JP2012512641A5 - - Google Patents
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- Publication number
- JP2012512641A5 JP2012512641A5 JP2011541469A JP2011541469A JP2012512641A5 JP 2012512641 A5 JP2012512641 A5 JP 2012512641A5 JP 2011541469 A JP2011541469 A JP 2011541469A JP 2011541469 A JP2011541469 A JP 2011541469A JP 2012512641 A5 JP2012512641 A5 JP 2012512641A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- light chain
- binding protein
- variable region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13898008P | 2008-12-19 | 2008-12-19 | |
| US61/138,980 | 2008-12-19 | ||
| PCT/EP2009/067515 WO2010070094A1 (en) | 2008-12-19 | 2009-12-18 | Myostatin binding proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512641A JP2012512641A (ja) | 2012-06-07 |
| JP2012512641A5 true JP2012512641A5 (enExample) | 2013-01-31 |
Family
ID=41786068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541469A Ceased JP2012512641A (ja) | 2008-12-19 | 2009-12-18 | ミオスタチン結合タンパク質 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20110256132A1 (enExample) |
| EP (1) | EP2358753A1 (enExample) |
| JP (1) | JP2012512641A (enExample) |
| KR (1) | KR20110103431A (enExample) |
| CN (1) | CN102325793A (enExample) |
| AR (1) | AR074777A1 (enExample) |
| AU (1) | AU2009329533A1 (enExample) |
| BR (1) | BRPI0922405A2 (enExample) |
| CA (1) | CA2747062A1 (enExample) |
| CL (1) | CL2011001503A1 (enExample) |
| CO (1) | CO6400149A2 (enExample) |
| CR (1) | CR20110358A (enExample) |
| DO (1) | DOP2011000189A (enExample) |
| EA (1) | EA201190018A1 (enExample) |
| IL (1) | IL213243A0 (enExample) |
| MA (1) | MA32980B1 (enExample) |
| MX (1) | MX2011006611A (enExample) |
| NZ (1) | NZ593297A (enExample) |
| PE (1) | PE20120429A1 (enExample) |
| SG (1) | SG172039A1 (enExample) |
| TW (1) | TW201029662A (enExample) |
| UY (1) | UY32341A (enExample) |
| WO (1) | WO2010070094A1 (enExample) |
| ZA (1) | ZA201104397B (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| EP2275443B1 (en) | 2008-04-11 | 2015-12-02 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| TWI654204B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| PH12013502378A1 (en) | 2011-06-02 | 2014-01-06 | Dyax Corp | Fc RECEPTOR BINDING PROTEINS |
| JP6177249B2 (ja) | 2011-11-14 | 2017-08-09 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｇｄｆ８及び／又はアクチビンａに特異的に拮抗することによって筋肉量及び筋力を増加させる組成物及び方法 |
| WO2013125667A1 (ja) | 2012-02-24 | 2013-08-29 | 中外製薬株式会社 | FcγRIIBを介して抗原の消失を促進する抗原結合分子 |
| WO2014030750A1 (ja) | 2012-08-24 | 2014-02-27 | 中外製薬株式会社 | マウスFcγRII特異的Fc抗体 |
| SG11201500873XA (en) | 2012-08-24 | 2015-04-29 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc region variant |
| HUE043482T2 (hu) * | 2012-09-13 | 2019-08-28 | Bristol Myers Squibb Co | Miosztatint megkötõ fibronektin alapú váz domén proteinek |
| TWI636062B (zh) | 2013-04-02 | 2018-09-21 | 中外製藥股份有限公司 | Fc region variant |
| HUE052232T2 (hu) | 2013-05-06 | 2021-04-28 | Scholar Rock Inc | Készítmények és eljárások növekedési faktor modulálására |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| US10307480B2 (en) * | 2014-11-06 | 2019-06-04 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| NZ730607A (en) | 2014-12-19 | 2022-07-01 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
| WO2016168613A1 (en) * | 2015-04-15 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| PT3922645T (pt) | 2015-09-15 | 2025-05-29 | Scholar Rock Inc | ¿anticorpos anti-pró-miostatina/miostatina latente e suas utilizações |
| EP3390443A4 (en) * | 2015-12-18 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES, POLYPEPTIDES WITH DEVIANT FC REGIONS AND METHOD OF USE |
| WO2017110981A1 (en) * | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| KR20210082548A (ko) | 2016-06-13 | 2021-07-05 | 스칼러 락, 인크. | 미오스타틴 억제제의 용도 및 조합 요법 |
| MX2018014375A (es) * | 2016-06-17 | 2019-04-22 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina y metodos de uso. |
| BR112019001902A2 (pt) | 2016-08-05 | 2019-07-09 | Chugai Seiyaku Kabushiki Kaisha | composição para profilaxia ou tratamento de doenças relacionadas à il-8 |
| FR3055548B1 (fr) | 2016-09-05 | 2018-09-28 | Metabrain Research | Utilisation de metabolites du tryptophane dans le traitement de l'atrophie musculaire |
| US11155611B2 (en) * | 2017-01-06 | 2021-10-26 | Scholar Rock, Inc. | Compositions and methods for making and using anti-myostatin antibodies |
| PT3565592T (pt) * | 2017-01-06 | 2023-05-31 | Scholar Rock Inc | Tratamento de doenças metabólicas através da inibição da ativação da miostatina |
| KR20200128125A (ko) | 2018-03-01 | 2020-11-11 | 리제너론 파아마슈티컬스, 인크. | 신체 조성을 변경하기 위한 방법 |
| LT3773713T (lt) | 2018-04-06 | 2025-08-25 | Regeneron Pharmaceuticals, Inc. | Leptino receptoriaus agonistinis antikūnas, skirtas kaulų masės didinimui subjektui, kuriam pasireiškia medžiagų apykaitos sutrikimas arba hipoleptinemija |
| MX2021007394A (es) | 2018-12-18 | 2021-07-15 | Regeneron Pharma | Composiciones y metodos para aumentar el peso corporal y la masa muscular magra mediante el uso de antagonistas contra el receptor de leptina, gdf8 y activina a. |
| TWI836364B (zh) * | 2021-04-28 | 2024-03-21 | 沛爾生技醫藥股份有限公司 | 慢病毒包裝系統以及使用其以提高宿主細胞之慢病毒產量的方法 |
| TWI758171B (zh) | 2021-04-28 | 2022-03-11 | 沛爾生技醫藥股份有限公司 | 慢病毒包裝系統及使用其以提高宿主細胞之慢病毒產量的方法 |
| US20240389949A1 (en) * | 2021-10-20 | 2024-11-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems, methods, and apparatuses for implementing cloud-based health, nutritional, and body composition analysis |
| KR20250075642A (ko) | 2022-09-21 | 2025-05-28 | 리제너론 파아마슈티컬스, 인크. | 비만, 당뇨병 및 간 기능 장애를 치료하는 방법 |
| AU2023413166A1 (en) | 2022-12-22 | 2025-07-03 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
| ES2052027T5 (es) | 1988-11-11 | 2005-04-16 | Medical Research Council | Clonacion de secuencias de dominio variable de inmunoglobulina. |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| EP0605522B1 (en) | 1991-09-23 | 1999-06-23 | Medical Research Council | Methods for the production of humanized antibodies |
| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
| ES2201076T3 (es) | 1993-03-19 | 2004-03-16 | The Johns Hopkins University School Of Medicine | Factor-8 de diferenciacion del crecimiento. |
| DE69420137T2 (de) | 1993-06-03 | 1999-12-23 | Therapeutic Antibodies, Inc. | Herstellung von antikörperfragmenten |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| US5795737A (en) | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| CA2280195A1 (en) | 1997-02-07 | 1998-08-13 | Merck & Co., Inc. | Synthetic hiv gag genes |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| CA2388245C (en) | 1999-10-19 | 2012-01-10 | Kyowa Kirin Co., Ltd. | The use of serum-free adapted rat cells for producing heterologous polypeptides |
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| NZ581474A (en) | 2001-08-03 | 2011-04-29 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
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| WO2004029207A2 (en) | 2002-09-27 | 2004-04-08 | Xencor Inc. | Optimized fc variants and methods for their generation |
| US7261893B2 (en) * | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
| EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
| EP1641818B1 (en) | 2003-07-04 | 2008-12-03 | Affibody AB | Polypeptides having binding affinity for her2 |
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| WO2005056764A2 (en) | 2003-12-05 | 2005-06-23 | Compound Therapeutics, Inc. | Inhibitors of type 2 vascular endothelial growth factor receptors |
| US20070178095A1 (en) | 2004-03-23 | 2007-08-02 | Eli Lilly And Company | Anti-myostatin antibodies |
| AU2005269759A1 (en) | 2004-07-21 | 2006-02-09 | Glycofi, Inc. | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
| GB0425555D0 (en) | 2004-11-19 | 2004-12-22 | Glaxo Group Ltd | Novel compounds |
| EP1877075A4 (en) * | 2005-04-25 | 2008-07-30 | Pfizer | ANTIBODY TO MYOSTATIN |
| US8221998B2 (en) | 2005-05-20 | 2012-07-17 | Glaxosmithkline Llc | Expression of protein GB1 domain fusion proteins in mammalian cells |
| PL2407486T3 (pl) * | 2005-08-19 | 2018-05-30 | Wyeth Llc | Przeciwciała antagonistyczne względem GDF-8 i zastosowania w leczeniu ALS i innych zaburzeń związanych z GDF-8 |
| ES2533464T3 (es) | 2005-10-06 | 2015-04-10 | Eli Lilly And Company | Anticuerpos anti-miostatina |
| UA92504C2 (en) * | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| PL2066695T3 (pl) | 2006-09-05 | 2013-08-30 | Lilly Co Eli | Przeciwciała przeciwko miostatynie |
| GB0702888D0 (en) * | 2007-02-14 | 2007-03-28 | Glaxo Group Ltd | Novel Antibodies |
| EP1958957A1 (en) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprising a knottin protein moiety |
-
2009
- 2009-12-17 AR ARP090104946A patent/AR074777A1/es not_active Application Discontinuation
- 2009-12-17 UY UY0001032341A patent/UY32341A/es unknown
- 2009-12-17 TW TW098143432A patent/TW201029662A/zh unknown
- 2009-12-18 BR BRPI0922405A patent/BRPI0922405A2/pt not_active IP Right Cessation
- 2009-12-18 AU AU2009329533A patent/AU2009329533A1/en not_active Abandoned
- 2009-12-18 JP JP2011541469A patent/JP2012512641A/ja not_active Ceased
- 2009-12-18 CN CN2009801573934A patent/CN102325793A/zh active Pending
- 2009-12-18 EP EP09804126A patent/EP2358753A1/en not_active Withdrawn
- 2009-12-18 KR KR1020117016877A patent/KR20110103431A/ko not_active Withdrawn
- 2009-12-18 CA CA2747062A patent/CA2747062A1/en not_active Abandoned
- 2009-12-18 MA MA34031A patent/MA32980B1/fr unknown
- 2009-12-18 WO PCT/EP2009/067515 patent/WO2010070094A1/en not_active Ceased
- 2009-12-18 EA EA201190018A patent/EA201190018A1/ru unknown
- 2009-12-18 NZ NZ593297A patent/NZ593297A/xx not_active IP Right Cessation
- 2009-12-18 SG SG2011041886A patent/SG172039A1/en unknown
- 2009-12-18 US US13/140,841 patent/US20110256132A1/en not_active Abandoned
- 2009-12-18 MX MX2011006611A patent/MX2011006611A/es not_active Application Discontinuation
- 2009-12-18 PE PE2011001257A patent/PE20120429A1/es not_active Application Discontinuation
-
2011
- 2011-05-31 IL IL213243A patent/IL213243A0/en unknown
- 2011-06-13 ZA ZA2011/04397A patent/ZA201104397B/en unknown
- 2011-06-15 DO DO2011000189A patent/DOP2011000189A/es unknown
- 2011-06-17 CL CL2011001503A patent/CL2011001503A1/es unknown
- 2011-06-23 CR CR20110358A patent/CR20110358A/es unknown
- 2011-06-28 CO CO11080753A patent/CO6400149A2/es not_active Application Discontinuation