CY1124525T1 - Προσδετες τροποποιημενοι με κυκλικη μεταθεση ως αγωνιστες και ανταγωνιστες - Google Patents
Προσδετες τροποποιημενοι με κυκλικη μεταθεση ως αγωνιστες και ανταγωνιστεςInfo
- Publication number
- CY1124525T1 CY1124525T1 CY20211100009T CY211100009T CY1124525T1 CY 1124525 T1 CY1124525 T1 CY 1124525T1 CY 20211100009 T CY20211100009 T CY 20211100009T CY 211100009 T CY211100009 T CY 211100009T CY 1124525 T1 CY1124525 T1 CY 1124525T1
- Authority
- CY
- Cyprus
- Prior art keywords
- increased
- competitors
- modified
- agonist
- prodates
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5412—IL-6
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- C07K14/575—Hormones
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Abstract
Η παρούσα εφεύρεση παρέχει πολυπεπτίδια σύντηξης που περιέχουν προσδέτες πολυπεπτιδίων οι οποίοι είναι τροποποιημένοι με κυκλική μετάθεση και συντηγμένοι με τουλάχιστον έναν συνεργάτη σύντηξης πολυπεπτιδίων όπου τέτοια πολυπεπτίδια σύντηξης έχουν νέες, βελτιωμένες ή ενισχυμένες βιολογικές λειτουργίες ή δραστικότητες. Τέτοιες βελτιώσεις περιλαμβάνουν, ενδεικτικά, αυξημένη συγγένεια δέσμευσης, αυξημένη δραστικότητα, αυξημένη δραστικότητα αγωνιστή (υπερ-αγωνιστή), δραστικότητα ανταγωνιστή, αυξημένη προσβασιμότητα, αυξημένη ευκαμψία της δραστικής θέσης, αυξημένη σταθερότητα, ευρύτερη και/ή μεταλλαγμένη ειδικότητα υποστρώματος, και συνδυασμούς αυτών.
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261657285P | 2012-06-08 | 2012-06-08 | |
US201261657264P | 2012-06-08 | 2012-06-08 | |
US201261657378P | 2012-06-08 | 2012-06-08 | |
US201261723081P | 2012-11-06 | 2012-11-06 | |
US201361778575P | 2013-03-13 | 2013-03-13 | |
US201361778812P | 2013-03-13 | 2013-03-13 | |
EP13801437.8A EP2859015B1 (en) | 2012-06-08 | 2013-06-06 | Ligands modified by circular permutation as agonists and antagonists |
PCT/US2013/044556 WO2013184942A1 (en) | 2012-06-08 | 2013-06-06 | Ligands modified by circular permutation as agonists and antagonists |
Publications (1)
Publication Number | Publication Date |
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CY1124525T1 true CY1124525T1 (el) | 2022-07-22 |
Family
ID=49712642
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100640T CY1120522T1 (el) | 2012-06-08 | 2018-06-20 | Προσδετες τροποποιημενοι μεσω κυκλικης μεταθεσης ως αγωνιστες και ανταγωνιστες |
CY20211100009T CY1124525T1 (el) | 2012-06-08 | 2021-01-07 | Προσδετες τροποποιημενοι με κυκλικη μεταθεση ως αγωνιστες και ανταγωνιστες |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100640T CY1120522T1 (el) | 2012-06-08 | 2018-06-20 | Προσδετες τροποποιημενοι μεσω κυκλικης μεταθεσης ως αγωνιστες και ανταγωνιστες |
Country Status (20)
Country | Link |
---|---|
US (8) | US9156897B2 (el) |
EP (5) | EP2858672B1 (el) |
JP (7) | JP6322626B2 (el) |
AU (3) | AU2013271545C1 (el) |
CA (3) | CA2869787C (el) |
CY (2) | CY1120522T1 (el) |
DK (2) | DK3401402T3 (el) |
ES (4) | ES2675784T3 (el) |
HK (3) | HK1203969A1 (el) |
HR (2) | HRP20180914T1 (el) |
HU (2) | HUE037849T2 (el) |
LT (2) | LT2859015T (el) |
ME (1) | ME03079B (el) |
NZ (4) | NZ630849A (el) |
PL (2) | PL3401402T3 (el) |
PT (2) | PT3401402T (el) |
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