CY1116011T1 - Hla-a*1101-περιορισμενο wt1 πεπτιδιο και φαρμακευτικη συνθεση που το περιλαμβανει - Google Patents
Hla-a*1101-περιορισμενο wt1 πεπτιδιο και φαρμακευτικη συνθεση που το περιλαμβανειInfo
- Publication number
- CY1116011T1 CY1116011T1 CY20151100113T CY151100113T CY1116011T1 CY 1116011 T1 CY1116011 T1 CY 1116011T1 CY 20151100113 T CY20151100113 T CY 20151100113T CY 151100113 T CY151100113 T CY 151100113T CY 1116011 T1 CY1116011 T1 CY 1116011T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hla
- peptide
- pharmaceutical composition
- ability
- pipe
- Prior art date
Links
- 108010075704 HLA-A Antigens Proteins 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 102000011786 HLA-A Antigens Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 102100028972 HLA class I histocompatibility antigen, A alpha chain Human genes 0.000 abstract 3
- 102000040856 WT1 Human genes 0.000 abstract 2
- 108700020467 WT1 Proteins 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 235000001014 amino acid Nutrition 0.000 abstract 2
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464452—Transcription factors, e.g. SOX or c-MYC
- A61K39/464453—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Wood Science & Technology (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με ΗLΑ-Α*1101-περιορισμένο WT1 πεπτίδιο, πιο συγκεκριμένα με πεπτίδιο που περιλαμβάνει αμινοξική αλληλουχία αποτελούμενη από 9 διαδοχικά αμινοξέα από πρωτεΐνη WT1, όπου το πεπτίδιο έχει την ικανότητα να δεσμεύεται σε ΗLΑ-Α*1011 μόριο, και επίσης έχει την ικανότητα να επάγει CTL. Η παρούσα εφεύρεση επίσης σχετίζεται με πεπτιδοδιμερές που έχει την ικανότητα να δεσμεύεται σε ΗLΑ-Α*1011 μόριο και που έχει την ικανότητα να επάγει CTL, στο οποίο δύο πεπτιδομονομερή -με έκαστο να περιλαμβάνει αμινοξική αλληλουχία αποτελούμενη από 9 διαδοχικά αμινοξέα από πρωτεΐνη WT1 και να περιλαμβάνει τουλάχιστον ένα κατάλοιπο κυστεΐνης- είναι ενωμένα μεταξύ τους μέσω δισουλφιδικού δεσμού. Περαιτέρω, η παρούσα εφεύρεση σχετίζεται με πολυνουκλεοτίδιο που κωδικεύει το πεπτίδιο, με φαρμακευτική σύνθεση για τη θεραπευτική αγωγή και/ή πρόληψη καρκίνου που περιλαμβάνει το πεπτίδιο και τα όμοια.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2006355356 | 2006-12-28 | ||
| EP10191234.3A EP2341142B8 (en) | 2006-12-28 | 2007-12-14 | HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1116011T1 true CY1116011T1 (el) | 2017-01-25 |
Family
ID=39588385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20151100113T CY1116011T1 (el) | 2006-12-28 | 2015-02-04 | Hla-a*1101-περιορισμενο wt1 πεπτιδιο και φαρμακευτικη συνθεση που το περιλαμβανει |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US8653038B2 (el) |
| EP (6) | EP2479275B1 (el) |
| JP (1) | JP5484734B2 (el) |
| KR (1) | KR101525261B1 (el) |
| CN (5) | CN102295682A (el) |
| AR (1) | AR064555A1 (el) |
| AU (1) | AU2007340679B2 (el) |
| BR (1) | BRPI0720988A2 (el) |
| CA (5) | CA2886622A1 (el) |
| CY (1) | CY1116011T1 (el) |
| DK (3) | DK2479276T3 (el) |
| ES (4) | ES2554775T3 (el) |
| HK (3) | HK1159686A1 (el) |
| IL (4) | IL199052A0 (el) |
| MX (1) | MX2009007008A (el) |
| MY (1) | MY161664A (el) |
| NO (1) | NO20092774L (el) |
| NZ (4) | NZ601175A (el) |
| PH (1) | PH12014500902A1 (el) |
| PL (1) | PL2341142T3 (el) |
| PT (1) | PT2341142E (el) |
| RU (1) | RU2481398C2 (el) |
| SG (1) | SG177222A1 (el) |
| SI (1) | SI2341142T1 (el) |
| TW (3) | TWI417103B (el) |
| UA (1) | UA103154C2 (el) |
| WO (1) | WO2008081701A1 (el) |
| ZA (1) | ZA200903633B (el) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2378264T3 (es) | 2003-11-05 | 2012-04-10 | International Institute Of Cancer Immunology, Inc. | Péptido antigénico de unión a HLA-DR derivado de WT1 |
| CA2900087C (en) | 2005-10-17 | 2024-02-13 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| EP3117836A1 (en) | 2006-04-10 | 2017-01-18 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and uses thereof |
| RU2680539C2 (ru) | 2007-02-27 | 2019-02-22 | Интернешнл Инститьют Оф Кэнсер Иммунолоджи, Инк. | Способ активации хелперных т-клеток и композиция для применения в данном способе |
| SG189287A1 (en) | 2010-10-05 | 2013-05-31 | Int Inst Cancer Immunology Inc | Method for activating helper t cell |
| SG193956A1 (en) * | 2011-04-01 | 2013-11-29 | Sloan Kettering Inst Cancer | T cell receptor-like antibodies specific for a wt1 peptide presented by hla-a2 |
| EP2757373A4 (en) * | 2011-09-14 | 2015-07-01 | Int Inst Cancer Immunology Inc | METHOD FOR MEASURING ANTI-WT1 ANTIBODIES |
| WO2013106834A2 (en) | 2012-01-13 | 2013-07-18 | Memorial Sloan Kettering Cancer Center | Immunogenic wt-1 peptides and methods of use thereof |
| WO2014042226A1 (ja) | 2012-09-12 | 2014-03-20 | 株式会社癌免疫研究所 | 抗原特異的ヘルパーｔ細胞レセプター遺伝子 |
| KR102208505B1 (ko) | 2012-12-11 | 2021-01-27 | 앨버트 아인슈타인 컬리지 오브 메디신 | 고처리량 수용체:리간드 확인을 위한 방법 |
| TWI646970B (zh) * | 2012-12-17 | 2019-01-11 | 大塚製藥股份有限公司 | 活化輔助ｔ細胞的方法 |
| PT2945647T (pt) | 2013-01-15 | 2020-11-26 | Memorial Sloan Kettering Cancer Center | Péptidos imunogénicos wt-1 e métodos de uso dos mesmos |
| US10815273B2 (en) | 2013-01-15 | 2020-10-27 | Memorial Sloan Kettering Cancer Center | Immunogenic WT-1 peptides and methods of use thereof |
| RU2014102939A (ru) | 2013-02-05 | 2015-08-10 | Нитто Денко Корпорейшн | Вакцинная композиция для чрескожного введения |
| JP6512568B2 (ja) | 2013-02-05 | 2019-05-15 | 日東電工株式会社 | 経皮投与用ｗｔ１ペプチド癌ワクチン組成物 |
| US10206985B2 (en) | 2013-02-05 | 2019-02-19 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for mucosal administration |
| CA2840959A1 (en) | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Vaccine composition |
| US20140220058A1 (en) | 2013-02-05 | 2014-08-07 | Nitto Denko Corporation | Vaccine composition for transdermal or mucosal administration |
| EP2762156A1 (en) | 2013-02-05 | 2014-08-06 | Nitto Denko Corporation | Tape preparation of WT1 peptide cancer vaccine for transdermal administration |
| KR20140099828A (ko) | 2013-02-05 | 2014-08-13 | 닛토덴코 가부시키가이샤 | 점막 투여용 백신 조성물 |
| JP6512567B2 (ja) | 2013-02-05 | 2019-05-15 | 日東電工株式会社 | 経皮投与用ｗｔ１ペプチド癌ワクチン組成物 |
| JP6671956B2 (ja) * | 2013-03-29 | 2020-03-25 | 大日本住友製薬株式会社 | Ｅｒａｐ１によるトリミング機能をきっかけとしたコンジュゲートワクチン |
| RU2668560C2 (ru) * | 2013-03-29 | 2018-10-02 | Сумитомо Дайниппон Фарма Ко., Лтд. | Конъюгированная вакцина на основе пептида антигена wt1 |
| EP3231438B1 (en) | 2014-12-11 | 2020-06-17 | International Institute of Cancer Immunology, Inc. | Wt1 immunotherapy for intraocular angiogenic disease |
| EP3458095A4 (en) | 2016-05-18 | 2019-11-27 | Albert Einstein College of Medicine | PD-L1 POLYPEPTIDE VARIANTS, T-LYMPHOCYTE MODULATOR MULTIMERIC POLYPEPTIDES AND METHODS OF USING SAME |
| CN109475628A (zh) | 2016-05-18 | 2019-03-15 | 库尔生物制药有限公司 | T细胞调节性多聚体多肽及其使用方法 |
| EP3558339B1 (en) | 2016-12-22 | 2024-01-24 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| EP3565829A4 (en) | 2017-01-09 | 2021-01-27 | Cue Biopharma, Inc. | MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE |
| IL309479A (en) | 2017-03-15 | 2024-02-01 | Cue Biopharma Inc | Methods for modulating an immune response |
| US20200368338A1 (en) * | 2017-12-27 | 2020-11-26 | Sumitomo Dainippon Pharma Co., Ltd. | Conjugate of wt1-derived peptides and composition comprising the same |
| EP3737689A4 (en) | 2018-01-09 | 2021-12-01 | Cue Biopharma, Inc. | MULTIMERIC T CELL-MODULATING POLYPEPTIDES AND METHOD OF USING THEREOF |
| CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| KR20230009426A (ko) * | 2020-05-12 | 2023-01-17 | 스미토모 파마 가부시키가이샤 | 암을 처치하기 위한 의약 조성물 |
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| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
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| US6207375B1 (en) * | 1996-12-11 | 2001-03-27 | Mayo Foundation For Medical Educational & Research | TGF-β inducible early factor-1 (TIEF-1) and a method to detect breast cancer |
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| US20030072767A1 (en) | 1998-09-30 | 2003-04-17 | Alexander Gaiger | Compositions and methods for WT1 specific immunotherapy |
| US20030235557A1 (en) * | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
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| US7655249B2 (en) * | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7115272B1 (en) * | 1998-09-30 | 2006-10-03 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7901693B2 (en) * | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
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| YU72901A (sh) * | 1999-04-02 | 2004-07-15 | Corixa Corporation | Preparati za primenu u terapiji i dijagnozi raka pluća |
| WO2001025273A2 (en) * | 1999-10-04 | 2001-04-12 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
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2007
- 2007-12-14 US US12/521,533 patent/US8653038B2/en not_active Expired - Fee Related
- 2007-12-14 JP JP2008552080A patent/JP5484734B2/ja active Active
- 2007-12-14 CA CA2886622A patent/CA2886622A1/en not_active Abandoned
- 2007-12-14 EP EP12164855.4A patent/EP2479275B1/en not_active Not-in-force
- 2007-12-14 ES ES12164855.4T patent/ES2554775T3/es active Active
- 2007-12-14 EP EP12164856.2A patent/EP2479276B1/en not_active Not-in-force
- 2007-12-14 CA CA 2886619 patent/CA2886619A1/en not_active Abandoned
- 2007-12-14 DK DK12164856.2T patent/DK2479276T3/en active
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