JP5676458B2 - 変異ｈ因子結合タンパク質を含むワクチン組成物 - Google Patents

変異ｈ因子結合タンパク質を含むワクチン組成物 Download PDF

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Publication number
JP5676458B2
JP5676458B2 JP2011532725A JP2011532725A JP5676458B2 JP 5676458 B2 JP5676458 B2 JP 5676458B2 JP 2011532725 A JP2011532725 A JP 2011532725A JP 2011532725 A JP2011532725 A JP 2011532725A JP 5676458 B2 JP5676458 B2 JP 5676458B2
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Prior art keywords
factor
binding protein
binding
composition
meningitidis
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Japanese (ja)
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JP2012506411A (ja
JP2012506411A5 (enExample
Inventor
レイチェル エクスレイ，
レイチェル エクスレイ，
クリストフ タン，
クリストフ タン，
スーザン エム． リア，
スーザン エム． リア，
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Ip2ipo Innovations Ltd
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Imperial Innovations Ltd
Ip2ipo Innovations Ltd
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Publication of JP2012506411A publication Critical patent/JP2012506411A/ja
Publication of JP2012506411A5 publication Critical patent/JP2012506411A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011532725A 2008-10-25 2009-10-26 変異ｈ因子結合タンパク質を含むワクチン組成物 Expired - Fee Related JP5676458B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0819633.9A GB0819633D0 (en) 2008-10-25 2008-10-25 Composition
GB0819633.9 2008-10-25
PCT/GB2009/051439 WO2010046715A1 (en) 2008-10-25 2009-10-26 Vaccine compositions comprising a mutated factor h binding protein

Related Child Applications (1)

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JP2014261910A Division JP6076326B2 (ja) 2008-10-25 2014-12-25 変異ｈ因子結合タンパク質を含むワクチン組成物

Publications (3)

Publication Number Publication Date
JP2012506411A JP2012506411A (ja) 2012-03-15
JP2012506411A5 JP2012506411A5 (enExample) 2012-12-06
JP5676458B2 true JP5676458B2 (ja) 2015-02-25

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2011532725A Expired - Fee Related JP5676458B2 (ja) 2008-10-25 2009-10-26 変異ｈ因子結合タンパク質を含むワクチン組成物
JP2014261910A Expired - Fee Related JP6076326B2 (ja) 2008-10-25 2014-12-25 変異ｈ因子結合タンパク質を含むワクチン組成物

Family Applications After (1)

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JP2014261910A Expired - Fee Related JP6076326B2 (ja) 2008-10-25 2014-12-25 変異ｈ因子結合タンパク質を含むワクチン組成物

Country Status (23)

Country Link
US (1) US20120052092A1 (enExample)
EP (2) EP3501534B1 (enExample)
JP (2) JP5676458B2 (enExample)
KR (3) KR20170000390A (enExample)
CN (2) CN102245202A (enExample)
AU (1) AU2009306114B2 (enExample)
BR (1) BRPI0919926A2 (enExample)
CA (1) CA2741619A1 (enExample)
CO (1) CO6382140A2 (enExample)
DK (1) DK3501534T5 (enExample)
ES (1) ES2970878T3 (enExample)
FI (1) FI3501534T3 (enExample)
GB (1) GB0819633D0 (enExample)
HR (1) HRP20240226T1 (enExample)
HU (1) HUE065348T2 (enExample)
LT (1) LT3501534T (enExample)
MX (1) MX2011004322A (enExample)
NZ (2) NZ592444A (enExample)
PL (1) PL3501534T3 (enExample)
PT (1) PT3501534T (enExample)
RU (1) RU2559528C2 (enExample)
SI (1) SI3501534T1 (enExample)
WO (1) WO2010046715A1 (enExample)

Families Citing this family (33)

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EP2261339B1 (en) 1998-05-01 2017-03-22 GlaxoSmithKline Biologicals SA Neisseria meningitidis antigens and compositions
DK2270173T3 (en) 1999-05-19 2016-03-07 Glaxosmithkline Biolog Sa Neisserial combination compositions
DK1801219T3 (en) 1999-10-29 2015-12-07 Glaxosmithkline Biolog Sa Neisseriale antigenic peptides.
EP2270031A3 (en) 2000-02-28 2011-02-16 Novartis Vaccines and Diagnostics S.r.l. Heterologous expression of neisserial proteins
GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
GB0121591D0 (en) 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
AU2003274511B2 (en) 2002-10-11 2009-06-04 Glaxosmithkline Biologicals S.A. Polypeptide-vaccines for broad protection against hypervirulent meningococcal lineages
GB0227346D0 (en) 2002-11-22 2002-12-31 Chiron Spa 741
GB0408977D0 (en) 2004-04-22 2004-05-26 Chiron Srl Immunising against meningococcal serogroup Y using proteins
GB0524066D0 (en) 2005-11-25 2006-01-04 Chiron Srl 741 ii
US9579372B2 (en) 2008-02-21 2017-02-28 Glaxosmithkline Biologicals Sa Meningococcal fHBP polypeptides
EP2265640B1 (en) 2008-03-10 2015-11-04 Children's Hospital & Research Center at Oakland Chimeric factor h binding proteins (fhbp) containing a heterologous b domain and methods of use
BRPI1009828A2 (pt) 2009-03-24 2019-03-12 Novartis Ag adjuvante de proteína de ligação de fator h meningocócica
AU2010242905B2 (en) 2009-04-30 2014-10-23 Children's Hospital & Research Center At Oakland Chimeric factor H binding proteins (fHbp) and methods of use
BR112012010531A2 (pt) * 2009-10-27 2019-09-24 Novartis Ag "polipeptídeos de modificação meningocócica fhbp"
BR112012022669A2 (pt) * 2010-03-10 2017-02-14 Glaxosmithkline Biologicals Sa composição imunogênica, método de tratamento ou prevenção de infecção ou doença, uso de um antígeno, kit, métodos para a fabricação de uma composição imunogênica e para melhorar uma vacina.
BR112012024348B1 (pt) 2010-03-30 2022-11-08 Children's Hospital & Research Center At Oakland Composição imunogênica, seu uso, proteína de ligação ao fator h de ocorrência não natural, e célula bacteriana geneticamente modificada
US10478483B2 (en) 2010-06-25 2019-11-19 Glaxosmithkline Biologicals Sa Combinations of meningococcal factor H binding proteins
CA2861946A1 (en) 2012-02-02 2013-08-08 Novartis Ag Promoters for increased protein expression in meningococcus
RU2644340C2 (ru) 2012-06-14 2018-02-08 Новартис Аг Вакцины для менингококка серогруппы х
HK1205138A1 (en) 2012-07-27 2015-12-11 Institut National De La Santé Et De La Recherche Médicale (Inserm) Cd147 as receptor for pilus-mediated adhesion of meningococci to vascular endothelia
WO2014140562A1 (en) * 2013-03-14 2014-09-18 Isis Innovation Limited Immunogenic composition to neisseria
KR20160034401A (ko) 2013-08-02 2016-03-29 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 비-천연적으로 발생하는 인자 h 결합 단백질(fhbp) 및 이의 사용 방법
AU2015222121B2 (en) 2014-02-28 2018-01-18 Glaxosmithkline Biologicals Sa Modified meningococcal fHbp polypeptides
CN119613509A (zh) 2014-07-23 2025-03-14 奥克兰儿童医院及研究中心 因子h结合蛋白变体及其使用方法
BR122023020102A2 (pt) * 2014-08-20 2023-12-12 Stichting Sanquin Bloedvoorziening Anticorpos de potenciamento do fator h e seus usos
GB201614687D0 (en) * 2016-08-31 2016-10-12 Univ Oxford Innovation Ltd fHbp scaffold
EP3607967A1 (en) 2018-08-09 2020-02-12 GlaxoSmithKline Biologicals S.A. Modified meningococcal fhbp polypeptides
KR20210119397A (ko) 2018-12-21 2021-10-05 그리피스 유니버시티 면역 반응을 유도하기 위한 조성물, 방법 및 용도
EP3997108A4 (en) * 2019-07-08 2024-03-20 Crapaud Bio, Inc. METHODS OF PRODUCING AND USING LIPOOLIGOSACCHARIDE COMPOSITIONS AND VACCINES
CA3147638A1 (en) 2019-07-17 2021-01-21 Gemini Therapeutics Sub, Inc. Factor h potentiating antibodies and uses thereof
JP2024507828A (ja) 2021-02-19 2024-02-21 サノフィ パスツール インコーポレイテッド Ｂ群髄膜炎菌組換えワクチン
TW202423477A (zh) 2022-08-03 2024-06-16 美商賽諾菲巴斯德公司 針對腦膜炎奈瑟氏菌b的含佐劑免疫原性組成物

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786592A (en) * 1986-06-18 1988-11-22 Scripps Clinic And Research Foundation Neisseria gonorrhoeae lectin useful as a vaccine and diagnostic marker and means for producing this lectin
US5476784A (en) * 1993-04-06 1995-12-19 Rice; Peter A. Gonococcal anti-idiotypic antibodies and methods and compositions using them
GB0220194D0 (en) * 2002-08-30 2002-10-09 Chiron Spa Improved vesicles
US20070253964A1 (en) * 2003-04-16 2007-11-01 Zlotnick Gary W Novel Immunogenic Compositions for the Prevention and Treatment of Meningococcal Disease
US9034345B2 (en) * 2005-01-27 2015-05-19 Children's Hospital & Research Center Oakland GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis
GB0524066D0 (en) * 2005-11-25 2006-01-04 Chiron Srl 741 ii
RU2450019C2 (ru) * 2006-06-29 2012-05-10 Новартис Аг Полипептиды из neisseria meningitidis
NZ598458A (en) * 2009-08-27 2014-03-28 Novartis Ag Hybrid polypeptides including meningococcal fhbp sequences
BR112012024348B1 (pt) * 2010-03-30 2022-11-08 Children's Hospital & Research Center At Oakland Composição imunogênica, seu uso, proteína de ligação ao fator h de ocorrência não natural, e célula bacteriana geneticamente modificada

Also Published As

Publication number Publication date
HRP20240226T1 (hr) 2024-05-10
AU2009306114B2 (en) 2015-10-01
EP3501534B1 (en) 2023-11-29
DK3501534T5 (da) 2024-09-02
SI3501534T1 (sl) 2024-03-29
JP2015063558A (ja) 2015-04-09
CN102245202A (zh) 2011-11-16
GB0819633D0 (en) 2008-12-03
EP3501534A1 (en) 2019-06-26
CN105412920A (zh) 2016-03-23
JP6076326B2 (ja) 2017-02-08
KR20110092282A (ko) 2011-08-17
DK3501534T3 (da) 2024-02-05
ES2970878T3 (es) 2024-05-31
WO2010046715A1 (en) 2010-04-29
PL3501534T3 (pl) 2024-04-02
NZ592444A (en) 2012-11-30
KR20170000390A (ko) 2017-01-02
CO6382140A2 (es) 2012-02-15
US20120052092A1 (en) 2012-03-01
LT3501534T (lt) 2024-03-12
PT3501534T (pt) 2024-02-07
JP2012506411A (ja) 2012-03-15
EP2355845B1 (en) 2018-12-05
HUE065348T2 (hu) 2024-05-28
KR20190011836A (ko) 2019-02-07
CA2741619A1 (en) 2010-04-29
EP2355845A1 (en) 2011-08-17
AU2009306114A1 (en) 2010-04-29
FI3501534T3 (fi) 2024-02-09
NZ601538A (en) 2014-01-31
RU2559528C2 (ru) 2015-08-10
RU2011120706A (ru) 2012-11-27
MX2011004322A (es) 2011-06-16
BRPI0919926A2 (pt) 2016-02-16

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