EA201291345A1 - Цитруллинированные гистоновые пептиды и их применение - Google Patents

Цитруллинированные гистоновые пептиды и их применение

Info

Publication number
EA201291345A1
EA201291345A1 EA201291345A EA201291345A EA201291345A1 EA 201291345 A1 EA201291345 A1 EA 201291345A1 EA 201291345 A EA201291345 A EA 201291345A EA 201291345 A EA201291345 A EA 201291345A EA 201291345 A1 EA201291345 A1 EA 201291345A1
Authority
EA
Eurasian Patent Office
Prior art keywords
citrulinated
histon
peptides
application
citrulline
Prior art date
Application number
EA201291345A
Other languages
English (en)
Inventor
Федерико Пратези
Мариа Клаудиа Алькаро
Марио Келли
Франческо Лолли
Илариа Паолини
Анна Мариа Папини
Паоло Роверо
Паола Мильорини
Original Assignee
Тоскана Байомаркерз С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Тоскана Байомаркерз С.Р.Л. filed Critical Тоскана Байомаркерз С.Р.Л.
Publication of EA201291345A1 publication Critical patent/EA201291345A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к цитруллинированным синтетическим пептидам, полученным из гистонового белка Н4, и их применению в диагностике аутоиммунных заболеваний, в частности ревматоидного артрита (RA).
EA201291345A 2010-07-02 2011-06-30 Цитруллинированные гистоновые пептиды и их применение EA201291345A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10168270A EP2402368A1 (en) 2010-07-02 2010-07-02 Histone citrullinated peptides and uses thereof
PCT/EP2011/061006 WO2012001103A1 (en) 2010-07-02 2011-06-30 Histone citrullinated peptides and uses thereof

Publications (1)

Publication Number Publication Date
EA201291345A1 true EA201291345A1 (ru) 2013-08-30

Family

ID=43086494

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291345A EA201291345A1 (ru) 2010-07-02 2011-06-30 Цитруллинированные гистоновые пептиды и их применение

Country Status (11)

Country Link
US (1) US20130115636A1 (ru)
EP (2) EP2402368A1 (ru)
CN (1) CN102971339A (ru)
AU (1) AU2011273451B2 (ru)
BR (1) BR112013001229A2 (ru)
CA (1) CA2803234A1 (ru)
DK (1) DK2588495T3 (ru)
EA (1) EA201291345A1 (ru)
ES (1) ES2539255T3 (ru)
WO (1) WO2012001103A1 (ru)
ZA (1) ZA201300494B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2015257929B2 (en) * 2014-05-05 2020-06-25 Novio Th B.V. Method for the serological diagnosis of rheumatoid arthritis.
CN104987366B (zh) * 2014-08-21 2018-09-25 上海市东方医院 一种类风湿关节炎自身抗体结合抗原及其应用
US10441644B2 (en) 2015-05-05 2019-10-15 The Regents Of The University Of California H3.3 CTL peptides and uses thereof
CN107022028B (zh) * 2017-02-22 2020-07-28 哈桑·阿拉姆 特异性抗CitH3单克隆抗体及其酶联免疫吸附试验试剂盒在脓毒症诊断中的应用
CN108196073B (zh) * 2018-03-13 2019-09-13 江苏浩欧博生物医药股份有限公司 一种测定抗环瓜氨酸肽抗体的试剂盒及其应用
CN112638935A (zh) * 2019-01-27 2021-04-09 中国医药大学 一种类风湿性关节炎自体抗体结合的肽及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144473A1 (en) 1992-09-16 2003-07-31 Michael Zeppezauer Peptides for the production of preparations for the diagnosis and therapy of autoimmun diseases
FR2752842B1 (fr) 1996-08-30 1998-11-06 Biomerieux Sa Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
AU2155899A (en) 1997-11-28 1999-06-16 Innogenetics N.V. Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment
FR2795735B1 (fr) 1999-07-01 2001-09-07 Univ Toulouse Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
ES2174770T1 (es) 1999-12-21 2002-11-16 Innogenetics Nv Peptidos diseñados para el diagnostico y el tratamiento de artritis reumatoide.
NL1019540C2 (nl) 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
CA2518187A1 (en) * 2003-03-07 2004-09-16 London Health Sciences Centre Reseach, Inc. Peptides associated with hla-dr mhc class ii molecules involved in autoimmune diseases
ITTO20030246A1 (it) 2003-03-31 2004-10-01 Univ Pisa Nuovi peptidi sintetici citrullinati e loro usi.
ES2310853T3 (es) 2004-11-04 2009-01-16 Biomerieux Peptidos citrulinados derivados de la fibrina reconocidos por autoanticuerpos especificos de la poliartritis reumatoide y usos de los mismos.
FI20050814A0 (fi) 2005-08-11 2005-08-11 Procollagen Oy Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi
US20070148704A1 (en) 2005-10-06 2007-06-28 Ursula Klause Anti-CCPand antinuclear antibodies in diagnosis of rheumatoid arthritis
GB0609119D0 (en) 2006-05-09 2006-06-21 Univ Birmingham Histones
ES2307421B1 (es) 2007-04-30 2009-09-28 Consejo Superiorde Investigaciones Cientificas (Csic) Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide.
WO2009007846A2 (en) 2007-06-15 2009-01-15 Universitetet If Oslo Methods for modifying, isolating, detecting, visualizing, and quantifying citrullinated and/or homocitrullinated peptides, polypeptides and proteins
US8323656B2 (en) 2007-06-25 2012-12-04 Yijun Xu Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof
CA2726511C (en) * 2008-06-04 2018-07-10 Modiquest B.V. Anti-inflammatory agents
BR122013006960A2 (pt) * 2009-03-30 2019-10-15 Nestec S.A. Peptídeo sintético que é imunologicamente reativo com um anticorpo de proteína anti-citrulinado, seu uso e seu método de identificação, bem como kit compreendendo o referido peptídeo

Also Published As

Publication number Publication date
DK2588495T3 (en) 2015-06-15
ZA201300494B (en) 2013-09-25
US20130115636A1 (en) 2013-05-09
EP2402368A1 (en) 2012-01-04
CN102971339A (zh) 2013-03-13
EP2588495A1 (en) 2013-05-08
CA2803234A1 (en) 2012-01-05
ES2539255T3 (es) 2015-06-29
AU2011273451B2 (en) 2014-12-11
EP2588495B1 (en) 2015-04-01
WO2012001103A1 (en) 2012-01-05
BR112013001229A2 (pt) 2019-09-24
AU2011273451A1 (en) 2013-02-07

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