TR201906295T4 - IL-4 R alfaya bağlanan gözyaşı lipokalini muteinleri. - Google Patents
IL-4 R alfaya bağlanan gözyaşı lipokalini muteinleri. Download PDFInfo
- Publication number
- TR201906295T4 TR201906295T4 TR2019/06295T TR201906295T TR201906295T4 TR 201906295 T4 TR201906295 T4 TR 201906295T4 TR 2019/06295 T TR2019/06295 T TR 2019/06295T TR 201906295 T TR201906295 T TR 201906295T TR 201906295 T4 TR201906295 T4 TR 201906295T4
- Authority
- TR
- Turkey
- Prior art keywords
- tear lipocalin
- bind
- human tear
- alpha
- mutein
- Prior art date
Links
- 108090000978 Interleukin-4 Proteins 0.000 title 1
- 102000003752 Lipocalin 1 Human genes 0.000 title 1
- 108010057281 Lipocalin 1 Proteins 0.000 title 1
- 101000946124 Homo sapiens Lipocalin-1 Proteins 0.000 abstract 3
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 102000010787 Interleukin-4 Receptors Human genes 0.000 abstract 1
- 108010038486 Interleukin-4 Receptors Proteins 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Mevcut buluş, insan gözyaşı lipokalininden türetilen, IL 4 reseptörü alfaya bağlanan yeni muteinlerle ilgilidir. Muteinlerin dizileri amino asitlerin belirli kombinasyonlarını içerir. Özellikle mutasyona uğratılmış bir amino asit kalıntısı, olgun insan gözyaşı lipokalininin doğrusal polipeptit dizisinin 27, 28, 30, 31, 33, 53, 57, 61, 64, 66, 80, 83, 104-106 ve 108 dizi konumlarının herhangi birinde veya daha fazlasında mevcuttur. Mutasyona uğratılmış bir amino asit kalıntısı ayrıca olgun insan gözyaşı lipokalininin doğrusal polipeptit dizisinin 26, 32, 34, 55, 56, 58 ve 63 dizi konumlarının herhangi 2?sinde veya daha fazlasında mevcuttur. Buluş ayrıca, bu tip bir muteini kodlayan bir karşılık gelen nükleik asit molekülü ve bu tip bir muteinin ve bunun kodlayıcı nükleik asit molekülünün üretilmesi için bir yöntem de sağlamaktadır.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35246110P | 2010-06-08 | 2010-06-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201906295T4 true TR201906295T4 (tr) | 2019-05-21 |
Family
ID=44627297
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/06295T TR201906295T4 (tr) | 2010-06-08 | 2011-06-08 | IL-4 R alfaya bağlanan gözyaşı lipokalini muteinleri. |
Country Status (22)
Country | Link |
---|---|
US (5) | US8986951B2 (tr) |
EP (1) | EP2580236B1 (tr) |
JP (3) | JP5902679B2 (tr) |
CN (3) | CN111499725A (tr) |
AU (1) | AU2011263786B2 (tr) |
CA (1) | CA2800026C (tr) |
CY (1) | CY1122339T1 (tr) |
DK (1) | DK2580236T3 (tr) |
ES (1) | ES2729652T3 (tr) |
HR (1) | HRP20190689T1 (tr) |
HU (1) | HUE043835T2 (tr) |
LT (1) | LT2580236T (tr) |
NZ (1) | NZ603562A (tr) |
PL (1) | PL2580236T3 (tr) |
PT (1) | PT2580236T (tr) |
RS (1) | RS58839B1 (tr) |
RU (1) | RU2569745C2 (tr) |
SG (1) | SG186161A1 (tr) |
SI (1) | SI2580236T1 (tr) |
TR (1) | TR201906295T4 (tr) |
WO (1) | WO2011154420A2 (tr) |
ZA (1) | ZA201209160B (tr) |
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EP4086283A1 (en) | 2011-11-16 | 2022-11-09 | AdrenoMed AG | Anti-adrenomedullin (adm) antibody or anti-adm antibody fragment or anti-adm non-ig scaffold for prevention or reduction of organ dysfunction or organ failure in a patient having a chronic or acute disease or acute condition |
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2011
- 2011-06-08 PT PT11726380T patent/PT2580236T/pt unknown
- 2011-06-08 PL PL11726380T patent/PL2580236T3/pl unknown
- 2011-06-08 CN CN202010135181.4A patent/CN111499725A/zh active Pending
- 2011-06-08 NZ NZ603562A patent/NZ603562A/en unknown
- 2011-06-08 LT LTEP11726380.6T patent/LT2580236T/lt unknown
- 2011-06-08 CN CN201610143597.4A patent/CN105949301B/zh active Active
- 2011-06-08 CA CA2800026A patent/CA2800026C/en active Active
- 2011-06-08 RU RU2012150766/15A patent/RU2569745C2/ru active
- 2011-06-08 CN CN201180028367.9A patent/CN103038249B/zh active Active
- 2011-06-08 EP EP11726380.6A patent/EP2580236B1/en active Active
- 2011-06-08 AU AU2011263786A patent/AU2011263786B2/en active Active
- 2011-06-08 TR TR2019/06295T patent/TR201906295T4/tr unknown
- 2011-06-08 DK DK11726380.6T patent/DK2580236T3/da active
- 2011-06-08 SI SI201131711T patent/SI2580236T1/sl unknown
- 2011-06-08 ES ES11726380T patent/ES2729652T3/es active Active
- 2011-06-08 SG SG2012089116A patent/SG186161A1/en unknown
- 2011-06-08 HU HUE11726380A patent/HUE043835T2/hu unknown
- 2011-06-08 JP JP2013513670A patent/JP5902679B2/ja active Active
- 2011-06-08 US US13/702,792 patent/US8986951B2/en active Active
- 2011-06-08 RS RS20190510A patent/RS58839B1/sr unknown
- 2011-06-08 WO PCT/EP2011/059420 patent/WO2011154420A2/en active Application Filing
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2012
- 2012-12-05 ZA ZA2012/09160A patent/ZA201209160B/en unknown
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2015
- 2015-03-23 US US14/665,692 patent/US9687524B2/en active Active
- 2015-11-06 JP JP2015218174A patent/JP2016028604A/ja active Pending
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2017
- 2017-06-05 US US15/613,958 patent/US10232014B2/en active Active
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2019
- 2019-01-24 US US16/256,331 patent/US10898545B2/en active Active
- 2019-01-30 JP JP2019014631A patent/JP6766194B2/ja active Active
- 2019-04-12 HR HRP20190689TT patent/HRP20190689T1/hr unknown
- 2019-06-06 CY CY20191100604T patent/CY1122339T1/el unknown
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2020
- 2020-12-16 US US17/124,141 patent/US20210196788A1/en not_active Abandoned
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