EA201291362A1 - Слитый белок против злокачественных новообразований - Google Patents

Слитый белок против злокачественных новообразований

Info

Publication number
EA201291362A1
EA201291362A1 EA201291362A EA201291362A EA201291362A1 EA 201291362 A1 EA201291362 A1 EA 201291362A1 EA 201291362 A EA201291362 A EA 201291362A EA 201291362 A EA201291362 A EA 201291362A EA 201291362 A1 EA201291362 A1 EA 201291362A1
Authority
EA
Eurasian Patent Office
Prior art keywords
fusion protein
sequence
domain
fused protein
malignant neoplasms
Prior art date
Application number
EA201291362A
Other languages
English (en)
Other versions
EA023005B1 (ru
Inventor
Ежи Щепан Печиколан
Себастьян Доминик Павлак
Бартломей Мацей Жерек
Кшиштоф Казимеж Лемке
Original Assignee
Адамед Сп. З О.О.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Адамед Сп. З О.О. filed Critical Адамед Сп. З О.О.
Publication of EA201291362A1 publication Critical patent/EA201291362A1/ru
Publication of EA023005B1 publication Critical patent/EA023005B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/191—Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/80—Cytochromes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/04—Fusion polypeptide containing a localisation/targetting motif containing an ER retention signal such as a C-terminal HDEL motif
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/07—Fusion polypeptide containing a localisation/targetting motif containing a mitochondrial localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site

Abstract

Слитый белок, в особенности рекомбинантный, содержащий домен (а), который представляет собой функциональный фрагмент последовательности растворимого белка hTRAIL, начинающийся с аминокислоты в положении, ниже, чем hTRAIL95, или последовательности, имеющей по меньшей мере 70% гомологичность этому; и домен (b), который представляет собой последовательность проапоптотического эффекторного пептида, где данная последовательность домена (b) присоединена к С-концу или N-концу домена (а). Данный слитый белок обладает противоопухолевой активностью. Нуклеотидная последовательность, кодирующая данный слитый белок, вектор экспрессии и клетка-хозяин для получения данного слитого белка, и применение данного слитого белка для лечения онкологических заболеваний.
EA201291362A 2010-06-25 2011-06-24 Слитый белок против злокачественных новообразований EA023005B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL391627A PL391627A1 (pl) 2010-06-25 2010-06-25 Przeciwnowotworowe białko fuzyjne
PCT/EP2011/060666 WO2011161260A1 (en) 2010-06-25 2011-06-24 Anticancer fusion protein

Publications (2)

Publication Number Publication Date
EA201291362A1 true EA201291362A1 (ru) 2013-06-28
EA023005B1 EA023005B1 (ru) 2016-04-29

Family

ID=44627460

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201291362A EA023005B1 (ru) 2010-06-25 2011-06-24 Слитый белок против злокачественных новообразований

Country Status (24)

Country Link
US (1) US9102759B2 (ru)
EP (1) EP2585480B1 (ru)
JP (1) JP5911481B2 (ru)
KR (1) KR101861872B1 (ru)
CN (1) CN102958940B (ru)
AU (1) AU2011268876B2 (ru)
BR (1) BR112012032708A2 (ru)
CA (1) CA2800841C (ru)
CY (1) CY1116099T1 (ru)
DK (1) DK2585480T5 (ru)
EA (1) EA023005B1 (ru)
ES (1) ES2531288T3 (ru)
HK (1) HK1178908A1 (ru)
HR (1) HRP20150241T1 (ru)
IL (1) IL223640A (ru)
MX (1) MX2012015246A (ru)
PL (2) PL391627A1 (ru)
PT (1) PT2585480E (ru)
RS (1) RS53851B1 (ru)
SG (1) SG186439A1 (ru)
SI (1) SI2585480T1 (ru)
UA (1) UA111722C2 (ru)
WO (1) WO2011161260A1 (ru)
ZA (1) ZA201300677B (ru)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL219845B1 (pl) 2011-01-05 2015-07-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
ES2388020B1 (es) * 2011-03-10 2013-10-01 Universitat De Girona Proteínas recombinantes con efecto antitumoral.
PL394618A1 (pl) * 2011-04-19 2012-10-22 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe bialko fuzyjne
RU2619187C2 (ru) * 2012-12-05 2017-05-12 Тевакс Дженетикс Вэксин Ко., Лтд. Слитые белки для применения в качестве иммуногенных усиливающих агентов для индуцирования антигенспецифического т-клеточного ответа
WO2014141094A1 (en) 2013-03-14 2014-09-18 Adamed Sp. Z O.O. Anticancer conjugate
CN103255160A (zh) * 2013-05-06 2013-08-21 徐霞 重组人可溶性肿瘤坏死因子相关的凋亡诱导配体的制备方法
CN103524627A (zh) * 2013-10-14 2014-01-22 成都华创生物技术有限公司 一种增强trail抗肿瘤活性的双靶点融合蛋白
JP2017513921A (ja) 2014-03-03 2017-06-01 アーチャルジー、スジャータ ジストロフィン異常症を治療するためのキメラジストロフィン−ｖｓｖ−ｇタンパク質
BR102014031185A8 (pt) * 2014-12-12 2021-05-04 Fund De Amparo A Pesquisa Do Estado De Sao Paulo Fapesp proteína recombinante indutora da apoptose; processo de obtenção da dita proteína e o seu uso no tratamento do câncer
MA41374A (fr) * 2015-01-20 2017-11-28 Cytomx Therapeutics Inc Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci
CN105985445B (zh) * 2015-02-11 2020-02-04 四川大学华西医院 一种肿瘤坏死因子相关凋亡诱导配体变异体及其制备方法和用途
US10428132B2 (en) * 2015-02-11 2019-10-01 West China Hospital, Sichuan University Tumor necrosis factor-related apoptosis-inducing ligand variant, as well as a preparation method and use thereof
EP3261667A4 (en) * 2015-02-26 2018-10-24 TheVax Genetics Vaccine Co., Ltd. A vaccine composition comprising an immunogenic protein and combination adjuvants for use in eliciting antigen-specific t-cell responses
WO2016138625A1 (zh) * 2015-03-02 2016-09-09 成都华创生物技术有限公司 TRAIL穿膜肽样突变体MuR6、制备方法及应用
EP3266796B1 (en) * 2015-03-02 2018-12-19 Chengdu Huachuang Biotechnology Co., Ltd Trail membrane-penetrating peptide-like mutant mur5, preparation method therefor, and application thereof
US10676723B2 (en) 2015-05-11 2020-06-09 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
WO2017066963A1 (zh) * 2015-10-22 2017-04-27 成都华创生物技术有限公司 一种TRAIL双靶点突变蛋白MuR6S4TR、其制备方法及其应用
EP3348577B1 (en) * 2015-10-22 2020-02-12 Chengdu Huachuang Biotechnology Co., Ltd Double-target mutein mur5s4tr of trail, and preparation method and use thereof
MA55153A (fr) * 2016-02-19 2021-09-29 Immatics Biotechnologies Gmbh Nouveaux peptides et combinaison de peptides pour une utilisation dans l'immunothérapie contre le lymphome non hodgkinien et d'autres cancers
GB201602918D0 (en) * 2016-02-19 2016-04-06 Immatics Biotechnologies Gmbh Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers
US11939609B2 (en) 2017-07-24 2024-03-26 The Board Of Trustees Of The Leland Stanford Junior University Rewiring aberrant cancer signaling to a therapeutic effector response with a synthetic two-component system
CN111479822A (zh) * 2017-12-13 2020-07-31 艾诺奥医药品有限公司 靶向lemd1的癌症疫苗和其用途
US20210040469A1 (en) * 2018-01-25 2021-02-11 University Of Washington Engineered cell death-inducing enzymes and methods of use
CN108324692B (zh) * 2018-04-26 2019-09-24 北京爱泰浦生物医药科技有限责任公司 Atap多肽和紫杉醇类药物共晶药及其制备方法和应用
EP3802619A1 (en) * 2018-06-08 2021-04-14 F. Hoffmann-La Roche AG Peptidic linker with reduced post-translational modification
MX2021005313A (es) * 2018-11-08 2021-10-13 Summation Bio Inc Proteínas de núcleo de mininucleosoma y uso en entrega de ácido nucleico.
CA3140430A1 (en) * 2019-05-14 2020-11-19 Harpoon Therapeutics, Inc. Epcam binding proteins and methods of use
MX2022004410A (es) * 2019-10-11 2022-08-08 Univ Leland Stanford Junior Polipeptidos recombinantes para localizacion celular regulable.
CN113549143B (zh) * 2021-07-21 2022-05-27 吉林大学 一种抗肿瘤多肽Bax-BH3、荧光高分子纳米胶束及其制备方法和应用
CN113717289A (zh) * 2021-07-23 2021-11-30 华东理工大学 一种sac-trail融合蛋白及其制备方法和应用
WO2023031215A2 (en) * 2021-09-02 2023-03-09 Umc Utrecht Holding B.V. Pro-apoptotic construct and use thereof
WO2023076768A1 (en) * 2021-10-26 2023-05-04 Navicure Biopharmaceuticals Limited Combination therapies against cancer and infectious diseases

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60226816A (ja) 1984-11-16 1985-11-12 Asahi Chem Ind Co Ltd 抗腫瘍活性をもつヒト由来蛋白質
DE3841768A1 (de) 1988-12-12 1990-06-13 Basf Ag Neue tnf-peptide
US6284236B1 (en) * 1995-06-29 2001-09-04 Immunex Corporation Cytokine that induces apoptosis
WO1997001633A1 (en) 1995-06-29 1997-01-16 Immunex Corporation Cytokine that induces apoptosis
US6962696B1 (en) * 1999-10-04 2005-11-08 Vion Pharmaceuticals Inc. Compositions and methods for tumor-targeted delivery of effector molecules
DE60118935D1 (de) 2000-04-24 2006-05-24 Univ Yale New Haven Dna & protein bindende miniatur proteine
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
DE10247755B4 (de) * 2002-10-14 2006-01-19 Pfizenmaier, Klaus, Prof. Dr. Selektive, lokale Aktivierung von Mitgliedern der TNF-Rezeptorfamilie durch systemisch inaktive nicht-Antikörper-TNF-Liganden-Fusionsproteine
CN1257187C (zh) * 2003-10-22 2006-05-24 上海恰尔生物技术有限公司 钙网蛋白－肿瘤坏死因子相关凋亡诱导配体的融合蛋白及其制法和用途
CN1256347C (zh) * 2003-12-10 2006-05-17 中国人民解放军第二军医大学 激肽原第五结构域－肿瘤坏死因子相关凋亡诱导配体的融合蛋白及其制法和用途
KR100685345B1 (ko) 2004-03-27 2007-02-22 학교법인조선대학교 세포사 유도 펩타이드
CN101365951B (zh) 2005-08-16 2013-09-11 健泰科生物技术公司 通过检测细胞/组织中galnac-t14的表达判定对apo2l/trail的凋亡敏感性
CN101168742A (zh) * 2007-03-08 2008-04-30 中山大学肿瘤防治中心 一种溶癌病毒及其制备方法
WO2009002947A2 (en) 2007-06-22 2008-12-31 Affymax, Inc. Compounds and peptides that bind the trail receptor
CN101157729B (zh) * 2007-10-23 2011-01-12 南京大学 一种肿瘤坏死因子相关凋亡配体变体及其应用
CL2009001191A1 (es) 2008-05-14 2010-07-02 Genentech Inc Uso del peptido apo2l/trail porque sirve para preparar un medicamento para tratar el cancer de pulmon y el linfoma de hodkin.
US8039437B2 (en) * 2008-06-30 2011-10-18 The Trustees Of The University Of Pennsylvania Fn14/TRAIL fusion proteins
US8546320B2 (en) 2008-11-14 2013-10-01 Kyoto University Hsp9O-targeted anti-cancer chimeric peptide

Also Published As

Publication number Publication date
PT2585480E (pt) 2015-03-02
DK2585480T3 (en) 2015-03-23
PL391627A1 (pl) 2012-01-02
HRP20150241T1 (en) 2015-06-05
EA023005B1 (ru) 2016-04-29
DK2585480T5 (en) 2015-06-08
PL2585480T3 (pl) 2015-05-29
ZA201300677B (en) 2013-09-25
CN102958940B (zh) 2015-12-02
CN102958940A (zh) 2013-03-06
KR20130088137A (ko) 2013-08-07
ES2531288T3 (es) 2015-03-12
AU2011268876A1 (en) 2013-01-10
US9102759B2 (en) 2015-08-11
US20130164254A1 (en) 2013-06-27
SG186439A1 (en) 2013-01-30
MX2012015246A (es) 2013-02-07
RS53851B1 (en) 2015-08-31
AU2011268876B2 (en) 2014-01-30
CA2800841A1 (en) 2011-12-29
EP2585480A1 (en) 2013-05-01
KR101861872B1 (ko) 2018-05-28
WO2011161260A1 (en) 2011-12-29
CY1116099T1 (el) 2017-02-08
JP2013532972A (ja) 2013-08-22
IL223640A (en) 2016-05-31
UA111722C2 (uk) 2016-06-10
EP2585480B1 (en) 2014-12-10
JP5911481B2 (ja) 2016-04-27
BR112012032708A2 (pt) 2016-10-11
SI2585480T1 (sl) 2015-02-27
CA2800841C (en) 2018-07-10
HK1178908A1 (en) 2013-09-19

Similar Documents

Publication Publication Date Title
EA201291362A1 (ru) Слитый белок против злокачественных новообразований
EA201391005A1 (ru) Слитый белок против злокачественной опухоли
EA201390820A1 (ru) Слитый белок против рака
EA201491049A1 (ru) Противораковый слитый белок
EA201590545A1 (ru) Полипептиды, содержащие fc с измененным гликозилированием и сниженной эффекторной функцией
FI3256579T3 (fi) Kysteiiniproteaasi
JP2015525217A5 (ru)
RU2011106744A (ru) Инсулин, стабилизированный галогеном
ES2676023T3 (es) Polipéptidos de IL-22 y proteínas de fusión de IL-22 Fc y métodos de uso
EA036805B8 (ru) Белок cd24 для подавления ответа хозяина на damp
NZ629843A (en) Identification of channelrhodopsin-2 (chop2) mutations and methods of use
EA201491277A1 (ru) Противораковый слитый белок
EP2589658A4 (en) PARTICLE POLYPEPTIDE OF THE REIC / DKK-3 PROTEIN
NZ599590A (en) Factor involved in latent infection with herpesvirus, and use thereof
JP2015524403A5 (ru)
NZ609916A (en) Hla-binding peptides derived from prostate-associated antigenic molecules and methods of use thereof
MX2020010806A (es) Peptidos anti-inflamatorios y usos de los mismos.
EA201391546A1 (ru) Противораковый слитый белок
WO2009024327A3 (en) New proteins for use in human and animal staphylococcus infections
EA201492068A1 (ru) Гидрохлоридная соль пептида и ее применение в комбинации с другими пептидами в иммунотерапии
RU2017122029A (ru) Новые способы опосредованного ферментами конъюгирования полипептидов с использованием сортазы
RU2010125678A (ru) Способ получения рекомбинантной вакцины
EA201290384A1 (ru) Вирусные цитруллинированные пептиды и их применение
MX2016002556A (es) Métodos y composiciones para el tratamiento de patologías del tejido de cartílago y disco.
NZ748614A (en) Fusion protein comprising ccl3 variant and use thereof cross-reference to related applications

Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU