JP2012506411A5 - - Google Patents
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- Publication number
- JP2012506411A5 JP2012506411A5 JP2011532725A JP2011532725A JP2012506411A5 JP 2012506411 A5 JP2012506411 A5 JP 2012506411A5 JP 2011532725 A JP2011532725 A JP 2011532725A JP 2011532725 A JP2011532725 A JP 2011532725A JP 2012506411 A5 JP2012506411 A5 JP 2012506411A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- binding protein
- immune response
- composition according
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 36
- 101710186862 Factor H binding protein Proteins 0.000 claims description 31
- 230000028993 immune response Effects 0.000 claims description 22
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims description 16
- 150000001413 amino acids Chemical class 0.000 claims description 12
- 241000588650 Neisseria meningitidis Species 0.000 claims description 7
- 102000016550 Complement Factor H Human genes 0.000 claims description 6
- 108010053085 Complement Factor H Proteins 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 230000001681 protective effect Effects 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 201000009906 Meningitis Diseases 0.000 claims description 3
- 206010040047 Sepsis Diseases 0.000 claims description 3
- 206010040070 Septic Shock Diseases 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000036303 septic shock Effects 0.000 claims description 3
- 238000002255 vaccination Methods 0.000 claims description 3
- 229960005486 vaccine Drugs 0.000 claims description 3
- 230000007423 decrease Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims description 2
- 229940021993 prophylactic vaccine Drugs 0.000 claims description 2
- 229940021747 therapeutic vaccine Drugs 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 230000003053 immunization Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0819633.9A GB0819633D0 (en) | 2008-10-25 | 2008-10-25 | Composition |
| GB0819633.9 | 2008-10-25 | ||
| PCT/GB2009/051439 WO2010046715A1 (en) | 2008-10-25 | 2009-10-26 | Vaccine compositions comprising a mutated factor h binding protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014261910A Division JP6076326B2 (ja) | 2008-10-25 | 2014-12-25 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012506411A JP2012506411A (ja) | 2012-03-15 |
| JP2012506411A5 true JP2012506411A5 (enExample) | 2012-12-06 |
| JP5676458B2 JP5676458B2 (ja) | 2015-02-25 |
Family
ID=40133849
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532725A Expired - Fee Related JP5676458B2 (ja) | 2008-10-25 | 2009-10-26 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
| JP2014261910A Expired - Fee Related JP6076326B2 (ja) | 2008-10-25 | 2014-12-25 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014261910A Expired - Fee Related JP6076326B2 (ja) | 2008-10-25 | 2014-12-25 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20120052092A1 (enExample) |
| EP (2) | EP3501534B1 (enExample) |
| JP (2) | JP5676458B2 (enExample) |
| KR (3) | KR20170000390A (enExample) |
| CN (2) | CN102245202A (enExample) |
| AU (1) | AU2009306114B2 (enExample) |
| BR (1) | BRPI0919926A2 (enExample) |
| CA (1) | CA2741619A1 (enExample) |
| CO (1) | CO6382140A2 (enExample) |
| DK (1) | DK3501534T5 (enExample) |
| ES (1) | ES2970878T3 (enExample) |
| FI (1) | FI3501534T3 (enExample) |
| GB (1) | GB0819633D0 (enExample) |
| HR (1) | HRP20240226T1 (enExample) |
| HU (1) | HUE065348T2 (enExample) |
| LT (1) | LT3501534T (enExample) |
| MX (1) | MX2011004322A (enExample) |
| NZ (2) | NZ592444A (enExample) |
| PL (1) | PL3501534T3 (enExample) |
| PT (1) | PT3501534T (enExample) |
| RU (1) | RU2559528C2 (enExample) |
| SI (1) | SI3501534T1 (enExample) |
| WO (1) | WO2010046715A1 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2261339B1 (en) | 1998-05-01 | 2017-03-22 | GlaxoSmithKline Biologicals SA | Neisseria meningitidis antigens and compositions |
| DK2270173T3 (en) | 1999-05-19 | 2016-03-07 | Glaxosmithkline Biolog Sa | Neisserial combination compositions |
| DK1801219T3 (en) | 1999-10-29 | 2015-12-07 | Glaxosmithkline Biolog Sa | Neisseriale antigenic peptides. |
| EP2270031A3 (en) | 2000-02-28 | 2011-02-16 | Novartis Vaccines and Diagnostics S.r.l. | Heterologous expression of neisserial proteins |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| AU2003274511B2 (en) | 2002-10-11 | 2009-06-04 | Glaxosmithkline Biologicals S.A. | Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| US9579372B2 (en) | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
| EP2265640B1 (en) | 2008-03-10 | 2015-11-04 | Children's Hospital & Research Center at Oakland | Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use |
| BRPI1009828A2 (pt) | 2009-03-24 | 2019-03-12 | Novartis Ag | adjuvante de proteína de ligação de fator h meningocócica |
| AU2010242905B2 (en) | 2009-04-30 | 2014-10-23 | Children's Hospital & Research Center At Oakland | Chimeric factor H binding proteins (fHbp) and methods of use |
| BR112012010531A2 (pt) * | 2009-10-27 | 2019-09-24 | Novartis Ag | "polipeptídeos de modificação meningocócica fhbp" |
| BR112012022669A2 (pt) * | 2010-03-10 | 2017-02-14 | Glaxosmithkline Biologicals Sa | composição imunogênica, método de tratamento ou prevenção de infecção ou doença, uso de um antígeno, kit, métodos para a fabricação de uma composição imunogênica e para melhorar uma vacina. |
| BR112012024348B1 (pt) | 2010-03-30 | 2022-11-08 | Children's Hospital & Research Center At Oakland | Composição imunogênica, seu uso, proteína de ligação ao fator h de ocorrência não natural, e célula bacteriana geneticamente modificada |
| US10478483B2 (en) | 2010-06-25 | 2019-11-19 | Glaxosmithkline Biologicals Sa | Combinations of meningococcal factor H binding proteins |
| CA2861946A1 (en) | 2012-02-02 | 2013-08-08 | Novartis Ag | Promoters for increased protein expression in meningococcus |
| RU2644340C2 (ru) | 2012-06-14 | 2018-02-08 | Новартис Аг | Вакцины для менингококка серогруппы х |
| HK1205138A1 (en) | 2012-07-27 | 2015-12-11 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
| WO2014140562A1 (en) * | 2013-03-14 | 2014-09-18 | Isis Innovation Limited | Immunogenic composition to neisseria |
| KR20160034401A (ko) | 2013-08-02 | 2016-03-29 | 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 | 비-천연적으로 발생하는 인자 h 결합 단백질(fhbp) 및 이의 사용 방법 |
| AU2015222121B2 (en) | 2014-02-28 | 2018-01-18 | Glaxosmithkline Biologicals Sa | Modified meningococcal fHbp polypeptides |
| CN119613509A (zh) | 2014-07-23 | 2025-03-14 | 奥克兰儿童医院及研究中心 | 因子h结合蛋白变体及其使用方法 |
| BR122023020102A2 (pt) * | 2014-08-20 | 2023-12-12 | Stichting Sanquin Bloedvoorziening | Anticorpos de potenciamento do fator h e seus usos |
| GB201614687D0 (en) * | 2016-08-31 | 2016-10-12 | Univ Oxford Innovation Ltd | fHbp scaffold |
| EP3607967A1 (en) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
| KR20210119397A (ko) | 2018-12-21 | 2021-10-05 | 그리피스 유니버시티 | 면역 반응을 유도하기 위한 조성물, 방법 및 용도 |
| EP3997108A4 (en) * | 2019-07-08 | 2024-03-20 | Crapaud Bio, Inc. | METHODS OF PRODUCING AND USING LIPOOLIGOSACCHARIDE COMPOSITIONS AND VACCINES |
| CA3147638A1 (en) | 2019-07-17 | 2021-01-21 | Gemini Therapeutics Sub, Inc. | Factor h potentiating antibodies and uses thereof |
| JP2024507828A (ja) | 2021-02-19 | 2024-02-21 | サノフィ パスツール インコーポレイテッド | Ｂ群髄膜炎菌組換えワクチン |
| TW202423477A (zh) | 2022-08-03 | 2024-06-16 | 美商賽諾菲巴斯德公司 | 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4786592A (en) * | 1986-06-18 | 1988-11-22 | Scripps Clinic And Research Foundation | Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin |
| US5476784A (en) * | 1993-04-06 | 1995-12-19 | Rice; Peter A. | Gonococcal anti-idiotypic antibodies and methods and compositions using them |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| US20070253964A1 (en) * | 2003-04-16 | 2007-11-01 | Zlotnick Gary W | Novel Immunogenic Compositions for the Prevention and Treatment of Meningococcal Disease |
| US9034345B2 (en) * | 2005-01-27 | 2015-05-19 | Children's Hospital & Research Center Oakland | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
| GB0524066D0 (en) * | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| RU2450019C2 (ru) * | 2006-06-29 | 2012-05-10 | Новартис Аг | Полипептиды из neisseria meningitidis |
| NZ598458A (en) * | 2009-08-27 | 2014-03-28 | Novartis Ag | Hybrid polypeptides including meningococcal fhbp sequences |
| BR112012024348B1 (pt) * | 2010-03-30 | 2022-11-08 | Children's Hospital & Research Center At Oakland | Composição imunogênica, seu uso, proteína de ligação ao fator h de ocorrência não natural, e célula bacteriana geneticamente modificada |
-
2008
- 2008-10-25 GB GBGB0819633.9A patent/GB0819633D0/en not_active Ceased
-
2009
- 2009-10-26 HU HUE18209661A patent/HUE065348T2/hu unknown
- 2009-10-26 WO PCT/GB2009/051439 patent/WO2010046715A1/en not_active Ceased
- 2009-10-26 CN CN2009801480003A patent/CN102245202A/zh active Pending
- 2009-10-26 NZ NZ592444A patent/NZ592444A/xx unknown
- 2009-10-26 EP EP18209661.0A patent/EP3501534B1/en active Active
- 2009-10-26 EP EP09753188.3A patent/EP2355845B1/en not_active Not-in-force
- 2009-10-26 BR BRPI0919926A patent/BRPI0919926A2/pt not_active Application Discontinuation
- 2009-10-26 PT PT182096610T patent/PT3501534T/pt unknown
- 2009-10-26 PL PL18209661.0T patent/PL3501534T3/pl unknown
- 2009-10-26 RU RU2011120706/10A patent/RU2559528C2/ru not_active IP Right Cessation
- 2009-10-26 JP JP2011532725A patent/JP5676458B2/ja not_active Expired - Fee Related
- 2009-10-26 AU AU2009306114A patent/AU2009306114B2/en not_active Ceased
- 2009-10-26 CN CN201510119007.XA patent/CN105412920A/zh active Pending
- 2009-10-26 KR KR1020167035443A patent/KR20170000390A/ko not_active Ceased
- 2009-10-26 NZ NZ601538A patent/NZ601538A/en not_active IP Right Cessation
- 2009-10-26 US US13/125,957 patent/US20120052092A1/en not_active Abandoned
- 2009-10-26 ES ES18209661T patent/ES2970878T3/es active Active
- 2009-10-26 KR KR1020117011885A patent/KR20110092282A/ko not_active Ceased
- 2009-10-26 HR HRP20240226TT patent/HRP20240226T1/hr unknown
- 2009-10-26 CA CA2741619A patent/CA2741619A1/en not_active Abandoned
- 2009-10-26 MX MX2011004322A patent/MX2011004322A/es active IP Right Grant
- 2009-10-26 DK DK18209661.0T patent/DK3501534T5/da active
- 2009-10-26 LT LTEP18209661.0T patent/LT3501534T/lt unknown
- 2009-10-26 FI FIEP18209661.0T patent/FI3501534T3/fi active
- 2009-10-26 SI SI200932190T patent/SI3501534T1/sl unknown
- 2009-10-26 KR KR1020197002691A patent/KR20190011836A/ko not_active Ceased
-
2011
- 2011-05-05 CO CO11055224A patent/CO6382140A2/es not_active Application Discontinuation
-
2014
- 2014-12-25 JP JP2014261910A patent/JP6076326B2/ja not_active Expired - Fee Related
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