CN101679516B - 靶向金黄色葡萄球菌ORF0657n的抗原结合蛋白 - Google Patents
靶向金黄色葡萄球菌ORF0657n的抗原结合蛋白 Download PDFInfo
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- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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Abstract
Description
Ala、Val、Ile、Leu、Met |
Ser、Thr |
Tyr、Trp |
Asn、Gln |
Asp、Glu |
Lys、Arg、His |
SDS PAGE条带 | 表观MW(SDS PAGE) | Western阳性 | Western阴性 | ORF0657n[氨基酸] | 计算的MW |
1 | 47kDa | X | [42-396] | 40.7kDa | |
2 | 44kDa | X | [42-362] | 36.5kDa | |
4 | 37kDa | X | [42-342] | 34.1kDa | |
5 | 35kDa | X | [42-342] | 34.1kDa | |
[156-486] | 38.5kDa | ||||
6 | 32kDa | X | [42-342] | 34.1kDa | |
7 | 26kDa | X | [42-254] | 23.8kDa | |
[255-486] | 26.9kDa | ||||
8 | 16kDa | X | [254-384] | 15.3kDa | |
[254-396] | 16.8kDa | ||||
[343-486] | 16.6kDa | ||||
9 | 13kDa | X | [156-254] | 11.5kDa | |
[255-375] | 14.2kDa | ||||
[375-486] | 12.9kDa | ||||
10 | 10kDa | X | [156-254] | 11.5kDa | |
[255-342] | 10.3kDa |
SDS PAGE条带 | 表观MW(SDS PAGE) | Western阳性 | Western阴性 | ORF0657n[氨基酸] | 计算的MW |
[397-486] | 10.1kDa |
条带 | 通过串联质变法鉴定的ORF0657n区域[氨基酸] | 计算分子量 | SDS PAGE条带大小 |
1 | [117-456] | 39.7kDa | 47.7kDa |
2 | [117-196] | 9.2kDa | 23.3kDa |
3 | [117-224] | 12.5kDa | 19.5kD |
抗体 | KD |
D7scFv | 179pM±5pM |
D7IgG | 422pM±11pM |
mAb(4mb) | 培养阴性导管的数目 | P值 |
CS-D7 | 5个中有4个(80%) | 0.0036(与20C2HA相比较) |
20C2HA(同种型对照) | 5个中都不(0%) | |
PBS | 5个中有1个(20%) | 0.0496(与CS-D7相比较) |
单克隆 | 试验编号 | 凝聚 | %存活率 |
2H2.IgG1 | 6 | 30/30 | 100% |
10B4.IgG1同种型对照 | 6 | 2/30 | 7% |
13C7.IgG2b | 2 | 0/10 | 0% |
6G6.IgG2b同种型对照 | 2 | 0/10 | 0% |
CS-D7 | 4 | 5/20 | 25% |
20C2HA同种型对照 | 4 | 3/20 | 15% |
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US61/007,998 | 2007-12-17 | ||
PCT/US2008/006791 WO2009029132A2 (en) | 2007-05-31 | 2008-05-29 | Antigen-binding proteins targeting s. aureus orf0657n |
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CN101375161A (zh) * | 2006-01-27 | 2009-02-25 | 默克公司 | 靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白 |
US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
JP5658564B2 (ja) | 2007-08-31 | 2015-01-28 | ザ・ユニバーシティ・オブ・シカゴThe University Of Chicago | ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物 |
US8758765B2 (en) | 2008-07-29 | 2014-06-24 | The University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
BRPI1010307B1 (pt) | 2009-04-03 | 2021-07-27 | University Of Chicago | Polipeptídeos variantes de proteína a (spa), composição imunogênica compreendendo os mesmos, vacina, método de produção da referida vacina, bem como uso dos referidos polipeptídeos |
NZ612315A (en) | 2009-04-14 | 2014-10-31 | Novartis Ag | Compositions for immunising against staphylococcus aureus |
CA2779798C (en) | 2009-09-30 | 2019-03-19 | Novartis Ag | Conjugation of staphylococcus aureus type 5 and type 8 capsular polysaccharides |
US20120208986A1 (en) * | 2009-10-20 | 2012-08-16 | Wenger Marc D | Use of mixed mode chromatography for the capture and purification of basic antibody products |
CN102971009A (zh) | 2009-10-30 | 2013-03-13 | 诺华有限公司 | 金黄色葡萄球菌5型和8型荚膜多糖的纯化 |
GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
ES2655701T3 (es) | 2010-07-02 | 2018-02-21 | The University Of Chicago | Composiciones y métodos relacionados con variantes de la proteína A (SpA) |
CA2826566C (en) * | 2011-02-08 | 2022-09-13 | Medimmune, Llc | Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use |
CN102649817A (zh) * | 2011-02-24 | 2012-08-29 | 复旦大学 | 一种抑制细菌生物膜形成的单克隆抗体 |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
US9988439B2 (en) | 2011-12-23 | 2018-06-05 | Nicholas B. Lydon | Immunoglobulins and variants directed against pathogenic microbes |
WO2013096948A1 (en) | 2011-12-23 | 2013-06-27 | Lydon Nicholas B | Immunoglobulins and variants directed against pathogenic microbes |
KR102100009B1 (ko) | 2016-05-04 | 2020-04-10 | 이길봉 | 3축 트레일러의 조향장치 |
KR20170003596U (ko) | 2017-06-16 | 2017-10-17 | 배경률 | 자동차용 스노우 체인 |
CA3076632A1 (en) | 2017-09-29 | 2019-04-04 | Regeneron Pharmaceuticals, Inc. | Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof |
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EP2164869A2 (en) | 2010-03-24 |
IL201906A0 (en) | 2010-06-16 |
RU2009149294A (ru) | 2011-07-10 |
CN101679516A (zh) | 2010-03-24 |
WO2009029132A2 (en) | 2009-03-05 |
MX2009012891A (es) | 2009-12-10 |
JP2010528607A (ja) | 2010-08-26 |
KR20100021577A (ko) | 2010-02-25 |
BRPI0811193A2 (pt) | 2014-11-11 |
US20100166772A1 (en) | 2010-07-01 |
AU2008294038A1 (en) | 2009-03-05 |
CA2687681A1 (en) | 2009-03-05 |
WO2009029132A3 (en) | 2009-05-14 |
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