RU2017132689A - СЛИТАЯ С Fc α-ЦЕПЬ ВЫСОКОАФФИННОГО РЕЦЕПТОРА IgE - Google Patents
СЛИТАЯ С Fc α-ЦЕПЬ ВЫСОКОАФФИННОГО РЕЦЕПТОРА IgE Download PDFInfo
- Publication number
- RU2017132689A RU2017132689A RU2017132689A RU2017132689A RU2017132689A RU 2017132689 A RU2017132689 A RU 2017132689A RU 2017132689 A RU2017132689 A RU 2017132689A RU 2017132689 A RU2017132689 A RU 2017132689A RU 2017132689 A RU2017132689 A RU 2017132689A
- Authority
- RU
- Russia
- Prior art keywords
- fusion protein
- high affinity
- ige receptor
- amino acid
- acid sequence
- Prior art date
Links
- 102000009438 IgE Receptors Human genes 0.000 title claims 2
- 108010073816 IgE Receptors Proteins 0.000 title claims 2
- 108091006020 Fc-tagged proteins Proteins 0.000 claims 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 239000000539 dimer Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Claims (7)
1. Fc-слитый белок, содержащий: (i) α-цепь высокоаффинного рецептора IgE; и
(ii) Fc-область IgG1, где
область фрагмента линкера между (i) и (ii) представляет собой аминокислотную последовательность, представленную в SEQ ID NO: 2.
2. Fc-слитый белок по п. 1, содержащий аминокислотную последовательность, представленную в SEQ ID NO: 3, или аминокислотную последовательность, содержащую делецию лизина (K) на C-конце аминокислотной последовательности, представленной в SEQ ID NO: 3.
3. Fc-слитый белок по п. 1 или 2, который представляет собой димер.
4. Fc-слитый белок по п. 3, где остатки цистеина в области фрагмента линкера образуют три дисульфидные связи.
5. Фармацевтическая композиция, содержащая в качестве активного ингредиента Fc-слитый белок по любому из пп. 1-4.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-032231 | 2015-02-20 | ||
| JP2015032231 | 2015-02-20 | ||
| JP2015-252231 | 2015-12-24 | ||
| JP2015252231 | 2015-12-24 | ||
| PCT/JP2016/054854 WO2016133197A1 (ja) | 2015-02-20 | 2016-02-19 | Ｆｃ融合高親和性ＩｇＥ受容体α鎖 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017132689A true RU2017132689A (ru) | 2019-03-20 |
| RU2017132689A3 RU2017132689A3 (ru) | 2019-08-15 |
| RU2715606C2 RU2715606C2 (ru) | 2020-03-02 |
Family
ID=56692248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017132689A RU2715606C2 (ru) | 2015-02-20 | 2016-02-19 | СЛИТАЯ С Fc α-ЦЕПЬ ВЫСОКОАФФИННОГО РЕЦЕПТОРА IgE |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US10077297B2 (ru) |
| EP (1) | EP3260469B1 (ru) |
| JP (1) | JP6192862B2 (ru) |
| KR (2) | KR20230132610A (ru) |
| CN (1) | CN107207623B (ru) |
| AU (1) | AU2016220766B2 (ru) |
| BR (1) | BR112017017609A2 (ru) |
| CA (1) | CA2976623C (ru) |
| ES (1) | ES2806205T3 (ru) |
| HK (1) | HK1244016A1 (ru) |
| IL (1) | IL253832B (ru) |
| MX (1) | MX2017010359A (ru) |
| PL (1) | PL3260469T3 (ru) |
| PT (1) | PT3260469T (ru) |
| RU (1) | RU2715606C2 (ru) |
| SG (1) | SG11201706543UA (ru) |
| TW (1) | TWI691512B (ru) |
| WO (1) | WO2016133197A1 (ru) |
| ZA (2) | ZA201706281B (ru) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7127859B2 (ja) * | 2016-11-09 | 2022-08-30 | ノース カロライナ ステート ユニバーシティ | キメラタンパク質を用いたアレルギー疾患の治療 |
| WO2019135666A1 (ko) * | 2018-01-08 | 2019-07-11 | 주식회사 프로젠 | Ige fc 수용체의 알파 서브유닛의 세포외 도메인을 포함하는 약학적 조성물 |
| SG11202005858WA (en) * | 2018-01-08 | 2020-07-29 | Gi Innovation Inc | Extracellular domain of alpha subunit of ige fc receptor, pharmaceutical composition comprising same and method for producing same |
| JP7041272B2 (ja) * | 2018-01-12 | 2022-03-23 | ジーアイ・イノベイション・インコーポレイテッド | プロバイオティクスおよびＩｇＥへの結合親和性を有するポリペプチドを含む組成物およびその使用 |
| WO2021006603A1 (ko) * | 2019-07-08 | 2021-01-14 | 주식회사 프로젠 | 신규 알러지 질환 치료용 약학적 조성물 |
| WO2021006375A1 (ko) * | 2019-07-08 | 2021-01-14 | (주)지아이이노베이션 | Ige fc 수용체의 알파 서브유닛의 세포외 도메인을 포함하는 시알산 함량이 높은 폴리펩티드 이량체 및 이를 포함하는 약학적 조성물 |
| BR112022000246A2 (pt) * | 2019-07-08 | 2022-02-22 | Gi Innovation Inc | Dímero polipeptídico com elevado teor de ácido siálico, compreendendo o domínio extracelular da subunidade alfa do receptor fc de ige e composição farmacêutica compreendendo o mesmo |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| EP2354791A1 (en) * | 2001-12-04 | 2011-08-10 | Merck Patent GmbH | Immunocytokines with modulated selectivity |
| WO2008028068A2 (en) | 2006-08-30 | 2008-03-06 | Genentech, Inc. | NON-HUMAN PRIMATE FCεR1α POLYPEPTIDES |
| AR065368A1 (es) | 2007-02-15 | 2009-06-03 | Astrazeneca Ab | Anticuerpos para moleculas de ige |
| WO2008099188A1 (en) | 2007-02-15 | 2008-08-21 | Astrazeneca Ab | Binding members for ige molecules |
| PL2132230T3 (pl) * | 2007-03-22 | 2014-09-30 | Genentech Inc | Apoptotyczne przeciwciała anty-IgE wiążące IgE związaną z błoną |
| KR101631454B1 (ko) | 2008-10-31 | 2016-06-17 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 논리회로 |
| CN101633698B (zh) | 2009-08-26 | 2011-12-21 | 北京精益泰翔技术发展有限公司 | 一种免疫融合蛋白及其编码基因与应用 |
| MX344935B (es) | 2009-10-26 | 2017-01-11 | Genentech Inc | Analisis para detectar anticuerpos especificos a anticuerpos anti-ige terapeuticos y su uso en anafilaxis. |
| WO2011103584A2 (en) * | 2010-02-19 | 2011-08-25 | Xencor, Inc. | Novel ctla4-ig immunoadhesins |
| GB201014033D0 (en) * | 2010-08-20 | 2010-10-06 | Ucb Pharma Sa | Biological products |
| WO2012169735A2 (ko) * | 2011-06-07 | 2012-12-13 | (주)네오팜 | FCεRI의 수용성 단편을 포함하는 복합체 및 이를 포함하는 IGE 매개 알레르기성 질환 치료용 조성물 |
| GB201203051D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| GB201203071D0 (en) * | 2012-02-22 | 2012-04-04 | Ucb Pharma Sa | Biological products |
| WO2014087010A1 (en) | 2012-12-07 | 2014-06-12 | Ablynx N.V. | IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE |
-
2016
- 2016-02-17 TW TW105104590A patent/TWI691512B/zh active
- 2016-02-19 KR KR1020237029823A patent/KR20230132610A/ko not_active Application Discontinuation
- 2016-02-19 AU AU2016220766A patent/AU2016220766B2/en active Active
- 2016-02-19 US US15/552,065 patent/US10077297B2/en active Active
- 2016-02-19 RU RU2017132689A patent/RU2715606C2/ru active
- 2016-02-19 SG SG11201706543UA patent/SG11201706543UA/en unknown
- 2016-02-19 ES ES16752583T patent/ES2806205T3/es active Active
- 2016-02-19 EP EP16752583.1A patent/EP3260469B1/en active Active
- 2016-02-19 PL PL16752583T patent/PL3260469T3/pl unknown
- 2016-02-19 WO PCT/JP2016/054854 patent/WO2016133197A1/ja active Application Filing
- 2016-02-19 CA CA2976623A patent/CA2976623C/en active Active
- 2016-02-19 JP JP2016574302A patent/JP6192862B2/ja active Active
- 2016-02-19 PT PT167525831T patent/PT3260469T/pt unknown
- 2016-02-19 BR BR112017017609-2A patent/BR112017017609A2/pt not_active Application Discontinuation
- 2016-02-19 CN CN201680010238.XA patent/CN107207623B/zh active Active
- 2016-02-19 MX MX2017010359A patent/MX2017010359A/es unknown
- 2016-02-19 KR KR1020177021139A patent/KR102602539B1/ko active IP Right Grant
-
2017
- 2017-08-03 IL IL253832A patent/IL253832B/en active IP Right Grant
- 2017-09-15 ZA ZA2017/06281A patent/ZA201706281B/en unknown
-
2018
- 2018-03-13 HK HK18103481.0A patent/HK1244016A1/zh unknown
- 2018-06-22 ZA ZA2018/04191A patent/ZA201804191B/en unknown
- 2018-07-13 US US16/034,648 patent/US20180312566A1/en not_active Abandoned
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