CY1122339T1 - Μουτεϊνες δακρυϊκης λιποκαλινης που δεσμευουν il-4 r αλφα - Google Patents

Μουτεϊνες δακρυϊκης λιποκαλινης που δεσμευουν il-4 r αλφα

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Publication number
CY1122339T1
CY1122339T1 CY20191100604T CY191100604T CY1122339T1 CY 1122339 T1 CY1122339 T1 CY 1122339T1 CY 20191100604 T CY20191100604 T CY 20191100604T CY 191100604 T CY191100604 T CY 191100604T CY 1122339 T1 CY1122339 T1 CY 1122339T1
Authority
CY
Cyprus
Prior art keywords
present
tear lipocalin
human tear
lipocalin muteins
alpha binding
Prior art date
Application number
CY20191100604T
Other languages
English (en)
Inventor
Andreas Hohlbaum
Alexandra Baehre
Gabriele Matschiner
Stefan Trentmann
Klaus KIRCHFLED
Hans-Juergen Christian
Original Assignee
Pieris Pharmaceuticals Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pieris Pharmaceuticals Gmbh filed Critical Pieris Pharmaceuticals Gmbh
Publication of CY1122339T1 publication Critical patent/CY1122339T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

Η παρούσα εφεύρεση σχετίζεται με νέες μουτεΐνες που προέρχονται από την ανθρώπινη δακρυϊκή λιποκαλίνη, οι οποίες δεσμεύονται στον υποδοχέα άλφα της IL4. Οι αλληλουχίες των μουτεϊνών περιλαμβάνουν συγκεκριμένους συνδυασμούς αμινοξέων. Συγκεκριμένα, ένα μεταλλαγμένο αμινοξικό κατάλοιπο είναι παρόν σε οποιαδήποτε μία ή περισσότερες από τις θέσεις αλληλουχίας 27, 28, 30, 31, 33, 53, 57, 61, 64, 66, 80, 83, 104- 106 και 108 της γραμμικής πολυπεπτιδικής αλληλουχίας της ώριμης ανθρώπινης δακρυϊκής λιποκαλίνης. Ένα μεταλλαγμένο αμινοξικό κατάλοιπο είναι επίσης παρόν σε οποιεσδήποτε 2 ή περισσότερες από τις θέσεις αλληλουχίας 26, 32, 34, 55, 56, 58 και 63 της γραμμικής πολυπεπτιδικής αλληλουχίας της ώριμης ανθρώπινης δακρυϊκής λιποκαλίνης. Η εφεύρεση παρέχει επίσης ένα αντίστοιχο μόριο νουκλεϊκού οξέος που κωδικοποιεί μία τέτοια μουτεΐνη και μία μέθοδο για την παραγωγή μίας τέτοιας μουτεΐνης και του μορίου νουκλεϊκού οξέος που την κωδικοποιεί.
CY20191100604T 2010-06-08 2019-06-06 Μουτεϊνες δακρυϊκης λιποκαλινης που δεσμευουν il-4 r αλφα CY1122339T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US35246110P 2010-06-08 2010-06-08
PCT/EP2011/059420 WO2011154420A2 (en) 2010-06-08 2011-06-08 Tear lipocalin muteins binding il-4 r alpha

Publications (1)

Publication Number Publication Date
CY1122339T1 true CY1122339T1 (el) 2021-01-27

Family

ID=44627297

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100604T CY1122339T1 (el) 2010-06-08 2019-06-06 Μουτεϊνες δακρυϊκης λιποκαλινης που δεσμευουν il-4 r αλφα

Country Status (22)

Country Link
US (5) US8986951B2 (el)
EP (1) EP2580236B1 (el)
JP (3) JP5902679B2 (el)
CN (3) CN111499725A (el)
AU (1) AU2011263786B2 (el)
CA (1) CA2800026C (el)
CY (1) CY1122339T1 (el)
DK (1) DK2580236T3 (el)
ES (1) ES2729652T3 (el)
HR (1) HRP20190689T1 (el)
HU (1) HUE043835T2 (el)
LT (1) LT2580236T (el)
NZ (1) NZ603562A (el)
PL (1) PL2580236T3 (el)
PT (1) PT2580236T (el)
RS (1) RS58839B1 (el)
RU (1) RU2569745C2 (el)
SG (1) SG186161A1 (el)
SI (1) SI2580236T1 (el)
TR (1) TR201906295T4 (el)
WO (1) WO2011154420A2 (el)
ZA (1) ZA201209160B (el)

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US20150283207A1 (en) 2015-10-08
HUE043835T2 (hu) 2019-09-30
CN105949301B (zh) 2020-03-27
PL2580236T3 (pl) 2019-09-30
SG186161A1 (en) 2013-01-30
EP2580236A2 (en) 2013-04-17
JP2016028604A (ja) 2016-03-03
AU2011263786A1 (en) 2012-11-29
US20130085113A1 (en) 2013-04-04
US9687524B2 (en) 2017-06-27
JP2013537400A (ja) 2013-10-03
JP6766194B2 (ja) 2020-10-07
US10232014B2 (en) 2019-03-19
CA2800026C (en) 2023-05-09
SI2580236T1 (sl) 2019-08-30
ZA201209160B (en) 2014-01-29
US20190240289A1 (en) 2019-08-08
DK2580236T3 (da) 2019-06-11
CN105949301A (zh) 2016-09-21
US8986951B2 (en) 2015-03-24
US20170340703A1 (en) 2017-11-30
JP5902679B2 (ja) 2016-04-13
JP2019115342A (ja) 2019-07-18
WO2011154420A3 (en) 2012-12-20
RU2569745C2 (ru) 2015-11-27
CA2800026A1 (en) 2011-12-15
ES2729652T3 (es) 2019-11-05
US20210196788A1 (en) 2021-07-01
LT2580236T (lt) 2019-06-25
CN103038249A (zh) 2013-04-10
EP2580236B1 (en) 2019-04-03
PT2580236T (pt) 2019-05-30
AU2011263786A2 (en) 2014-08-21
RU2012150766A (ru) 2014-07-20
CN103038249B (zh) 2016-04-13
HRP20190689T1 (hr) 2019-06-14
TR201906295T4 (tr) 2019-05-21
CN111499725A (zh) 2020-08-07
NZ603562A (en) 2014-07-25
US10898545B2 (en) 2021-01-26
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