JP2015504052A5 - - Google Patents

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Publication number

JP2015504052A5

JP2015504052A5 JP2014549601A JP2014549601A JP2015504052A5 JP 2015504052 A5 JP2015504052 A5 JP 2015504052A5 JP 2014549601 A JP2014549601 A JP 2014549601A JP 2014549601 A JP2014549601 A JP 2014549601A JP 2015504052 A5 JP2015504052 A5 JP 2015504052A5

Authority

JP

Japan

Prior art keywords

seq

peptide

domain

fusion protein

gly gly

Prior art date

2012-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 43
• 102000037865 fusion proteins Human genes 0.000 claims 26
• 108020001507 fusion proteins Proteins 0.000 claims 26
• 150000001413 amino acids Chemical class 0.000 claims 15
• 235000001014 amino acid Nutrition 0.000 claims 14
• XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims 10
• 230000004927 fusion Effects 0.000 claims 8
• 239000012634 fragment Substances 0.000 claims 7
• 230000032258 transport Effects 0.000 claims 7
• 108010051479 Bombesin Proteins 0.000 claims 6
• 241000224432 Entamoeba histolytica Species 0.000 claims 6
• 229940007078 entamoeba histolytica Drugs 0.000 claims 6
• 108010067216 glycyl-glycyl-glycine Proteins 0.000 claims 6
• 102000013585 Bombesin Human genes 0.000 claims 4
• 102000004961 Furin Human genes 0.000 claims 4
• 108090001126 Furin Proteins 0.000 claims 4
• 102000001708 Protein Isoforms Human genes 0.000 claims 4
• 108010029485 Protein Isoforms Proteins 0.000 claims 4
• DNDCVAGJPBKION-DOPDSADYSA-N bombesin Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC=1NC2=CC=CC=C2C=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1NC(=O)CC1)C(C)C)C1=CN=CN1 DNDCVAGJPBKION-DOPDSADYSA-N 0.000 claims 4
• 230000002101 lytic effect Effects 0.000 claims 4
• 235000018102 proteins Nutrition 0.000 claims 4
• 102000004169 proteins and genes Human genes 0.000 claims 4
• 108090000623 proteins and genes Proteins 0.000 claims 4
• HKZAAJSTFUZYTO-LURJTMIESA-N (2s)-2-[[2-[[2-[[2-[(2-aminoacetyl)amino]acetyl]amino]acetyl]amino]acetyl]amino]-3-hydroxypropanoic acid Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O HKZAAJSTFUZYTO-LURJTMIESA-N 0.000 claims 3
• TVYMKYUSZSVOAG-ZLUOBGJFSA-N Cys-Ala-Ala Chemical compound [H]N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(O)=O TVYMKYUSZSVOAG-ZLUOBGJFSA-N 0.000 claims 3
• 108010056995 Perforin Proteins 0.000 claims 3
• 102000004503 Perforin Human genes 0.000 claims 3
• YMTLKLXDFCSCNX-BYPYZUCNSA-N Ser-Gly-Gly Chemical compound OC[C@H](N)C(=O)NCC(=O)NCC(O)=O YMTLKLXDFCSCNX-BYPYZUCNSA-N 0.000 claims 3
• 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 3
• 210000000170 cell membrane Anatomy 0.000 claims 3
• 239000012636 effector Substances 0.000 claims 3
• RTZCUEHYUQZIDE-WHFBIAKZSA-N Ala-Ser-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](CO)C(=O)NCC(O)=O RTZCUEHYUQZIDE-WHFBIAKZSA-N 0.000 claims 2
• 101710092462 Alpha-hemolysin Proteins 0.000 claims 2
• 101710197219 Alpha-toxin Proteins 0.000 claims 2
• 241000193830 Bacillus <bacterium> Species 0.000 claims 2
• 241000193468 Clostridium perfringens Species 0.000 claims 2
• SKSJPIBFNFPTJB-NKWVEPMBSA-N Cys-Gly-Pro Chemical compound C1C[C@@H](N(C1)C(=O)CNC(=O)[C@H](CS)N)C(=O)O SKSJPIBFNFPTJB-NKWVEPMBSA-N 0.000 claims 2
• YWAQATDNEKZFFK-BYPYZUCNSA-N Gly-Gly-Ser Chemical compound NCC(=O)NCC(=O)N[C@@H](CO)C(O)=O YWAQATDNEKZFFK-BYPYZUCNSA-N 0.000 claims 2
• SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims 2
• 101710154606 Hemagglutinin Proteins 0.000 claims 2
• 101001040751 Homo sapiens Granulysin Proteins 0.000 claims 2
• 108010036176 Melitten Proteins 0.000 claims 2
• 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 2
• 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 2
• 108091008606 PDGF receptors Proteins 0.000 claims 2
• KHGNFPUMBJSZSM-UHFFFAOYSA-N Perforine Natural products COC1=C2CCC(O)C(CCC(C)(C)O)(OC)C2=NC2=C1C=CO2 KHGNFPUMBJSZSM-UHFFFAOYSA-N 0.000 claims 2
• 101710124951 Phospholipase C Proteins 0.000 claims 2
• 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 claims 2
• 101710176177 Protein A56 Proteins 0.000 claims 2
• 108010079194 Type C Phospholipases Proteins 0.000 claims 2
• 102000014384 Type C Phospholipases Human genes 0.000 claims 2
• 108010086434 alanyl-seryl-glycine Proteins 0.000 claims 2
• 239000002776 alpha toxin Substances 0.000 claims 2
• 239000005557 antagonist Substances 0.000 claims 2
• 108010008355 arginyl-glutamine Proteins 0.000 claims 2
• 230000000694 effects Effects 0.000 claims 2
• 108010001064 glycyl-glycyl-glycyl-glycine Proteins 0.000 claims 2
• 239000000185 hemagglutinin Substances 0.000 claims 2
• 239000003112 inhibitor Substances 0.000 claims 2
• 229930192851 perforin Natural products 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 108010073128 phosphatidylcholine-specific phospholipase C Proteins 0.000 claims 2
• 108091033319 polynucleotide Proteins 0.000 claims 2
• 102000040430 polynucleotide Human genes 0.000 claims 2
• 239000002157 polynucleotide Substances 0.000 claims 2
• 108010070643 prolylglutamic acid Proteins 0.000 claims 2
• VYXXMAGSIYIYGD-NWAYQTQBSA-N propan-2-yl 2-[[[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-(pyrimidine-4-carbonylamino)phosphoryl]amino]-2-methylpropanoate Chemical compound CC(C)OC(=O)C(C)(C)NP(=O)(CO[C@H](C)Cn1cnc2c(N)ncnc12)NC(=O)c1ccncn1 VYXXMAGSIYIYGD-NWAYQTQBSA-N 0.000 claims 2
• 230000026683 transduction Effects 0.000 claims 2
• 238000010361 transduction Methods 0.000 claims 2
• 241000712461 unidentified influenza virus Species 0.000 claims 2
• ZIIUUSVHCHPIQD-UHFFFAOYSA-N 2,4,6-trimethyl-N-[3-(trifluoromethyl)phenyl]benzenesulfonamide Chemical compound CC1=CC(C)=CC(C)=C1S(=O)(=O)NC1=CC=CC(C(F)(F)F)=C1 ZIIUUSVHCHPIQD-UHFFFAOYSA-N 0.000 claims 1
• QMOQBVOBWVNSNO-UHFFFAOYSA-N 2-[[2-[[2-[(2-azaniumylacetyl)amino]acetyl]amino]acetyl]amino]acetate Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(O)=O QMOQBVOBWVNSNO-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• HHGYNJRJIINWAK-FXQIFTODSA-N Ala-Ala-Arg Chemical compound C[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N HHGYNJRJIINWAK-FXQIFTODSA-N 0.000 claims 1
• DECCMEWNXSNSDO-ZLUOBGJFSA-N Ala-Cys-Ala Chemical compound C[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(O)=O DECCMEWNXSNSDO-ZLUOBGJFSA-N 0.000 claims 1
• 241000024188 Andala Species 0.000 claims 1
• YBIAYFFIVAZXPK-AVGNSLFASA-N Arg-His-Arg Chemical compound [H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O YBIAYFFIVAZXPK-AVGNSLFASA-N 0.000 claims 1
• BTJVOUQWFXABOI-IHRRRGAJSA-N Arg-Lys-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CCCNC(N)=N BTJVOUQWFXABOI-IHRRRGAJSA-N 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• INKFLNZBTSNFON-CIUDSAMLSA-N Gln-Ala-Arg Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O INKFLNZBTSNFON-CIUDSAMLSA-N 0.000 claims 1
• XUMFMAVDHQDATI-DCAQKATOSA-N Gln-Pro-Arg Chemical compound NC(=O)CC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O XUMFMAVDHQDATI-DCAQKATOSA-N 0.000 claims 1
• NIOPEYHPOBWLQO-KBPBESRZSA-N Gly-Trp-Glu Chemical compound NCC(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(O)=O NIOPEYHPOBWLQO-KBPBESRZSA-N 0.000 claims 1
• 108010006464 Hemolysin Proteins Proteins 0.000 claims 1
• HDXNWVLQSQFJOX-SRVKXCTJSA-N His-Arg-Gln Chemical compound C1=C(NC=N1)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(=O)N)C(=O)O)N HDXNWVLQSQFJOX-SRVKXCTJSA-N 0.000 claims 1
• 241000282412 Homo Species 0.000 claims 1
• 108700000788 Human immunodeficiency virus 1 tat peptide (47-57) Proteins 0.000 claims 1
• PMGDADKJMCOXHX-UHFFFAOYSA-N L-Arginyl-L-glutamin-acetat Natural products NC(=N)NCCCC(N)C(=O)NC(CCC(N)=O)C(O)=O PMGDADKJMCOXHX-UHFFFAOYSA-N 0.000 claims 1
• WNGVUZWBXZKQES-YUMQZZPRSA-N Leu-Ala-Gly Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](C)C(=O)NCC(O)=O WNGVUZWBXZKQES-YUMQZZPRSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• AJHCSUXXECOXOY-UHFFFAOYSA-N N-glycyl-L-tryptophan Natural products C1=CC=C2C(CC(NC(=O)CN)C(O)=O)=CNC2=C1 AJHCSUXXECOXOY-UHFFFAOYSA-N 0.000 claims 1
• 102000035195 Peptidases Human genes 0.000 claims 1
• 108091005804 Peptidases Proteins 0.000 claims 1
• 108010064785 Phospholipases Proteins 0.000 claims 1
• 102000015439 Phospholipases Human genes 0.000 claims 1
• BNBBNGZZKQUWCD-IUCAKERBSA-N Pro-Arg-Gly Chemical compound NC(N)=NCCC[C@@H](C(=O)NCC(O)=O)NC(=O)[C@@H]1CCCN1 BNBBNGZZKQUWCD-IUCAKERBSA-N 0.000 claims 1
• FXGIMYRVJJEIIM-UWVGGRQHSA-N Pro-Leu-Gly Chemical compound OC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1 FXGIMYRVJJEIIM-UWVGGRQHSA-N 0.000 claims 1
• QAAYIXYLEMRULP-SRVKXCTJSA-N Pro-Pro-Met Chemical compound CSCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NCCC1 QAAYIXYLEMRULP-SRVKXCTJSA-N 0.000 claims 1
• 239000004365 Protease Substances 0.000 claims 1
• 101710149951 Protein Tat Proteins 0.000 claims 1
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
• NQVDGKYAUHTCME-QTKMDUPCSA-N Thr-His-Arg Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC1=CN=CN1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N)O NQVDGKYAUHTCME-QTKMDUPCSA-N 0.000 claims 1
• 102000007238 Transferrin Receptors Human genes 0.000 claims 1
• 108010033576 Transferrin Receptors Proteins 0.000 claims 1
• PHNBFZBKLWEBJN-BPUTZDHNSA-N Trp-Glu-Gln Chemical compound C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)O)N PHNBFZBKLWEBJN-BPUTZDHNSA-N 0.000 claims 1
• GEGYPBOPIGNZIF-CWRNSKLLSA-N Trp-Ser-Pro Chemical compound C1C[C@@H](N(C1)C(=O)[C@H](CO)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N)C(=O)O GEGYPBOPIGNZIF-CWRNSKLLSA-N 0.000 claims 1
• NIHNMOSRSAYZIT-BPNCWPANSA-N Tyr-Ala-Arg Chemical compound NC(=N)NCCC[C@@H](C(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC1=CC=C(O)C=C1 NIHNMOSRSAYZIT-BPNCWPANSA-N 0.000 claims 1
• AYHNXCJKBLYVOA-KSZLIROESA-N Val-Trp-Pro Chemical compound CC(C)[C@@H](C(=O)N[C@@H](CC1=CNC2=CC=CC=C21)C(=O)N3CCC[C@@H]3C(=O)O)N AYHNXCJKBLYVOA-KSZLIROESA-N 0.000 claims 1
• RTJPAGFXOWEBAI-SRVKXCTJSA-N Val-Val-Arg Chemical compound CC(C)[C@H](N)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(O)=O)CCCN=C(N)N RTJPAGFXOWEBAI-SRVKXCTJSA-N 0.000 claims 1
• 239000004480 active ingredient Substances 0.000 claims 1
• 108010029539 arginyl-prolyl-proline Proteins 0.000 claims 1
• 210000004899 c-terminal region Anatomy 0.000 claims 1
• 238000003776 cleavage reaction Methods 0.000 claims 1
• 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
• 230000001461 cytolytic effect Effects 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000002255 enzymatic effect Effects 0.000 claims 1
• 230000014509 gene expression Effects 0.000 claims 1
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
• YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims 1
• 108010084389 glycyltryptophan Proteins 0.000 claims 1
• 239000003228 hemolysin Substances 0.000 claims 1
• 125000005647 linker group Chemical group 0.000 claims 1
• 108010034507 methionyltryptophan Proteins 0.000 claims 1
• 230000001613 neoplastic effect Effects 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• MXHCPCSDRGLRER-UHFFFAOYSA-N pentaglycine Chemical compound NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(O)=O MXHCPCSDRGLRER-UHFFFAOYSA-N 0.000 claims 1
• 229920000724 poly(L-arginine) polymer Polymers 0.000 claims 1
• 108010011110 polyarginine Proteins 0.000 claims 1
• 229920002704 polyhistidine Polymers 0.000 claims 1
• 239000011148 porous material Substances 0.000 claims 1
• 108700042769 prolyl-leucyl-glycine Proteins 0.000 claims 1
• 230000007017 scission Effects 0.000 claims 1