EA201200515A1 - Полипептиды и их применение - Google Patents
Полипептиды и их применениеInfo
- Publication number
- EA201200515A1 EA201200515A1 EA201200515A EA201200515A EA201200515A1 EA 201200515 A1 EA201200515 A1 EA 201200515A1 EA 201200515 A EA201200515 A EA 201200515A EA 201200515 A EA201200515 A EA 201200515A EA 201200515 A1 EA201200515 A1 EA 201200515A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- fragment
- variant
- hybrid
- derivative
- polypeptides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
- A61K38/57—Protease inhibitors from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Изобретение относится к полипептидам, включающим или состоящим из аминокислотной последовательности, полученной из встречающегося в природе белка, который модулирует свертывание крови, или ее фрагмента, варианта, гибрида или производного, или гибрида указанного фрагмента, варианта или производного, для применения при лечении и предупреждении воспаления и/или чрезмерного свертывания крови. Соответствующие аспекты изобретения относятся к изолированным полипептидам, включающим или состоящим из аминокислотной последовательности из SEQ ED NO: 1-3, или ее фрагмента, варианта, гибрида или производного, или гибрида указанного фрагмента, варианта или производного, которые проявляют противовоспалительную активность, наряду с изолированными молекулами нуклеиновой кислоты, векторами и клетками-хозяевами для их получения. Кроме того, изобретение относится к фармацевтическим композициям, включающим полипептид по изобретению, а также к способам применения их при лечении и/или предупреждении воспаления и/или чрезмерной коагуляции.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0916578.8A GB0916578D0 (en) | 2009-09-22 | 2009-09-22 | Polypeptides and uses thereof |
PCT/GB2010/001780 WO2011036444A1 (en) | 2009-09-22 | 2010-09-21 | Heparin cofactor ii fragments with anti-inflammatory and anti-coagulant activity |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201200515A1 true EA201200515A1 (ru) | 2012-10-30 |
Family
ID=41278086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201200515A EA201200515A1 (ru) | 2009-09-22 | 2010-09-21 | Полипептиды и их применение |
Country Status (12)
Country | Link |
---|---|
US (2) | US9169315B2 (ru) |
EP (2) | EP2480244A1 (ru) |
JP (2) | JP2013505030A (ru) |
CN (2) | CN102655874B (ru) |
AU (2) | AU2010299630A1 (ru) |
BR (2) | BR112012006502A2 (ru) |
CA (2) | CA2774288A1 (ru) |
EA (1) | EA201200515A1 (ru) |
GB (1) | GB0916578D0 (ru) |
IN (2) | IN2012DN02981A (ru) |
MX (1) | MX2012003425A (ru) |
WO (2) | WO2011036444A1 (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013028069A1 (en) * | 2011-08-23 | 2013-02-28 | Synapse B.V. | Thermostable inhibitors of activation of the blood clotting system through contact with foreign surfaces. |
RU2476231C1 (ru) * | 2011-10-11 | 2013-02-27 | Федеральное государственное бюджетное учреждение "Российский научный центр "Восстановительная травматология и ортопедия" имени академика Г.А. Илизарова" Министерства здравоохранения и социального развития Российской Федерации | Способ купирования некроза краев кожи послеоперационной раны после эндопротезирования голеностопного сустава |
GB2500184A (en) * | 2012-03-12 | 2013-09-18 | Ximmune Ab | Polypeptide derived from helix A of heparin cofactor II |
CN104292309B (zh) * | 2014-09-29 | 2017-04-12 | 广西中医药大学 | 一种小分子多肽 |
WO2016104436A1 (ja) * | 2014-12-22 | 2016-06-30 | 国立大学法人 岡山大学 | サイトカインストーム抑制剤 |
RU2606836C2 (ru) * | 2015-03-12 | 2017-01-10 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Московский государственный университет имени М.В. Ломоносова" (МГУ) | Антикоагулянтный, антитромбоцитарный и фибриндеполимеризационный комплекс на основе гепарина, способ его получения и применение |
RU2610433C1 (ru) * | 2016-02-17 | 2017-02-10 | Людмила Анисимовна Ляпина | Антикоагулянт |
CN107875372A (zh) * | 2017-12-20 | 2018-04-06 | 辽宁师范大学 | 重组肽rLj‑112在制备协同肝素抗凝药物中的应用 |
CN108338163A (zh) * | 2018-03-28 | 2018-07-31 | 陈太师 | 一种持效型杀菌灭藻剂的制备方法 |
JPWO2019230509A1 (ja) * | 2018-05-31 | 2021-06-24 | 国立大学法人 岡山大学 | 活性酸素の産生抑制剤及び/又は消去促進剤 |
EP3815706A4 (en) * | 2018-06-28 | 2022-03-16 | National University Corporation Okayama University | AGENT FOR IMPROVING THE PHAGOCYTOTIC ABILITY OF NEUTROPHILS |
EP3837549A1 (en) * | 2018-08-16 | 2021-06-23 | Roche Diagnostics GmbH | Circulating tfpi-2 (tissue factor pathway inhibitor 2) in the assessment of atrial fibrillation and anticoagulation therapy |
CN109432513B (zh) * | 2018-12-12 | 2021-03-23 | 中国医科大学 | 一种具有抗血栓再形成功能的生物材料及其制备方法 |
US11904000B2 (en) | 2019-05-06 | 2024-02-20 | Brown University | Compositions and methods to enhance cutaneous wound healing |
WO2021240371A1 (en) * | 2020-05-26 | 2021-12-02 | Universitätsmedizin Der Johannes Gutenberg-Universität Mainz | Methods and compositions for treatment of coronavirus infection and associated coagulopathy |
CN114886116B (zh) * | 2022-03-18 | 2023-11-21 | 广东丸美生物技术股份有限公司 | 一种调理育龄女性健康的组合物及其制备方法和饮料及应用 |
CN116836233B (zh) * | 2023-08-31 | 2023-11-14 | 中国农业大学 | 抗炎活性多肽及其应用 |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
SE459005B (sv) | 1985-07-12 | 1989-05-29 | Aake Rikard Lindahl | Saett att framstaella sfaeriska polymerpartiklar |
US5118793A (en) * | 1989-10-20 | 1992-06-02 | Washington University | Modified heparin cofactor II |
US5102995A (en) * | 1989-10-20 | 1992-04-07 | Washington University | Dna encoding modified heparin cofactor ii |
US5643872A (en) | 1989-10-23 | 1997-07-01 | Smithkline Beecham Corporation | Cyclic anti-aggregatory peptides |
WO1992018139A1 (en) * | 1991-04-09 | 1992-10-29 | Brigham And Women's Hospital | Chimeric molecule with plasminogen activator activity and affinity for atherosclerotic plaques |
US6008058A (en) | 1993-06-18 | 1999-12-28 | University Of Louisville | Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis |
US5589359A (en) * | 1994-08-05 | 1996-12-31 | Chiron Corporation | Chimeric proteins |
US5712247A (en) * | 1995-02-21 | 1998-01-27 | University Of North Carolina | Use of lactoferrin to modulate and/or neutralize heparin activity |
CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
JPH09176040A (ja) * | 1995-12-27 | 1997-07-08 | Green Cross Corp:The | ヘパリンコファクターiiの医薬用途 |
US6946439B2 (en) * | 1997-02-06 | 2005-09-20 | Entre Med, Inc. | Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments |
WO1999043810A1 (en) * | 1998-02-27 | 1999-09-02 | The University Of North Carolina At Chapel Hill | Mutant heparin cofactor ii |
WO2001036632A2 (en) * | 1999-11-17 | 2001-05-25 | Compugen Ltd. | Variants of alternative splicing |
US7060681B2 (en) * | 2001-07-20 | 2006-06-13 | Ecole Polytechnique Federale De Lausanne (Epfl) | Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids |
GB0131112D0 (en) | 2001-12-31 | 2002-02-13 | Univ London Pharmacy | Block copolymers |
AU2003243381A1 (en) * | 2002-05-31 | 2003-12-19 | University Of Utah Research Foundation | Variants of antithrombin iii |
KR20050085130A (ko) * | 2002-11-22 | 2005-08-29 | 유 망 | 광범위 스펙트럼의 항-바이러스 치료제 및 예방제 |
GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
EP1654545A2 (en) * | 2003-08-08 | 2006-05-10 | Genova Ltd. | Secreted polypeptide species associated with cardiovascular disorders |
SG150552A1 (en) * | 2004-03-17 | 2009-03-30 | Chiron Corp | Treatment of severe community-acquired pneumonia by administration of tissue factor pathway inhibitor (tfpi) |
US20050261241A1 (en) * | 2004-05-19 | 2005-11-24 | Celsus Biopharmaceuticals, Inc. | Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses |
JP2008540460A (ja) * | 2005-05-06 | 2008-11-20 | ノバルティス アーゲー | 重症細菌感染を処置するためのtfpiの使用 |
RU2008106460A (ru) * | 2005-07-22 | 2009-08-27 | Новартис АГ (CH) | Антимикробный агент, взаимодействующий с системой комплемента |
EP1976985B1 (en) * | 2005-12-29 | 2013-07-17 | The Regents of the University of California Office of Technology Transfer | Methods and compositions related to mutant kunitz domain i of tfpi-2 |
PT1981519T (pt) * | 2005-12-29 | 2018-02-23 | Dyax Corp | Inibição de protéases |
WO2007091959A1 (en) * | 2006-02-10 | 2007-08-16 | Dermagen Ab | Novel antimicrobial peptides and use thereof |
JP5761782B2 (ja) * | 2007-04-13 | 2015-08-12 | カタリスト・バイオサイエンシーズ・インコーポレイテッドCatalyst Biosciences, Inc. | 改変第vii因子ポリペプチド及びその使用 |
AU2008279129A1 (en) * | 2007-07-24 | 2009-01-29 | Nexbio, Inc. | Technology for the preparation of microparticles |
-
2009
- 2009-09-22 GB GBGB0916578.8A patent/GB0916578D0/en not_active Ceased
-
2010
- 2010-09-21 WO PCT/GB2010/001780 patent/WO2011036444A1/en active Application Filing
- 2010-09-21 EA EA201200515A patent/EA201200515A1/ru unknown
- 2010-09-21 EP EP10777056A patent/EP2480244A1/en not_active Withdrawn
- 2010-09-21 CN CN201080052695.8A patent/CN102655874B/zh not_active Expired - Fee Related
- 2010-09-21 IN IN2981DEN2012 patent/IN2012DN02981A/en unknown
- 2010-09-21 JP JP2012530325A patent/JP2013505030A/ja active Pending
- 2010-09-21 AU AU2010299630A patent/AU2010299630A1/en not_active Abandoned
- 2010-09-21 US US13/497,006 patent/US9169315B2/en not_active Expired - Fee Related
- 2010-09-21 CA CA2774288A patent/CA2774288A1/en not_active Abandoned
- 2010-09-21 BR BR112012006502A patent/BR112012006502A2/pt not_active IP Right Cessation
- 2010-09-21 MX MX2012003425A patent/MX2012003425A/es not_active Application Discontinuation
- 2010-09-22 BR BR112012006501A patent/BR112012006501A8/pt not_active IP Right Cessation
- 2010-09-22 JP JP2012530326A patent/JP2013505286A/ja not_active Abandoned
- 2010-09-22 CN CN2010800527096A patent/CN102639556A/zh active Pending
- 2010-09-22 IN IN3368DEN2012 patent/IN2012DN03368A/en unknown
- 2010-09-22 US US13/497,195 patent/US20120189673A1/en not_active Abandoned
- 2010-09-22 WO PCT/GB2010/001781 patent/WO2011036445A2/en active Application Filing
- 2010-09-22 EP EP10777057A patent/EP2480564A2/en not_active Withdrawn
- 2010-09-22 CA CA2774296A patent/CA2774296A1/en not_active Abandoned
- 2010-09-22 AU AU2010299631A patent/AU2010299631A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2013505030A (ja) | 2013-02-14 |
BR112012006501A2 (pt) | 2016-08-16 |
CN102655874A (zh) | 2012-09-05 |
MX2012003425A (es) | 2012-10-09 |
AU2010299630A2 (en) | 2012-05-03 |
IN2012DN03368A (ru) | 2015-10-23 |
BR112012006502A2 (pt) | 2016-08-16 |
US20120189673A1 (en) | 2012-07-26 |
BR112012006501A8 (pt) | 2017-07-11 |
WO2011036445A2 (en) | 2011-03-31 |
WO2011036445A3 (en) | 2011-09-01 |
CN102655874B (zh) | 2015-06-10 |
US9169315B2 (en) | 2015-10-27 |
CA2774296A1 (en) | 2011-03-31 |
AU2010299631A1 (en) | 2012-05-03 |
JP2013505286A (ja) | 2013-02-14 |
CA2774288A1 (en) | 2011-03-31 |
WO2011036444A1 (en) | 2011-03-31 |
GB0916578D0 (en) | 2009-10-28 |
IN2012DN02981A (ru) | 2015-07-31 |
WO2011036444A4 (en) | 2011-06-23 |
US20120177715A1 (en) | 2012-07-12 |
AU2010299630A1 (en) | 2012-04-26 |
CN102639556A (zh) | 2012-08-15 |
EP2480244A1 (en) | 2012-08-01 |
EP2480564A2 (en) | 2012-08-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201200515A1 (ru) | Полипептиды и их применение | |
CY1122800T1 (el) | Συνθεσεις του παραγοντα viii και μεθοδοι δημιουργιας και χρησης αυτων | |
PH12019500644A1 (en) | Improved amino acid sequences directed against human respiratory syncytial virus (hrsv) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections | |
WO2011036442A3 (en) | Thrombin c- terminal polypeptides and uses thereof for treating inflammation coagulation disorders | |
NZ602943A (en) | Modified binding proteins inhibiting the vegf-a receptor interaction | |
WO2017058892A3 (en) | Methods and compositions for antibody-evading virus vectors | |
EA201170993A1 (ru) | Удлиненные рекомбинантные полипептиды и содержащие их композиции | |
EA201190326A1 (ru) | Полипептиды гормона роста и способы их получения и применения | |
WO2010115998A3 (en) | Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders | |
RU2016146198A (ru) | Терапевтические dll4-связывающие белки | |
WO2009147248A3 (en) | Amino acid sequences directed against envelope proteins of a virus and polypeptides comprising the same for the treatment of viral diseases | |
MX2009012650A (es) | Secuencias de aminoacido dirigidas contra rank-l y polipeptidos que comprenden lo mismo para el tratamiento de enfermedades y trastornos de huesos. | |
BR112015004696A2 (pt) | polipeptídeos quiméricos tendo especificidade de ligação alvejada | |
NZ603570A (en) | Biological materials related to her3 | |
WO2007104529A3 (en) | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling | |
EA201390739A1 (ru) | Способ лечения fgf21-ассоциированных расстройств | |
EA201491049A1 (ru) | Противораковый слитый белок | |
EA201491784A1 (ru) | Антитела против лигандов рецептора в1 брадикинина | |
EA201590611A1 (ru) | Новые молекулы, связывающие il-17a, и их медицинское применение | |
EA201491277A1 (ru) | Противораковый слитый белок | |
EA201291345A1 (ru) | Цитруллинированные гистоновые пептиды и их применение | |
BR112013022557A2 (pt) | ligantes de peptídeo composições de polipeptídeo e métodos para uso dos mesmos | |
EP4219521A3 (en) | Cellular growth promoting peptides derived from rice proteins (oryza sativa) and uses thereof | |
EA201390811A1 (ru) | Пептиды tomm34 и содержащие их вакцины | |
ATE552271T1 (de) | Antitumorarzneimittel, medikament, zusammensetzung und anwendung davon |