HRP20240135T1 - Fgf21 mutanti i njihove upotrebe - Google Patents
Fgf21 mutanti i njihove upotrebe Download PDFInfo
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- HRP20240135T1 HRP20240135T1 HRP20240135TT HRP20240135T HRP20240135T1 HR P20240135 T1 HRP20240135 T1 HR P20240135T1 HR P20240135T T HRP20240135T T HR P20240135TT HR P20240135 T HRP20240135 T HR P20240135T HR P20240135 T1 HRP20240135 T1 HR P20240135T1
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- Prior art keywords
- polypeptide
- seq
- amino acid
- substituted
- residue
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- 102000003973 Fibroblast growth factor 21 Human genes 0.000 title 1
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 claims 16
- 102000004196 processed proteins & peptides Human genes 0.000 claims 16
- 108090000765 processed proteins & peptides Proteins 0.000 claims 16
- 125000000539 amino acid group Chemical group 0.000 claims 7
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 6
- 239000000825 pharmaceutical preparation Substances 0.000 claims 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 4
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 4
- 241000124008 Mammalia Species 0.000 claims 4
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008103 glucose Substances 0.000 claims 4
- 235000013922 glutamic acid Nutrition 0.000 claims 4
- 239000004220 glutamic acid Substances 0.000 claims 4
- 239000004475 Arginine Substances 0.000 claims 3
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 3
- 235000004279 alanine Nutrition 0.000 claims 3
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 claims 3
- 150000001413 amino acids Chemical group 0.000 claims 3
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 3
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 208000030159 metabolic disease Diseases 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 3
- 239000004471 Glycine Substances 0.000 claims 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims 2
- 210000004899 c-terminal region Anatomy 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 claims 2
- 208000008338 non-alcoholic fatty liver disease Diseases 0.000 claims 2
- 206010053219 non-alcoholic steatohepatitis Diseases 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 1
- 235000001014 amino acid Nutrition 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 1
- 239000000017 hydrogel Substances 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000004904 shortening Methods 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/50—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1825—Fibroblast growth factor [FGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Vascular Medicine (AREA)
Claims (15)
1. Polipeptid koji sadrži aminokiselinsku sekvencu SEQ ID NO: 4, gdje:
(a) aminokiselinski ostatak na položaju 180 u SEQ ID NO:4 je supstituiran s aminokiselinom odabranom iz skupine koju čine glicin, prolin, serin i glutaminska kiselina; i
(b) aminokiselinski ostatak na položaju 98 u SEQ ID NO: 4 je supstituiran s argininom ili je aminokiselinski ostatak na položaju 171 u SEQ ID NO: 4 glicin, i pri čemu je polipeptid sposoban sniziti razinu glukoze u krvi kod sisavaca.
2. Polipeptid sukladno patentnom zahtjevu 1, naznačen time, da nadalje sadrži slijed linkera koji sadrži SEQ ID NO:31
3. Polipeptid sukladno patentnom zahtjevu 1 ili patentnom zahtjevu 2, naznačen time, da nadalje sadrži Fc domenu koja sadrži SEQ ID NO:11.
4. Polipeptid sukladno bilo kojem od zahtjeva 1-3, naznačen time, da (i) polipeptid SEQ ID NO: 4 sadrži: (a) skraćivanje amino-kraja ne više od 8 aminokiselinskih ostataka, pri čemu je polipeptid sposoban za snižavanje glukoze u krvi kod sisavaca; (b) skraćivanje karboksi kraja ne više od 12 aminokiselinskih ostataka, pri čemu je polipeptid sposoban sniziti glukozu u krvi kod sisavaca; ili (c) skraćivanje amino-kraja od najviše 8 aminokiselinskih ostataka, i skraćivanje karboksi-terminusa od najviše 12 aminokiselinskih ostataka, pri čemu je polipeptid sposoban sniziti glukozu u krvi kod sisavaca, ili (ii) polipeptid je kovalentno vezan za jedan ili više polimera, po izboru polimer je PEG.
5. Farmaceutski pripravak koji sadrži polipeptid prema bilo kojem od zahtjeva 1-3, i farmaceutski prihvatljivo sredstvo za formuliranje.
6. Farmaceutski pripravak sukladno zahtjevu 5, naznačen time, da je farmaceutski prihvatljivo sredstvo za formuliranje hidrogel.
7. Farmaceutski pripravak sukladno patentnom zahtjevu 5 ili 6, za upotrebu u liječenju metaboličkog poremećaja.
8. Farmaceutski pripravak za upotrebu sukladno zahtjevu 7, naznačen time, da je metabolički poremećaj dijabetes tipa 2 ili pretilost.
9. Farmaceutski pripravak za upotrebu sukladno zahtjevu 7, naznačen time, da je metabolički poremećaj nealkoholni steatohepatitis (NASH).
10. Farmaceutski pripravak za upotrebu sukladno zahtjevu 9, naznačen time, da polipeptid sadrži aminokiselinsku sekvencu SEQ ID NO: 4 koja nadalje uključuje supstituciju argininskog ostatka s leucinskim ostatkom na položaju 98, glicinskog ostatka s prolinskim ostatkom na poziciji 171 i glutaminsku kiselinu s alaninom na poziciji 180.
11. Nukleinska kiselina koja kodira polipeptid sukladno bilo kojem od patentnih zahtjeva 1-3.
12. Vektor koji sadrži molekulu nukleinske kiseline sukladno zahtjevu 10.
13. Stanica domaćin koja sadrži molekulu nukleinske kiseline sukladno zahtjevu 10.
14. Multimer koji sadrži dva ili više od polipeptida sukladno patentnom zahtjevu 3.
15. Multimer sukladno patentnom zahtjevu 14, koji sadrži prvi i drugi lanac, pri čemu prvi lanac sadrži:
(a.1) polipeptid SEQ ID NO: 4, gdje je (i) leucin na položaju 98 supstituiran s argininom; (ii) prolin na položaju 171 je supstituiran s glicinom; i (iii) alanin na položaju 180 je supstituiran s glutaminskom kiselinom;
(b.1) linker sekvenca koja sadrži SEQ ID NO:31; i
(c.1) Fc domena koja sadrži SEQ ID NO: 11; i
drugi lanac koji sadrži:
(a.2) polipeptid SEQ ID NO: 4, gdje je (i) leucin na položaju 98 supstituiran s argininom; (ii) prolin na položaju 171 je supstituiran s glicinom; i (iii) alanin na položaju 180 je supstituiran s glutaminskom kiselinom;
(b.2) linker sekvenca koja sadrži SEQ ID NO:31; i
(c.2) Fc domena koja sadrži SEQ ID NO:11.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17573609P | 2009-05-05 | 2009-05-05 | |
| US28511809P | 2009-12-09 | 2009-12-09 | |
| EP17167682.8A EP3248610B1 (en) | 2009-05-05 | 2010-05-04 | Fgf21 mutants and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20240135T1 true HRP20240135T1 (hr) | 2024-04-12 |
Family
ID=42455356
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HRP20240135TT HRP20240135T1 (hr) | 2009-05-05 | 2010-05-04 | Fgf21 mutanti i njihove upotrebe |
Country Status (37)
| Country | Link |
|---|---|
| US (4) | US8188040B2 (hr) |
| EP (3) | EP3248610B1 (hr) |
| JP (1) | JP5823954B2 (hr) |
| KR (2) | KR101860572B1 (hr) |
| CN (2) | CN107188950B (hr) |
| AR (1) | AR076541A1 (hr) |
| AU (1) | AU2010246108B2 (hr) |
| BR (1) | BRPI1011404B1 (hr) |
| CA (1) | CA2760196C (hr) |
| CL (1) | CL2011002768A1 (hr) |
| CO (1) | CO6470863A2 (hr) |
| CR (1) | CR20110639A (hr) |
| DK (1) | DK3248610T5 (hr) |
| EA (1) | EA021425B1 (hr) |
| ES (2) | ES2632742T3 (hr) |
| FI (1) | FI3248610T3 (hr) |
| HK (1) | HK1247134A1 (hr) |
| HR (1) | HRP20240135T1 (hr) |
| HU (1) | HUE065036T2 (hr) |
| IL (2) | IL215937A (hr) |
| JO (1) | JO3469B1 (hr) |
| LT (1) | LT3248610T (hr) |
| MA (1) | MA33716B1 (hr) |
| MX (1) | MX2011011709A (hr) |
| MY (1) | MY156542A (hr) |
| NZ (1) | NZ596037A (hr) |
| PE (2) | PE20120358A1 (hr) |
| PH (1) | PH12015502433A1 (hr) |
| PL (1) | PL3248610T3 (hr) |
| PT (1) | PT3248610T (hr) |
| RS (1) | RS65153B1 (hr) |
| SG (3) | SG10201402038WA (hr) |
| SI (1) | SI3248610T1 (hr) |
| TW (2) | TWI436776B (hr) |
| UY (2) | UY32607A (hr) |
| WO (1) | WO2010129503A1 (hr) |
| ZA (1) | ZA201108371B (hr) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190083A1 (ar) | 2008-06-04 | 2017-06-16 | Amgen Inc | بولي ببتيدات اندماجية طافرة لـfgf21 واستخداماتها |
| EA201990619A1 (ru) | 2008-10-10 | 2019-07-31 | Амген Инк. | Fgf21 мутанты и их применение |
| UY32607A (es) | 2009-05-05 | 2010-12-31 | Amgen Inc | Mutantes de fgf21 y usos del mismo |
| EP2427207B1 (en) | 2009-05-05 | 2017-08-16 | Amgen, Inc | Fgf21 mutants and uses thereof |
| JP2012530493A (ja) | 2009-06-17 | 2012-12-06 | アムジエン・インコーポレーテツド | キメラポリペプチドおよびその使用 |
| MX2012006397A (es) | 2009-12-02 | 2012-11-30 | Amgen Inc | PROTEINAS DE ENLACE QUE ENLAZAN A FGFR1C HUMANO, ß-KLOTHO HUMANA Y TANTO FGFR1C HUMANO COMO ß-KLOTHO HUMANA. |
| UA109888C2 (uk) | 2009-12-07 | 2015-10-26 | ІЗОЛЬОВАНЕ АНТИТІЛО АБО ЙОГО ФРАГМЕНТ, ЩО ЗВ'ЯЗУЄТЬСЯ З β-КЛОТО, РЕЦЕПТОРАМИ FGF І ЇХНІМИ КОМПЛЕКСАМИ | |
| CA2796055A1 (en) | 2010-04-15 | 2011-10-20 | Amgen Inc. | Human fgf receptor and .beta.-klotho binding proteins |
| EP2558115B1 (en) | 2010-04-16 | 2019-07-31 | The Salk Institute for Biological Studies | Methods for treating metabolic disorders using fgf |
| CA2835101A1 (en) * | 2011-05-10 | 2012-11-15 | Amgen Inc. | Method of identifying compounds that specifically modulate the interaction of fgfr1 and .beta.-klotho |
| KR102077721B1 (ko) | 2011-07-01 | 2020-02-14 | 엔지엠 바이오파마슈티컬스, 아이엔씨. | 대사성 장애 및 질환의 치료를 위한 조성물, 용도 및 방법 |
| MX2014002260A (es) * | 2011-08-31 | 2014-08-18 | Amgen Inc | Factor de crecimiento de fibroblasto 21 para usar en el tratamiento de diabetes tipo 1. |
| AU2015202304C1 (en) * | 2011-09-26 | 2017-03-09 | Novartis Ag | Fusion proteins for treating metabolic disorders |
| UY34347A (es) | 2011-09-26 | 2013-04-30 | Novartis Ag | Proteínas de función dual para tratar trastornos metabólicos |
| TWI593708B (zh) * | 2011-09-26 | 2017-08-01 | 諾華公司 | 治療代謝病症之融合蛋白質 |
| AR087973A1 (es) | 2011-10-04 | 2014-04-30 | Lilly Co Eli | Variantes del factor 21 del crecimiento de fibroblastos |
| US9475856B2 (en) | 2012-03-02 | 2016-10-25 | New York University | Chimeric FGF21 proteins with enhanced binding affinity for β-klotho for the treatment of type II diabetes, obesity, and related metabolic disorders |
| EP2830646B1 (en) | 2012-03-27 | 2018-03-07 | NGM Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
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