JP2016520534A5 - - Google Patents

Info

Publication number

JP2016520534A5

JP2016520534A5 JP2016503642A JP2016503642A JP2016520534A5 JP 2016520534 A5 JP2016520534 A5 JP 2016520534A5 JP 2016503642 A JP2016503642 A JP 2016503642A JP 2016503642 A JP2016503642 A JP 2016503642A JP 2016520534 A5 JP2016520534 A5 JP 2016520534A5

Authority

JP

Japan

Prior art keywords

fusion protein

seq

sequence

nucleic acid

antigen

Prior art date

2014-03-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 108020001507 fusion proteins Proteins 0.000 claims 13
• 102000037865 fusion proteins Human genes 0.000 claims 13
• 239000000427 antigen Substances 0.000 claims 9
• 102000036639 antigens Human genes 0.000 claims 9
• 108091007433 antigens Proteins 0.000 claims 9
• 108020004707 nucleic acids Proteins 0.000 claims 7
• 102000039446 nucleic acids Human genes 0.000 claims 7
• 150000007523 nucleic acids Chemical class 0.000 claims 7
• 102000011931 Nucleoproteins Human genes 0.000 claims 6
• 108010061100 Nucleoproteins Proteins 0.000 claims 6
• 230000002163 immunogen Effects 0.000 claims 5
• 102100037084 C4b-binding protein alpha chain Human genes 0.000 claims 4
• 101710159767 C4b-binding protein alpha chain Proteins 0.000 claims 4
• 241000287828 Gallus gallus Species 0.000 claims 4
• 238000006384 oligomerization reaction Methods 0.000 claims 4
• 102000014914 Carrier Proteins Human genes 0.000 claims 3
• 108010078791 Carrier Proteins Proteins 0.000 claims 3
• 206010022000 influenza Diseases 0.000 claims 3
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
• 150000001413 amino acids Chemical class 0.000 claims 2
• 230000003834 intracellular effect Effects 0.000 claims 2
• 239000003446 ligand Substances 0.000 claims 2
• 239000004475 Arginine Substances 0.000 claims 1
• 239000004472 Lysine Substances 0.000 claims 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 1
• 108010076504 Protein Sorting Signals Proteins 0.000 claims 1
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 210000004027 cell Anatomy 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 230000002708 enhancing effect Effects 0.000 claims 1
• 230000028993 immune response Effects 0.000 claims 1
• 238000009169 immunotherapy Methods 0.000 claims 1
• 208000037797 influenza A Diseases 0.000 claims 1
• 230000035772 mutation Effects 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 238000006467 substitution reaction Methods 0.000 claims 1
• 229960005486 vaccine Drugs 0.000 claims 1
• 239000012646 vaccine adjuvant Substances 0.000 claims 1
• 229940124931 vaccine adjuvant Drugs 0.000 claims 1