MX338914B - Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos. - Google Patents

Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos.

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Publication number
MX338914B
MX338914B MX2012013286A MX2012013286A MX338914B MX 338914 B MX338914 B MX 338914B MX 2012013286 A MX2012013286 A MX 2012013286A MX 2012013286 A MX2012013286 A MX 2012013286A MX 338914 B MX338914 B MX 338914B
Authority
MX
Mexico
Prior art keywords
polypeptide
amino acid
random coil
biosynthetic
proline
Prior art date
Application number
MX2012013286A
Other languages
English (en)
Other versions
MX2012013286A (es
Inventor
Arne Skerra
Uli Binder
Martin Schlapschy
Original Assignee
Xl Protein Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xl Protein Gmbh filed Critical Xl Protein Gmbh
Publication of MX2012013286A publication Critical patent/MX2012013286A/es
Publication of MX338914B publication Critical patent/MX338914B/es

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    • C—CHEMISTRY; METALLURGY
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C07K14/615—Extraction from natural sources
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    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
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    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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Abstract

La presente invención se refiere a un polipéptido biosintético de espira aleatoria o un segmento del polipéptido biosintético de espira aleatoria o conjugado biosintético, en donde el polipéptido biosintético de espira aleatoria, el segmento del polipéptido biosintético de espira aleatoria o el conjugado biosintético comprende una secuencia de aminoácidos que consiste únicamente de residuos de aminoácidos de prolina y alanina, en donde la secuencia de aminoácidos consiste de al menos aproximadamente 50 residuos de aminoácidos de prolina (Pro) y alanina (Ala). Al menos aproximadamente 50 residuos de aminoácidos de prolina (Pro) y alanina (Ala) pueden ser los constituyentes de un polipéptido heterólogo o un constructo de un polipéptido heterólogo. También se describen los usos y métodos de uso de estos polipéptidos biosintéticos de espira aleatoria o los segmentos de polipéptido o conjugados.
MX2012013286A 2010-05-21 2011-05-20 Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos. MX338914B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10163564 2010-05-21
US201061428016P 2010-12-29 2010-12-29
PCT/EP2011/058307 WO2011144756A1 (en) 2010-05-21 2011-05-20 Biosynthetic proline/alanine random coil polypeptides and their uses

Publications (2)

Publication Number Publication Date
MX2012013286A MX2012013286A (es) 2013-03-05
MX338914B true MX338914B (es) 2016-05-06

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MX2016005860A MX357674B (es) 2010-05-21 2011-05-20 Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos.
MX2012013286A MX338914B (es) 2010-05-21 2011-05-20 Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos.

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EP (2) EP3473261A1 (es)
JP (2) JP5828889B2 (es)
KR (1) KR101872541B1 (es)
CN (2) CN105477641B (es)
AU (1) AU2011254564B2 (es)
BR (1) BR112012029577B1 (es)
CA (1) CA2794614C (es)
DK (1) DK2571510T3 (es)
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Families Citing this family (83)

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Publication number Priority date Publication date Assignee Title
SI2571510T1 (sl) 2010-05-21 2019-02-28 Xl-Protein Gmbh Biosintetični prolin/alaninski naključno zviti polipeptidi in njihove uporabe
EP2741782B1 (en) * 2011-08-12 2020-05-06 Ascendis Pharma A/S Protein carrier-linked prodrugs
SG11201405276PA (en) 2012-02-27 2014-10-30 Amunix Operating Inc Xten conjugate compositions and methods of making same
EA031986B1 (ru) 2012-04-04 2019-03-29 Галозим, Инк. Способ и комбинация для лечения солидной раковой опухоли и набор, содержащий комбинацию
US10066007B2 (en) * 2013-01-22 2018-09-04 Deutsches Zentrum Für Neurodegenerative Erkrankungen E.V. (Dzne) Dipeptide-repeat proteins as therapeutic target in neurodegenerative diseases with hexanucleotide repeat expansion
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