JP2012506411A5 - - Google Patents
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- Publication number
- JP2012506411A5 JP2012506411A5 JP2011532725A JP2011532725A JP2012506411A5 JP 2012506411 A5 JP2012506411 A5 JP 2012506411A5 JP 2011532725 A JP2011532725 A JP 2011532725A JP 2011532725 A JP2011532725 A JP 2011532725A JP 2012506411 A5 JP2012506411 A5 JP 2012506411A5
- Authority
- JP
- Japan
- Prior art keywords
- factor
- binding protein
- immune response
- composition according
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 36
- 101710186862 Factor H binding protein Proteins 0.000 claims description 31
- 230000028993 immune response Effects 0.000 claims description 22
- 241000588652 Neisseria gonorrhoeae Species 0.000 claims description 16
- 150000001413 amino acids Chemical class 0.000 claims description 12
- 241000588650 Neisseria meningitidis Species 0.000 claims description 7
- 102000016550 Complement Factor H Human genes 0.000 claims description 6
- 108010053085 Complement Factor H Proteins 0.000 claims description 6
- 239000003814 drug Substances 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 125000000539 amino acid group Chemical group 0.000 claims description 4
- 229940079593 drug Drugs 0.000 claims description 4
- 230000001681 protective effect Effects 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 201000009906 Meningitis Diseases 0.000 claims description 3
- 206010040047 Sepsis Diseases 0.000 claims description 3
- 206010040070 Septic Shock Diseases 0.000 claims description 3
- 230000001939 inductive effect Effects 0.000 claims description 3
- 230000036303 septic shock Effects 0.000 claims description 3
- 238000002255 vaccination Methods 0.000 claims description 3
- 229960005486 vaccine Drugs 0.000 claims description 3
- 230000007423 decrease Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 claims description 2
- 230000002163 immunogen Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 230000000069 prophylactic effect Effects 0.000 claims description 2
- 229940021993 prophylactic vaccine Drugs 0.000 claims description 2
- 229940021747 therapeutic vaccine Drugs 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims 1
- 238000000034 method Methods 0.000 description 4
- 230000003053 immunization Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0819633.9A GB0819633D0 (en) | 2008-10-25 | 2008-10-25 | Composition |
| GB0819633.9 | 2008-10-25 | ||
| PCT/GB2009/051439 WO2010046715A1 (en) | 2008-10-25 | 2009-10-26 | Vaccine compositions comprising a mutated factor h binding protein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014261910A Division JP6076326B2 (ja) | 2008-10-25 | 2014-12-25 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012506411A JP2012506411A (ja) | 2012-03-15 |
| JP2012506411A5 true JP2012506411A5 (enExample) | 2012-12-06 |
| JP5676458B2 JP5676458B2 (ja) | 2015-02-25 |
Family
ID=40133849
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532725A Expired - Fee Related JP5676458B2 (ja) | 2008-10-25 | 2009-10-26 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
| JP2014261910A Expired - Fee Related JP6076326B2 (ja) | 2008-10-25 | 2014-12-25 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014261910A Expired - Fee Related JP6076326B2 (ja) | 2008-10-25 | 2014-12-25 | 変異ｈ因子結合タンパク質を含むワクチン組成物 |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20120052092A1 (enExample) |
| EP (2) | EP3501534B1 (enExample) |
| JP (2) | JP5676458B2 (enExample) |
| KR (3) | KR20170000390A (enExample) |
| CN (2) | CN105412920A (enExample) |
| AU (1) | AU2009306114B2 (enExample) |
| BR (1) | BRPI0919926A2 (enExample) |
| CA (1) | CA2741619A1 (enExample) |
| CO (1) | CO6382140A2 (enExample) |
| DK (1) | DK3501534T5 (enExample) |
| ES (1) | ES2970878T3 (enExample) |
| FI (1) | FI3501534T3 (enExample) |
| GB (1) | GB0819633D0 (enExample) |
| HR (1) | HRP20240226T1 (enExample) |
| HU (1) | HUE065348T2 (enExample) |
| LT (1) | LT3501534T (enExample) |
| MX (1) | MX2011004322A (enExample) |
| NZ (2) | NZ592444A (enExample) |
| PL (1) | PL3501534T3 (enExample) |
| PT (1) | PT3501534T (enExample) |
| RU (1) | RU2559528C2 (enExample) |
| SI (1) | SI3501534T1 (enExample) |
| WO (1) | WO2010046715A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2261341A3 (en) | 1998-05-01 | 2012-01-04 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
| EP1860191A3 (en) | 1999-05-19 | 2008-02-13 | Novartis Vaccines and Diagnostics S.r.l. | Combination neisserial compositions |
| EP2275552B1 (en) | 1999-10-29 | 2015-09-09 | GlaxoSmithKline Biologicals SA | Neisserial antigenic peptides |
| CN101139590B (zh) | 2000-02-28 | 2012-07-18 | 启龙股份公司 | 奈瑟球菌蛋白质的杂交表达 |
| GB0118249D0 (en) | 2001-07-26 | 2001-09-19 | Chiron Spa | Histidine vaccines |
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| DE60335477D1 (de) | 2002-10-11 | 2011-02-03 | Novartis Vaccines & Diagnostic | Polypeptidimpstoffe zum breiten schutz gegen hypervirulente meningokokken-linien |
| GB0227346D0 (en) | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
| GB0408977D0 (en) | 2004-04-22 | 2004-05-26 | Chiron Srl | Immunising against meningococcal serogroup Y using proteins |
| GB0524066D0 (en) | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| US9579372B2 (en) | 2008-02-21 | 2017-02-28 | Glaxosmithkline Biologicals Sa | Meningococcal fHBP polypeptides |
| ES2557282T3 (es) | 2008-03-10 | 2016-01-25 | Children's Hospital & Research Center At Oakland | Proteínas quiméricas de unión al factor H (fHBP) que contienen un dominio B heterólogo, y métodos de uso |
| ES2797504T3 (es) | 2009-03-24 | 2020-12-02 | Glaxosmithkline Biologicals Sa | Proteína de enlace del factor H meningocócico utilizada como adyuvante |
| NZ595361A (en) | 2009-04-30 | 2013-09-27 | Childrens Hosp & Res Ct Oak | Chimeric factor h binding proteins (fhbp) and methods of use |
| EP2493499A1 (en) * | 2009-10-27 | 2012-09-05 | Novartis AG | Modified meningococcal fhbp polypeptides |
| JP2013521326A (ja) * | 2010-03-10 | 2013-06-10 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物 |
| BR122021020829B8 (pt) | 2010-03-30 | 2022-12-27 | Children´S Hospital & Res Center At Oakland | Proteína de ligação ao fator h de ocorrência não natural (fhbp), composição, e célula hospedeira de neisseria meningitidis geneticamente modificada |
| AU2011268507B2 (en) | 2010-06-25 | 2014-08-14 | Novartis Ag | Combinations of meningococcal factor H binding proteins |
| MX2014008988A (es) | 2012-02-02 | 2014-08-27 | Novartis Ag | Promotores para aumento de expresion de proteinas en meningococo. |
| US10376573B2 (en) | 2012-06-14 | 2019-08-13 | Glaxosmithkline Biologicals Sa | Vaccines for serogroup X meningococcus |
| AU2013295242C1 (en) | 2012-07-27 | 2018-08-09 | Institut National De La Sante Et De La Recherche Medicale | CD147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia |
| WO2014140562A1 (en) * | 2013-03-14 | 2014-09-18 | Isis Innovation Limited | Immunogenic composition to neisseria |
| CA2918547A1 (en) | 2013-08-02 | 2015-02-05 | Peter T. Beernink | Non-naturally occurring factor h binding proteins (fhbp) and methods of use thereof |
| CA2940447C (en) | 2014-02-28 | 2023-07-11 | Glaxosmithkline Biologicals Sa | Modified meningococcal fhbp polypeptides |
| KR102761870B1 (ko) | 2014-07-23 | 2025-02-05 | 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 | 인자 h 결합 단백질 변이체 및 이의 사용 방법 |
| KR102709811B1 (ko) * | 2014-08-20 | 2024-09-24 | 스티흐팅 산퀸 불드포르지닝 | 인자 h 강화 항체 및 그의 용도 |
| EP3607967A1 (en) | 2018-08-09 | 2020-02-12 | GlaxoSmithKline Biologicals S.A. | Modified meningococcal fhbp polypeptides |
| CN113453709A (zh) | 2018-12-21 | 2021-09-28 | 格里菲斯大学 | 用于引发免疫应答的组合物、方法和用途 |
| JP2022541757A (ja) * | 2019-07-08 | 2022-09-27 | クラポード バイオ，インコーポレイテッド | リポオリゴ糖組成物およびワクチンの製造および使用方法 |
| KR20220057530A (ko) | 2019-07-17 | 2022-05-09 | 제미니 테라퓨틱스 서브, 인코포레이티드 | 인자 h 강화 항체 및 이의 용도 |
| US12053516B2 (en) | 2021-02-19 | 2024-08-06 | Sanofi Pasteur Inc. | Meningococcal B recombinant vaccine |
| TW202423477A (zh) | 2022-08-03 | 2024-06-16 | 美商賽諾菲巴斯德公司 | 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4786592A (en) * | 1986-06-18 | 1988-11-22 | Scripps Clinic And Research Foundation | Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin |
| US5476784A (en) * | 1993-04-06 | 1995-12-19 | Rice; Peter A. | Gonococcal anti-idiotypic antibodies and methods and compositions using them |
| GB0220194D0 (en) * | 2002-08-30 | 2002-10-09 | Chiron Spa | Improved vesicles |
| EP1618185A4 (en) * | 2003-04-16 | 2009-05-27 | Wyeth Corp | NEW IMMUNOLOGICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF MENINGOCOCCOULAR DISEASE |
| DK2682126T3 (en) * | 2005-01-27 | 2017-02-27 | Children's Hospital & Res Center At Oakland | GNA1870-based vesicle vaccines for broad-spectrum protection against diseases caused by Neisseria meningitidis |
| GB0524066D0 (en) * | 2005-11-25 | 2006-01-04 | Chiron Srl | 741 ii |
| WO2008001224A2 (en) * | 2006-06-29 | 2008-01-03 | Novartis Ag | Polypeptides from neisseria meningitidis |
| BR112012004275A2 (pt) * | 2009-08-27 | 2016-11-16 | Novartis Ag | polipeptídios híbridos incluindo sequências meningocócicas de fhbp |
| BR122021020829B8 (pt) * | 2010-03-30 | 2022-12-27 | Children´S Hospital & Res Center At Oakland | Proteína de ligação ao fator h de ocorrência não natural (fhbp), composição, e célula hospedeira de neisseria meningitidis geneticamente modificada |
-
2008
- 2008-10-25 GB GBGB0819633.9A patent/GB0819633D0/en not_active Ceased
-
2009
- 2009-10-26 BR BRPI0919926A patent/BRPI0919926A2/pt not_active Application Discontinuation
- 2009-10-26 FI FIEP18209661.0T patent/FI3501534T3/fi active
- 2009-10-26 US US13/125,957 patent/US20120052092A1/en not_active Abandoned
- 2009-10-26 MX MX2011004322A patent/MX2011004322A/es active IP Right Grant
- 2009-10-26 CN CN201510119007.XA patent/CN105412920A/zh active Pending
- 2009-10-26 PL PL18209661.0T patent/PL3501534T3/pl unknown
- 2009-10-26 EP EP18209661.0A patent/EP3501534B1/en active Active
- 2009-10-26 WO PCT/GB2009/051439 patent/WO2010046715A1/en not_active Ceased
- 2009-10-26 CA CA2741619A patent/CA2741619A1/en not_active Abandoned
- 2009-10-26 LT LTEP18209661.0T patent/LT3501534T/lt unknown
- 2009-10-26 NZ NZ592444A patent/NZ592444A/xx unknown
- 2009-10-26 KR KR1020167035443A patent/KR20170000390A/ko not_active Ceased
- 2009-10-26 JP JP2011532725A patent/JP5676458B2/ja not_active Expired - Fee Related
- 2009-10-26 AU AU2009306114A patent/AU2009306114B2/en not_active Ceased
- 2009-10-26 EP EP09753188.3A patent/EP2355845B1/en not_active Not-in-force
- 2009-10-26 NZ NZ601538A patent/NZ601538A/en not_active IP Right Cessation
- 2009-10-26 HU HUE18209661A patent/HUE065348T2/hu unknown
- 2009-10-26 KR KR1020197002691A patent/KR20190011836A/ko not_active Ceased
- 2009-10-26 RU RU2011120706/10A patent/RU2559528C2/ru not_active IP Right Cessation
- 2009-10-26 KR KR1020117011885A patent/KR20110092282A/ko not_active Ceased
- 2009-10-26 ES ES18209661T patent/ES2970878T3/es active Active
- 2009-10-26 CN CN2009801480003A patent/CN102245202A/zh active Pending
- 2009-10-26 DK DK18209661.0T patent/DK3501534T5/da active
- 2009-10-26 PT PT182096610T patent/PT3501534T/pt unknown
- 2009-10-26 HR HRP20240226TT patent/HRP20240226T1/hr unknown
- 2009-10-26 SI SI200932190T patent/SI3501534T1/sl unknown
-
2011
- 2011-05-05 CO CO11055224A patent/CO6382140A2/es not_active Application Discontinuation
-
2014
- 2014-12-25 JP JP2014261910A patent/JP6076326B2/ja not_active Expired - Fee Related
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