KR20160010466A - Ｉｃｏｓｌ에 대한 치료학적 표적 특이적 ｖｎａｒ 도메인의 단리 - Google Patents
Ｉｃｏｓｌ에 대한 치료학적 표적 특이적 ｖｎａｒ 도메인의 단리 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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- C—CHEMISTRY; METALLURGY
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
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- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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- G—PHYSICS
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- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
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| PCT/EP2014/058276 WO2014173975A1 (en) | 2013-04-23 | 2014-04-23 | Isolation of therapeutic target specific vnar domains to icosl |
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| WO2013167883A1 (en) | 2012-05-07 | 2013-11-14 | The University Court Of The University Of Aberdeen | Single domain binding molecule |
| CN105531370A (zh) | 2013-04-23 | 2016-04-27 | 阿伯丁大学理事会 | 治疗靶向特异性vnar结构域与icosl的分离 |
| EP3160995A2 (en) | 2014-06-26 | 2017-05-03 | Ossianix Inc. | Semi-synthetic nurse shark vnar libraries for making and using selective binding compounds |
| AU2015342264B2 (en) * | 2014-11-03 | 2021-08-12 | Merck Patent Gmbh | Methods for generating bispecific shark variable antibody domains and use thereof |
| WO2016077840A2 (en) | 2014-11-14 | 2016-05-19 | Ossianix, Inc. | TfR SELECTIVE BINDING COMPOUNDS AND RELATED METHODS |
| ITUB20151014A1 (it) * | 2015-05-27 | 2016-11-27 | Univ Degli Studi Del Piemonte Orientale Amedeo Avogadro | Ligandi del recettore b7h nel trattamento di osteopenia e osteoporosi |
| KR102536850B1 (ko) | 2016-04-15 | 2023-05-26 | 알파인 이뮨 사이언시즈, 인코포레이티드 | Icos 리간드 변이체 면역조절 단백질 및 그의 용도 |
| CN107130300A (zh) * | 2016-10-08 | 2017-09-05 | 深圳劲宇生物科技有限公司 | 一种dna编码分子库的合成方法及dna模板 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| EP3688030B1 (en) | 2017-09-27 | 2024-12-11 | Elasmogen Ltd | Specific binding molecules |
| US11180544B2 (en) * | 2017-11-07 | 2021-11-23 | City University Of Hong Kong | Method of producing antibody fragment |
| GB201721802D0 (en) | 2017-12-22 | 2018-02-07 | Almac Discovery Ltd | Ror1-specific antigen binding molecules |
| WO2020056327A1 (en) | 2018-09-14 | 2020-03-19 | Ossianix, Inc. | Tfr-specific binding moieties and transcytosis method to select vnars that cross cellular barriers |
| CN111197074B (zh) * | 2018-11-20 | 2023-08-15 | 深圳华大生命科学研究院 | 条纹斑竹鲨免疫球蛋白新抗原受体可变区库引物及应用 |
| US20220130494A1 (en) * | 2019-02-11 | 2022-04-28 | Neal W. Woodbury | Systems, methods, and media for molecule design using machine learning mechanisms |
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| GB201908886D0 (en) * | 2019-06-20 | 2019-08-07 | Almac Discovery Ltd | Anthracycline derivatives |
| EP4143582A4 (en) * | 2020-05-01 | 2024-09-25 | University of Pittsburgh - of the Commonwealth System of Higher Education | COMPOSITIONS AND METHODS FOR IDENTIFYING NANOBODIES AND NANOBODY AFFINITIES |
| CN112301431B (zh) * | 2020-08-12 | 2023-01-31 | 华东理工大学 | 基于鲨鱼抗体可变区v-nar的噬菌体文库及其构建方法 |
| GB202020154D0 (en) * | 2020-12-18 | 2021-02-03 | Almac Discovery Ltd | ROR1-specific variant antigen binding molecules |
| GB202020152D0 (en) | 2020-12-18 | 2021-02-03 | Elasmogen Ltd | Fast-track humanisation of specific binding molecules |
| WO2022212429A1 (en) * | 2021-03-31 | 2022-10-06 | Sachdev Sidhu | Anti-viral compositions for rift valley fever virus infections and methods of using same |
| EP4141028A1 (en) | 2021-08-31 | 2023-03-01 | Johann-Wolfgang-Goethe-Universität Frankfurt am Main | Personalized vnar-based chimeric antigen receptors (vnar-car) for the treatment of clonal b-and t cell malignancies, and methods for producing vnar-cars |
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| GB0008419D0 (en) * | 2000-04-05 | 2000-05-24 | Bioinvent Int Ab | A method for invitro molecular evolution of antibody function |
| AU2002319544B2 (en) * | 2001-08-10 | 2008-07-10 | Aberdeen University | Antigen binding domains from fish |
| CA2488441C (en) | 2002-06-03 | 2015-01-27 | Genentech, Inc. | Synthetic antibody phage libraries |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| WO2005042743A2 (en) * | 2003-08-18 | 2005-05-12 | Medimmune, Inc. | Humanization of antibodies |
| WO2005021719A2 (en) | 2003-08-27 | 2005-03-10 | Proterec Ltd | Libraries of recombinant chimeric proteins |
| EP1751181B1 (en) | 2004-06-02 | 2012-08-15 | AdAlta Pty Ltd | BINDING MOIETIES BASED ON SHARK IgNAR DOMAINS |
| EA010350B1 (ru) * | 2004-06-03 | 2008-08-29 | Новиммун С.А. | Антитела против cd3 и способы их применения |
| WO2006003999A1 (ja) * | 2004-07-05 | 2006-01-12 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | ヒト抗ヒトb7rp-1抗体およびその抗体フラグメント |
| WO2006102095A2 (en) | 2005-03-18 | 2006-09-28 | Medimmune, Inc. | Framework-shuffling of antibodies |
| JP5171611B2 (ja) | 2005-03-25 | 2013-03-27 | ナショナル リサーチ カウンシル オブ カナダ | 可溶性ポリペプチドの単離方法 |
| EP3613767A1 (en) | 2005-05-18 | 2020-02-26 | Ablynx N.V. | Improved nanobodiestm against tumor cecrosis factor-alpha |
| PL1915398T3 (pl) | 2005-07-18 | 2016-10-31 | Ludzkie przeciwciała neutralizujące anty-B7RP1 | |
| US20100113339A1 (en) | 2006-09-08 | 2010-05-06 | Ablynx N. V. | Serum albumin binding proteins with long half-lives |
| CA2666511A1 (en) | 2006-10-11 | 2008-04-17 | Ablynx N.V. | Amino acid sequences that bind to serum proteins in a manner that is essentially independent of the ph, compounds comprising the same, and uses thereof |
| WO2009026638A1 (en) | 2007-08-31 | 2009-03-05 | Melbourne Health | Marine-animal derived therapeutic and diagnostic agents for hepatitis b |
| WO2010040175A1 (en) | 2008-10-06 | 2010-04-15 | Commonwealth Scientific And Industrial Research Organisation | Amyloid-beta peptide crystal structure |
| AU2009301630A1 (en) * | 2008-10-07 | 2010-04-15 | Zap Holdings Limited | Synchronization of relational databases with OLAP cubes |
| WO2011056056A2 (es) | 2009-11-04 | 2011-05-12 | Laboratorios Silanes, S.A. De C.V. | Dominios vhnar anti -citocinas |
| US20140154241A1 (en) * | 2010-12-03 | 2014-06-05 | Cyclogenix Ltd | Binding peptides i |
| WO2013167883A1 (en) * | 2012-05-07 | 2013-11-14 | The University Court Of The University Of Aberdeen | Single domain binding molecule |
| CN103031304A (zh) * | 2012-12-27 | 2013-04-10 | 苏州大学 | 一种微小rna用于调控b7-h2基因表达 |
| CN105531370A (zh) | 2013-04-23 | 2016-04-27 | 阿伯丁大学理事会 | 治疗靶向特异性vnar结构域与icosl的分离 |
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2014
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