BR112013001229A2 - peptídeo, método para o diagnóstico de uma doenaç autoimune, kit para o diagnóstico de uma doença autoimune, anticorpo direcionado contra o peptídeo - Google Patents

peptídeo, método para o diagnóstico de uma doenaç autoimune, kit para o diagnóstico de uma doença autoimune, anticorpo direcionado contra o peptídeo

Info

Publication number
BR112013001229A2
BR112013001229A2 BR112013001229A BR112013001229A BR112013001229A2 BR 112013001229 A2 BR112013001229 A2 BR 112013001229A2 BR 112013001229 A BR112013001229 A BR 112013001229A BR 112013001229 A BR112013001229 A BR 112013001229A BR 112013001229 A2 BR112013001229 A2 BR 112013001229A2
Authority
BR
Brazil
Prior art keywords
diagnosing
peptide
autoimmune disease
kit
directed against
Prior art date
Application number
BR112013001229A
Other languages
English (en)
Inventor
Maria Papini Anna
Lolli Francesso
Pratesi Frederico
Paolini Ilaria
Claudia Alcaro Maria
Chelli Mario
Rovero Paolo
Original Assignee
Toscana Biomarkes S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toscana Biomarkes S R L filed Critical Toscana Biomarkes S R L
Publication of BR112013001229A2 publication Critical patent/BR112013001229A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/24—Immunology or allergic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

peptídeo, método para o diagnóstico de uma doenaç autoimune, kit para o diagnóstico de uma doença autoimune, anticorpo direcionado contra o peptídeo. a presente invenção se refere a peptídeos sintéticos citrulinados derivados da proteína histona h4 e seu uso no diagnóstico de doenças autoimunes, particularmente artrite reumatoide (ar).
BR112013001229A 2010-07-02 2011-06-30 peptídeo, método para o diagnóstico de uma doenaç autoimune, kit para o diagnóstico de uma doença autoimune, anticorpo direcionado contra o peptídeo BR112013001229A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10168270A EP2402368A1 (en) 2010-07-02 2010-07-02 Histone citrullinated peptides and uses thereof
PCT/EP2011/061006 WO2012001103A1 (en) 2010-07-02 2011-06-30 Histone citrullinated peptides and uses thereof

Publications (1)

Publication Number Publication Date
BR112013001229A2 true BR112013001229A2 (pt) 2019-09-24

Family

ID=43086494

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013001229A BR112013001229A2 (pt) 2010-07-02 2011-06-30 peptídeo, método para o diagnóstico de uma doenaç autoimune, kit para o diagnóstico de uma doença autoimune, anticorpo direcionado contra o peptídeo

Country Status (11)

Country Link
US (1) US20130115636A1 (pt)
EP (2) EP2402368A1 (pt)
CN (1) CN102971339A (pt)
AU (1) AU2011273451B2 (pt)
BR (1) BR112013001229A2 (pt)
CA (1) CA2803234A1 (pt)
DK (1) DK2588495T3 (pt)
EA (1) EA201291345A1 (pt)
ES (1) ES2539255T3 (pt)
WO (1) WO2012001103A1 (pt)
ZA (1) ZA201300494B (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2674393T3 (es) * 2014-05-05 2018-06-29 Novio Th B.V. Método para el diagnóstico serológico de la artritis reumatoide
CN104987366B (zh) * 2014-08-21 2018-09-25 上海市东方医院 一种类风湿关节炎自身抗体结合抗原及其应用
US10441644B2 (en) 2015-05-05 2019-10-15 The Regents Of The University Of California H3.3 CTL peptides and uses thereof
CN107022028B (zh) * 2017-02-22 2020-07-28 哈桑·阿拉姆 特异性抗CitH3单克隆抗体及其酶联免疫吸附试验试剂盒在脓毒症诊断中的应用
CN108196073B (zh) * 2018-03-13 2019-09-13 江苏浩欧博生物医药股份有限公司 一种测定抗环瓜氨酸肽抗体的试剂盒及其应用
CN112638935A (zh) * 2019-01-27 2021-04-09 中国医药大学 一种类风湿性关节炎自体抗体结合的肽及其应用

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144473A1 (en) 1992-09-16 2003-07-31 Michael Zeppezauer Peptides for the production of preparations for the diagnosis and therapy of autoimmun diseases
FR2752842B1 (fr) 1996-08-30 1998-11-06 Biomerieux Sa Antigenes derives des filaggrines et leur utilisation pour le diagnostic de la polyarthrite rhumatoide
NL1004539C2 (nl) 1996-11-15 1998-05-20 Stichting Tech Wetenschapp Peptide afgeleid van een door auto-antilichamen van patiënten met reumatoïde artritis herkend antigeen, antilichaam daartegen en werkwijze voor het detecteren van auto-immuunantilichamen.
WO1999028344A2 (en) 1997-11-28 1999-06-10 Innogenetics N.V. Synthetic peptides containing citrulline recognized by rheumatoid arthritis sera as tools for diagnosis and treatment
FR2795735B1 (fr) 1999-07-01 2001-09-07 Univ Toulouse Derives citrullines de la fibrine et leur utilisation pour le diagnostic ou le traitement de la polyarthrite rhumatoide
WO2001046222A2 (en) 1999-12-21 2001-06-28 Innogenetics N.V. Peptides designed for the diagnosis and treatment of rheumatoid arthritis
NL1019540C2 (nl) 2001-12-11 2003-07-01 Stichting Tech Wetenschapp Werkwijze voor het detecteren van auto-antilichamen van patienten die lijden aan reumatoïde artritis, peptide en assaykit.
JP2007524583A (ja) * 2003-03-07 2007-08-30 ロンドン・ヘルス・サイエンシズ・センター・リサーチ・インコーポレーテッド 自己免疫異常に関わるｈｌａ−ｄｒｍｈｃクラスｉｉ分子に関するペプチド
ITTO20030246A1 (it) 2003-03-31 2004-10-01 Univ Pisa Nuovi peptidi sintetici citrullinati e loro usi.
ES2310853T3 (es) 2004-11-04 2009-01-16 Biomerieux Peptidos citrulinados derivados de la fibrina reconocidos por autoanticuerpos especificos de la poliartritis reumatoide y usos de los mismos.
FI20050814A0 (fi) 2005-08-11 2005-08-11 Procollagen Oy Menetelmä nivelreumassa muodostuvien kollageeniautovasta-aineiden havaitsemiseksi
US20070148704A1 (en) 2005-10-06 2007-06-28 Ursula Klause Anti-CCPand antinuclear antibodies in diagnosis of rheumatoid arthritis
GB0609119D0 (en) 2006-05-09 2006-06-21 Univ Birmingham Histones
ES2307421B1 (es) 2007-04-30 2009-09-28 Consejo Superiorde Investigaciones Cientificas (Csic) Polipeptido quimerico fibrina-filagrina citruinado capaz de detectar los anticuerpos generados en la artritis reumatoide.
US20110165606A1 (en) 2007-06-15 2011-07-07 Tutturen Astrid E V Methods for modifying, isolating, detecting, visualizing, and quantifying citrullinated and/or homocitrullinated peptides, polypeptides and proteins
US8323656B2 (en) 2007-06-25 2012-12-04 Yijun Xu Antigen determinant of rheumatoid arthritis-specific autoantibody and use thereof
JP5528436B2 (ja) * 2008-06-04 2014-06-25 モディクエスト べー．フェー． 抗炎症剤
AU2010234942B2 (en) * 2009-03-30 2015-03-05 Nestec S.A. Citrullinated peptides for diagnosing and prognosing rheumatoid arthritis

Also Published As

Publication number Publication date
WO2012001103A1 (en) 2012-01-05
EA201291345A1 (ru) 2013-08-30
CN102971339A (zh) 2013-03-13
EP2588495B1 (en) 2015-04-01
DK2588495T3 (en) 2015-06-15
ZA201300494B (en) 2013-09-25
AU2011273451A1 (en) 2013-02-07
EP2402368A1 (en) 2012-01-04
CA2803234A1 (en) 2012-01-05
EP2588495A1 (en) 2013-05-08
AU2011273451B2 (en) 2014-12-11
US20130115636A1 (en) 2013-05-09
ES2539255T3 (es) 2015-06-29

Similar Documents

Publication Publication Date Title
BR112013001229A2 (pt) peptídeo, método para o diagnóstico de uma doenaç autoimune, kit para o diagnóstico de uma doença autoimune, anticorpo direcionado contra o peptídeo
GT201200271A (es) Proteínas que se unen al tnf-a
TN2014000120A1 (en) Cd27l antigen binding proteins
NZ701444A (en) Antibodies to matrix metalloproteinase 9
CO6710903A2 (es) Un anticuerpo que reconoce y se une específicamente con un fosfo-epítope en la proteína tau de mamífero o en uno de sus fragmentos y una composición comprendiendo el mismo
CY1123304T1 (el) Αναστολη πεπτιδιων που προερχονται απο μεταγραφημα 1 τυπου trem (tlt-1) και χρησεις αυτωn
CR20120371A (es) Antagonistas de pcsk9
WO2006086799A3 (en) Prion-specific peptide reagents
BR112012007365A2 (pt) proteínas de ligação à il-1
CR20120210A (es) Proteínas de enlace al antigeno il-23 humanas
CL2011002129A1 (es) Proteinas de union a il-17; construccion de proteina de union a il-17 que comprende un polipeptido ligador o un dominio constante de una inmunoglobulina; conjugado de proteina de union a il-17; vector y celula huesped; composicion para la liberacion de una proteina de union; metodo para reducir la actividad de la il-17.
BR112017006598A2 (pt) anticorpo de repetições antidipeptídeo derivado de ser humano (dprs)
BR112014026755B8 (pt) anticorpos contra claudin 18.2 úteis no diagnóstico de câncer
AR081696A1 (es) Anticuerpo para el diagnostico y/o pronostico de cancer
CL2012002081A1 (es) Anticuerpo humanizado que se une a la cadena alfa del receptor de il-7 humano (cd127); proteina de enlace a antigeno que comprende una o mas regiones determinantes de complementariedad de dicho anticuerpo; molecula de acido nucleico que codifica una anticuerpo o proteina de enalce; vector de expresion, celula huesped recombinante; procedimiento para la produccion de una proteina de enlace a antigeno; procedimiento para tratar enfermedad autoinmune o inflamatoria.
UY32752A (es) Polipéptidos y Métodos de Tratamiento
CY1119976T1 (el) Μιμητικα καλσιτονινης για την αντιμετωπιση ασθενειων και διαταραχων
TR201902439T4 (tr) Fukoz analogları kullanarak in vivo protein fukosilasyonunun inhibisyon yöntemleri .
EP3546481A3 (en) Anti-interleukin 22 (il-22) antibody and uses thereof
MX346500B (es) Metodos y composiciones para inmunoterapia para enfermedad neural.
EA201590459A1 (ru) Специфические антитела к островковому амилоидному полипептиду человека (hiapp) и их применение
BRPI0914925A2 (pt) peptídeo cíclico, uso de um peptídeo, métodos para produzir um peptídeo cíclico e para diagnosticar uma doença ou condição, e, anticorpo
NZ602548A (en) Oligomer-specific amyloid beta epitope and antibodies
WO2012149145A3 (en) Ocular detection of amyloid proteins
BR112015008036A2 (pt) população de peptídeos isolados, método para detectar em uma amostra um anticorpo, método para diagnosticar erliquiose monocítica e/ou granulocítica e kit

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.