JP2009511579A5 - - Google Patents
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- Publication number
- JP2009511579A5 JP2009511579A5 JP2008535569A JP2008535569A JP2009511579A5 JP 2009511579 A5 JP2009511579 A5 JP 2009511579A5 JP 2008535569 A JP2008535569 A JP 2008535569A JP 2008535569 A JP2008535569 A JP 2008535569A JP 2009511579 A5 JP2009511579 A5 JP 2009511579A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- myostatin
- antibody
- monoclonal antibody
- muscle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72573805P | 2005-10-12 | 2005-10-12 | |
| US60/725,738 | 2005-10-12 | ||
| PCT/US2006/038817 WO2007047112A2 (en) | 2005-10-12 | 2006-10-05 | Anti-myostatin antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009511579A JP2009511579A (ja) | 2009-03-19 |
| JP2009511579A5 true JP2009511579A5 (enExample) | 2009-11-05 |
| JP5031756B2 JP5031756B2 (ja) | 2012-09-26 |
Family
ID=37681692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008535569A Expired - Fee Related JP5031756B2 (ja) | 2005-10-12 | 2006-10-05 | 抗ミオスタチン抗体 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7632499B2 (enExample) |
| EP (2) | EP2816058B1 (enExample) |
| JP (1) | JP5031756B2 (enExample) |
| KR (1) | KR101128548B1 (enExample) |
| CN (1) | CN101282992B (enExample) |
| AU (1) | AU2006303921B2 (enExample) |
| BR (1) | BRPI0617345A2 (enExample) |
| CA (1) | CA2624935C (enExample) |
| DK (2) | DK1951755T3 (enExample) |
| EA (1) | EA015903B1 (enExample) |
| ES (2) | ES2533462T3 (enExample) |
| HR (1) | HRP20150176T1 (enExample) |
| HU (1) | HUE036566T2 (enExample) |
| IL (1) | IL189580A (enExample) |
| LT (1) | LT2816058T (enExample) |
| NO (1) | NO20082167L (enExample) |
| PL (2) | PL1951755T3 (enExample) |
| PT (2) | PT1951755E (enExample) |
| RS (2) | RS56755B1 (enExample) |
| SI (2) | SI2816058T1 (enExample) |
| UA (1) | UA92504C2 (enExample) |
| WO (1) | WO2007047112A2 (enExample) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130036378A (ko) | 2002-12-20 | 2013-04-11 | 암겐 인코포레이티드 | 미오스타틴을 저해하는 결합제 |
| ES2533464T3 (es) * | 2005-10-06 | 2015-04-10 | Eli Lilly And Company | Anticuerpos anti-miostatina |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| IN2014DN10515A (enExample) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
| UA98308C2 (en) | 2006-09-05 | 2012-05-10 | Эли Лилли Энд Компани | Anti-myostatin antibody |
| MX336725B (es) | 2007-09-26 | 2016-01-28 | Chugai Pharmaceutical Co Ltd | Metodo de modificacion del punto isoelectrico de anticuerpos medinate la sustitucion de aminoacidos en region de determinacion de complementariedad (cdr). |
| PE20091163A1 (es) * | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
| TWI700293B (zh) | 2008-04-11 | 2020-08-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗體 |
| CN104004094B (zh) | 2008-06-25 | 2017-09-22 | 艾斯巴技术-诺华有限责任公司 | 使用通用抗体构架进行的兔抗体的人源化 |
| RU2653753C1 (ru) | 2008-06-25 | 2018-05-14 | ИЭсБиЭйТЕК, ЭН АЛЬКОН БАЙОМЕДИКАЛ РИСЕРЧ ЮНИТ ЭлЭлСи | СТАБИЛЬНЫЕ И РАСТВОРИМЫЕ АНТИТЕЛА, ИНГИБИРУЮЩИЕ TNFα |
| UY32341A (es) * | 2008-12-19 | 2010-07-30 | Glaxo Group Ltd | Proteínas de unión antígeno novedosas |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| UY33421A (es) | 2010-06-03 | 2011-12-30 | Glaxo Wellcome House | Proteinas de union al antígeno humanizados |
| SG187867A1 (en) * | 2010-08-16 | 2013-03-28 | Amgen Inc | Antibodies that bind myostatin, compositions and methods |
| AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
| KR102568454B1 (ko) | 2010-11-30 | 2023-08-18 | 추가이 세이야쿠 가부시키가이샤 | 복수 분자의 항원에 반복해서 결합하는 항원 결합 분자 |
| US9402916B2 (en) | 2011-03-17 | 2016-08-02 | The University Of Birmingham | Re-directed immunotherapy |
| EP2554353B1 (de) | 2011-08-05 | 2017-06-07 | Trisa Holding AG | Verfahren zur Herstellung einer Zahnbürste und Zahnbürste |
| RS56796B1 (sr) | 2011-11-14 | 2018-04-30 | Regeneron Pharma | Kompozicije i postupci za uvećanje mišićne mase i jačine mišića specifičnim antagonizovanjem gdf8 i/ili aktivina a |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| EP3597747B1 (en) | 2012-08-24 | 2023-03-15 | Chugai Seiyaku Kabushiki Kaisha | Mouse fcgammarii-specific fc antibody |
| US8853154B2 (en) | 2012-09-13 | 2014-10-07 | Bristol-Myers Squibb Company | Fibronectin based scaffold domain proteins that bind to myostatin |
| JP6401172B2 (ja) | 2012-10-24 | 2018-10-10 | セルジーン コーポレイション | 貧血の治療方法 |
| JPWO2014119634A1 (ja) * | 2013-01-30 | 2017-01-26 | 国立研究開発法人国立精神・神経医療研究センター | 筋増加剤及びそれを含む医薬組成物 |
| AU2014250434B2 (en) | 2013-04-02 | 2019-08-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| SMT202100008T1 (it) | 2013-05-06 | 2021-03-15 | Scholar Rock Inc | Composizioni e metodi per la modulazione di fattore di crescita |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| EP3100056A2 (en) | 2014-01-27 | 2016-12-07 | Novartis AG | Biomarkers predictive of muscle atrophy, method and use |
| EP3215175A4 (en) | 2014-11-06 | 2018-06-27 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| WO2016073906A2 (en) * | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Transforming growth factor-related immunoassays |
| TWI656133B (zh) | 2014-12-19 | 2019-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法 |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| WO2016128523A1 (en) | 2015-02-12 | 2016-08-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
| JP6877357B2 (ja) * | 2015-04-15 | 2021-05-26 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｇｄｆ８阻害剤を用いて、強度及び機能を増加させる方法 |
| IL305148A (en) | 2015-09-15 | 2023-10-01 | Scholar Rock Inc | Anti-pro/hidden myostatin antibodies and their uses |
| AR107078A1 (es) | 2015-12-18 | 2018-03-21 | Chugai Pharmaceutical Co Ltd | Anticuerpo antimiostatina, polipéptidos que contienen regiones fc variantes así como métodos de uso |
| WO2017110981A1 (en) * | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| JP2019504064A (ja) | 2016-01-08 | 2019-02-14 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | 抗プロ／潜在型ミオスタチン抗体およびその使用方法 |
| EP3785728A3 (en) | 2016-06-13 | 2021-04-28 | Scholar Rock, Inc. | Use of myostatin inhibitors and combination therapies |
| KR102306744B1 (ko) | 2016-06-17 | 2021-09-28 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체 및 사용 방법 |
| CN109689099B (zh) | 2016-08-05 | 2023-02-28 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| JP7198757B2 (ja) | 2017-01-06 | 2023-01-04 | スカラー ロック インコーポレイテッド | ミオスタチン活性化の阻害により代謝疾患を処置するための方法 |
| US11248044B2 (en) | 2018-03-01 | 2022-02-15 | Regeneron Pharmaceuticals, Inc. | Methods for altering body composition by administering a GDF8 inhibitor and an Activin A inhibitor |
| PT3773713T (pt) | 2018-04-06 | 2025-07-29 | Regeneron Pharma | Anticorpo agonista do recetor de leptina para usar no aumento da massa óssea num sujeito que sofre de disfunção metabólica ou de hipoleptinemia |
| CA3120800A1 (en) | 2018-12-17 | 2020-06-25 | Revitope Limited | Twin immune cell engager |
| EP3898672A1 (en) | 2018-12-18 | 2021-10-27 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for enhancing body weight and lean muscle mass using antagonists against leptin receptor, gdf8 and activin a |
| KR20250075642A (ko) | 2022-09-21 | 2025-05-28 | 리제너론 파아마슈티컬스, 인크. | 비만, 당뇨병 및 간 기능 장애를 치료하는 방법 |
| CN120677175A (zh) | 2022-12-22 | 2025-09-19 | 供石公司 | 肌生成抑制蛋白活化的选择性和强效抑制剂 |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
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| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
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| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
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| US5994618A (en) | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
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| AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
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| WO2004108157A2 (en) * | 2003-06-02 | 2004-12-16 | Wyeth | Use of myostatin (gdf8) inhibitors in conjunction with corticosteroids for treating neuromuscular disorders |
| WO2005005604A2 (en) | 2003-06-30 | 2005-01-20 | Centocor, Inc. | Engineered anti-target immunoglobulin derived proteins, compositions, methods and uses |
| NZ529860A (en) * | 2003-11-28 | 2006-10-27 | Ovita Ltd | Muscle growth regulator mighty and use in promoting muscle mass and treating muscle wasting diseases |
| SG153874A1 (en) * | 2003-12-31 | 2009-07-29 | Schering Plough Ltd | Neutralizing epitope-based growth enhancing vaccine |
| US20070178095A1 (en) | 2004-03-23 | 2007-08-02 | Eli Lilly And Company | Anti-myostatin antibodies |
| US20060034831A1 (en) | 2004-08-12 | 2006-02-16 | Wyeth | Combination therapy for diabetes, obesity and cardiovascular diseases using GDF-8 inhibitors |
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| BRPI0610248A2 (pt) | 2005-04-25 | 2010-06-08 | Pfizer | anticorpos contra miostatina, composição farmacêutica compreendendo os mesmos, linhas celulares que os produzem , moléculas de ácido nucleico codificantes dos mesmos bem como seus usos |
| WO2006128190A2 (en) * | 2005-05-27 | 2006-11-30 | The Regents Of The University Of California | Compositions and methods for treatment of neural disorders using transforming growth factor-beta superfamily proteins and their antagonists |
| EP1915397B1 (en) * | 2005-08-19 | 2015-01-14 | Wyeth LLC | Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8-associated disorders |
| ES2533464T3 (es) | 2005-10-06 | 2015-04-10 | Eli Lilly And Company | Anticuerpos anti-miostatina |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| CA2632544C (en) | 2005-12-06 | 2014-09-23 | Amgen Inc. | Use of myostatin antagonist for treating the effects of hypogonadism |
| US20070190056A1 (en) * | 2006-02-07 | 2007-08-16 | Ravi Kambadur | Muscle regeneration compositions and uses therefor |
| UA98308C2 (en) | 2006-09-05 | 2012-05-10 | Эли Лилли Энд Компани | Anti-myostatin antibody |
| TW201718635A (zh) | 2007-03-06 | 2017-06-01 | 安美基公司 | 變異之活動素受體多肽及其用途 |
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2006
- 2006-05-10 UA UAA200803004A patent/UA92504C2/ru unknown
- 2006-10-05 CN CN2006800375720A patent/CN101282992B/zh not_active Expired - Fee Related
- 2006-10-05 EP EP14181801.3A patent/EP2816058B1/en active Active
- 2006-10-05 RS RS20180031A patent/RS56755B1/sr unknown
- 2006-10-05 PT PT06816225T patent/PT1951755E/pt unknown
- 2006-10-05 ES ES06816225.4T patent/ES2533462T3/es active Active
- 2006-10-05 SI SI200632235T patent/SI2816058T1/en unknown
- 2006-10-05 HU HUE14181801A patent/HUE036566T2/hu unknown
- 2006-10-05 PL PL06816225T patent/PL1951755T3/pl unknown
- 2006-10-05 BR BRPI0617345-4A patent/BRPI0617345A2/pt not_active Application Discontinuation
- 2006-10-05 DK DK06816225.4T patent/DK1951755T3/en active
- 2006-10-05 ES ES14181801.3T patent/ES2657292T3/es active Active
- 2006-10-05 AU AU2006303921A patent/AU2006303921B2/en not_active Ceased
- 2006-10-05 PL PL14181801T patent/PL2816058T3/pl unknown
- 2006-10-05 HR HRP20150176TT patent/HRP20150176T1/hr unknown
- 2006-10-05 KR KR1020087008707A patent/KR101128548B1/ko not_active Expired - Fee Related
- 2006-10-05 EP EP06816225.4A patent/EP1951755B1/en active Active
- 2006-10-05 WO PCT/US2006/038817 patent/WO2007047112A2/en not_active Ceased
- 2006-10-05 CA CA2624935A patent/CA2624935C/en active Active
- 2006-10-05 DK DK14181801.3T patent/DK2816058T3/en active
- 2006-10-05 JP JP2008535569A patent/JP5031756B2/ja not_active Expired - Fee Related
- 2006-10-05 LT LTEP14181801.3T patent/LT2816058T/lt unknown
- 2006-10-05 SI SI200631876T patent/SI1951755T1/sl unknown
- 2006-10-05 US US12/066,838 patent/US7632499B2/en not_active Expired - Fee Related
- 2006-10-05 RS RS20150157A patent/RS54046B1/sr unknown
- 2006-10-05 EA EA200801065A patent/EA015903B1/ru not_active IP Right Cessation
- 2006-10-05 PT PT141818013T patent/PT2816058T/pt unknown
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2008
- 2008-02-18 IL IL189580A patent/IL189580A/en not_active IP Right Cessation
- 2008-05-09 NO NO20082167A patent/NO20082167L/no not_active Application Discontinuation
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2009
- 2009-11-03 US US12/611,470 patent/US8066995B2/en not_active Expired - Fee Related