JP7273421B2 - ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 - Google Patents
ナチュラルキラー細胞の活性化および拡大のための方法ならびにその使用 Download PDFInfo
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Description
本願は、2018年2月21日出願の米国特許仮出願第62/633,592号の利益を主張し、その全体が参照により本明細書中に援用される。
I.定義
II.ナチュラルキラー(NK)細胞
A.キメラ抗原レセプター
B.抗原提示細胞
III.使用方法
IV.キット
以下の実施例は、本発明の好ましい実施形態を示すために含められる。以下の実施例に開示される手法は、本発明の実施においてうまく機能すると本発明者が発見した手法であり、ゆえに、それらの手法は、実施するための好ましい形態を構成すると見なされ得ることが、当業者によって認識されるべきである。しかしながら、当業者は、本開示に鑑みて、開示される具体的な実施形態では、本発明の趣旨および範囲から逸脱することなく多くの変更が行われ得、なおも同様または類似の結果が得られることを認識するはずである。
実施例1-NK細胞のプレ活性化および拡大
以下の参考文献は、それらが本明細書に記載されたものを補足する例示的な手順または他の詳細を提供する範囲で、参照により本明細書に具体的に援用される。
国際公開番号 WO2007/103009
Leong et al., Biol Blood Marrow Transplant. 20(4):463-73, 2014.
Singh et al., Cancer Research, 71:3516-3527, 2011.
U.S. Patent No. 4,690,915
U.S. Patent No. 6,225,042
U.S. Patent No. 6,355,479
U.S. Patent No. 6,362,001
U.S. Patent No. 6,410,319
U.S. Patent No. 6,790,662
U.S. Patent No. 7,109,304
U.S. Patent Publication No. 2009/0004142
U.S. Patent Publication No. 2009/0017000
Claims (21)
- ナチュラルキラー(NK)細胞を拡大するためのインビトロ方法であって、
(a)NK細胞の集団を得る工程;
(b)該NK細胞の集団を、有効濃度のIL-12、IL-15およびIL-18を含むプレ活性化培養物中でプレ活性化して、プレ活性化されたNK細胞を得る工程;および
(c)該プレ活性化されたNK細胞を、CD137リガンドを発現する人工抗原提示細胞(aAPC)を含む拡大培養物中で拡大することにより、拡大されたNK細胞を生成する工程
を含む、方法。 - 前記NK細胞の集団が、臍帯血(CB)、末梢血(PB)、幹細胞または骨髄から得られる、請求項1に記載の方法。
- 前記NK細胞の集団が、CBから得られる、請求項1に記載の方法。
- 前記NK細胞の集団がさらに、CD56<+>NK細胞と定義される、請求項1に記載の方法。
- 前記aAPCがさらに、膜結合型サイトカインを発現する、請求項1に記載の方法。
- 前記膜結合型サイトカインが、膜結合型IL-21(mIL-21)または膜結合型IL-15(mIL-15)である、請求項5に記載の方法。
- 前記aAPCが、内在性のHLAクラスI、IIまたはCD1d分子を本質的に発現しない、請求項1~6のいずれか1項に記載の方法。
- 前記aAPCが、ICAM-1(CD54)およびLFA-3(CD58)を発現する、請求項1に記載の方法。
- 前記aAPCがさらに、白血病細胞由来aAPCと定義される、請求項1に記載の方法。
- 前記白血病細胞由来aAPCが、CD137リガンドおよび/またはmIL-21を発現するように操作されたK562細胞である、請求項9に記載の方法。
- 前記K562細胞が、CD137リガンドおよびmIL-21を発現するように操作される、請求項10に記載の方法。
- 前記aAPCが、レトロウイルス導入によって操作されたものである、請求項11に記載の方法。
- 前記aAPCが、放射線照射される、請求項1に記載の方法。
- 前記プレ活性化工程が、10~20時間である、請求項1に記載の方法。
- 前記プレ活性化されたNK細胞とaAPCとが、前記拡大培養物中に3:1~1:3の比で存在する、請求項1に記載の方法。
- 前記拡大培養物が、IL-2をさらに含む、請求項1~15のいずれか1項に記載の方法。
- 前記NK細胞が、キメラ抗原レセプター(CAR)を発現するように操作される、請求項1~16のいずれか1項に記載の方法。
- ナチュラルキラー(NK)細胞を拡大するためのインビトロ方法であって、
(a)NK細胞の集団を得る工程;
(b)該NK細胞の集団を、有効濃度のIL-12、IL-15およびIL-18を含むプレ活性化培養物中でプレ活性化して、プレ活性化されたNK細胞を得る工程;および
(c)該プレ活性化されたNK細胞を、CD137リガンドを発現する人工抗原提示細胞(aAPC)を含む拡大培養物中で拡大することにより、拡大されたNK細胞を生成する工程
を含む、方法に従って作製され、拡大されたNK細胞の集団。 - 請求項18に記載の拡大されたNK細胞の集団および薬学的に許容され得るキャリアを含む医薬。
- 癌、炎症、移植片対宿主病、移植片拒絶、自己免疫障害、免疫不全症、B細胞悪性疾患または感染症を処置するための、請求項19に記載の医薬。
- 多発性硬化症、炎症性腸疾患、関節リウマチ、I型糖尿病、全身性エリテマトーデス、接触過敏症、喘息またはシェーグレン症候群を処置するための、請求項19に記載の医薬。
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US20210077527A1 (en) * | 2019-09-13 | 2021-03-18 | The Research Institute At Nationwide Children's Hospital | Universal donor selection method to identify nk-cell-donors |
US20220347216A1 (en) * | 2019-09-13 | 2022-11-03 | Ohio State Innovation Foundation | Nk cell immunotherapy compositions, methods of making and methods of using same |
US20210260115A1 (en) * | 2020-02-21 | 2021-08-26 | FullHope Biomedical Co., Ltd. | Modified natural killer cells, pharmaceutical composition, manufacturing method thereof, and method of using the same |
JP2023538012A (ja) * | 2020-08-14 | 2023-09-06 | カイト ファーマ インコーポレイテッド | 免疫細胞機能の改善 |
EP4079312A1 (en) * | 2021-04-22 | 2022-10-26 | Guizhou Sinorda Biotechnology CO., Ltd. | New treatment of sepsis |
JP2024510403A (ja) * | 2021-03-23 | 2024-03-07 | グイジョウ シノルダ バイオテクノロジー カンパニー,リミテッド | 敗血症の新しい治療法 |
EP4376857A1 (en) * | 2021-07-28 | 2024-06-05 | Nkarta, Inc. | Selection of optimal cell donors and methods and compositions for enhanced expansion and cytotoxicity of donor cells |
WO2023034758A1 (en) * | 2021-08-30 | 2023-03-09 | Cytoimmune Therapeutics, Inc. | Methods and compositions for cell expansion |
CN113786416B (zh) * | 2021-09-22 | 2022-08-05 | 北京赛尔再生医学生物科技有限公司 | 转基因的nk细胞在治疗癌症中的用途 |
CN114058584B (zh) * | 2022-01-07 | 2022-07-01 | 山东省齐鲁干细胞工程有限公司 | 一种临床用自然杀伤细胞的制备方法 |
WO2023163240A1 (ko) * | 2022-02-22 | 2023-08-31 | 신동혁 | 자연살해세포 활성도 신속검사용 자극조성물 및 이를 이용한 자연살해세포 활성도 신속검사방법 |
CN115369086B (zh) * | 2022-02-22 | 2023-05-12 | 北京景达生物科技有限公司 | 一种nk细胞扩大培养的培养方案 |
WO2023230529A1 (en) | 2022-05-26 | 2023-11-30 | Caribou Biosciences, Inc. | Cytokine-receptor fusions for immune cell stimulation |
WO2024020537A2 (en) * | 2022-07-22 | 2024-01-25 | Board Of Regents, The University Of Texas System | Cd3-expressing natural killer cells with enhanced function for adoptive immunotherapy |
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