JP2013522302A5 - - Google Patents
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- Publication number
- JP2013522302A5 JP2013522302A5 JP2013500127A JP2013500127A JP2013522302A5 JP 2013522302 A5 JP2013522302 A5 JP 2013522302A5 JP 2013500127 A JP2013500127 A JP 2013500127A JP 2013500127 A JP2013500127 A JP 2013500127A JP 2013522302 A5 JP2013522302 A5 JP 2013522302A5
- Authority
- JP
- Japan
- Prior art keywords
- yeast
- immunotherapy composition
- interferon
- based immunotherapy
- individual
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 42
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 42
- 238000009169 immunotherapy Methods 0.000 claims 32
- 108010050904 Interferons Proteins 0.000 claims 20
- 102000014150 Interferons Human genes 0.000 claims 20
- 229940079322 interferon Drugs 0.000 claims 20
- 230000000840 anti-viral effect Effects 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 19
- 102100020992 Interferon lambda-3 Human genes 0.000 claims 14
- 101001002466 Homo sapiens Interferon lambda-3 Proteins 0.000 claims 13
- 241000711549 Hepacivirus C Species 0.000 claims 12
- 239000003795 chemical substances by application Substances 0.000 claims 8
- 208000015181 infectious disease Diseases 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 208000006154 Chronic hepatitis C Diseases 0.000 claims 3
- 241000700721 Hepatitis B virus Species 0.000 claims 3
- 208000005176 Hepatitis C Diseases 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 208000010710 hepatitis C virus infection Diseases 0.000 claims 3
- 229960004556 tenofovir Drugs 0.000 claims 2
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 208000000419 Chronic Hepatitis B Diseases 0.000 claims 1
- 229940124683 HCV polymerase inhibitor Drugs 0.000 claims 1
- 102100040018 Interferon alpha-2 Human genes 0.000 claims 1
- 101710099621 Interferon lambda-3 Proteins 0.000 claims 1
- 108010079944 Interferon-alpha2b Proteins 0.000 claims 1
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims 1
- 229960001997 adefovir Drugs 0.000 claims 1
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 229960000980 entecavir Drugs 0.000 claims 1
- YXPVEXCTPGULBZ-WQYNNSOESA-N entecavir hydrate Chemical compound O.C1=NC=2C(=O)NC(N)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)C1=C YXPVEXCTPGULBZ-WQYNNSOESA-N 0.000 claims 1
- 108020001507 fusion proteins Proteins 0.000 claims 1
- 102000037865 fusion proteins Human genes 0.000 claims 1
- 208000002672 hepatitis B Diseases 0.000 claims 1
- 238000002649 immunization Methods 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 229960001627 lamivudine Drugs 0.000 claims 1
- JTEGQNOMFQHVDC-NKWVEPMBSA-N lamivudine Chemical compound O=C1N=C(N)C=CN1[C@H]1O[C@@H](CO)SC1 JTEGQNOMFQHVDC-NKWVEPMBSA-N 0.000 claims 1
- 229960000329 ribavirin Drugs 0.000 claims 1
- HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31377610P | 2010-03-14 | 2010-03-14 | |
| US31377510P | 2010-03-14 | 2010-03-14 | |
| US31377410P | 2010-03-14 | 2010-03-14 | |
| US61/313,776 | 2010-03-14 | ||
| US61/313,774 | 2010-03-14 | ||
| US61/313,775 | 2010-03-14 | ||
| US37089910P | 2010-08-05 | 2010-08-05 | |
| US61/370,899 | 2010-08-05 | ||
| US40785910P | 2010-10-28 | 2010-10-28 | |
| US61/407,859 | 2010-10-28 | ||
| PCT/US2011/028359 WO2011115914A1 (en) | 2010-03-14 | 2011-03-14 | Pharmacogenomic and response-guided treatment of infectious disease using yeast-based immunotherapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013522302A JP2013522302A (ja) | 2013-06-13 |
| JP2013522302A5 true JP2013522302A5 (enExample) | 2014-05-01 |
Family
ID=44649537
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013500127A Withdrawn JP2013522302A (ja) | 2010-03-14 | 2011-03-14 | 酵母系免疫療法を使用した感染症の薬理ゲノミクス及び治療反応性ガイド治療 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20130121964A1 (enExample) |
| EP (1) | EP2547792A4 (enExample) |
| JP (1) | JP2013522302A (enExample) |
| WO (1) | WO2011115914A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2121013T3 (pl) | 2007-02-02 | 2015-05-29 | Globeimmune Inc | Sposoby wytwarzania szczepionek na bazie drożdży |
| RU2505313C2 (ru) | 2007-03-19 | 2014-01-27 | Глоубиммьюн, Инк. | Композиции и способы направленного устранения мутационного ускользания в направленной терапии рака |
| JP5759980B2 (ja) | 2009-04-17 | 2015-08-05 | グローブイミューン，インコーポレイテッド | 癌および感染症に対する免疫療法組成物の組み合わせ |
| WO2011032119A1 (en) | 2009-09-14 | 2011-03-17 | The Regents Of The University Of Colorado | Modulation of yeast-based immunotherapy products and responses |
| EP3216789A1 (en) | 2010-02-12 | 2017-09-13 | Chimerix, Inc. | Methods of treating viral infection |
| AU2011248620B2 (en) | 2010-04-26 | 2015-11-26 | Chimerix, Inc. | Methods of treating retroviral infections and related dosage regimes |
| US20120196272A1 (en) * | 2010-08-05 | 2012-08-02 | Roche Molecular Systems, Inc. | Prediction of HCV Viral Kinetics in Interferon-Free Treatment |
| US9254320B2 (en) | 2010-12-17 | 2016-02-09 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
| PH12013501683A1 (en) | 2011-02-12 | 2019-07-17 | Globeimmune Inc | Yeast-based therapeutic for chronic hepatitis b infection |
| CN103648513B (zh) | 2011-03-17 | 2018-10-12 | 全球免疫股份有限公司 | 酵母-Brachyury(短尾畸形)免疫治疗组合物 |
| SG10201605265TA (en) | 2011-06-14 | 2016-08-30 | Globeimmune Inc | Yeast-Based Compositions and Methods for the Treatment or Prevention of Hepatitis Delta Virus Infection |
| EP2744918A4 (en) | 2011-08-17 | 2015-06-10 | Globeimmune Inc | IMMUNOTHERAPEUTIC YEAST MUC1 COMPOSITIONS AND USES THEREOF |
| US9653272B2 (en) | 2012-06-26 | 2017-05-16 | Biodesix, Inc. | Mass-spectral method for selection, and de-selection, of cancer patients for treatment with immune response generating therapies |
| CA2877335A1 (en) * | 2012-07-03 | 2014-01-09 | Chimerix, Inc. | Method of treating retroviral infections and related dosage regimes |
| CN102816838A (zh) * | 2012-07-06 | 2012-12-12 | 吉林艾迪康医学检验所有限公司 | 用于检测丙型肝炎患者il28b snp12980275多态性的试剂盒 |
| SG11201507328RA (en) | 2013-03-19 | 2015-10-29 | Globeimmune Inc | Yeast-based immunotherapy for chordoma |
| EP2978449B1 (en) | 2013-03-26 | 2021-09-08 | Globeimmune, Inc. | Compositions and methods for the treatment or prevention of human immunodeficiency virus infection |
| TWI654200B (zh) | 2013-08-30 | 2019-03-21 | 環球免疫公司 | 治療或預防結核病的組合物及方法 |
| EP3129036B1 (en) | 2014-04-11 | 2021-08-11 | Globeimmune, Inc. | Yeast-based immunotherapy and type i interferon sensitivity |
| WO2016096800A1 (en) * | 2014-12-18 | 2016-06-23 | F. Hoffmann-La Roche Ag | Biomarkers for hbv treatment response |
| CN113456812B (zh) | 2015-01-09 | 2024-08-20 | 埃图比克斯公司 | 用于联合免疫治疗的方法和组合物 |
| EP3256140B1 (en) | 2015-01-09 | 2020-04-01 | Etubics Corporation | Compositions for ebola virus vaccination |
| JP6738319B2 (ja) * | 2015-03-30 | 2020-08-12 | 雅史 溝上 | インターフェロン治療効果予測方法及びそれを用いたｂ型肝炎患者の治療用医薬組成物 |
| US11149087B2 (en) | 2015-04-20 | 2021-10-19 | Etubics Corporation | Methods and compositions for combination immunotherapy |
| HK1250744A1 (zh) * | 2015-07-15 | 2019-01-11 | F. Hoffmann-La Roche Ag | Hbv治疗应答的生物标志物 |
| EP3331552B1 (en) | 2015-08-03 | 2021-01-27 | Globeimmune, Inc. | Modified yeast-brachyury immunotherapeutic compositions |
| RU2623151C2 (ru) * | 2015-11-03 | 2017-06-22 | Федеральное государственное казенное учреждение Главный клинический военный госпиталь ФСБ России | Способ прогнозирования динамики фиброза печени у пациентов с хроническим гепатитом С, генотипом 1, не ответивших на лечение пегилированными интерферонами и рибавирином |
| GB201714745D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| WO2019222073A1 (en) | 2018-05-15 | 2019-11-21 | Globeimmune, Inc. | Lysates of recombinant yeast for inducing cellular immune responses |
| GB201903832D0 (en) | 2019-03-20 | 2019-05-01 | Atrogi Ab | New compounds and methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7439042B2 (en) * | 2002-12-16 | 2008-10-21 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis C infection |
| EP1809773B1 (en) * | 2004-10-18 | 2014-07-16 | Globeimmune, Inc. | Yeast-based therapeutic for chronic hepatitis c infection |
| BRPI0613025A2 (pt) * | 2005-07-11 | 2010-12-14 | Globeimmune Inc | composiÇço para reduzir a resistÊncia a um agente, mÉtodo para a preparaÇço de um veÍculo de levedura e uso da composiÇço |
| EP2432898B1 (en) * | 2009-05-21 | 2014-11-26 | Merck Sharp & Dohme Corp. | Genetic markers associated with interferon-alpha response |
| US20100316608A1 (en) * | 2009-06-15 | 2010-12-16 | Vijayaprakash Suppiah | Method of Determining A Response To Treatment With Immunomodulatory Composition |
-
2011
- 2011-03-14 JP JP2013500127A patent/JP2013522302A/ja not_active Withdrawn
- 2011-03-14 EP EP11756806.3A patent/EP2547792A4/en not_active Withdrawn
- 2011-03-14 WO PCT/US2011/028359 patent/WO2011115914A1/en not_active Ceased
- 2011-03-14 US US13/635,254 patent/US20130121964A1/en not_active Abandoned
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