JP2009523422A5 - - Google Patents
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- Publication number
- JP2009523422A5 JP2009523422A5 JP2008550435A JP2008550435A JP2009523422A5 JP 2009523422 A5 JP2009523422 A5 JP 2009523422A5 JP 2008550435 A JP2008550435 A JP 2008550435A JP 2008550435 A JP2008550435 A JP 2008550435A JP 2009523422 A5 JP2009523422 A5 JP 2009523422A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid molecule
- immunogen
- composition
- antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 25
- 108020004707 nucleic acids Proteins 0.000 claims 22
- 102000039446 nucleic acids Human genes 0.000 claims 22
- 239000000427 antigen Substances 0.000 claims 12
- 102000036639 antigens Human genes 0.000 claims 12
- 108091007433 antigens Proteins 0.000 claims 12
- 230000002163 immunogen Effects 0.000 claims 10
- 239000000203 mixture Substances 0.000 claims 10
- 244000052769 pathogen Species 0.000 claims 10
- 230000001717 pathogenic effect Effects 0.000 claims 10
- 108010008038 Synthetic Vaccines Proteins 0.000 claims 6
- 229940124551 recombinant vaccine Drugs 0.000 claims 6
- 108091026890 Coding region Proteins 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 3
- 108010076504 Protein Sorting Signals Proteins 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 239000012634 fragment Substances 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 239000013612 plasmid Substances 0.000 claims 2
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 206010046865 Vaccinia virus infection Diseases 0.000 claims 1
- 230000002238 attenuated effect Effects 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 208000007089 vaccinia Diseases 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75885606P | 2006-01-13 | 2006-01-13 | |
| US60/758,856 | 2006-01-13 | ||
| PCT/US2007/000886 WO2007087178A2 (en) | 2006-01-13 | 2007-01-12 | Vaccines and immunotherapeutics using codon optimized il-15 and methods for using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012272266A Division JP5801279B2 (ja) | 2006-01-13 | 2012-12-13 | コドン最適化したｉｌ−１５を用いるワクチンおよび免疫治療とその使用方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009523422A JP2009523422A (ja) | 2009-06-25 |
| JP2009523422A5 true JP2009523422A5 (enExample) | 2011-02-10 |
| JP5346588B2 JP5346588B2 (ja) | 2013-11-20 |
Family
ID=38309748
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008550435A Expired - Fee Related JP5346588B2 (ja) | 2006-01-13 | 2007-01-12 | コドン最適化したｉｌ−１５を用いるワクチンおよび免疫治療とその使用方法 |
| JP2012272266A Expired - Fee Related JP5801279B2 (ja) | 2006-01-13 | 2012-12-13 | コドン最適化したｉｌ−１５を用いるワクチンおよび免疫治療とその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012272266A Expired - Fee Related JP5801279B2 (ja) | 2006-01-13 | 2012-12-13 | コドン最適化したｉｌ−１５を用いるワクチンおよび免疫治療とその使用方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8178660B2 (enExample) |
| EP (1) | EP1976871B1 (enExample) |
| JP (2) | JP5346588B2 (enExample) |
| KR (1) | KR101421745B1 (enExample) |
| CN (1) | CN101432300A (enExample) |
| AT (1) | ATE533782T1 (enExample) |
| AU (1) | AU2007208452B2 (enExample) |
| CA (1) | CA2636867C (enExample) |
| DK (1) | DK1976871T3 (enExample) |
| ES (1) | ES2374458T3 (enExample) |
| MX (1) | MX336112B (enExample) |
| WO (1) | WO2007087178A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1976871T3 (da) * | 2006-01-13 | 2011-12-12 | Univ Pennsylvania | Vacciner og immunterapeutika under anvendelse af codonoptimerede IL-15 og fremgangsmåder til anvendelse deraf |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP3431485B2 (en) | 2010-10-01 | 2024-09-04 | ModernaTX, Inc. | Engineered nucleic acids and methods of use thereof |
| WO2012109788A1 (zh) * | 2011-02-16 | 2012-08-23 | 中国水产科学研究院黄海水产研究所 | 一种提高蛋白表达效率的方法及表达载体 |
| WO2012135805A2 (en) | 2011-03-31 | 2012-10-04 | modeRNA Therapeutics | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| EP2763701B1 (en) | 2011-10-03 | 2018-12-19 | Moderna Therapeutics, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9878056B2 (en) | 2012-04-02 | 2018-01-30 | Modernatx, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| DE18200782T1 (de) | 2012-04-02 | 2021-10-21 | Modernatx, Inc. | Modifizierte polynukleotide zur herstellung von proteinen im zusammenhang mit erkrankungen beim menschen |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| CA2892529C (en) | 2012-11-26 | 2023-04-25 | Moderna Therapeutics, Inc. | Terminally modified rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EA201690675A1 (ru) | 2013-10-03 | 2016-08-31 | Модерна Терапьютикс, Инк. | Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности |
| DK4023249T3 (da) | 2014-04-23 | 2025-01-13 | Modernatx Inc | Nukleinsyrevacciner |
| US10166288B2 (en) * | 2014-10-01 | 2019-01-01 | The Trustees Of The University Of Pennsylvania | Vaccines having an antigen and interleukin-21 as an adjuvant |
| EP3458034A4 (en) | 2016-05-18 | 2020-01-01 | ModernaTX, Inc. | POLYNUCLEOTIDES ENCODING RELAXIN |
| SG10202111394XA (en) | 2017-04-13 | 2021-12-30 | Senti Biosciences Inc | Combinatorial cancer immunotherapy |
| CN110753555A (zh) | 2017-04-19 | 2020-02-04 | 得克萨斯州大学系统董事会 | 表达工程化抗原受体的免疫细胞 |
| JP6437591B1 (ja) | 2017-05-29 | 2018-12-12 | 旭化成株式会社 | ポリエチレンパウダー及びその成形物 |
| CN107868131A (zh) * | 2017-10-13 | 2018-04-03 | 长春西诺生物科技有限公司 | 一种猪细小病毒病亚单位疫苗及其制备方法 |
| EP3723798A4 (en) | 2017-12-13 | 2021-11-17 | Inovio Pharmaceuticals, Inc. | CANCER VACCINES TARGETING BORIS AND RELATED USES |
| CN111741772A (zh) | 2017-12-13 | 2020-10-02 | 艾诺奥医药品有限公司 | 靶向muc16的癌症疫苗和其用途 |
| BR112020010499A2 (pt) | 2017-12-13 | 2020-11-24 | Inovio Pharmaceuticals, Inc. | vacinas de câncer de alvo de mesotelina e usos das mesmas |
| EP3755349A4 (en) | 2018-02-21 | 2021-11-17 | Board of Regents, The University of Texas System | PROCESS FOR ACTIVATION AND EXPANSION OF NATURAL KILLER CELLS AND THEIR USES |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| CN117120617A (zh) * | 2021-02-05 | 2023-11-24 | St制药株式会社 | 新型核酸分子 |
| US20230151095A1 (en) | 2021-11-12 | 2023-05-18 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and nkg2d |
| WO2024102636A1 (en) | 2022-11-07 | 2024-05-16 | Xencor, Inc. | Bispecific antibodies that bind to b7h3 and mica/b |
| US20250243279A1 (en) | 2023-10-17 | 2025-07-31 | Xencor, Inc. | Bispecific antibodies that bind to nkp46 and mica/b |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2157994A (en) | 1937-11-08 | 1939-05-09 | Kelsey Hayes Wheel Co | Brake mechanism |
| US5077044A (en) * | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
| US5338683A (en) * | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US5174993A (en) * | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US5110587A (en) * | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
| US4722848A (en) * | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| ZW17385A1 (en) | 1984-11-06 | 1986-02-19 | Hoffmann La Roche | Tricyclic pyridine derivatives |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) * | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| GB8508845D0 (en) * | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US5223424A (en) * | 1985-09-06 | 1993-06-29 | Prutech Research And Development | Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence |
| US5310668A (en) * | 1986-06-20 | 1994-05-10 | Merck & Co., Inc. | Varicella-zoster virus as a live recombinant vaccine |
| US5242829A (en) * | 1986-09-23 | 1993-09-07 | Therion Biologics Corporation | Recombinant pseudorabies virus |
| US5387744A (en) * | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| IL86583A0 (en) * | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5294441A (en) * | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| US5112749A (en) * | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| US5225336A (en) * | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
| JP3044062B2 (ja) * | 1989-03-08 | 2000-05-22 | ヘルス・リサーチ・インク | 組換えポックスウイルス宿主選択系 |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| AU645489B2 (en) * | 1989-03-31 | 1994-01-20 | Washington University | Vaccines containing avirulent phoP-type microorganisms |
| ES2070997T3 (es) * | 1989-12-04 | 1995-06-16 | Akzo Nobel Nv | Virus de herpes recombinante de pavos y vacunas vector vivas derivadas de los mismos. |
| US5294548A (en) * | 1990-04-02 | 1994-03-15 | American Biogenetic Sciences, Inc | Recombianant Hepatitis a virus |
| US5462734A (en) * | 1990-11-02 | 1995-10-31 | Wisconsin Alumni Research Foundation | Bovine herpesvirus vaccine and method of using same |
| US5240703A (en) * | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5593972A (en) * | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| PT681483E (pt) | 1993-01-26 | 2005-11-30 | Wyeth Corp | Composicoes e metodos para distribuicao de material genetico |
| US5739118A (en) * | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| NL9401820A (nl) * | 1994-11-02 | 1996-06-03 | Meyn Maschf | Inrichting voor het bewerken van aan zijn poten opgehangen gevogelte. |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| DE10260805A1 (de) * | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins |
| NZ570709A (en) | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| WO2005011874A2 (en) * | 2003-07-31 | 2005-02-10 | Smart Solar Limited | Water feature |
| US20090069256A1 (en) * | 2004-06-04 | 2009-03-12 | Smith Larry R | Enhancing protein expression |
| DK1976871T3 (da) * | 2006-01-13 | 2011-12-12 | Univ Pennsylvania | Vacciner og immunterapeutika under anvendelse af codonoptimerede IL-15 og fremgangsmåder til anvendelse deraf |
| KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
-
2007
- 2007-01-12 DK DK07762574.7T patent/DK1976871T3/da active
- 2007-01-12 AU AU2007208452A patent/AU2007208452B2/en not_active Ceased
- 2007-01-12 JP JP2008550435A patent/JP5346588B2/ja not_active Expired - Fee Related
- 2007-01-12 CA CA2636867A patent/CA2636867C/en not_active Expired - Fee Related
- 2007-01-12 KR KR1020087019727A patent/KR101421745B1/ko not_active Expired - Fee Related
- 2007-01-12 CN CNA2007800059408A patent/CN101432300A/zh active Pending
- 2007-01-12 EP EP07762574A patent/EP1976871B1/en not_active Not-in-force
- 2007-01-12 US US12/160,766 patent/US8178660B2/en not_active Expired - Fee Related
- 2007-01-12 AT AT07762574T patent/ATE533782T1/de active
- 2007-01-12 WO PCT/US2007/000886 patent/WO2007087178A2/en not_active Ceased
- 2007-01-12 ES ES07762574T patent/ES2374458T3/es active Active
-
2008
- 2008-07-10 MX MX2012002587A patent/MX336112B/es unknown
-
2012
- 2012-05-03 US US13/463,805 patent/US8592567B2/en active Active
- 2012-12-13 JP JP2012272266A patent/JP5801279B2/ja not_active Expired - Fee Related
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