JP6692293B2 - Cnsにおける酵素活性を増大するための方法および組成物 - Google Patents

Cnsにおける酵素活性を増大するための方法および組成物 Download PDF

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JP6692293B2
JP6692293B2 JP2016529759A JP2016529759A JP6692293B2 JP 6692293 B2 JP6692293 B2 JP 6692293B2 JP 2016529759 A JP2016529759 A JP 2016529759A JP 2016529759 A JP2016529759 A JP 2016529759A JP 6692293 B2 JP6692293 B2 JP 6692293B2
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sgsh
amino acid
fusion antibody
fusion
acid sequence
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JP2016525545A (ja
JP2016525545A5 (enExample
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ウィリアム・エム・パードリッジ
ルーベン・ジェイ・ボアド
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Armagen Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y310/00Hydrolases acting on sulfur-nitrogen bonds (3.10)
    • C12Y310/01Hydrolases acting on sulfur-nitrogen bonds (3.10) acting on sulfur-nitrogen bonds (3.10.1)
    • C12Y310/01001N-Sulfoglucosamine sulfohydrolase (3.10.1.1)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2016529759A 2013-07-22 2014-05-19 Cnsにおける酵素活性を増大するための方法および組成物 Active JP6692293B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2020072208A JP6914392B2 (ja) 2013-07-22 2020-04-14 Cnsにおける酵素活性を増大するための方法および組成物

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361857140P 2013-07-22 2013-07-22
US61/857,140 2013-07-22
PCT/US2014/038660 WO2015012944A1 (en) 2013-07-22 2014-05-19 Methods and compositions for increasing enzyme activity in the cns

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JP2020072208A Division JP6914392B2 (ja) 2013-07-22 2020-04-14 Cnsにおける酵素活性を増大するための方法および組成物

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JP2016525545A JP2016525545A (ja) 2016-08-25
JP2016525545A5 JP2016525545A5 (enExample) 2017-06-29
JP6692293B2 true JP6692293B2 (ja) 2020-05-13

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JP2016529759A Active JP6692293B2 (ja) 2013-07-22 2014-05-19 Cnsにおける酵素活性を増大するための方法および組成物
JP2020072208A Active JP6914392B2 (ja) 2013-07-22 2020-04-14 Cnsにおける酵素活性を増大するための方法および組成物
JP2021115534A Pending JP2021180658A (ja) 2013-07-22 2021-07-13 Cnsにおける酵素活性を増大するための方法および組成物
JP2023153971A Pending JP2024012225A (ja) 2013-07-22 2023-09-20 Cnsにおける酵素活性を増大するための方法および組成物
JP2024230169A Pending JP2025041923A (ja) 2013-07-22 2024-12-26 Cnsにおける酵素活性を増大するための方法および組成物

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JP2020072208A Active JP6914392B2 (ja) 2013-07-22 2020-04-14 Cnsにおける酵素活性を増大するための方法および組成物
JP2021115534A Pending JP2021180658A (ja) 2013-07-22 2021-07-13 Cnsにおける酵素活性を増大するための方法および組成物
JP2023153971A Pending JP2024012225A (ja) 2013-07-22 2023-09-20 Cnsにおける酵素活性を増大するための方法および組成物
JP2024230169A Pending JP2025041923A (ja) 2013-07-22 2024-12-26 Cnsにおける酵素活性を増大するための方法および組成物

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US (3) US20150023956A1 (enExample)
EP (2) EP3024848B1 (enExample)
JP (5) JP6692293B2 (enExample)
AU (2) AU2014293626A1 (enExample)
CA (1) CA2918579C (enExample)
WO (1) WO2015012944A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7741446B2 (en) 2006-08-18 2010-06-22 Armagen Technologies, Inc. Fusion antibodies that cross the blood-brain barrier in both directions
EP2997976A1 (en) 2007-07-27 2016-03-23 Armagen Technologies, Inc. Methods and compositions for increasing alpha-l-iduronidase activity in the cns
US9533055B2 (en) 2009-03-18 2017-01-03 Armagen Technologies, Inc. Compositions and methods for blood-brain barrier delivery of IgG-decoy receptor fusion proteins
WO2011044542A1 (en) 2009-10-09 2011-04-14 Armagen Technologies, Inc. Methods and compositions for increasing iduronate 2-sulfatase activity in the cns
JP6266529B2 (ja) * 2011-12-02 2018-01-24 アーマジェン・インコーポレイテッドArmagen, Inc. Cnsにおけるアリールスルファターゼa活性を増加するための方法および組成物
US10538589B2 (en) 2015-01-14 2020-01-21 Armagen Inc. Methods and compositions for increasing N-acetylglucosaminidase (NAGLU) activity in the CNS using a fusion antibody comprising an anti-human insulin receptor antibody and NAGLU
CA3019398A1 (en) 2016-04-26 2017-11-02 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
MX2020002918A (es) 2017-10-02 2020-07-22 Denali Therapeutics Inc Proteinas de fusion que comprenden enzimas de terapia de reemplazo de enzimas.
AU2019317460A1 (en) * 2018-08-07 2021-03-18 Armagen, Inc. Methods and compositions for increasing the activity in the CNS of hexosaminidase a, acid sphingomyelinase, and palmitoyl-protein thioesterase 1
WO2022081765A1 (en) 2020-10-14 2022-04-21 Denali Therapeutics Inc. Fusion proteins comprising sulfoglucosamine sulfohydrolase enzymes and methods thereof
WO2023214833A1 (ko) * 2022-05-04 2023-11-09 이뮤노포지 주식회사 Glp-1, 면역글로불린 fc, 및 igf-1을 포함하는 융합단백질 및 이의 용도
WO2023240220A1 (en) * 2022-06-09 2023-12-14 The University Of North Carolina At Chapel Hill Aav-sgsh vectors for treatment of mucopolysaccharidosis iiia

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JP2020171284A (ja) 2020-10-22
JP2024012225A (ja) 2024-01-26
AU2020200250A1 (en) 2020-02-06
US20150023956A1 (en) 2015-01-22
CA2918579A1 (en) 2015-01-29
JP2025041923A (ja) 2025-03-26
EP3024848A1 (en) 2016-06-01
JP6914392B2 (ja) 2021-08-04
JP2016525545A (ja) 2016-08-25
CA2918579C (en) 2023-01-03
US20200308292A1 (en) 2020-10-01
EP3730516A1 (en) 2020-10-28
AU2014293626A1 (en) 2016-02-18
WO2015012944A1 (en) 2015-01-29
US20220348672A1 (en) 2022-11-03
EP3024848B1 (en) 2020-07-08
JP2021180658A (ja) 2021-11-25

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