ES2563646T3 - Composiciones y métodos relacionados con variantes de la proteína A (SpA) - Google Patents

Composiciones y métodos relacionados con variantes de la proteína A (SpA) Download PDF

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Publication number
ES2563646T3
ES2563646T3 ES10797468.5T ES10797468T ES2563646T3 ES 2563646 T3 ES2563646 T3 ES 2563646T3 ES 10797468 T ES10797468 T ES 10797468T ES 2563646 T3 ES2563646 T3 ES 2563646T3
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amino acid
spa
protein
variants
compositions
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Olaf Schneewind
Alice Cheng
Dominique Missiakas
Hwan Kim
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University of Chicago
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University of Chicago
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/085—Staphylococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Polipéptido inmunogénico aislado que comprende un dominio D de la variante de la Proteína A (SpA) que tiene (a) al menos dos sustituciones de aminoácidos que alteran la unión a Fc, que comprende una sustitución de aminoácido en cada una de las posiciones de aminoácidos que corresponde a las posiciones de aminoácidos 9 y 10 de SEQ ID NO:2 y (b) al menos dos sustituciones de aminoácidos que alteran la unión a VH3, que comprende una sustitución de aminoácidos en cada una de las posiciones correspondientes a las posiciones de aminoácidos 36 y 37 de SEQ ID NO:2 y (c) una secuencia de aminoácidos que es al menos un 70% idéntica a la secuencia de aminoácidos de SEQ ID NO:2.

Description

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ES10797468.5T 2009-04-03 2010-04-05 Composiciones y métodos relacionados con variantes de la proteína A (SpA) Active ES2563646T3 (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US16643209P 2009-04-03 2009-04-03
US166432P 2009-04-03
US23795609P 2009-08-28 2009-08-28
US237956P 2009-08-28
US28799609P 2009-12-18 2009-12-18
US287996P 2009-12-18
PCT/US2010/029959 WO2011005341A2 (en) 2009-04-03 2010-04-05 Compositions and methods related to protein a (spa) variants

Publications (1)

Publication Number Publication Date
ES2563646T3 true ES2563646T3 (es) 2016-03-15

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ID=43429726

Family Applications (2)

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ES10797468.5T Active ES2563646T3 (es) 2009-04-03 2010-04-05 Composiciones y métodos relacionados con variantes de la proteína A (SpA)
ES17193256T Active ES2784957T3 (es) 2009-04-03 2010-04-05 Composiciones y métodos relacionados con variantes de la proteína A (SPA)

Family Applications After (1)

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ES17193256T Active ES2784957T3 (es) 2009-04-03 2010-04-05 Composiciones y métodos relacionados con variantes de la proteína A (SPA)

Country Status (22)

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US (1) US9567379B2 (es)
EP (3) EP3281947B1 (es)
JP (1) JP5789250B2 (es)
KR (2) KR101773368B1 (es)
CN (1) CN102612523B (es)
AU (1) AU2010271116B2 (es)
BR (1) BRPI1010307B1 (es)
CA (1) CA2757543C (es)
CY (1) CY1123052T1 (es)
DK (2) DK3281947T3 (es)
ES (2) ES2563646T3 (es)
HK (1) HK1162533A1 (es)
HR (2) HRP20160274T1 (es)
HU (2) HUE026855T2 (es)
LT (1) LT3281947T (es)
PL (2) PL2414387T3 (es)
PT (2) PT2414387E (es)
SG (1) SG174968A1 (es)
SI (2) SI2414387T1 (es)
SM (1) SMT201600033B (es)
WO (1) WO2011005341A2 (es)
ZA (1) ZA201107702B (es)

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KR101773368B1 (ko) 2009-04-03 2017-08-31 유니버시티 오브 시카고 단백질 Ａ(ＳｐＡ) 변이체와 관련된 조성물 및 방법
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