JP2015524403A5 - - Google Patents
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- Publication number
- JP2015524403A5 JP2015524403A5 JP2015522106A JP2015522106A JP2015524403A5 JP 2015524403 A5 JP2015524403 A5 JP 2015524403A5 JP 2015522106 A JP2015522106 A JP 2015522106A JP 2015522106 A JP2015522106 A JP 2015522106A JP 2015524403 A5 JP2015524403 A5 JP 2015524403A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fusion protein
- domain
- functional fragment
- extracellular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020001507 fusion proteins Proteins 0.000 claims 13
- 102000037865 fusion proteins Human genes 0.000 claims 13
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 6
- 239000012634 fragment Substances 0.000 claims 6
- 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 claims 5
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 5
- 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 3
- 239000003623 enhancer Substances 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 238000009472 formulation Methods 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 1
- 239000000600 sorbitol Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12176980.6 | 2012-07-18 | ||
| EP12176978 | 2012-07-18 | ||
| EP12176980 | 2012-07-18 | ||
| EP12176978.0 | 2012-07-18 | ||
| PCT/EP2013/065248 WO2014013037A1 (en) | 2012-07-18 | 2013-07-18 | Shortened cd95-fc variants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015524403A JP2015524403A (ja) | 2015-08-24 |
| JP2015524403A5 true JP2015524403A5 (enExample) | 2016-08-12 |
| JP6317739B2 JP6317739B2 (ja) | 2018-04-25 |
Family
ID=48794121
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015522107A Active JP6231562B2 (ja) | 2012-07-18 | 2013-07-18 | ＣＤ９５−Ｆｃアイソフォームの混合物を含む組成物 |
| JP2015522106A Expired - Fee Related JP6317739B2 (ja) | 2012-07-18 | 2013-07-18 | 短縮されたＣＤ９５−Ｆｃ変異体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015522107A Active JP6231562B2 (ja) | 2012-07-18 | 2013-07-18 | ＣＤ９５−Ｆｃアイソフォームの混合物を含む組成物 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US9434783B2 (enExample) |
| EP (4) | EP2875045B1 (enExample) |
| JP (2) | JP6231562B2 (enExample) |
| KR (1) | KR102201694B1 (enExample) |
| CN (3) | CN104640876A (enExample) |
| AU (2) | AU2013291982B2 (enExample) |
| BR (1) | BR112015000732B1 (enExample) |
| CA (2) | CA2877989C (enExample) |
| DK (2) | DK2875045T3 (enExample) |
| ES (2) | ES2674662T3 (enExample) |
| HK (1) | HK1207095A1 (enExample) |
| IL (1) | IL236659A (enExample) |
| MX (1) | MX371430B (enExample) |
| NZ (1) | NZ703546A (enExample) |
| RU (2) | RU2648157C2 (enExample) |
| SG (1) | SG11201500134QA (enExample) |
| UA (1) | UA116889C2 (enExample) |
| WO (2) | WO2014013039A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG11201500134QA (en) * | 2012-07-18 | 2015-03-30 | Apogenix Gmbh | Composition comprising a mixture of cd95-fc isoforms |
| BR112015027249A2 (pt) * | 2013-04-29 | 2017-09-26 | Apogenix Gmbh | método de diagnóstico de câncer |
| NO2776305T3 (enExample) * | 2014-04-23 | 2018-01-27 | ||
| WO2015165973A1 (en) | 2014-04-29 | 2015-11-05 | Apogenix Gmbh | Diagnostic anti-cd95l antibody |
| US9587215B2 (en) | 2014-08-07 | 2017-03-07 | General Electric Company | Devices, systems and methods for automated transfer of a sample |
| WO2016106291A1 (en) * | 2014-12-22 | 2016-06-30 | Alexion Pharmaceuticals, Inc. | Methods of purifying recombinant proteins |
| CA3134144A1 (en) | 2019-03-29 | 2020-10-08 | Myst Therapeutics, Llc | Ex vivo methods for producing a t cell therapeutic and related compositions and methods |
| AU2020391231A1 (en) | 2019-11-27 | 2022-07-14 | Turnstone Biologics Corp. | Method of producing tumor-reactive T cell composition using modulatory agents |
| CN114829371A (zh) * | 2019-12-12 | 2022-07-29 | Emd密理博公司 | 使用透析过滤缓冲液强化的病毒过滤 |
| IL295934A (en) | 2020-02-27 | 2022-10-01 | Myst Therapeutics Llc | Methods for ex vivo enrichment and expansion of tumor reactive t cells and related compositions thereof |
| CN115894706A (zh) * | 2021-09-30 | 2023-04-04 | 北京康辰药业股份有限公司 | 靶向PD-L1和FasL的融合蛋白、核苷酸序列及其应用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0965637B1 (en) * | 1996-05-02 | 2005-07-20 | Mochida Pharmaceutical Co., Ltd. | Fas ANTIGEN DERIVATIVES |
| JP4339405B2 (ja) * | 1996-10-31 | 2009-10-07 | 持田製薬株式会社 | 予防・治療剤 |
| PT990703E (pt) * | 1997-02-27 | 2008-08-27 | Ono Pharmaceutical Co | Novo polipéptido, o adn que codifica o mesmo e a sua utilização |
| EP1029550A4 (en) * | 1997-11-10 | 2001-09-26 | Mochida Pharm Co Ltd | PREVENTIVE AND THERAPEUTIC DRUGS FOR DIFFUSED PULMONARY CONDITIONS |
| CN1911965B (zh) * | 2001-01-17 | 2013-05-29 | 新兴产品开发西雅图有限公司 | 结合域-免疫球蛋白融合蛋白 |
| EP1273297A1 (en) * | 2001-07-06 | 2003-01-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Vitamin E for the treatment of diseases in which the binding of the transcription factor NF-KB and/or AP-1 to promoter target sites has a beneficial effect (eg AIDS, cardiac infarction) |
| ES2327409T3 (es) * | 2003-03-26 | 2009-10-29 | Apogenix Gmbh | Proteinas de fusion fc mejoradas. |
| WO2007109857A1 (en) * | 2006-03-28 | 2007-10-04 | Biopharmica Ltd | Agent for the treatment of hormone-dependent disorders and uses thereof |
| BRPI0713484A2 (pt) * | 2006-06-21 | 2012-11-06 | Apogenix Gmbh | expressão diferencial de citocina em cáncer humano |
| US9309320B2 (en) * | 2006-12-28 | 2016-04-12 | Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts | Neutralization of CD95 activity blocks invasion of glioblastoma cells in vivo |
| WO2008101671A2 (en) * | 2007-02-19 | 2008-08-28 | Apogenix Gmbh | Il-4 fc fusion proteins |
| EP2009022A1 (en) * | 2007-06-26 | 2008-12-31 | Apogenix GmbH | Trimeric death ligands with enhanced activity (tenascin) |
| WO2010003766A2 (en) | 2008-06-17 | 2010-01-14 | Apogenix Gmbh | Multimeric tnf receptors |
| WO2010078966A1 (en) * | 2009-01-09 | 2010-07-15 | Apogenix Gmbh | Fusion proteins forming trimers |
| WO2011010156A1 (en) * | 2009-07-21 | 2011-01-27 | Queen Mary & Westfield College | Fas (apo-1, cd95) targeted platforms for intracellular drug delivery |
| CA2782320A1 (en) * | 2009-12-02 | 2011-06-09 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins |
| SG11201500134QA (en) * | 2012-07-18 | 2015-03-30 | Apogenix Gmbh | Composition comprising a mixture of cd95-fc isoforms |
| BR112015027249A2 (pt) | 2013-04-29 | 2017-09-26 | Apogenix Gmbh | método de diagnóstico de câncer |
-
2013
- 2013-07-18 SG SG11201500134QA patent/SG11201500134QA/en unknown
- 2013-07-18 WO PCT/EP2013/065250 patent/WO2014013039A1/en not_active Ceased
- 2013-07-18 US US14/415,871 patent/US9434783B2/en not_active Expired - Fee Related
- 2013-07-18 BR BR112015000732-5A patent/BR112015000732B1/pt active IP Right Grant
- 2013-07-18 CN CN201380043661.6A patent/CN104640876A/zh active Pending
- 2013-07-18 JP JP2015522107A patent/JP6231562B2/ja active Active
- 2013-07-18 KR KR1020157004183A patent/KR102201694B1/ko active Active
- 2013-07-18 CN CN201380038208.6A patent/CN104662039B/zh not_active Expired - Fee Related
- 2013-07-18 AU AU2013291982A patent/AU2013291982B2/en not_active Ceased
- 2013-07-18 HK HK15107778.6A patent/HK1207095A1/xx unknown
- 2013-07-18 US US14/415,866 patent/US9315570B2/en active Active
- 2013-07-18 AU AU2013291984A patent/AU2013291984B2/en active Active
- 2013-07-18 UA UAA201500254A patent/UA116889C2/uk unknown
- 2013-07-18 RU RU2015105328A patent/RU2648157C2/ru active
- 2013-07-18 CA CA2877989A patent/CA2877989C/en not_active Expired - Fee Related
- 2013-07-18 EP EP13742412.3A patent/EP2875045B1/en active Active
- 2013-07-18 CA CA2878992A patent/CA2878992C/en active Active
- 2013-07-18 NZ NZ703546A patent/NZ703546A/en unknown
- 2013-07-18 EP EP18164139.0A patent/EP3409686B1/en active Active
- 2013-07-18 RU RU2015105330A patent/RU2648146C2/ru active
- 2013-07-18 DK DK13742412.3T patent/DK2875045T3/en active
- 2013-07-18 EP EP13737631.5A patent/EP2875044B1/en not_active Not-in-force
- 2013-07-18 MX MX2015000731A patent/MX371430B/es active IP Right Grant
- 2013-07-18 ES ES13742412.3T patent/ES2674662T3/es active Active
- 2013-07-18 ES ES18164139T patent/ES2924109T3/es active Active
- 2013-07-18 EP EP18166228.9A patent/EP3406630B1/en not_active Not-in-force
- 2013-07-18 JP JP2015522106A patent/JP6317739B2/ja not_active Expired - Fee Related
- 2013-07-18 DK DK18164139.0T patent/DK3409686T3/da active
- 2013-07-18 WO PCT/EP2013/065248 patent/WO2014013037A1/en not_active Ceased
- 2013-07-18 CN CN201910254827.8A patent/CN109897115A/zh active Pending
-
2015
- 2015-01-11 IL IL236659A patent/IL236659A/en active IP Right Grant
-
2016
- 2016-04-18 US US15/131,219 patent/US9657083B2/en active Active
- 2016-08-17 US US15/239,127 patent/US9908928B2/en active Active
-
2018
- 2018-02-22 US US15/902,175 patent/US10370441B2/en active Active
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