JP2012512641A5 - - Google Patents
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- Publication number
- JP2012512641A5 JP2012512641A5 JP2011541469A JP2011541469A JP2012512641A5 JP 2012512641 A5 JP2012512641 A5 JP 2012512641A5 JP 2011541469 A JP2011541469 A JP 2011541469A JP 2011541469 A JP2011541469 A JP 2011541469A JP 2012512641 A5 JP2012512641 A5 JP 2012512641A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- light chain
- binding protein
- variable region
- heavy chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13898008P | 2008-12-19 | 2008-12-19 | |
| US61/138,980 | 2008-12-19 | ||
| PCT/EP2009/067515 WO2010070094A1 (en) | 2008-12-19 | 2009-12-18 | Myostatin binding proteins |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012512641A JP2012512641A (ja) | 2012-06-07 |
| JP2012512641A5 true JP2012512641A5 (enExample) | 2013-01-31 |
Family
ID=41786068
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011541469A Ceased JP2012512641A (ja) | 2008-12-19 | 2009-12-18 | ミオスタチン結合タンパク質 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US20110256132A1 (enExample) |
| EP (1) | EP2358753A1 (enExample) |
| JP (1) | JP2012512641A (enExample) |
| KR (1) | KR20110103431A (enExample) |
| CN (1) | CN102325793A (enExample) |
| AR (1) | AR074777A1 (enExample) |
| AU (1) | AU2009329533A1 (enExample) |
| BR (1) | BRPI0922405A2 (enExample) |
| CA (1) | CA2747062A1 (enExample) |
| CL (1) | CL2011001503A1 (enExample) |
| CO (1) | CO6400149A2 (enExample) |
| CR (1) | CR20110358A (enExample) |
| DO (1) | DOP2011000189A (enExample) |
| EA (1) | EA201190018A1 (enExample) |
| IL (1) | IL213243A0 (enExample) |
| MA (1) | MA32980B1 (enExample) |
| MX (1) | MX2011006611A (enExample) |
| NZ (1) | NZ593297A (enExample) |
| PE (1) | PE20120429A1 (enExample) |
| SG (1) | SG172039A1 (enExample) |
| TW (1) | TW201029662A (enExample) |
| UY (1) | UY32341A (enExample) |
| WO (1) | WO2010070094A1 (enExample) |
| ZA (1) | ZA201104397B (enExample) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| TW201920257A (zh) | 2008-04-11 | 2019-06-01 | 日商中外製藥股份有限公司 | 重複結合複數個抗原的抗原結合分子 |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| TWI654203B (zh) | 2010-11-30 | 2019-03-21 | Chugai Seiyaku Kabushiki Kaisha | 具有鈣依存性的抗原結合能力之抗體 |
| BR112013030352B1 (pt) * | 2011-06-02 | 2020-05-19 | Dyax Corp. | anticorpo anti-fcrn isolado, composição farmacêutica que compreende o dito anticorpo, ácido nucleico isolado, vetor, célula e uso terapêutico do dito anticorpo |
| SMT201800092T1 (it) | 2011-11-14 | 2018-03-08 | Regeneron Pharma | Composizioni e metodi per aumentare la massa muscolare e la forza muscolare antagonizzando specificamente gdf8 e/o activina a |
| CA2865158C (en) | 2012-02-24 | 2022-11-01 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule for promoting disappearance of antigen via fc.gamma.riib |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| TWI855488B (zh) | 2012-08-24 | 2024-09-11 | 日商中外製藥股份有限公司 | FcγRIIb特異性Fc區域變異體 |
| RS58801B1 (sr) * | 2012-09-13 | 2019-07-31 | Bristol Myers Squibb Co | Skafold domenski proteini na bazi fibronektina koji se vezuju za miostatin |
| SG11201508170TA (en) | 2013-04-02 | 2015-11-27 | Chugai Pharmaceutical Co Ltd | Fc REGION VARIANT |
| HRP20201914T1 (hr) | 2013-05-06 | 2021-01-22 | Scholar Rock, Inc. | Sastavi i postupci za modulaciju faktora rasta |
| TWI655207B (zh) | 2013-07-30 | 2019-04-01 | 再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| WO2016073853A1 (en) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| MX2017005774A (es) | 2014-12-19 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipeptidos que contienen regiones fc variantes, y metodos de uso. |
| CN114773469B (zh) | 2015-02-05 | 2025-12-19 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| WO2016168613A1 (en) * | 2015-04-15 | 2016-10-20 | Regeneron Pharmaceuticals, Inc. | Methods of increasing strength and functionality with gdf8 inhibitors |
| EA038146B1 (ru) | 2015-09-15 | 2021-07-13 | Сколар Рок, Инк. | Антитела к про-/латентному миостатину и их применения |
| EA201891420A1 (ru) * | 2015-12-18 | 2019-02-28 | Чугаи Сейяку Кабусики Кайся | Антитела к миостатину, полипептиды, содержащие варианты fc-областей, и способы их применения |
| EP3394098A4 (en) * | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHOD OF USE |
| CN115814077A (zh) | 2016-01-08 | 2023-03-21 | 供石公司 | 抗-原肌生长抑制素/潜伏肌生长抑制素抗体及其使用方法 |
| PL4218804T3 (pl) | 2016-06-13 | 2026-05-25 | Scholar Rock, Inc. | Stosowanie inhibitorów miostatyny i terapii skojarzonych |
| TWI760396B (zh) | 2016-06-17 | 2022-04-11 | 日商中外製藥股份有限公司 | 抗肌抑素抗體及使用方法 |
| CN116271014A (zh) | 2016-08-05 | 2023-06-23 | 中外制药株式会社 | 用于预防或治疗il-8相关疾病的组合物 |
| FR3055548B1 (fr) * | 2016-09-05 | 2018-09-28 | Metabrain Research | Utilisation de metabolites du tryptophane dans le traitement de l'atrophie musculaire |
| WO2018129395A1 (en) * | 2017-01-06 | 2018-07-12 | Scholar Rock, Inc. | Methods for treating metabolic diseases by inhibiting myostatin activation |
| HRP20230308T1 (hr) * | 2017-01-06 | 2023-05-12 | Scholar Rock, Inc. | Liječenje metaboličkih bolesti putem inhibiranja aktivacije miostatina |
| IL276921B2 (en) | 2018-03-01 | 2025-12-01 | Regeneron Pharma | Methods for altering body composition |
| SMT202500283T1 (it) | 2018-04-06 | 2025-09-12 | Regeneron Pharma | Un anticorpo agonista del recettore della leptina da utilizzare per aumentare la massa ossea in un soggetto affetto da disfunzione metabolica o ipoleptinemia |
| CN113195532B (zh) | 2018-12-18 | 2025-04-11 | 瑞泽恩制药公司 | 使用针对瘦素受体、gdf8和活化素a的拮抗剂增加体重和瘦肌肉质量的组合物和方法 |
| TWI758171B (zh) | 2021-04-28 | 2022-03-11 | 沛爾生技醫藥股份有限公司 | 慢病毒包裝系統及使用其以提高宿主細胞之慢病毒產量的方法 |
| TWI836364B (zh) * | 2021-04-28 | 2024-03-21 | 沛爾生技醫藥股份有限公司 | 慢病毒包裝系統以及使用其以提高宿主細胞之慢病毒產量的方法 |
| WO2023069605A1 (en) * | 2021-10-20 | 2023-04-27 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems, methods, and apparatuses for implementing a cloud-based health, nutritional, and body composition analysis platform |
| JP2025532651A (ja) | 2022-09-21 | 2025-10-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 肥満、糖尿病および肝機能障害を処置する方法 |
| CN120677175A (zh) | 2022-12-22 | 2025-09-19 | 供石公司 | 肌生成抑制蛋白活化的选择性和强效抑制剂 |
| US20260199503A1 (en) | 2025-01-10 | 2026-07-16 | Regeneron Pharmaceuticals, Inc. | Glp1r agonist-tethered gdf8 antibody conjugates and uses thereof |
Family Cites Families (54)
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| JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| JP3101690B2 (ja) * | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| FI903489A7 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Yhden osan sisältävät ligandit, näitä ligandeja sisältävät reseptorit, menetelmiä niiden valmistamiseksi sekä ligandien ja reseptorien käytt ö |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| JP3540315B2 (ja) | 1991-09-23 | 2004-07-07 | メディカル リサーチ カウンシル | キメラ抗体の製造−組合せアプローチ |
| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| DE69308573T2 (de) | 1992-08-17 | 1997-08-07 | Genentech Inc | Bispezifische immunoadhesine |
| CA2157577C (en) | 1993-03-19 | 2009-11-17 | Se-Jin Lee | Growth differentiation factor-8 |
| CA2163032C (en) | 1993-06-03 | 2001-02-06 | John Landon | Antibody fragments in therapy |
| US5429746A (en) | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| US5795737A (en) | 1994-09-19 | 1998-08-18 | The General Hospital Corporation | High level expression of proteins |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| EE9900343A (et) | 1997-02-07 | 2000-02-15 | Merck & Co., Inc. | Sünteetiline polünukleotiid, immuunvastuste tekitamise meetod, immunogeenne kompositsioon, anti-HIV immuunvastuste indutseerimise meetod, meetod antigeeni tekitava raku indutseerimiseks ja farmatseutiline kompositsioon |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
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| CA2388245C (en) | 1999-10-19 | 2012-01-10 | Kyowa Kirin Co., Ltd. | The use of serum-free adapted rat cells for producing heterologous polypeptides |
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| EP1423510A4 (en) | 2001-08-03 | 2005-06-01 | Glycart Biotechnology Ag | ANTIBODY GLYCOSYLATION VARIANTS WITH INCREASED ANTIBODY-DEPENDENT CELLULAR CYTOTOXICITY |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| AR040778A1 (es) | 2002-08-06 | 2005-04-20 | Glaxo Group Ltd | Anticuerpos alterados o fragmentos funcionales que se unen a mag (glicoproteina asociada a mielina). |
| CA2832136C (en) | 2002-09-27 | 2015-11-17 | Xencor | Optimized fc variants and methods for their generation |
| US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
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| CA2531238C (en) | 2003-07-04 | 2015-02-24 | Affibody Ab | Polypeptides having binding affinity for her2 |
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| BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
| US20070178095A1 (en) | 2004-03-23 | 2007-08-02 | Eli Lilly And Company | Anti-myostatin antibodies |
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| TW200724548A (en) * | 2005-04-25 | 2007-07-01 | Pfizer | Antibodies to myostatin |
| JP5249751B2 (ja) | 2005-05-20 | 2013-07-31 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 新規方法 |
| US7888486B2 (en) * | 2005-08-19 | 2011-02-15 | Wyeth Llc | Antagonist antibodies against GDF-8 |
| KR101135220B1 (ko) | 2005-10-06 | 2012-04-24 | 일라이 릴리 앤드 캄파니 | 항-마이오스타틴 항체 |
| UA92504C2 (en) * | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| HRP20130320T1 (en) | 2006-09-05 | 2013-05-31 | Eli Lilly And Company | Anti-myostatin antibodies |
| GB0702888D0 (en) * | 2007-02-14 | 2007-03-28 | Glaxo Group Ltd | Novel Antibodies |
| EP1958957A1 (en) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprising a knottin protein moiety |
-
2009
- 2009-12-17 TW TW098143432A patent/TW201029662A/zh unknown
- 2009-12-17 UY UY0001032341A patent/UY32341A/es unknown
- 2009-12-17 AR ARP090104946A patent/AR074777A1/es not_active Application Discontinuation
- 2009-12-18 EA EA201190018A patent/EA201190018A1/ru unknown
- 2009-12-18 WO PCT/EP2009/067515 patent/WO2010070094A1/en not_active Ceased
- 2009-12-18 BR BRPI0922405A patent/BRPI0922405A2/pt not_active IP Right Cessation
- 2009-12-18 EP EP09804126A patent/EP2358753A1/en not_active Withdrawn
- 2009-12-18 PE PE2011001257A patent/PE20120429A1/es not_active Application Discontinuation
- 2009-12-18 KR KR1020117016877A patent/KR20110103431A/ko not_active Withdrawn
- 2009-12-18 MA MA34031A patent/MA32980B1/fr unknown
- 2009-12-18 JP JP2011541469A patent/JP2012512641A/ja not_active Ceased
- 2009-12-18 AU AU2009329533A patent/AU2009329533A1/en not_active Abandoned
- 2009-12-18 CN CN2009801573934A patent/CN102325793A/zh active Pending
- 2009-12-18 US US13/140,841 patent/US20110256132A1/en not_active Abandoned
- 2009-12-18 CA CA2747062A patent/CA2747062A1/en not_active Abandoned
- 2009-12-18 SG SG2011041886A patent/SG172039A1/en unknown
- 2009-12-18 NZ NZ593297A patent/NZ593297A/xx not_active IP Right Cessation
- 2009-12-18 MX MX2011006611A patent/MX2011006611A/es not_active Application Discontinuation
-
2011
- 2011-05-31 IL IL213243A patent/IL213243A0/en unknown
- 2011-06-13 ZA ZA2011/04397A patent/ZA201104397B/en unknown
- 2011-06-15 DO DO2011000189A patent/DOP2011000189A/es unknown
- 2011-06-17 CL CL2011001503A patent/CL2011001503A1/es unknown
- 2011-06-23 CR CR20110358A patent/CR20110358A/es unknown
- 2011-06-28 CO CO11080753A patent/CO6400149A2/es not_active Application Discontinuation