WO2008081701A1 - Ｈｌａ－ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物 - Google Patents

Ｈｌａ－ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物 Download PDF

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Publication number
WO2008081701A1
WO2008081701A1 PCT/JP2007/074146 JP2007074146W WO2008081701A1 WO 2008081701 A1 WO2008081701 A1 WO 2008081701A1 JP 2007074146 W JP2007074146 W JP 2007074146W WO 2008081701 A1 WO2008081701 A1 WO 2008081701A1
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WO
WIPO (PCT)
Prior art keywords
peptide
hla
amino acid
restricted
pharmaceutical composition
Prior art date
Application number
PCT/JP2007/074146
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English (en)
French (fr)
Inventor
Haruo Sugiyama
Original Assignee
International Institute Of Cancer Immunology, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/521,533 priority Critical patent/US8653038B2/en
Priority to RU2009128979/10A priority patent/RU2481398C2/ru
Application filed by International Institute Of Cancer Immunology, Inc. filed Critical International Institute Of Cancer Immunology, Inc.
Priority to EP07850650A priority patent/EP2098595A4/en
Priority to JP2008552080A priority patent/JP5484734B2/ja
Priority to KR1020097013472A priority patent/KR101525261B1/ko
Priority to EP15181734.3A priority patent/EP2980219B1/en
Priority to CN2007800487491A priority patent/CN101573448B/zh
Priority to NZ577443A priority patent/NZ577443A/en
Priority to AU2007340679A priority patent/AU2007340679B2/en
Priority to CA002670658A priority patent/CA2670658A1/en
Priority to BRPI0720988-6A priority patent/BRPI0720988A2/pt
Priority to UAA200907944A priority patent/UA103154C2/uk
Priority to MX2009007008A priority patent/MX2009007008A/es
Publication of WO2008081701A1 publication Critical patent/WO2008081701A1/ja
Priority to ZA2009/03633A priority patent/ZA200903633B/en
Priority to IL199052A priority patent/IL199052A0/en
Priority to NO20092774A priority patent/NO20092774L/no
Priority to IL215332A priority patent/IL215332A0/en
Priority to IL215333A priority patent/IL215333A0/en
Priority to IL215334A priority patent/IL215334A0/en
Priority to US14/140,698 priority patent/US9272026B2/en
Priority to PH12014500902A priority patent/PH12014500902A1/en
Priority to US15/003,882 priority patent/US20160199472A1/en
Priority to US15/796,368 priority patent/US20180064795A1/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001152—Transcription factors, e.g. SOX or c-MYC
    • A61K39/001153—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464452—Transcription factors, e.g. SOX or c-MYC
    • A61K39/464453—Wilms tumor 1 [WT1]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5158—Antigen-pulsed cells, e.g. T-cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

　本発明は、ＨＬＡ－Ａ＊１１０１拘束性ＷＴ１ペプチド、詳細には、ＷＴ１タンパク質由来の９個の連続するアミノ酸からなるアミノ酸配列を含むペプチドであって、ＨＬＡ－Ａ＊１１０１分子と結合能を有し、かつＣＴＬ誘導能を有するペプチド、および少なくとも１個のシステイン残基を含むＷＴ１タンパク質由来の９個の連続するアミノ酸からなるアミノ酸配列を含む２個のペプチド単量体が、ジスルフィド結合により互いに結合しているペプチド二量体であって、ＨＬＡ－Ａ＊１１０１分子と結合能を有し、かつＣＴＬ誘導能を有する、ペプチド二量体に関する。さらに本発明は、該ペプチドをコードするポリヌクレオチド、それらを含む癌治療および／または予防用医薬組成物などに関するものである。
PCT/JP2007/074146 2006-12-28 2007-12-14 Ｈｌａ－ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物 WO2008081701A1 (ja)

Priority Applications (23)

Application Number Priority Date Filing Date Title
RU2009128979/10A RU2481398C2 (ru) 2006-12-28 2007-12-14 Hla-a*1101-ограниченный пептид wt1 и содержащая его фармацевтическая композиция
UAA200907944A UA103154C2 (uk) 2006-12-28 2007-12-14 Hla-a*1101-обмежений пептид wt1 і фармацевтична композиція, яка містить його
EP07850650A EP2098595A4 (en) 2006-12-28 2007-12-14 HLA-A * 1101 RESTRICTED WT1 PEPTIDE AND PHARMACEUTICAL COMPOSITION CONTAINING THEREOF
MX2009007008A MX2009007008A (es) 2006-12-28 2007-12-14 Peptido wt1 restringido a hla-a*1101 y composicion farmaceutica que comprende el mismo.
KR1020097013472A KR101525261B1 (ko) 2006-12-28 2007-12-14 Ｈｌａ-ａ*1101 구속성 ｗｔ1 펩티드 및 이를 포함하는 의약 조성물
EP15181734.3A EP2980219B1 (en) 2006-12-28 2007-12-14 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
CN2007800487491A CN101573448B (zh) 2006-12-28 2007-12-14 Hla-a*1101限制的wt1肽及含有其的药物组合物
NZ577443A NZ577443A (en) 2006-12-28 2007-12-14 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
AU2007340679A AU2007340679B2 (en) 2006-12-28 2007-12-14 HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same
CA002670658A CA2670658A1 (en) 2006-12-28 2007-12-14 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
BRPI0720988-6A BRPI0720988A2 (pt) 2006-12-28 2007-12-14 Peptídeo wt1 hla-a*1101 restrito e composição farmacêutica compreendendo o mesmo
US12/521,533 US8653038B2 (en) 2006-12-28 2007-12-14 HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same
JP2008552080A JP5484734B2 (ja) 2006-12-28 2007-12-14 Ｈｌａ−ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物
ZA2009/03633A ZA200903633B (en) 2006-12-28 2009-05-26 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
IL199052A IL199052A0 (en) 2006-12-28 2009-06-01 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
NO20092774A NO20092774L (no) 2006-12-28 2009-07-27 HLA-A*1101-begrenset WT1-peptid og farmasoytisk preparat som omfatter dette
IL215332A IL215332A0 (en) 2006-12-28 2011-09-22 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
IL215333A IL215333A0 (en) 2006-12-28 2011-09-22 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
IL215334A IL215334A0 (en) 2006-12-28 2011-09-22 Hla-a*1101-restricted wt1 peptide and pharmaceutical composition comprising the same
US14/140,698 US9272026B2 (en) 2006-12-28 2013-12-26 HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same
PH12014500902A PH12014500902A1 (en) 2006-12-28 2014-04-24 Hla-a* 1101-restricted wt1 peptide and pharmaceutical composition comprising the same
US15/003,882 US20160199472A1 (en) 2006-12-28 2016-01-22 Hla-a* 1101-restricted wt1 peptide and pharmaceutical composition comprising the same
US15/796,368 US20180064795A1 (en) 2006-12-28 2017-10-27 Hla-a* 1101-restricted wt1 peptide and pharmaceutical composition comprising the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006-355356 2006-12-28
JP2006355356 2006-12-28

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/521,533 A-371-Of-International US8653038B2 (en) 2006-12-28 2007-12-14 HLA-A* 1101-restricted WT1 peptide and pharmaceutical composition comprising the same
US14/140,698 Division US9272026B2 (en) 2006-12-28 2013-12-26 HLA-A*1101-restricted WT1 peptide and pharmaceutical composition comprising the same

Publications (1)

Publication Number Publication Date
WO2008081701A1 true WO2008081701A1 (ja) 2008-07-10

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PCT/JP2007/074146 WO2008081701A1 (ja) 2006-12-28 2007-12-14 Ｈｌａ－ａ＊１１０１拘束性ｗｔ１ペプチド、およびそれを含む医薬組成物

Country Status (28)

Country Link
US (4) US8653038B2 (ja)
EP (6) EP2341142B8 (ja)
JP (1) JP5484734B2 (ja)
KR (1) KR101525261B1 (ja)
CN (5) CN102295682A (ja)
AR (1) AR064555A1 (ja)
AU (1) AU2007340679B2 (ja)
BR (1) BRPI0720988A2 (ja)
CA (5) CA2886622A1 (ja)
CY (1) CY1116011T1 (ja)
DK (3) DK2479275T3 (ja)
ES (4) ES2556831T3 (ja)
HK (3) HK1173187A1 (ja)
IL (4) IL199052A0 (ja)
MX (1) MX2009007008A (ja)
MY (1) MY161664A (ja)
NO (1) NO20092774L (ja)
NZ (4) NZ592509A (ja)
PH (1) PH12014500902A1 (ja)
PL (1) PL2341142T3 (ja)
PT (1) PT2341142E (ja)
RU (1) RU2481398C2 (ja)
SG (1) SG177222A1 (ja)
SI (1) SI2341142T1 (ja)
TW (3) TWI554280B (ja)
UA (1) UA103154C2 (ja)
WO (1) WO2008081701A1 (ja)
ZA (1) ZA200903633B (ja)

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