CN112638935A - 一种类风湿性关节炎自体抗体结合的肽及其应用 - Google Patents
一种类风湿性关节炎自体抗体结合的肽及其应用 Download PDFInfo
- Publication number
- CN112638935A CN112638935A CN202080004129.3A CN202080004129A CN112638935A CN 112638935 A CN112638935 A CN 112638935A CN 202080004129 A CN202080004129 A CN 202080004129A CN 112638935 A CN112638935 A CN 112638935A
- Authority
- CN
- China
- Prior art keywords
- rheumatoid arthritis
- peptide
- antibody
- blood sample
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/08—Peptides being immobilised on, or in, an organic carrier the carrier being a synthetic polymer
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C07K17/10—Peptides being immobilised on, or in, an organic carrier the carrier being a carbohydrate
- C07K17/12—Cellulose or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54393—Improving reaction conditions or stability, e.g. by coating or irradiation of surface, by reduction of non-specific binding, by promotion of specific binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/102—Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Inorganic Chemistry (AREA)
- Peptides Or Proteins (AREA)
Abstract
本发明提供了一种能与类风湿性关节炎自体抗体结合的肽,其具有与类风湿性关节炎的自体抗体结合的抗原决定位点。进一步提供了利用所述肽检测类风湿性关节炎疾病的方法。
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962797351P | 2019-01-27 | 2019-01-27 | |
US62/797,351 | 2019-01-27 | ||
PCT/CN2020/073097 WO2020151631A1 (zh) | 2019-01-27 | 2020-01-20 | 一种类风湿性关节炎自体抗体结合的肽及其应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN112638935A true CN112638935A (zh) | 2021-04-09 |
Family
ID=71735682
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202080004129.3A Pending CN112638935A (zh) | 2019-01-27 | 2020-01-20 | 一种类风湿性关节炎自体抗体结合的肽及其应用 |
Country Status (4)
Country | Link |
---|---|
US (1) | US12105097B2 (zh) |
CN (1) | CN112638935A (zh) |
TW (1) | TWI744777B (zh) |
WO (1) | WO2020151631A1 (zh) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1602426A (zh) * | 2001-12-11 | 2005-03-30 | 技术科学基金会 | 从患有类风湿性关节炎的患者中检测自身抗体的方法、肽和检测试剂盒 |
CN102971339A (zh) * | 2010-07-02 | 2013-03-13 | 托斯卡纳生物标志有限公司 | 组蛋白瓜氨酸肽及其应用 |
CN104262489A (zh) * | 2014-09-30 | 2015-01-07 | 陈仁奋 | 一种环状瓜氨酸嵌合肽抗原及其应用 |
CN104987366A (zh) * | 2014-08-21 | 2015-10-21 | 上海市东方医院 | 一种类风湿关节炎自身抗体结合抗原及其应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5288931A (en) * | 1991-12-06 | 1994-02-22 | Genentech, Inc. | Method for refolding insoluble, misfolded insulin-like growth factor-I into an active conformation |
GB9912350D0 (en) * | 1999-05-26 | 1999-07-28 | European Molecular Biology Lab Embl | Modified cytokine |
FI117667B (fi) * | 2001-07-05 | 2007-01-15 | Univ Zuerich | Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä |
US9732143B2 (en) * | 2011-02-03 | 2017-08-15 | Xoma Technology Ltd. | Methods and materials for enhancing functional protein expression in bacteria |
-
2020
- 2020-01-20 CN CN202080004129.3A patent/CN112638935A/zh active Pending
- 2020-01-20 TW TW109101879A patent/TWI744777B/zh active
- 2020-01-20 US US17/269,257 patent/US12105097B2/en active Active
- 2020-01-20 WO PCT/CN2020/073097 patent/WO2020151631A1/zh active Application Filing
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1602426A (zh) * | 2001-12-11 | 2005-03-30 | 技术科学基金会 | 从患有类风湿性关节炎的患者中检测自身抗体的方法、肽和检测试剂盒 |
CN102971339A (zh) * | 2010-07-02 | 2013-03-13 | 托斯卡纳生物标志有限公司 | 组蛋白瓜氨酸肽及其应用 |
CN104987366A (zh) * | 2014-08-21 | 2015-10-21 | 上海市东方医院 | 一种类风湿关节炎自身抗体结合抗原及其应用 |
CN104262489A (zh) * | 2014-09-30 | 2015-01-07 | 陈仁奋 | 一种环状瓜氨酸嵌合肽抗原及其应用 |
Non-Patent Citations (3)
Title |
---|
LINDA JOHANSSON等: "Concentration of antibodies against Porphyromonas gingivalis is increased before the onset of symptoms of rheumatoid arthritis,PubMed,Porphyromonas gingivalis and arg-gingipain and rheumatoid arthritis", 《ARTHRITIS RESEARCH & THERAPY》 * |
TIM STOBERNACK等: "Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis", 《JOURNAL OF PROTEOME RESEARCH》 * |
YURIKO YASAKI-INAGAKI等: "Production of protective antibodies against Porphyromonas gingivalis strains by immunization with recombinant gingipain domains", 《FEMS IMMUNOL MED MICROBIOL》 * |
Also Published As
Publication number | Publication date |
---|---|
TW202041523A (zh) | 2020-11-16 |
WO2020151631A1 (zh) | 2020-07-30 |
US20210341491A1 (en) | 2021-11-04 |
TWI744777B (zh) | 2021-11-01 |
US12105097B2 (en) | 2024-10-01 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Božič et al. | Sera from patients with rheumatic diseases recognize different epitope regions on the 52‐kD Ro/SS‐A protein | |
JPH09512630A (ja) | 診断マーカーとしてのヒト好中球リポカリン(hnl)の使用および抗−hnl−抗体調製物 | |
Kurasawa et al. | Autoantibodies against platelet-derived growth factor receptor alpha in patients with systemic lupus erythematosus | |
Falkenburg et al. | Anti-hinge antibodies recognize IgG subclass–and protease-restricted neoepitopes | |
KR20160123238A (ko) | 스틸씨병 진단용 바이오마커 조성물, 진단 키트 및 진단 방법 | |
WO2018119626A1 (zh) | 中性粒细胞明胶酶相关脂质运载蛋白检测试剂盒 | |
Rajaei et al. | Evaluating the relationship between serum level of interleukin-6 and rheumatoid arthritis severity and disease activity | |
Won et al. | Pathogenic role of circulating citrullinated antigens and anti-cyclic monoclonal citrullinated peptide antibodies in rheumatoid arthritis | |
St Clair et al. | Temporal correlation of antibody responses to different epitopes of the human La autoantigen. | |
Perosa et al. | Clinical correlates of a subset of anti-CENP-A antibodies cross-reacting with FOXE3p53-62 in systemic sclerosis | |
JP6687391B2 (ja) | リウマチ性関節炎(ra)の存在を決定するためのサンプルの測定方法 | |
CN112638935A (zh) | 一种类风湿性关节炎自体抗体结合的肽及其应用 | |
JP6122779B2 (ja) | 抗wt1抗体の測定方法 | |
EP2653871B1 (en) | Novel test method for rheumatoid arthritis and kit for rheumatoid arthritis test | |
Hussain et al. | Moesin expression is correlated with its involvement in patients with Behcet’s disease | |
Costa et al. | Detection of antibodies to histones in human systemic lupus erythematosus and in murine lupus-like syndromes using micro-ELISA | |
JPH08508093A (ja) | 膵臓線維症又はcftr遺伝子の突然変異の検出 | |
Nakachi et al. | Epitopes recognised by tissue transglutaminase antibodies in coeliac disease | |
JPWO2006004207A1 (ja) | 抗シノビオリン抗体 | |
Choi et al. | Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis | |
US20140322211A1 (en) | Tenascin-c and use thereof in rheumatoid arthritis | |
KR102121927B1 (ko) | Tcp1 자가항체를 이용한 전신홍반성루푸스 진단방법 | |
RU2550255C2 (ru) | РЕКОМБИНАНТНАЯ ДНК pA3, РЕКОМБИНАНТНАЯ ДНК pQE 30-pA3, ОБЕСПЕЧИВАЮЩИЕ ПОЛУЧЕНИЕ ПОЛИПЕПТИДА A3, ШТАММ E. coli М 15-A3, ТРАНСФОРМИРОВАННЫЙ РЕКОМБИНАНТНОЙ ПЛАЗМИДНОЙ ДНК pQE 30-pA3 И ЭКСПРЕССИРУЮЩИЙ РЕКОМБИНАНТНЫЙ ПОЛИПЕПТИД A3, РЕКОМБИНАНТНЫЙ ПОЛИПЕПТИД A3, ОБЛАДАЮЩИЙ СПОСОБНОСТЬЮ СЕЛЕКТИВНО СВЯЗЫВАТЬ ЧСА, И ТЕСТ-СИСТЕМА РФА ДЛЯ КАЧЕСТВЕННОГО ВЫЯВЛЕНИЯ МИКРОАЛЬБУМИНУРИИ, ТЕСТ-СИСТЕМА ДЛЯ КОЛИЧЕСТВЕННОГО ОПРЕДЕЛЕНИЯ МИКРОАЛЬБУМИНУРИИ | |
KR102109105B1 (ko) | Smyd3 자가항체를 이용한 전신홍반성루푸스 진단방법 | |
CN103509087A (zh) | 抗CiP抗体在早期类风湿关节炎诊断中的应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |