MX357674B - Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos. - Google Patents

Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos.

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Publication number
MX357674B
MX357674B MX2016005860A MX2016005860A MX357674B MX 357674 B MX357674 B MX 357674B MX 2016005860 A MX2016005860 A MX 2016005860A MX 2016005860 A MX2016005860 A MX 2016005860A MX 357674 B MX357674 B MX 357674B
Authority
MX
Mexico
Prior art keywords
polypeptide
amino acid
random coil
biosynthetic
proline
Prior art date
Application number
MX2016005860A
Other languages
English (en)
Inventor
Arne Skerra
Uli Binder
Martin Schlapschy
Original Assignee
Xl Protein Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xl Protein Gmbh filed Critical Xl Protein Gmbh
Publication of MX357674B publication Critical patent/MX357674B/es

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    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
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Abstract

La presente invención se refiere en particular a un conjugado de un fármaco que comprende (i) un polipéptido o el segmento del polipéptido biosintético de espira aleatoria, que comprende una secuencia de aminoácidos que consiste únicamente de residuos de aminoácidos de prolina y alanina, en donde la secuencia de aminoácidos consiste de al menos 50 residuos de aminoácidos de prolina (Pro) y alanina (Ala), y (ii) un fármaco seleccionado del grupo que consiste de (a) una proteína o un polipéptido biológicamente activo, que comprende o que es una secuencia de aminoácidos que tiene o media una actividad biológica y (b) un fármaco de molécula pequeña. Además, se describen las moléculas de ácidos nucleicos que codifican el polipéptido o el segmento del polipéptido biosintético de espira aleatoria y/o las proteínas heterólogas biológicamente activas, así como los vectores y células que comprenden las moléculas de ácidos nucleicos. Además, la presente invención proporciona composiciones que comprenden los compuestos de la invención, así como los usos específicos del polipéptido o el segmento del polipéptido de espira aleatoria, la proteínas biológicamente activas, los conjugados de fármacos o las moléculas de ácidos nucleicos, vectores y células de la invención.
MX2016005860A 2010-05-21 2011-05-20 Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos. MX357674B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10163564 2010-05-21
US201061428016P 2010-12-29 2010-12-29
PCT/EP2011/058307 WO2011144756A1 (en) 2010-05-21 2011-05-20 Biosynthetic proline/alanine random coil polypeptides and their uses

Publications (1)

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MX357674B true MX357674B (es) 2018-07-18

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MX2016005860A MX357674B (es) 2010-05-21 2011-05-20 Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos.
MX2012013286A MX338914B (es) 2010-05-21 2011-05-20 Polipeptidos biosinteticos de espira aleatoria de prolina/alanina y sus usos.

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US (3) US9221882B2 (es)
EP (2) EP2571510B1 (es)
JP (2) JP5828889B2 (es)
KR (1) KR101872541B1 (es)
CN (2) CN102883734B (es)
AU (1) AU2011254564B2 (es)
BR (1) BR112012029577B1 (es)
CA (1) CA2794614C (es)
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EA (1) EA024755B1 (es)
ES (1) ES2691642T3 (es)
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LT (1) LT2571510T (es)
MX (2) MX357674B (es)
NZ (1) NZ602522A (es)
PL (1) PL2571510T3 (es)
SG (1) SG185440A1 (es)
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WO (1) WO2011144756A1 (es)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2571510T3 (pl) 2010-05-21 2019-03-29 Xl-Protein Gmbh Biosyntetyczne polipeptydy prolinowo/alaninowe o strukturze kłębka statystycznego i ich zastosowania
US20140323402A1 (en) * 2011-08-12 2014-10-30 Ascendis Phama A/S Protein Carrier-Linked Prodrugs
CA2865578C (en) * 2012-02-27 2023-01-17 Amunix Operating Inc. Xten conjugate compositions and methods of making same
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
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