JP2008527989A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008527989A5 JP2008527989A5 JP2007551754A JP2007551754A JP2008527989A5 JP 2008527989 A5 JP2008527989 A5 JP 2008527989A5 JP 2007551754 A JP2007551754 A JP 2007551754A JP 2007551754 A JP2007551754 A JP 2007551754A JP 2008527989 A5 JP2008527989 A5 JP 2008527989A5
- Authority
- JP
- Japan
- Prior art keywords
- specific binding
- binding member
- amino acid
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000009870 specific binding Effects 0.000 claims 38
- 125000003275 alpha amino acid group Chemical group 0.000 claims 29
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 8
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 8
- 229940053128 nerve growth factor Drugs 0.000 claims 8
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 7
- 102000046917 human NGF Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000027455 binding Effects 0.000 claims 6
- 210000004602 germ cell Anatomy 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000003472 neutralizing effect Effects 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 101100404651 Mus musculus Ngf gene Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 101100404655 Rattus norvegicus Ngf gene Proteins 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 102000015533 trkA Receptor Human genes 0.000 claims 1
- 108010064884 trkA Receptor Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64558705P | 2005-01-24 | 2005-01-24 | |
| US60/645,587 | 2005-01-24 | ||
| PCT/GB2006/000238 WO2006077441A1 (en) | 2005-01-24 | 2006-01-24 | Specific binding members for ngf |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008527989A JP2008527989A (ja) | 2008-07-31 |
| JP2008527989A5 true JP2008527989A5 (enExample) | 2009-03-05 |
| JP5096167B2 JP5096167B2 (ja) | 2012-12-12 |
Family
ID=36088563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551754A Expired - Fee Related JP5096167B2 (ja) | 2005-01-24 | 2006-01-24 | Ｎｇｆに対する特異的結合メンバー |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9315571B2 (enExample) |
| EP (2) | EP2298345A3 (enExample) |
| JP (1) | JP5096167B2 (enExample) |
| KR (1) | KR101298383B1 (enExample) |
| CN (1) | CN101107268B (enExample) |
| AU (1) | AU2006207338B2 (enExample) |
| BR (1) | BRPI0606933B8 (enExample) |
| CA (1) | CA2595800C (enExample) |
| ES (1) | ES2435691T3 (enExample) |
| IL (1) | IL183752A (enExample) |
| MX (1) | MX2007008722A (enExample) |
| NO (1) | NO343064B1 (enExample) |
| NZ (1) | NZ556157A (enExample) |
| PT (1) | PT1846451E (enExample) |
| RU (1) | RU2406728C2 (enExample) |
| WO (1) | WO2006077441A1 (enExample) |
| ZA (1) | ZA200705754B (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004032870A2 (en) | 2002-10-08 | 2004-04-22 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| DK1575517T3 (da) | 2002-12-24 | 2012-05-14 | Rinat Neuroscience Corp | Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme |
| KR20050111598A (ko) | 2003-02-19 | 2005-11-25 | 리나트 뉴로사이언스 코퍼레이션 | 신경 성장 인자 길항제 및 ｎｓａｉｄ를 투여함으로써통증을 치료하는 방법 및 그것을 함유하는 조성물 |
| UA97086C2 (uk) | 2003-07-15 | 2012-01-10 | Емджен, Інк. | Виділене людське антитіло, яке специфічно зв'язується з фактором росту нервової тканини (ngf) |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| KR101637908B1 (ko) | 2004-04-07 | 2016-07-11 | 리나트 뉴로사이언스 코프. | 신경성장인자 길항제의 투여에 의한 골암 통증의 치료방법 |
| ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| US7488630B2 (en) | 2007-03-06 | 2009-02-10 | International Business Machines Corporation | Method for preparing 2-dimensional semiconductor devices for integration in a third dimension |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
| PL2187964T3 (pl) * | 2007-08-10 | 2015-03-31 | Regeneron Pharma | Ludzkie przeciwciała o wysokim powinowactwie przeciw ludzkiemu czynnikowi wzrostu nerwu |
| BRPI0821383A2 (pt) * | 2007-12-20 | 2015-06-16 | Cytos Biotechnology Ag | Conjugados de ngf e usos dos mesmos |
| TW201034684A (en) * | 2009-02-18 | 2010-10-01 | Genentech Inc | Method for inhibiting neurodegeneration |
| ES2514319T3 (es) | 2009-05-04 | 2014-10-28 | Abbvie Research B.V. | Anticuerpos contra el factor de crecimiento nervioso (NGF) con estabilidad in vivo mejorada |
| US8530392B2 (en) * | 2009-05-13 | 2013-09-10 | Shionogi & Co., Ltd. | Test agent for visceral obesity and use thereof |
| KR20130031247A (ko) | 2010-03-17 | 2013-03-28 | 애보트 리서치 비.브이. | 항―신경 성장 인자（ｎｇｆ） 항체 조성물 |
| ES2665954T3 (es) | 2010-08-19 | 2018-04-30 | Zoetis Belgium S.A. | Anticuerpos anti-NGF y su uso |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US9783601B2 (en) * | 2010-12-01 | 2017-10-10 | Alderbio Holdings Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| RS56876B1 (sr) | 2011-08-11 | 2018-04-30 | Astellas Pharma Inc | Novo antitelo protiv humanog ngf |
| US9617334B2 (en) | 2012-06-06 | 2017-04-11 | Zoetis Services Llc | Caninized anti-NGF antibodies and methods thereof |
| US9127055B2 (en) | 2013-02-08 | 2015-09-08 | Astellas Pharma Inc. | Method of treating pain with anti-human NGF antibody |
| CA2938066C (en) * | 2014-02-02 | 2025-05-06 | Medimmune Limited | CHIMERIC PROTEIN COMPOSED OF NERVE GROWTH FACTOR ANTAGONIST DOMAIN AND TUMOR NECROSIS FACTOR-ANTAGONIST DOMAIN-A |
| WO2016190263A1 (ja) | 2015-05-22 | 2016-12-01 | アステラス製薬株式会社 | 新規抗ヒトＮＧＦ抗体Ｆａｂフラグメント |
| US9862760B2 (en) | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
| EP3368039A1 (en) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| CN111417651B (zh) | 2017-12-01 | 2023-09-29 | 诺华股份有限公司 | 多瘤病毒中和抗体 |
| BR112020017701A2 (pt) | 2018-03-12 | 2020-12-29 | Zoetis Services Llc | Anticorpos anti-ngf e métodos dos mesmos |
| JPWO2019221097A1 (ja) | 2018-05-15 | 2021-05-27 | アステラス製薬株式会社 | 抗ヒトｎｇｆ抗体又はその抗原結合フラグメントを有効成分とする心房細動の抑制用医薬組成物 |
| CN113924315B (zh) * | 2019-06-10 | 2022-06-28 | 山东博安生物技术股份有限公司 | 抗β-NGF纳米抗体及其应用 |
| WO2021012176A1 (en) | 2019-07-23 | 2021-01-28 | Shanghaitech University | Asic1 channel antagonist antibody |
| CN117186219B (zh) * | 2020-04-17 | 2024-07-12 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| CN117050175B (zh) * | 2020-04-17 | 2024-07-16 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| IL301548A (en) | 2020-09-28 | 2023-05-01 | Medimmune Ltd | Compounds and methods for treating pain |
| CN121410259B (zh) * | 2025-12-30 | 2026-03-20 | 北京索莱宝科技有限公司 | 用于检测人β-NGF含量的双抗夹心ELISA试剂盒 |
| CN121987655A (zh) * | 2026-02-12 | 2026-05-08 | 贵州省人民医院 | k-252a在制备抑制肺纤维化药物中的应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2097309A1 (en) * | 1990-11-30 | 1992-05-31 | Peter S. Distefano | Immunoassay and monoclonal antibodies useful for detecting truncated nerve growth factor receptor |
| IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| WO2001027279A1 (en) * | 1999-10-12 | 2001-04-19 | Cambridge Antibody Technology | Human anti-adipocyte monoclonal antibodies and their use |
| CA2393292A1 (en) | 1999-12-13 | 2001-06-21 | Cambridge Antibody Technology Limited | Brain specific binding members |
| US6548062B2 (en) | 2000-02-29 | 2003-04-15 | Cephalon, Inc. | Method of treating cancer with anti-neurotrophin agents |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| KR20100132559A (ko) * | 2001-05-30 | 2010-12-17 | 제넨테크, 인크. | 다양한 질환의 치료에 유용한 항-엔지에프 항체 |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| WO2003102136A2 (en) * | 2002-05-30 | 2003-12-11 | Human Genome Sciences, Inc. | Antibodies that specifically bind to neurokinin b |
| EP1545615A4 (en) | 2002-10-04 | 2006-03-01 | Rinat Neuroscience Corp | METHODS OF TREATING CARDIAC ARRHYTHMIA AND PREVENTING DEATH OF CARDIAC ARRHYTHMIA USING NGF ANTAGONISTS |
| WO2004032870A2 (en) | 2002-10-08 | 2004-04-22 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by admisnistering a nerve growth factor antagonist and compositions containing the same |
| JP4754219B2 (ja) * | 2002-12-02 | 2011-08-24 | アムジエン・フレモント・インコーポレイテツド | 腫瘍壊死因子を対象とする抗体、およびそれらの使用 |
| DK1575517T3 (da) | 2002-12-24 | 2012-05-14 | Rinat Neuroscience Corp | Anti-ngf-antistoffer og fremgangsmåder til anvendelse af samme |
| UA97086C2 (uk) * | 2003-07-15 | 2012-01-10 | Емджен, Інк. | Виділене людське антитіло, яке специфічно зв'язується з фактором росту нервової тканини (ngf) |
-
2006
- 2006-01-24 JP JP2007551754A patent/JP5096167B2/ja not_active Expired - Fee Related
- 2006-01-24 WO PCT/GB2006/000238 patent/WO2006077441A1/en not_active Ceased
- 2006-01-24 BR BRPI0606933A patent/BRPI0606933B8/pt active IP Right Grant
- 2006-01-24 PT PT67010991T patent/PT1846451E/pt unknown
- 2006-01-24 EP EP10008629A patent/EP2298345A3/en not_active Withdrawn
- 2006-01-24 MX MX2007008722A patent/MX2007008722A/es active IP Right Grant
- 2006-01-24 RU RU2007132020/10A patent/RU2406728C2/ru active
- 2006-01-24 AU AU2006207338A patent/AU2006207338B2/en not_active Expired
- 2006-01-24 ES ES06701099T patent/ES2435691T3/es not_active Expired - Lifetime
- 2006-01-24 CN CN2006800024090A patent/CN101107268B/zh not_active Expired - Lifetime
- 2006-01-24 US US11/814,668 patent/US9315571B2/en active Active
- 2006-01-24 EP EP06701099.1A patent/EP1846451B1/en not_active Expired - Lifetime
- 2006-01-24 KR KR1020077017099A patent/KR101298383B1/ko not_active Expired - Lifetime
- 2006-01-24 NZ NZ556157A patent/NZ556157A/en unknown
- 2006-01-24 CA CA2595800A patent/CA2595800C/en not_active Expired - Lifetime
-
2007
- 2007-06-07 IL IL183752A patent/IL183752A/en active IP Right Grant
- 2007-07-12 ZA ZA200705754A patent/ZA200705754B/xx unknown
- 2007-08-21 NO NO20074266A patent/NO343064B1/no unknown
-
2016
- 2016-04-18 US US15/131,825 patent/US9701746B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2495050C2 (ru) | Связующий элемент для рецептора gm-csf | |
| DK2574630T3 (en) | ANTIBODIES BINDING IL-4 AND / OR IL-13 AND APPLICATIONS THEREOF | |
| RU2007132020A (ru) | Партнеры специфического связывания с ngf | |
| JP2022065063A5 (enExample) | ||
| TWI511978B (zh) | 結合ｉｌ－１７ａ及ｉｌ－１７ｆ之抗體分子 | |
| JP2009533020A5 (enExample) | ||
| JP2014508511A5 (enExample) | ||
| JP2021524267A5 (enExample) | ||
| JP2012070737A5 (enExample) | ||
| JP2021513974A5 (enExample) | ||
| JP2021101720A5 (enExample) | ||
| RU2013123927A (ru) | ЭЛЕМЕНТ, СВЯЗЫВАЮЩИЙСЯ С α-РЕЦЕПТОРОМ ИНТЕРЛЕЙКИНА-4 (IL-4α)-173 | |
| RU2014151788A (ru) | Молекула, специфически связывающаяся с rsv | |
| RU2011122720A (ru) | Члены связывания против il-1r1 | |
| JP2008512995A5 (enExample) | ||
| JP2011508592A5 (enExample) | ||
| MX2009002554A (es) | Proteinas de enlace de interleucina-13. | |
| JP2015518857A5 (enExample) | ||
| JP2019518473A5 (enExample) | ||
| CN114829398B (zh) | 对人il-13具有结合特异性的抗体 | |
| EP4518906A1 (en) | Human interleukin-4 receptor alpha antibody glucocorticoid conjugates | |
| JP2024523034A5 (enExample) | ||
| HK40058161B (en) | Antibodies that bind il-4 and/or il-13 and their uses | |
| HK40069079A (en) | Antibody with binding specificity for human il-13. | |
| RU2009148270A (ru) | Молекулы антител человека к il-13 |