 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses |
| CN107417789A (zh) * | 2011-07-18 | 2017-12-01 | 生物医学学会 | 中和抗甲型流感病毒抗体及其用途 |
| MX352338B (es) * | 2011-07-18 | 2017-11-17 | Inst Res Biomedicine | Anticuerpos neutralizantes del virus de la influenza a y usos de estos. |
| EP2739312B1 (en) * | 2011-08-03 | 2017-10-04 | Children's Medical Center Corporation | A broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza hemagglutinin |
| EP2748184A1 (en) | 2011-08-27 | 2014-07-02 | Universität Zürich | Multi-strain-reactive antibodies for therapy and diagnosis of influenza |
| EA026527B1 (ru) * | 2011-09-30 | 2017-04-28 | Селлтрион Инк. | Связующая молекула, обладающая нейтрализующей активностью в отношении вируса гриппа а, полученная из в-клеток человека |
| EP2768858B1 (en) * | 2011-10-18 | 2018-08-01 | Emory University | Antibodies directed against influenza |
| KR20130059721A (ko) * | 2011-11-29 | 2013-06-07 | (주)셀트리온 | 인간 ｂ 세포에서 생산된 인플루엔자 ａ 바이러스 중화 활성을 가지는 결합 분자 |
| SG11201402780UA (en) | 2011-12-02 | 2014-10-30 | Aimm Therapeutics Bv | Influenza a virus specific antibodies |
| CA2861515A1 (en) * | 2011-12-05 | 2013-06-13 | Trellis Bioscience, Llc | Antibodies useful in passive influenza immunization |
| ES2564138T3 (es) * | 2011-12-12 | 2016-03-18 | Novartis Ag | Ensayo para Hemaglutinina del virus de la influenza |
| KR101749316B1 (ko) | 2011-12-15 | 2017-06-21 | (주) 에이프로젠 | Ｈ１ｎ１―감염된 환자들로부터 유도된 매우 잠재력 있는 넓은-스펙트럼 중화 단일클론 항체 및 이를 포함하는 바이러스의 치료용 조성물 |
| RU2502745C2 (ru) * | 2011-12-30 | 2013-12-27 | Общество с ограниченной ответственностью "Технофарма" | Наноантитело "anti-flu", рекомбинантные вирусные векторы и фармацевтические композиции для профилактики и терапии гриппа типа а |
| US8834881B2 (en) * | 2012-03-08 | 2014-09-16 | Crucell Holland B.V. | Human binding molecules capable of binding to and neutralizing influenza B viruses and uses thereof |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| US9683030B2 (en) | 2012-05-10 | 2017-06-20 | Massachusetts Institute Of Technology | Agents for influenza neutralization |
| CN103665155B (zh) * | 2012-09-14 | 2016-07-06 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1f2 |
| CN103665156B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的结合分子3e1 |
| CN103665157B (zh) * | 2012-09-14 | 2016-06-29 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子1c4 |
| CN103665154B (zh) * | 2012-09-14 | 2016-08-03 | 中国科学院上海生命科学研究院 | 一种抗流感病毒广谱中和性的中和分子3c4 |
| BR112015010817A8 (pt) | 2012-11-13 | 2018-01-23 | Genentech Inc | anticorpos anti-hemaglutinina isolado, método de tratamento, inibição ou prevenção de infecções, composição, composição farmacêutica, ácido nucleico isolado, célula hospedeira, método de produção de anticorpos e uso do anticorpo anti-hemaglutinina |
| JP6595448B2 (ja) | 2013-03-14 | 2019-10-23 | コントラフェクト コーポレイション | 治療効率の増強のために鼻腔内送達する中和抗体に基づく組成物および方法 |
| KR20140118682A (ko) * | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물 |
| US9650434B2 (en) | 2013-04-02 | 2017-05-16 | Xiamen University | Broad-spectrum monoclonal antibody recognizing HA1 domain of hemagglutinin of influenza virus |
| RS60938B1 (sr) * | 2013-10-02 | 2020-11-30 | Medimmune Llc | Neutrališuća antitela na grip a i njihova upotreba |
| EP3070167A4 (en) * | 2013-11-06 | 2017-06-07 | Osaka University | Antibody having broad neutralizing activity in group 1 influenza a virus |
| US10639370B2 (en) | 2014-02-04 | 2020-05-05 | Contrafect Corporation | Antibodies useful in passive influenza immunization, and compositions, combinations and methods for use thereof |
| RU2720282C1 (ru) | 2014-02-04 | 2020-04-28 | Контрафект Корпорейшн | Антитела, подходящие для пассивной иммунизации против гриппа, и их композиции, комбинации и способы применения |
| CN110642944B (zh) * | 2014-03-07 | 2021-06-11 | 神州细胞工程有限公司 | 一种中和人感染h7n9甲型流感病毒的抗体及其用途 |
| PT3142750T (pt) | 2014-05-13 | 2020-09-22 | Univ Pennsylvania | Composições que compreendem aav expressando construções de anticorpos duplos e suas utilizações |
| US10077309B2 (en) * | 2014-07-14 | 2018-09-18 | The Penn State Research Foundation | Compositions and methods for targeting of the surfactant protein A receptor |
| WO2016011035A2 (en) | 2014-07-15 | 2016-01-21 | Medlmmune, Llc | Neutralizing anti-influenza b antibodies and uses thereof |
| WO2016010160A1 (ja) * | 2014-07-18 | 2016-01-21 | 国立感染症研究所長が代表する日本国 | 抗インフルエンザウイルス抗体及びその利用 |
| WO2016089181A1 (ko) * | 2014-12-05 | 2016-06-09 | (주)셀트리온 | 1 이상의 인플루엔자 바이러스 중화 결합 분자를 포함하는 애주번트 조성물 및 이를 포함하는 백신 조성물 |
| US20180008702A1 (en) | 2014-12-05 | 2018-01-11 | Celltrion Inc. | Adjuvant composition containing at least one influenza virus neutralizing and binding molecule and vaccine composition containing same |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| MA48852A (fr) | 2015-05-13 | 2020-04-01 | Univ Pennsylvania | Expression médiée par aav d'anticorps anti-grippaux et leurs procédés d'utilisation |
| PT3303384T (pt) | 2015-06-01 | 2021-10-14 | Medimmune Llc | Moléculas de ligação neutralizantes anti-influenza e suas utilizações |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| IL304940A (en) | 2016-01-13 | 2023-10-01 | Medimmune Llc | A method for treating type A influenza |
| CN109195629A (zh) | 2016-02-24 | 2019-01-11 | 威特拉公司 | 流行性感冒抗体分子制剂 |
| KR102037041B1 (ko) * | 2016-08-10 | 2019-10-29 | (주)셀트리온 | 항-인플루엔자 바이러스 항체의 안정한 액체 약제학적 제제 |
| JP2017086068A (ja) * | 2016-10-31 | 2017-05-25 | インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ | Ａ型インフルエンザウイルス中和抗体及びその使用法 |
| RU2656142C1 (ru) * | 2016-12-30 | 2018-05-31 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA1FI6-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA1 |
| RU2671477C2 (ru) * | 2016-12-30 | 2018-10-31 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA2m1F16-ht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IGA2m1 |
| RU2664184C2 (ru) * | 2016-12-30 | 2018-08-15 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | РЕКОМБИНАНТНАЯ ПЛАЗМИДНАЯ ДНК pBiPr-ABIgA1FI6-Intht ДЛЯ ПОЛУЧЕНИЯ РЕКОМБИНАНТНОГО ИММУНОГЛОБУЛИНА А ИЗОТИПА IgA1 |
| JOP20190200A1 (ar) | 2017-02-28 | 2019-08-27 | Univ Pennsylvania | تركيبات نافعة في معالجة ضمور العضل النخاعي |
| WO2018160582A1 (en) | 2017-02-28 | 2018-09-07 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (aav) clade f vector and uses therefor |
| WO2018160573A1 (en) | 2017-02-28 | 2018-09-07 | The Trustees Of The University Of Pennsylvania | Influenza vaccines based on aav vectors |
| JP7403733B2 (ja) | 2017-09-04 | 2023-12-25 | 国立感染症研究所長 | インフルエンザｈａスプリットワクチンの製造方法 |
| BR112020005166A2 (pt) | 2017-09-18 | 2020-09-24 | Amyris, Inc. | métodos para integração genômica para células hospedeiras de kluyveromyces |
| US11390874B2 (en) * | 2017-09-18 | 2022-07-19 | Amyris, Inc. | Methods for genomic integration in pichia and other host cells |
| CN109988236B (zh) * | 2017-12-30 | 2022-04-01 | 中国科学院天津工业生物技术研究所 | 一种流感病毒抗体的应用 |
| BR112020014343A2 (pt) * | 2018-01-23 | 2020-12-08 | Janssen Vaccines & Prevention B.V. | Vacinas contra o vírus da influenza e seus usos |
| JP6622825B2 (ja) * | 2018-01-25 | 2019-12-18 | インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ | Ａ型インフルエンザウイルス中和抗体及びその使用法 |
| US11780907B2 (en) | 2018-01-26 | 2023-10-10 | Regeneron Pharmaceuticals, Inc. | Human antibodies to influenza hemagglutinin |
| IL280332B2 (en) | 2018-07-23 | 2025-05-01 | Japan As Represented By Director General Of Nat Institute Of Infectious Diseases | A preparation containing influenza vaccine |
| EP3917564A4 (en) | 2019-02-01 | 2022-12-21 | NovaRock Biotherapeutics, Ltd. | ANTI-CLAUDINE 18 ANTIBODIES AND THEIR METHODS OF USE |
| JP7545955B2 (ja) | 2019-03-04 | 2024-09-05 | 国立感染症研究所長 | インフルエンザｈａスプリットワクチンの製造方法 |
| CA3132521A1 (en) | 2019-03-25 | 2020-10-01 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| JP2020048568A (ja) * | 2019-11-22 | 2020-04-02 | インスティテュート・フォー・リサーチ・イン・バイオメディシンＩｎｓｔｉｔｕｔｅ Ｆｏｒ Ｒｅｓｅａｒｃｈ Ｉｎ Ｂｉｏｍｅｄｉｃｉｎｅ | Ａ型インフルエンザウイルス中和抗体及びその使用法 |
| WO2021119467A1 (en) | 2019-12-11 | 2021-06-17 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| WO2021201677A1 (en) | 2020-04-01 | 2021-10-07 | Kiadis Pharma Intellectual Property B.V. | Compositions and methods targeting influenza |
| CN111825763B (zh) * | 2020-07-15 | 2022-04-19 | 扬州大学 | 流感病毒ha蛋白茎部特异性单克隆抗体及其制备方法和应用 |
| CN114181303B (zh) * | 2020-09-14 | 2022-12-23 | 东莞市朋志生物科技有限公司 | 抗甲型流感病毒的抗体和试剂盒 |
| US20240024507A1 (en) | 2020-12-01 | 2024-01-25 | The Trustees Of The University Of Pennsylvania | Novel compositions with tissue-specific targeting motifs and compositions containing same |
| MX2023012643A (es) | 2021-04-27 | 2024-01-05 | Generation Bio Co | Vectores de adn no virales que expresan anticuerpos terapéuticos y usos de estos. |
| KR20240161965A (ko) | 2022-03-14 | 2024-11-13 | 제너레이션 바이오 컴퍼니 | 이종 프라임 부스트 백신 조성물 및 사용 방법 |
| KR20240088574A (ko) | 2022-11-21 | 2024-06-20 | (주)샤페론 | 인플루엔자 바이러스에 대한 단일 도메인 항체 및 이의 용도 |
| CN119930806B (zh) * | 2025-01-21 | 2025-12-02 | 中国医学科学院病原生物学研究所 | 一种甲型流感病毒中和抗体及其应用 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US630064A (en) * | 1899-02-10 | 1899-08-01 | William Martindale | Safety-hook. |
| NL154600B (nl) * | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| US3817837A (en) * | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3766162A (en) | 1971-08-24 | 1973-10-16 | Hoffmann La Roche | Barbituric acid antigens and antibodies specific therefor |
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| JPS5896026A (ja) | 1981-10-30 | 1983-06-07 | Nippon Chemiphar Co Ltd | 新規ウロキナ−ゼ誘導体およびその製造法ならびにそれを含有する血栓溶解剤 |
| EP0098110B1 (en) | 1982-06-24 | 1989-10-18 | NIHON CHEMICAL RESEARCH KABUSHIKI KAISHA also known as JAPAN CHEMICAL RESEARCH CO., LTD | Long-acting composition |
| US5807715A (en) * | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4766106A (en) * | 1985-06-26 | 1988-08-23 | Cetus Corporation | Solubilization of proteins for pharmaceutical compositions using polymer conjugation |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4831175A (en) | 1986-09-05 | 1989-05-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Backbone polysubstituted chelates for forming a metal chelate-protein conjugate |
| RU2031941C1 (ru) * | 1991-03-14 | 1995-03-27 | Научно-исследовательский институт гриппа РАМН | Штамм вируса гриппа а(нini) для получения живой гриппозной интраназальной вакцины для взрослых и детей |
| US5595721A (en) | 1993-09-16 | 1997-01-21 | Coulter Pharmaceutical, Inc. | Radioimmunotherapy of lymphoma using anti-CD20 |
| ES2176484T3 (es) * | 1995-08-18 | 2002-12-01 | Morphosys Ag | Bancos de proteinas/(poli)peptidos. |
| US6300104B1 (en) * | 1997-06-19 | 2001-10-09 | The Regents Of The University Of California | Secretory immunoglobulin produced by single cells and methods for making and using same |
| MY133346A (en) | 1999-03-01 | 2007-11-30 | Biogen Inc | Kit for radiolabeling ligands with yttrium-90 |
| US20020102208A1 (en) | 1999-03-01 | 2002-08-01 | Paul Chinn | Radiolabeling kit and binding assay |
| JP4656478B2 (ja) * | 2000-02-22 | 2011-03-23 | 株式会社医学生物学研究所 | 抗体ライブラリー |
| AU2003251809A1 (en) | 2002-07-11 | 2004-02-02 | The General Hospital Corporation | Polynucleotide and polypeptide fat metabolism regulators and uses thereof |
| CN1756562A (zh) * | 2003-03-07 | 2006-04-05 | 麦克公司 | 流感病毒疫苗 |
| CN103446582A (zh) | 2003-08-11 | 2013-12-18 | 财团法人阪大微生物病研究会 | 包含诱导粘膜免疫的佐剂的新型疫苗 |
| WO2006124269A2 (en) | 2005-05-16 | 2006-11-23 | Amgen Fremont Inc. | Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders |
| EP1957530A2 (en) | 2005-10-21 | 2008-08-20 | Novartis AG | Human antibodies against il13 and therapeutic uses |
| TWI477602B (zh) | 2006-02-09 | 2015-03-21 | Educational Foundation Jichi Medical Univ | Novel viral vector |
| US20080014205A1 (en) * | 2006-05-15 | 2008-01-17 | Lawrence Horowitz | Neutralizing Antibodies to Influenza Viruses |
| EA017203B1 (ru) * | 2006-09-07 | 2012-10-30 | Круселл Холланд Б.В. | Связывающие молекулы человека, способные нейтрализовать вирус гриппа h5n1, и их применение |
| PL2069403T3 (pl) | 2006-10-02 | 2015-08-31 | Regeneron Pharma | Przeciwciała ludzkie o wysokim powinowactwie wobec receptora ludzkiej IL-4 |
| JP5601836B2 (ja) | 2006-11-08 | 2014-10-08 | マクロジェニックス ウエスト， インコーポレイテッド | Ｔｅｓ７およびｔｅｓ７に結合する抗体 |
| EP1925318A1 (en) * | 2006-11-20 | 2008-05-28 | Paul-Ehrlich-Institut | Recombinant modified vaccinia virus Ankara (MVA)-based vaccine for the avian flu |
| NO347649B1 (no) * | 2006-12-14 | 2024-02-12 | Regeneron Pharma | Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse. |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| EP2125886A2 (en) | 2007-03-13 | 2009-12-02 | Humabs LLC | Antibodies against h5n1 strains of influenza a virus |
| ITTO20080204A1 (it) | 2008-03-17 | 2009-09-18 | Pomona Biotechnologies Llc | Anticorpi monoclonali atti a reagire con una pluralita di sottotipi del virus influenzale a |
| US8871207B2 (en) * | 2008-07-25 | 2014-10-28 | Humabs, LLC | Neutralizing anti-influenza A virus antibodies and uses thereof |
| RU2553325C2 (ru) | 2008-07-25 | 2015-06-10 | Институт Фо Ресёч Ин Биомедицин | Нейтрализующие антитела против вируса гриппа а и их использование |
-
2009
- 2009-07-27 RU RU2011105062/10A patent/RU2553325C2/ru active
- 2009-07-27 NZ NZ590891A patent/NZ590891A/xx not_active IP Right Cessation
- 2009-07-27 CA CA2731686A patent/CA2731686C/en active Active
- 2009-07-27 CN CN2009801329884A patent/CN102216327A/zh active Pending
- 2009-07-27 US US12/509,835 patent/US8685402B2/en active Active
- 2009-07-27 NZ NZ590890A patent/NZ590890A/xx not_active IP Right Cessation
- 2009-07-27 CN CN200980132989.9A patent/CN102164613B/zh active Active
- 2009-07-27 WO PCT/IB2009/006623 patent/WO2010010467A2/en not_active Ceased
- 2009-07-27 EP EP09759983A patent/EP2313433A2/en not_active Withdrawn
- 2009-07-27 AU AU2009275226A patent/AU2009275226B2/en active Active
- 2009-07-27 KR KR1020117003495A patent/KR20110049802A/ko not_active Withdrawn
- 2009-07-27 JP JP2011519252A patent/JP5607620B2/ja active Active
- 2009-07-27 KR KR1020117003526A patent/KR101732056B1/ko active Active
- 2009-07-27 MX MX2011000767A patent/MX2011000767A/es active IP Right Grant
- 2009-07-27 BR BRPI0911699A patent/BRPI0911699B8/pt active IP Right Grant
- 2009-07-27 JP JP2011519253A patent/JP2011528902A/ja active Pending
- 2009-07-27 ES ES09745097.7T patent/ES2662519T3/es active Active
- 2009-07-27 EP EP09745097.7A patent/EP2313112B1/en active Active
- 2009-07-27 CA CA2733218A patent/CA2733218A1/en not_active Abandoned
- 2009-07-27 WO PCT/IB2009/006616 patent/WO2010010466A2/en not_active Ceased
- 2009-07-27 MX MX2011000768A patent/MX2011000768A/es not_active Application Discontinuation
- 2009-07-27 AU AU2009275227A patent/AU2009275227A1/en not_active Abandoned
- 2009-07-27 US US12/509,731 patent/US9340603B2/en active Active
-
2011
- 2011-01-20 IL IL210772A patent/IL210772A0/en unknown
- 2011-01-20 IL IL210771A patent/IL210771A0/en unknown
- 2011-01-21 GT GT201100023A patent/GT201100023A/es unknown
- 2011-02-09 CO CO11015221A patent/CO6341572A2/es active IP Right Grant
- 2011-02-11 EC EC2011010823A patent/ECSP11010823A/es unknown
- 2011-02-11 ZA ZA2011/01113A patent/ZA201101113B/en unknown
- 2011-02-11 CR CR20110079A patent/CR20110079A/es unknown
- 2011-02-14 ZA ZA2011/01150A patent/ZA201101150B/en unknown
- 2011-02-14 CR CR20110084A patent/CR20110084A/es unknown
- 2011-02-22 MA MA33633A patent/MA32577B1/fr unknown
-
2014
- 2014-08-28 JP JP2014174221A patent/JP6022515B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014237714A5 (enExample) | ||
| JP2011528901A5 (enExample) | ||
| JP2010521147A5 (enExample) | ||
| PE20181270A1 (es) | Anticuerpo que neutraliza el virus respiratorio sincitial humano | |
| HRP20201975T1 (hr) | Neutralizirajuća protutijela anti-influenca a virusa i njihova uporaba | |
| HRP20161740T1 (hr) | Ljudske molekule za vezanje koje su sposobne neutralizirati viruse influence a filogenetske skupine 1 i filogenetske skupine 2, te viruse influence b | |
| JP2017176174A5 (enExample) | ||
| JP2019524645A5 (enExample) | ||
| AR099855A1 (es) | Anticuerpos hemaglutinina del virus antiinfluenza b y métodos de uso | |
| EA201991577A1 (ru) | Новые антитела против рецептора трансферрина человека, способные преодолевать гематоэнцефалический барьер | |
| JP2016503413A5 (enExample) | ||
| JP2013531993A5 (enExample) | ||
| FI3083694T3 (fi) | Kaninisoituja hiiren anti-koira-pd-1 -vasta-aineita | |
| JP2013539454A5 (enExample) | ||
| RU2018132044A (ru) | Антитела против тау | |
| ES2776179T3 (es) | Anticuerpos dirigidos contra determinantes de la superficie de S. aureus | |
| JP2014205674A5 (enExample) | ||
| JP2018504907A5 (enExample) | ||
| ES2685424T3 (es) | Anticuerpos anti-Jagged1 y procedimientos de uso | |
| JP2013517277A5 (enExample) | ||
| FI3683235T3 (fi) | Anti-IL-33-vasta-aineita ja niiden käyttöjä | |
| NZ626520A (en) | Anti-lrp5 antibodies and methods of use | |
| JP2010502207A5 (enExample) | ||
| JP2011528902A5 (enExample) | ||
| BR112017009817A2 (pt) | anticorpos anti-il-1beta e métodos de utilização |