JP2016525545A5 - - Google Patents

Info

Publication number

JP2016525545A5

JP2016525545A5 JP2016529759A JP2016529759A JP2016525545A5 JP 2016525545 A5 JP2016525545 A5 JP 2016525545A5 JP 2016529759 A JP2016529759 A JP 2016529759A JP 2016529759 A JP2016529759 A JP 2016529759A JP 2016525545 A5 JP2016525545 A5 JP 2016525545A5

Authority

JP

Japan

Prior art keywords

fusion antibody

acid sequence

amino acid

seq

heavy chain

Prior art date

2014-05-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 230000004927 fusion Effects 0.000 claims 21
• 150000001413 amino acids Chemical group 0.000 claims 11
• 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 8
• 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 8
• 230000008499 blood brain barrier function Effects 0.000 claims 7
• 210000001218 blood-brain barrier Anatomy 0.000 claims 7
• 101000651201 Homo sapiens N-sulphoglucosamine sulphohydrolase Proteins 0.000 claims 6
• 102100027661 N-sulphoglucosamine sulphohydrolase Human genes 0.000 claims 6
• 230000000694 effects Effects 0.000 claims 5
• 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 4
• 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 4
• 210000004027 cell Anatomy 0.000 claims 3
• 108091033319 polynucleotide Proteins 0.000 claims 3
• 102000040430 polynucleotide Human genes 0.000 claims 3
• 239000002157 polynucleotide Substances 0.000 claims 3
• 102000005962 receptors Human genes 0.000 claims 3
• 108020003175 receptors Proteins 0.000 claims 3
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 2
• 102000003746 Insulin Receptor Human genes 0.000 claims 2
• 108010001127 Insulin Receptor Proteins 0.000 claims 2
• 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
• 210000004899 c-terminal region Anatomy 0.000 claims 2
• 108020001507 fusion proteins Proteins 0.000 claims 2
• 102000037865 fusion proteins Human genes 0.000 claims 2
• 150000007523 nucleic acids Chemical group 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000699802 Cricetulus griseus Species 0.000 claims 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims 1
• 239000004471 Glycine Substances 0.000 claims 1
• 229920002971 Heparan sulfate Polymers 0.000 claims 1
• 108060003951 Immunoglobulin Proteins 0.000 claims 1
• 102100037852 Insulin-like growth factor I Human genes 0.000 claims 1
• 102000011965 Lipoprotein Receptors Human genes 0.000 claims 1
• 108010061306 Lipoprotein Receptors Proteins 0.000 claims 1
• UGJBHEZMOKVTIM-UHFFFAOYSA-N N-formylglycine Chemical compound OC(=O)CNC=O UGJBHEZMOKVTIM-UHFFFAOYSA-N 0.000 claims 1
• 102000005262 Sulfatase Human genes 0.000 claims 1
• 102000007238 Transferrin Receptors Human genes 0.000 claims 1
• 108010033576 Transferrin Receptors Proteins 0.000 claims 1
• 238000006243 chemical reaction Methods 0.000 claims 1
• 235000018417 cysteine Nutrition 0.000 claims 1
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
• 230000007062 hydrolysis Effects 0.000 claims 1
• 238000006460 hydrolysis reaction Methods 0.000 claims 1
• 102000018358 immunoglobulin Human genes 0.000 claims 1
• 102000005861 leptin receptors Human genes 0.000 claims 1
• 108010019813 leptin receptors Proteins 0.000 claims 1
• 230000001404 mediated effect Effects 0.000 claims 1
• 239000003607 modifier Substances 0.000 claims 1
• 210000001672 ovary Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 239000000546 pharmaceutical excipient Substances 0.000 claims 1
• 230000004481 post-translational protein modification Effects 0.000 claims 1
• 108060007951 sulfatase Proteins 0.000 claims 1
• QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1