JP5346588B2 - コドン最適化したｉｌ−１５を用いるワクチンおよび免疫治療とその使用方法 - Google Patents
コドン最適化したｉｌ−１５を用いるワクチンおよび免疫治療とその使用方法 Download PDFInfo
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| WO2012109788A1 (zh) * | 2011-02-16 | 2012-08-23 | 中国水产科学研究院黄海水产研究所 | 一种提高蛋白表达效率的方法及表达载体 |
| DE12722942T1 (de) | 2011-03-31 | 2021-09-30 | Modernatx, Inc. | Freisetzung und formulierung von manipulierten nukleinsäuren |
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| AU2018251898A1 (en) | 2017-04-13 | 2019-10-31 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| JP2020517259A (ja) | 2017-04-19 | 2020-06-18 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 操作された抗原受容体を発現する免疫細胞 |
| JP6437591B1 (ja) | 2017-05-29 | 2018-12-12 | 旭化成株式会社 | ポリエチレンパウダー及びその成形物 |
| CN107868131A (zh) * | 2017-10-13 | 2018-04-03 | 长春西诺生物科技有限公司 | 一种猪细小病毒病亚单位疫苗及其制备方法 |
| WO2019118760A1 (en) | 2017-12-13 | 2019-06-20 | Inovio Pharmaceuticals, Inc. | Cancer vaccines targeting mesothelin and uses thereof |
| RU2750689C1 (ru) | 2017-12-13 | 2021-07-01 | Иновио Фармасьютикалз, Инк. | Противораковые вакцины, направленные на muc16, и их применение |
| JP7485600B2 (ja) | 2017-12-13 | 2024-05-16 | イノビオ ファーマシューティカルズ，インコーポレイティド | Ｂｏｒｉｓを標的とするがんワクチンおよびその使用 |
| JP7273421B2 (ja) | 2018-02-21 | 2023-05-15 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 |
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|---|---|---|---|---|
| US2157994A (en) | 1937-11-08 | 1939-05-09 | Kelsey Hayes Wheel Co | Brake mechanism |
| US5077044A (en) | 1980-05-19 | 1991-12-31 | The Board Of Trustees Of The Leland Stanford Jr. University | Novel non-reverting shigella live vaccines |
| US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5110587A (en) | 1981-12-24 | 1992-05-05 | Health Research, Incorporated | Immunogenic composition comprising synthetically modified vaccinia virus |
| US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| ZW17385A1 (en) | 1984-11-06 | 1986-02-19 | Hoffmann La Roche | Tricyclic pyridine derivatives |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| GB8508845D0 (en) | 1985-04-04 | 1985-05-09 | Hoffmann La Roche | Vaccinia dna |
| US5223424A (en) | 1985-09-06 | 1993-06-29 | Prutech Research And Development | Attenuated herpesviruses and herpesviruses which include foreign DNA encoding an amino acid sequence |
| US5310668A (en) | 1986-06-20 | 1994-05-10 | Merck & Co., Inc. | Varicella-zoster virus as a live recombinant vaccine |
| US5242829A (en) | 1986-09-23 | 1993-09-07 | Therion Biologics Corporation | Recombinant pseudorabies virus |
| US5294441A (en) | 1987-06-04 | 1994-03-15 | Washington University | Avirulent microbes and uses therefor: salmonella typhi |
| US5387744A (en) | 1987-06-04 | 1995-02-07 | Washington University | Avirulent microbes and uses therefor: Salmonella typhi |
| IL86583A0 (en) | 1987-06-04 | 1988-11-15 | Molecular Eng Ass | Vaccine containing a derivative of a microbe and method for the production thereof |
| US5112749A (en) | 1987-10-02 | 1992-05-12 | Praxis Biologics, Inc. | Vaccines for the malaria circumsporozoite protein |
| AU625584B2 (en) | 1989-03-08 | 1992-07-16 | Health Research Inc. | Recombinant poxvirus host selection system |
| US5225336A (en) | 1989-03-08 | 1993-07-06 | Health Research Incorporated | Recombinant poxvirus host range selection system |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| JP3004049B2 (ja) | 1989-03-31 | 2000-01-31 | ワシントン ユニバーシティー | 病原性のないｐｈｏＰ型微生物を含有するワクチン |
| EP0431668B1 (en) | 1989-12-04 | 1995-02-15 | Akzo Nobel N.V. | Recombinant herpesvirus of turkeys and live vector vaccines derived thereof |
| US5294548A (en) | 1990-04-02 | 1994-03-15 | American Biogenetic Sciences, Inc | Recombianant Hepatitis a virus |
| US5462734A (en) | 1990-11-02 | 1995-10-31 | Wisconsin Alumni Research Foundation | Bovine herpesvirus vaccine and method of using same |
| US5240703A (en) | 1991-03-01 | 1993-08-31 | Syntro Corporation | Attenuated, genetically-engineered pseudorabies virus s-prv-155 and uses thereof |
| WO1994016737A1 (en) | 1993-01-26 | 1994-08-04 | Weiner David B | Compositions and methods for delivery of genetic material |
| US5593972A (en) | 1993-01-26 | 1997-01-14 | The Wistar Institute | Genetic immunization |
| US5981505A (en) | 1993-01-26 | 1999-11-09 | The Trustees Of The University Of Pennsylvania | Compositions and methods for delivery of genetic material |
| US5739118A (en) | 1994-04-01 | 1998-04-14 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| NL9401820A (nl) | 1994-11-02 | 1996-06-03 | Meyn Maschf | Inrichting voor het bewerken van aan zijn poten opgehangen gevogelte. |
| US5962428A (en) | 1995-03-30 | 1999-10-05 | Apollon, Inc. | Compositions and methods for delivery of genetic material |
| DE10260805A1 (de) * | 2002-12-23 | 2004-07-22 | Geneart Gmbh | Verfahren und Vorrichtung zum Optimieren einer Nucleotidsequenz zur Expression eines Proteins |
| NZ570709A (en) | 2003-06-13 | 2010-04-30 | Univ Pennsylvania | Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same |
| DE602004019095D1 (de) * | 2003-07-31 | 2009-03-05 | Smart Solar Ltd | Springbrunnen |
| AU2005250477A1 (en) * | 2004-06-04 | 2005-12-15 | Wyeth | Enhancing protein expression |
| DK1976871T3 (da) * | 2006-01-13 | 2011-12-12 | Univ Pennsylvania | Vacciner og immunterapeutika under anvendelse af codonoptimerede IL-15 og fremgangsmåder til anvendelse deraf |
| KR20140137679A (ko) | 2013-05-23 | 2014-12-03 | 삼성전자주식회사 | 카드 소켓 장치 |
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- 2007-01-12 AU AU2007208452A patent/AU2007208452B2/en not_active Ceased
- 2007-01-12 US US12/160,766 patent/US8178660B2/en not_active Expired - Fee Related
- 2007-01-12 JP JP2008550435A patent/JP5346588B2/ja not_active Expired - Fee Related
- 2007-01-12 AT AT07762574T patent/ATE533782T1/de active
- 2007-01-12 EP EP07762574A patent/EP1976871B1/en not_active Not-in-force
- 2007-01-12 ES ES07762574T patent/ES2374458T3/es active Active
- 2007-01-12 CN CNA2007800059408A patent/CN101432300A/zh active Pending
- 2007-01-12 CA CA2636867A patent/CA2636867C/en not_active Expired - Fee Related
- 2007-01-12 KR KR1020087019727A patent/KR101421745B1/ko not_active Expired - Fee Related
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013051972A (ja) * | 2006-01-13 | 2013-03-21 | Trustees Of The Univ Of Pennsylvania | コドン最適化したｉｌ−１５を用いるワクチンおよび免疫治療とその使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2374458T3 (es) | 2012-02-16 |
| ATE533782T1 (de) | 2011-12-15 |
| US20100003277A1 (en) | 2010-01-07 |
| JP2013051972A (ja) | 2013-03-21 |
| AU2007208452B2 (en) | 2012-07-05 |
| US8592567B2 (en) | 2013-11-26 |
| JP2009523422A (ja) | 2009-06-25 |
| CN101432300A (zh) | 2009-05-13 |
| JP5801279B2 (ja) | 2015-10-28 |
| US20120213815A1 (en) | 2012-08-23 |
| KR20080094044A (ko) | 2008-10-22 |
| US8178660B2 (en) | 2012-05-15 |
| EP1976871A4 (en) | 2009-05-13 |
| MX336112B (es) | 2016-01-08 |
| EP1976871A2 (en) | 2008-10-08 |
| KR101421745B1 (ko) | 2014-07-22 |
| DK1976871T3 (da) | 2011-12-12 |
| EP1976871B1 (en) | 2011-11-16 |
| WO2007087178A2 (en) | 2007-08-02 |
| AU2007208452A1 (en) | 2007-08-02 |
| CA2636867C (en) | 2015-12-01 |
| CA2636867A1 (en) | 2007-08-02 |
| WO2007087178A3 (en) | 2008-01-03 |
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