JP6147734B2 - 不活化チクングニアウイルス株を含むワクチン組成物 - Google Patents

不活化チクングニアウイルス株を含むワクチン組成物 Download PDF

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JP6147734B2
JP6147734B2 JP2014515342A JP2014515342A JP6147734B2 JP 6147734 B2 JP6147734 B2 JP 6147734B2 JP 2014515342 A JP2014515342 A JP 2014515342A JP 2014515342 A JP2014515342 A JP 2014515342A JP 6147734 B2 JP6147734 B2 JP 6147734B2
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chikungunya virus
protein
virus
combination
chikungunya
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JP2014520117A (ja
JP2014520117A5 (enExample
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クリシュナ ムルシ エラ
クリシュナ ムルシ エラ
スマシ カンダスワミ
スマシ カンダスワミ
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バハラ バイオテック インターナショナル リミテッド
バハラ バイオテック インターナショナル リミテッド
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    • A—HUMAN NECESSITIES
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
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    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
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    • A61K2039/55583—Polysaccharides
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
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    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
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    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/181—Alphaviruses or Group A arboviruses, e.g. sindbis, VEE, EEE, WEE or semliki forest virus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
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    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
    • G01N2333/185—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
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    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2014515342A 2011-06-17 2012-06-18 不活化チクングニアウイルス株を含むワクチン組成物 Expired - Fee Related JP6147734B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2067/CHE/2011 2011-06-17
IN2067CH2011 2011-06-17
PCT/IN2012/000432 WO2012172574A1 (en) 2011-06-17 2012-06-18 Vaccine composition comprising an inactivated chikungunya virus strain

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JP2014520117A JP2014520117A (ja) 2014-08-21
JP2014520117A5 JP2014520117A5 (enExample) 2015-07-16
JP6147734B2 true JP6147734B2 (ja) 2017-06-14

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US (1) US9844588B2 (enExample)
EP (1) EP2720715B1 (enExample)
JP (1) JP6147734B2 (enExample)
KR (1) KR101792684B1 (enExample)
CN (1) CN103796676B (enExample)
AU (1) AU2012269907B2 (enExample)
BR (1) BR112013032251B1 (enExample)
MY (1) MY173117A (enExample)
PH (1) PH12013502621A1 (enExample)
SG (1) SG10201607787RA (enExample)
WO (1) WO2012172574A1 (enExample)
ZA (1) ZA201309386B (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX357202B (es) * 2012-02-16 2018-06-28 Vlp Therapeutics Llc Composicion de particula tipo virus.
TWI676636B (zh) 2013-07-12 2019-11-11 Ｖｌｐ醫療股份有限公司 包含ｐｄ－１抗原或ｐｄ－１配體抗原的類病毒粒子
US10385101B2 (en) 2014-08-08 2019-08-20 Vlp Therapeutics, Llc Virus like particle comprising modified envelope protein E3
TWI720946B (zh) 2014-08-08 2021-03-11 美商Ｖｌｐ醫療股份有限公司 包含改質套膜蛋白質ｅ３之類病毒粒子
CA2960102C (en) 2014-09-11 2023-10-24 Vlp Therapeutics, Llc Flavivirus virus like particle
CA2992531C (en) * 2015-07-16 2023-09-26 Bharat Biotech International Limited Vaccine compositions
US20190054161A1 (en) * 2016-01-13 2019-02-21 United States, As Represented By The Secretary Of The Army Inactivated vaccine for chikungunya virus
CN105906694B (zh) * 2016-05-05 2019-05-14 中国人民解放军军事医学科学院微生物流行病研究所 基孔肯亚病毒特异性检测抗原及其应用
PH12018502460B1 (en) * 2016-05-27 2023-11-08 Univ Griffith Arthrogenic alphavirus vaccine
KR101875055B1 (ko) * 2016-10-19 2018-07-06 연세대학교 원주산학협력단 융합 단백질 및 그의 용도
KR102007203B1 (ko) * 2016-10-20 2019-08-05 연세대학교 원주산학협력단 융합 단백질 및 그의 용도
WO2018074884A1 (ko) * 2016-10-20 2018-04-26 연세대학교 원주산학협력단 재조합 단백질 및 그의 용도
CN118662621A (zh) * 2017-09-21 2024-09-20 瓦尔尼瓦公司 包含免疫原性屈公病毒chikv-delta5nsp3的医药组成物的制备方法
MY202505A (en) 2017-11-03 2024-05-01 Takeda Vaccines Inc Zika vaccines and immunogenic compositions, and methods of using the same
SG11202003975WA (en) 2017-11-30 2020-06-29 Takeda Vaccines Inc Method for inactivating zika virus and related methods
KR102823029B1 (ko) 2017-12-20 2025-06-20 브이엘피 테라퓨틱스 인코포레이티드 알파바이러스 레플리콘 입자
WO2019148086A1 (en) * 2018-01-26 2019-08-01 The Wistar Institute Of Anatomy And Biology Vaccines against mosquito-borne viruses, and methods of using same
CN109536464B (zh) * 2018-12-10 2022-06-10 中国科学院武汉病毒研究所 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用
KR102016668B1 (ko) 2018-12-19 2019-08-30 주식회사 엠디헬스케어 치쿤군야 바이러스 e2에 특이적으로 결합하는 dna 압타머 및 이의 용도
US11562105B2 (en) * 2019-07-11 2023-01-24 Yokogawa Electric Corporation System and method for module engineering with sequence libraries
KR102202082B1 (ko) 2019-09-25 2021-01-11 충북대학교 산학협력단 치쿤군야 바이러스의 외피단백질 도메인 ⅱ에 대해 특이적으로 결합하는 단일클론항체, 이를 생산하는 하이브리도마 세포주 및 이의 용도
TWI891771B (zh) 2020-04-17 2025-08-01 美商Ｖｌｐ醫療股份有限公司 冠狀病毒疫苗
MX2022013638A (es) 2020-04-30 2023-01-24 Vlp Therapeutics Inc Inmunoterapia con citocina.
AU2021315795A1 (en) * 2020-07-31 2023-02-23 Replicate Bioscience, Inc. Modified Chikungunya viruses and Sindbis viruses and uses thereof
CN117771353B (zh) * 2024-02-27 2024-05-14 中国医学科学院医学生物学研究所 一种以包膜蛋白为靶标的基孔肯雅病毒的mRNA疫苗及其制备方法
CN118561969B (zh) * 2024-08-02 2024-11-19 中国医学科学院医学生物学研究所 一种通过优化全长结构蛋白序列设计的基孔肯雅病毒广谱性mRNA疫苗
KR102864666B1 (ko) * 2025-04-21 2025-09-29 대한민국 치쿤구니아 바이러스 외피 재조합 dna를 포함하는 백신 조성물

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233209A1 (en) * 2005-08-11 2010-09-16 Higgs Stephen T Chikungunya virus infectious clones and uses therefor
BRPI0716145B1 (pt) 2006-09-01 2021-06-22 Bharat Biotech International Limited Composição de vacina e método para preparar uma composição de vacina para o vírus chikungunya
JP2009149583A (ja) * 2007-12-21 2009-07-09 National Institute Of Biomedical Innovation フラビウイルス感染症ワクチンおよびフラビウイルス感染症ワクチン用アジュバント
CN102317308A (zh) 2008-11-26 2012-01-11 美国国有健康与人类服务部 类病毒组合物颗粒及其使用方法

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PH12013502621A1 (en) 2014-02-03
CN103796676B (zh) 2017-09-12
US20140120125A1 (en) 2014-05-01
WO2012172574A1 (en) 2012-12-20
KR101792684B1 (ko) 2017-11-02
BR112013032251A2 (pt) 2016-12-20
US9844588B2 (en) 2017-12-19
KR20140043784A (ko) 2014-04-10
SG10201607787RA (en) 2016-11-29
ZA201309386B (en) 2014-08-27
BR112013032251B1 (pt) 2021-12-07
AU2012269907B2 (en) 2017-05-18
CN103796676A (zh) 2014-05-14
JP2014520117A (ja) 2014-08-21
AU2012269907A1 (en) 2014-01-09
EP2720715A1 (en) 2014-04-23
MY173117A (en) 2019-12-27
EP2720715B1 (en) 2017-08-09

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