JP2009511480A5 - - Google Patents
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- JP2009511480A5 JP2009511480A5 JP2008534657A JP2008534657A JP2009511480A5 JP 2009511480 A5 JP2009511480 A5 JP 2009511480A5 JP 2008534657 A JP2008534657 A JP 2008534657A JP 2008534657 A JP2008534657 A JP 2008534657A JP 2009511480 A5 JP2009511480 A5 JP 2009511480A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- peptide
- sequence shown
- antibody
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72467005P | 2005-10-06 | 2005-10-06 | |
| US60/724,670 | 2005-10-06 | ||
| US72523505P | 2005-10-11 | 2005-10-11 | |
| US60/725,235 | 2005-10-11 | ||
| US72606205P | 2005-10-12 | 2005-10-12 | |
| US60/726,062 | 2005-10-12 | ||
| PCT/US2006/038818 WO2007044411A2 (en) | 2005-10-06 | 2006-10-05 | Anti-myostatin antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511480A JP2009511480A (ja) | 2009-03-19 |
| JP2009511480A5 true JP2009511480A5 (enExample) | 2009-04-30 |
| JP5052517B2 JP5052517B2 (ja) | 2012-10-17 |
Family
ID=37943347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008534657A Expired - Fee Related JP5052517B2 (ja) | 2005-10-06 | 2006-10-05 | 抗ミオスタチン抗体 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7635760B2 (enExample) |
| EP (1) | EP1951756B1 (enExample) |
| JP (1) | JP5052517B2 (enExample) |
| KR (1) | KR101135220B1 (enExample) |
| CN (1) | CN101277976B (enExample) |
| AU (1) | AU2006302494B2 (enExample) |
| BR (1) | BRPI0616923A2 (enExample) |
| CA (1) | CA2624976A1 (enExample) |
| EA (1) | EA015589B1 (enExample) |
| ES (1) | ES2533464T3 (enExample) |
| IL (1) | IL189579A0 (enExample) |
| NO (1) | NO20082073L (enExample) |
| WO (1) | WO2007044411A2 (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2533464T3 (es) | 2005-10-06 | 2015-04-10 | Eli Lilly And Company | Anticuerpos anti-miostatina |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| UA98308C2 (en) * | 2006-09-05 | 2012-05-10 | Эли Лилли Энд Компани | Anti-myostatin antibody |
| MX2009013069A (es) | 2007-06-01 | 2010-03-17 | Wyeth Llc | Tratamiento de leucemia resistente al imatinib. |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| KR100857861B1 (ko) * | 2007-10-15 | 2008-09-11 | 주식회사 바이오리더스 | Myo-2 펩타이드 중합체와 마이오스타틴의 융합단백질표면발현용 벡터 및 상기 벡터로 형질전환된 미생물 |
| PE20091163A1 (es) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| WO2010027797A1 (en) * | 2008-08-26 | 2010-03-11 | Macrogenics Inc. | T-cell receptor antibodies and methods of use thereof |
| UY32341A (es) | 2008-12-19 | 2010-07-30 | Glaxo Group Ltd | Proteínas de unión antígeno novedosas |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| UY33421A (es) | 2010-06-03 | 2011-12-30 | Glaxo Wellcome House | Proteinas de union al antígeno humanizados |
| SG187867A1 (en) * | 2010-08-16 | 2013-03-28 | Amgen Inc | Antibodies that bind myostatin, compositions and methods |
| AR082641A1 (es) | 2010-09-07 | 2012-12-19 | Imclone Llc | Composiciones de anticuerpo anti-vegfr-3 |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| CN102212545B (zh) * | 2011-04-07 | 2013-05-08 | 北京济福霖生物技术有限公司 | 利用锌指核酸酶敲除牛β-乳球蛋白基因的方法 |
| CN102260711B (zh) * | 2011-06-24 | 2013-09-18 | 北京济福霖生物技术有限公司 | 利用锌指核酸酶敲除牛肌肉抑制素基因的方法 |
| RS56796B1 (sr) * | 2011-11-14 | 2018-04-30 | Regeneron Pharma | Kompozicije i postupci za uvećanje mišićne mase i jačine mišića specifičnim antagonizovanjem gdf8 i/ili aktivina a |
| CN102660577B (zh) * | 2012-04-18 | 2013-12-25 | 山东省农业科学院奶牛研究中心 | 利用锌指核酸酶敲除牛整合素β6亚基基因的方法 |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| US8853154B2 (en) | 2012-09-13 | 2014-10-07 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind to myostatin |
| JPWO2014119634A1 (ja) * | 2013-01-30 | 2017-01-26 | 国立研究開発法人国立精神・神経医療研究センター | 筋増加剤及びそれを含む医薬組成物 |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| SMT202100008T1 (it) * | 2013-05-06 | 2021-03-15 | Scholar Rock Inc | Composizioni e metodi per la modulazione di fattore di crescita |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素a之抗體及其用途 |
| KR20170003912A (ko) | 2014-03-19 | 2017-01-10 | 매카이 메디컬 파운데이션 더 프레즈비티리언 처치 인 타이완 매카이 메모리얼 호스피탈 | 면역원성 당펩타이드에 대한 항체, 이를 포함하는 조성물 및 이의 용도 |
| EP2960653A1 (en) * | 2014-06-24 | 2015-12-30 | Stichting Kwaliteitsgarantie Vleeskalversector | Diagnostic kit and method for the identification of the manipulation of muscle mass in a domestic animal |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| TWI656133B (zh) | 2014-12-19 | 2019-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Fc區域之多胜肽及使用方法 |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| JP6877357B2 (ja) | 2015-04-15 | 2021-05-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | Gdf8阻害剤を用いて、強度及び機能を増加させる方法 |
| IL305148A (en) | 2015-09-15 | 2023-10-01 | Scholar Rock Inc | Anti-pro/hidden myostatin antibodies and their uses |
| WO2017110981A1 (en) * | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| JP2019504064A (ja) | 2016-01-08 | 2019-02-14 | スカラー ロック インコーポレイテッドScholar Rock,Inc. | 抗プロ/潜在型ミオスタチン抗体およびその使用方法 |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| JP7198757B2 (ja) | 2017-01-06 | 2023-01-04 | スカラー ロック インコーポレイテッド | ミオスタチン活性化の阻害により代謝疾患を処置するための方法 |
| EP3593144A1 (en) * | 2017-03-10 | 2020-01-15 | UCL Business Ltd | Method relating to myostatin pathway inhibition |
| US11248044B2 (en) | 2018-03-01 | 2022-02-15 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition by administering a GDF8 inhibitor and an Activin A inhibitor |
| PT3773713T (pt) | 2018-04-06 | 2025-07-29 | Regeneron Pharma | Anticorpo agonista do recetor de leptina para usar no aumento da massa óssea num sujeito que sofre de disfunção metabólica ou de hipoleptinemia |
| EP3898672A1 (en) | 2018-12-18 | 2021-10-27 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for enhancing body weight and lean muscle mass using antagonists against leptin receptor, gdf8 and activin a |
| KR20250075642A (ko) | 2022-09-21 | 2025-05-28 | 리제너론 파아마슈티컬스, 인크. | 비만, 당뇨병 및 간 기능 장애를 치료하는 방법 |
| CN120677175A (zh) | 2022-12-22 | 2025-09-19 | 供石公司 | 肌生成抑制蛋白活化的选择性和强效抑制剂 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| US7393682B1 (en) * | 1993-03-19 | 2008-07-01 | The Johns Hopkins University School Of Medicine | Polynucleotides encoding promyostatin polypeptides |
| ES2201076T3 (es) | 1993-03-19 | 2004-03-16 | The Johns Hopkins University School Of Medicine | Factor-8 de diferenciacion del crecimiento. |
| KR100227406B1 (ko) | 1993-05-12 | 1999-12-01 | 브루스 엠. 에이센 | Bmp-11 조성물 |
| DK0776337T3 (da) | 1994-07-08 | 2005-12-12 | Univ Johns Hopkins Med | Vækstdifferentieringsfaktor-11 |
| US6008434A (en) | 1994-07-08 | 1999-12-28 | Johns Hopkins University School Of Medicine | Growth differentiation factor-11 transgenic mice |
| US6696260B1 (en) | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
| US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
| AU1276399A (en) | 1997-11-07 | 1999-05-31 | Genetics Institute Inc. | Neuronal uses of bmp-11 |
| GB2333706A (en) | 1998-02-02 | 1999-08-04 | Merck & Co Inc | Method for increasing muscle mass in animals |
| AU2586199A (en) | 1998-02-05 | 1999-08-23 | Johns Hopkins University School Of Medicine, The | Growth differentiation factor-8 |
| AU765214B2 (en) | 1998-05-06 | 2003-09-11 | Metamorphix International, Inc. | Methods for treating diabetes by inhibiting gdf-8 |
| US7504490B1 (en) * | 1998-10-16 | 2009-03-17 | Oscient Pharmaceuticals Corporation | Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics |
| EP1147413B1 (en) | 1999-01-21 | 2006-04-05 | Metamorphix, Inc. | Growth differentiation factor inhibitors and uses therefor |
| US7320789B2 (en) * | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| JP2006507356A (ja) | 2002-09-16 | 2006-03-02 | ワイエス | ミオスタチンのメタロプロテアーゼ活性化およびミオスタチン活性の調節方法 |
| AR047392A1 (es) | 2002-10-22 | 2006-01-18 | Wyeth Corp | Neutralizacion de anticuerpos contra gdf 8 y su uso para tales fines |
| KR20130036378A (ko) | 2002-12-20 | 2013-04-11 | 암겐 인코포레이티드 | 미오스타틴을 저해하는 결합제 |
| WO2004108157A2 (en) * | 2003-06-02 | 2004-12-16 | Wyeth | Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders |
| NZ529860A (en) * | 2003-11-28 | 2006-10-27 | Ovita Ltd | Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases |
| SG153874A1 (en) * | 2003-12-31 | 2009-07-29 | Schering Plough Ltd | Neutralizing epitope-based growth enhancing vaccine |
| US20070178095A1 (en) * | 2004-03-23 | 2007-08-02 | Eli Lilly And Company | Anti-myostatin antibodies |
| US20060034831A1 (en) * | 2004-08-12 | 2006-02-16 | Wyeth | Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors |
| NZ538097A (en) * | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
| JP2008537488A (ja) * | 2005-03-23 | 2008-09-18 | ワイス | Gdf−8モジュレート物質の検出 |
| BRPI0610248A2 (pt) * | 2005-04-25 | 2010-06-08 | Pfizer | anticorpos contra miostatina, composição farmacêutica compreendendo os mesmos, linhas celulares que os produzem , moléculas de ácido nucleico codificantes dos mesmos bem como seus usos |
| WO2006128190A2 (en) * | 2005-05-27 | 2006-11-30 | The Regents Of The University Of California | Compositions and methods for treatment of neural disorders using transforming growth factor-beta superfamily proteins and their antagonists |
| EP1915397B1 (en) * | 2005-08-19 | 2015-01-14 | Wyeth LLC | Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders |
| ES2533464T3 (es) * | 2005-10-06 | 2015-04-10 | Eli Lilly And Company | Anticuerpos anti-miostatina |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| CA2632544C (en) | 2005-12-06 | 2014-09-23 | Amgen Inc. | Use of myostatin antagonist for treating the effects of hypogonadism |
| US20070190056A1 (en) * | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
| UA98308C2 (en) | 2006-09-05 | 2012-05-10 | Эли Лилли Энд Компани | Anti-myostatin antibody |
| TW201718635A (zh) | 2007-03-06 | 2017-06-01 | 安美基公司 | 變異之活動素受體多肽及其用途 |
-
2006
- 2006-10-05 ES ES06816226.2T patent/ES2533464T3/es active Active
- 2006-10-05 JP JP2008534657A patent/JP5052517B2/ja not_active Expired - Fee Related
- 2006-10-05 CN CN2006800368248A patent/CN101277976B/zh not_active Expired - Fee Related
- 2006-10-05 CA CA002624976A patent/CA2624976A1/en not_active Abandoned
- 2006-10-05 BR BRPI0616923-6A patent/BRPI0616923A2/pt not_active IP Right Cessation
- 2006-10-05 US US12/066,664 patent/US7635760B2/en not_active Expired - Fee Related
- 2006-10-05 EP EP06816226.2A patent/EP1951756B1/en active Active
- 2006-10-05 AU AU2006302494A patent/AU2006302494B2/en not_active Ceased
- 2006-10-05 EA EA200801027A patent/EA015589B1/ru not_active IP Right Cessation
- 2006-10-05 WO PCT/US2006/038818 patent/WO2007044411A2/en not_active Ceased
- 2006-10-05 KR KR1020087008254A patent/KR101135220B1/ko not_active Expired - Fee Related
-
2008
- 2008-02-18 IL IL189579A patent/IL189579A0/en unknown
- 2008-05-02 NO NO20082073A patent/NO20082073L/no not_active Application Discontinuation
-
2009
- 2009-11-04 US US12/612,060 patent/US7745583B2/en not_active Expired - Fee Related
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