JP2014520117A5 - - Google Patents

Info

Publication number

JP2014520117A5

JP2014520117A5 JP2014515342A JP2014515342A JP2014520117A5 JP 2014520117 A5 JP2014520117 A5 JP 2014520117A5 JP 2014515342 A JP2014515342 A JP 2014515342A JP 2014515342 A JP2014515342 A JP 2014515342A JP 2014520117 A5 JP2014520117 A5 JP 2014520117A5

Authority

JP

Japan

Prior art keywords

virus

chikungunya virus

vaccine composition

composition according

oil

Prior art date

2012-06-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 241001502567 Chikungunya virus Species 0.000 claims 13
• 239000000203 mixture Substances 0.000 claims 12
• 229960005486 vaccine Drugs 0.000 claims 12
• 241000700605 Viruses Species 0.000 claims 7
• 239000000427 antigen Substances 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 6
• PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 claims 6
• BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 6
• PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 6
• 239000007764 o/w emulsion Substances 0.000 claims 6
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 6
• 229920000053 polysorbate 80 Polymers 0.000 claims 6
• 229940031439 squalene Drugs 0.000 claims 6
• TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 6
• 208000004293 Chikungunya Fever Diseases 0.000 claims 4
• 206010067256 Chikungunya virus infection Diseases 0.000 claims 4
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 4
• 229920001202 Inulin Polymers 0.000 claims 4
• QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 4
• WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 4
• VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 claims 4
• 239000003795 chemical substances by application Substances 0.000 claims 4
• 230000014509 gene expression Effects 0.000 claims 4
• 229940029339 inulin Drugs 0.000 claims 4
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims 4
• 239000007981 phosphate-citrate buffer Substances 0.000 claims 4
• QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 4
• 235000005282 vitamin D3 Nutrition 0.000 claims 4
• 239000011647 vitamin D3 Substances 0.000 claims 4
• 229940021056 vitamin d3 Drugs 0.000 claims 4
• 101710132906 Structural polyprotein Proteins 0.000 claims 3
• 230000001939 inductive effect Effects 0.000 claims 3
• 108700016947 Bos taurus structural-GP Proteins 0.000 claims 2
• 241000282412 Homo Species 0.000 claims 2
• 241000710842 Japanese encephalitis virus Species 0.000 claims 2
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 239000002671 adjuvant Substances 0.000 claims 2
• ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 2
• 239000007979 citrate buffer Substances 0.000 claims 2
• GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
• 230000028993 immune response Effects 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 239000002245 particle Substances 0.000 claims 2
• 229910052698 phosphorus Inorganic materials 0.000 claims 2
• 239000011574 phosphorus Substances 0.000 claims 2
• 230000009465 prokaryotic expression Effects 0.000 claims 2
• 230000001681 protective effect Effects 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 230000001225 therapeutic effect Effects 0.000 claims 2
• 229960001295 tocopherol Drugs 0.000 claims 2
• 229930003799 tocopherol Natural products 0.000 claims 2
• 235000010384 tocopherol Nutrition 0.000 claims 2
• 239000011732 tocopherol Substances 0.000 claims 2
• 230000003612 virological effect Effects 0.000 claims 2
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
• 241000256118 Aedes aegypti Species 0.000 claims 1
• 108090000565 Capsid Proteins Proteins 0.000 claims 1
• 102100023321 Ceruloplasmin Human genes 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
• 241000255925 Diptera Species 0.000 claims 1
• 206010014596 Encephalitis Japanese B Diseases 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 1
• 201000005807 Japanese encephalitis Diseases 0.000 claims 1
• 241000235058 Komagataella pastoris Species 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
• 240000004808 Saccharomyces cerevisiae Species 0.000 claims 1
• 229930006000 Sucrose Natural products 0.000 claims 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 230000006978 adaptation Effects 0.000 claims 1
• 239000000654 additive Substances 0.000 claims 1
• 230000000996 additive effect Effects 0.000 claims 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
• 238000010367 cloning Methods 0.000 claims 1
• 229940001442 combination vaccine Drugs 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 239000013604 expression vector Substances 0.000 claims 1
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
• 230000036039 immunity Effects 0.000 claims 1
• 230000002779 inactivation Effects 0.000 claims 1
• 238000007918 intramuscular administration Methods 0.000 claims 1
• 238000001990 intravenous administration Methods 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 210000000214 mouth Anatomy 0.000 claims 1
• 210000003928 nasal cavity Anatomy 0.000 claims 1
• 239000002773 nucleotide Substances 0.000 claims 1
• 125000003729 nucleotide group Chemical group 0.000 claims 1
• 239000008363 phosphate buffer Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 229960000380 propiolactone Drugs 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1
• 239000000600 sorbitol Substances 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1
• 239000005720 sucrose Substances 0.000 claims 1
• 238000009281 ultraviolet germicidal irradiation Methods 0.000 claims 1
• 229940125575 vaccine candidate Drugs 0.000 claims 1
• 230000009385 viral infection Effects 0.000 claims 1