CN106421774B - PreS1用于制备乙肝疫苗以及治疗慢性乙型肝炎的用途 - Google Patents
PreS1用于制备乙肝疫苗以及治疗慢性乙型肝炎的用途 Download PDFInfo
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- CN106421774B CN106421774B CN201610811599.6A CN201610811599A CN106421774B CN 106421774 B CN106421774 B CN 106421774B CN 201610811599 A CN201610811599 A CN 201610811599A CN 106421774 B CN106421774 B CN 106421774B
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
Claims (7)
Priority Applications (1)
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CN201610811599.6A CN106421774B (zh) | 2016-09-08 | 2016-09-08 | PreS1用于制备乙肝疫苗以及治疗慢性乙型肝炎的用途 |
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CN201610811599.6A CN106421774B (zh) | 2016-09-08 | 2016-09-08 | PreS1用于制备乙肝疫苗以及治疗慢性乙型肝炎的用途 |
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CN106421774A CN106421774A (zh) | 2017-02-22 |
CN106421774B true CN106421774B (zh) | 2019-05-28 |
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Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US11389532B2 (en) * | 2017-11-16 | 2022-07-19 | University Of Washington | Therapeutic vaccine for Hepatitis b virus (HBV) using the HBV PreS1 and/or PreS2, and/or s-HBsAg regions of the HBV envelope protein |
CN113876938B (zh) * | 2020-07-01 | 2024-04-19 | 中国科学院生物物理研究所 | 融合蛋白疫苗平台的构建与应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103476426A (zh) * | 2011-02-12 | 2013-12-25 | 全球免疫股份有限公司 | 用于慢性乙型肝炎病毒感染的基于酵母的治疗剂 |
CN104640565A (zh) * | 2012-09-19 | 2015-05-20 | 宾夕法尼亚大学理事会 | 乙型肝炎病毒核心蛋白和表面抗原蛋白以及包含其的疫苗 |
CN104744589A (zh) * | 2013-12-25 | 2015-07-01 | 苏州康宁杰瑞生物科技有限公司 | 抗-preS1抗体、其与干扰素的融合蛋白及用途 |
CN104873969A (zh) * | 2015-04-16 | 2015-09-02 | 江苏赛锘威生物医药有限公司 | 基于HBV PreS-S、C抗原及新型佐剂CpG的治疗性乙型肝炎疫苗 |
-
2016
- 2016-09-08 CN CN201610811599.6A patent/CN106421774B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103476426A (zh) * | 2011-02-12 | 2013-12-25 | 全球免疫股份有限公司 | 用于慢性乙型肝炎病毒感染的基于酵母的治疗剂 |
CN104640565A (zh) * | 2012-09-19 | 2015-05-20 | 宾夕法尼亚大学理事会 | 乙型肝炎病毒核心蛋白和表面抗原蛋白以及包含其的疫苗 |
CN104744589A (zh) * | 2013-12-25 | 2015-07-01 | 苏州康宁杰瑞生物科技有限公司 | 抗-preS1抗体、其与干扰素的融合蛋白及用途 |
CN104873969A (zh) * | 2015-04-16 | 2015-09-02 | 江苏赛锘威生物医药有限公司 | 基于HBV PreS-S、C抗原及新型佐剂CpG的治疗性乙型肝炎疫苗 |
Non-Patent Citations (2)
Title |
---|
乙肝病毒大分子表面抗原PreS1区相关片段的表达、免疫性质及应用;胡维国;《中国博士学位论文医药卫生科技辑》;20050131;E059-110 * |
胡维国.乙肝病毒大分子表面抗原PreS1区相关片段的表达、免疫性质及应用.《中国博士学位论文医药卫生科技辑》.2005,E059-110. * |
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