HRP20190689T1 - Muteini suznog lipokalina koji vežu il-4r alfa - Google Patents

Muteini suznog lipokalina koji vežu il-4r alfa Download PDF

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HRP20190689T1
HRP20190689T1 HRP20190689TT HRP20190689T HRP20190689T1 HR P20190689 T1 HRP20190689 T1 HR P20190689T1 HR P20190689T T HRP20190689T T HR P20190689TT HR P20190689 T HRP20190689 T HR P20190689T HR P20190689 T1 HRP20190689 T1 HR P20190689T1
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leu
ala
ser
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HRP20190689TT
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Andreas Hohlbaum
Alexandra Baehre
Gabriele Matschiner
Stefan Trentmann
Klaus KIRCHFLED
Hans-Juergen Christian
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Pieris Pharmaceuticals Gmbh
Astrazeneca Ab
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    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
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Claims (8)

1. Mutein ljudskog suznog lipokalina, naznačen time što mutein sadrži: (i) slijedeće supstitucije amino kiselina Glu 27 → Arg, Phe 28 → Cys, Glu 30 → Arg, Met 31 → Ala, Leu 33 → Tyr, Ile 57 → Arg, Cys 61 → Trp, Asp 80 → Ser, Lys 83 → Arg, Glu 104 → Leu, Leu 105 → Cys, His 106 → Pro, Lys 108 → Gin; i (ii) jedan od slijedećih skupova aminokiselinskih supstitucija (1) Arg 26 → Pro, Asn 32 → Tyr, Glu 34 → Ser, Met 55 → Ala, Leu 56 → Gin, Glu 63 → Lys; (2) Arg 26 → Ser, Asn 32 → Tyr, Glu 34 → Val, Met 55 → Ala, Leu 56 → Ala, Ser 58 → Ile, Glu 63 → Ser; (3) Arg 26 → Ser, Asn 32 → Val, Glu 34 → Asn, Met 55 → Ala, Leu 56 → Gln, Ser 58 → Lys, Glu 63 → Lys; (4) Arg 26 → Asn, Asn 32 → Lys, Glu 34 → Asp, Met 55 → Ala, Leu 56 → His, Ser 58 → Arg, Glu 63 → Gln; (5) Arg 26 → Tyr, Asn 32 → Tyr, Glu 34 → His, Met 55 → Ala, Leu 56 → His, Ser 58 → Ala, Glu 63 → Lys; (6) Arg 26 → Lys, Asn 32 → Tyr, Glu 34 → Arg, Met 55 → Ala, Leu 56 → Lys, Ser 58 → Asn, Glu 63 → Pro; ili (7) Arg 26 → Glu, Asn 32 → His, Glu 34 → Gly, Met 55 → Ala, Leu 56 → Met, Ser 58 → Leu, Glu 63 → Lys; i (iii) najmanje 75% identičnosti sa sekvencom zrelog ljudskog suznog lipokalina, pri čemu je sekvenca zrelog ljudskog suznog lipokalina i pri čemu se mutein veže na ljudski IL-4 receptor alfa s konstantom disocijacije (KD) od ispod 0.1 nM.
2. Mutein prema patentnom zahtjevu 1, naznačen time što nadalje sadrži sljedeći skup aminokiselinskih supstitucija: (1) Val 53 → Phe, Val 64 → Tyr, Ala 66 → Leu.
3. Mutein prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što su izbrisana prva četiri N-terminalna aminokiselinska ostatka o sekvence zrelog ljudskog suznog lipokalina i/ili posljednja dva C-terminalna aminokiselinska ostatka sekvence zrelog ljudskog suznog lipokalina.
4. Mutein prema bilo kojem od prethodnih patentnih zahtjeva, naznačen time što mutein ima aminokiselinsku sekvencu kao što je prikazano u SEQ ID No: 4, i 6-11.
5. Fuzijski protein naznačen time što sadrži mutein prema bilo kojem od zahtjeva 1 do 4.
6. Molekula nukleinske kiseline naznačena time što sadrži nukleotidnu sekvencu koja kodira mutein prema bilo kojem od zahtjeva 1 do 4 ili fuzijski protein prema zahtjevu 5.
7. Stanica domaćin naznačena time što sadrži molekulu nukleinske kiseline prema zahtjevu 6.
8. Farmaceutski ili dijagnostički pripravak naznačen time što sadrži mutein prema bilo kojem od zahtjeva 1 do 4 ili fuzijski protein prema zahtjevu 5.
HRP20190689TT 2010-06-08 2019-04-12 Muteini suznog lipokalina koji vežu il-4r alfa HRP20190689T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35246110P 2010-06-08 2010-06-08
PCT/EP2011/059420 WO2011154420A2 (en) 2010-06-08 2011-06-08 Tear lipocalin muteins binding il-4 r alpha
EP11726380.6A EP2580236B1 (en) 2010-06-08 2011-06-08 Tear lipocalin muteins binding il-4 r alpha

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HRP20190689T1 true HRP20190689T1 (hr) 2019-06-14

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US (5) US8986951B2 (hr)
EP (1) EP2580236B1 (hr)
JP (3) JP5902679B2 (hr)
CN (3) CN103038249B (hr)
AU (1) AU2011263786B2 (hr)
CA (1) CA2800026C (hr)
CY (1) CY1122339T1 (hr)
DK (1) DK2580236T3 (hr)
ES (1) ES2729652T3 (hr)
HR (1) HRP20190689T1 (hr)
HU (1) HUE043835T2 (hr)
LT (1) LT2580236T (hr)
NZ (1) NZ603562A (hr)
PL (1) PL2580236T3 (hr)
PT (1) PT2580236T (hr)
RS (1) RS58839B1 (hr)
RU (1) RU2569745C2 (hr)
SG (1) SG186161A1 (hr)
SI (1) SI2580236T1 (hr)
TR (1) TR201906295T4 (hr)
WO (1) WO2011154420A2 (hr)
ZA (1) ZA201209160B (hr)

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