JP2008527989A5 - - Google Patents
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- Publication number
- JP2008527989A5 JP2008527989A5 JP2007551754A JP2007551754A JP2008527989A5 JP 2008527989 A5 JP2008527989 A5 JP 2008527989A5 JP 2007551754 A JP2007551754 A JP 2007551754A JP 2007551754 A JP2007551754 A JP 2007551754A JP 2008527989 A5 JP2008527989 A5 JP 2008527989A5
- Authority
- JP
- Japan
- Prior art keywords
- specific binding
- binding member
- amino acid
- acid sequence
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000009870 specific binding Effects 0.000 claims 38
- 125000003275 alpha amino acid group Chemical group 0.000 claims 29
- 102000015336 Nerve Growth Factor Human genes 0.000 claims 8
- 108010025020 Nerve Growth Factor Proteins 0.000 claims 8
- 229940053128 nerve growth factor Drugs 0.000 claims 8
- 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 claims 7
- 102000046917 human NGF Human genes 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 230000027455 binding Effects 0.000 claims 6
- 210000004602 germ cell Anatomy 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 210000004027 cell Anatomy 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 230000003472 neutralizing effect Effects 0.000 claims 3
- 208000002193 Pain Diseases 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims 1
- 101100404651 Mus musculus Ngf gene Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 101100404655 Rattus norvegicus Ngf gene Proteins 0.000 claims 1
- 206010003119 arrhythmia Diseases 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000005069 pulmonary fibrosis Diseases 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 102000015533 trkA Receptor Human genes 0.000 claims 1
- 108010064884 trkA Receptor Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64558705P | 2005-01-24 | 2005-01-24 | |
| US60/645,587 | 2005-01-24 | ||
| PCT/GB2006/000238 WO2006077441A1 (en) | 2005-01-24 | 2006-01-24 | Specific binding members for ngf |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008527989A JP2008527989A (ja) | 2008-07-31 |
| JP2008527989A5 true JP2008527989A5 (enExample) | 2009-03-05 |
| JP5096167B2 JP5096167B2 (ja) | 2012-12-12 |
Family
ID=36088563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551754A Expired - Fee Related JP5096167B2 (ja) | 2005-01-24 | 2006-01-24 | Ｎｇｆに対する特異的結合メンバー |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US9315571B2 (enExample) |
| EP (2) | EP1846451B1 (enExample) |
| JP (1) | JP5096167B2 (enExample) |
| KR (1) | KR101298383B1 (enExample) |
| CN (1) | CN101107268B (enExample) |
| AU (1) | AU2006207338B2 (enExample) |
| BR (1) | BRPI0606933B8 (enExample) |
| CA (1) | CA2595800C (enExample) |
| ES (1) | ES2435691T3 (enExample) |
| IL (1) | IL183752A (enExample) |
| MX (1) | MX2007008722A (enExample) |
| NO (1) | NO343064B1 (enExample) |
| NZ (1) | NZ556157A (enExample) |
| PT (1) | PT1846451E (enExample) |
| RU (1) | RU2406728C2 (enExample) |
| WO (1) | WO2006077441A1 (enExample) |
| ZA (1) | ZA200705754B (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2357948T3 (es) | 2002-10-08 | 2011-05-04 | Rinat Neuroscience Corp. | Procedimientos para tratar dolor postquirúrgico mediante la administración de un anticuerpo frente al factor de crecimiento nervioso y composiciones que contienen el mismo. |
| US9498530B2 (en) | 2002-12-24 | 2016-11-22 | Rinat Neuroscience Corp. | Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same |
| US7569364B2 (en) * | 2002-12-24 | 2009-08-04 | Pfizer Inc. | Anti-NGF antibodies and methods using same |
| CA2511598C (en) | 2002-12-24 | 2016-09-13 | Rinat Neuroscience Corp. | Anti-ngf antibodies and methods using same |
| PL379983A1 (pl) | 2003-02-19 | 2006-11-27 | Rinat Neuroscience Corp. | Sposoby leczenia bólu polegające na podaniu antagonisty czynnika wzrostu nerwów i niesteroidowego leku przeciwzapalnego oraz zawierające je kompozycje |
| TWI503328B (zh) | 2003-07-15 | 2015-10-11 | Amgen Inc | 作為選擇性神經生長因子（ｎｇｆ）通道抑制劑之人類抗-ｎｇｆ中和抗體 |
| ITRM20030601A1 (it) | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| DK2206728T3 (en) | 2004-04-07 | 2018-04-23 | Rinat Neuroscience Corp | METHODS OF TREATING BONE CANCER PAIN BY SUBMITTING A NERVOUS FACTOR-ANTAGONISTIC ANTIBODY |
| ME00226B (me) | 2004-07-15 | 2011-02-10 | Medarex Llc | Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| US7488630B2 (en) | 2007-03-06 | 2009-02-10 | International Business Machines Corporation | Method for preparing 2-dimensional semiconductor devices for integration in a third dimension |
| US8309088B2 (en) | 2007-08-10 | 2012-11-13 | Regeneron Pharmaceuticals, Inc. | Method of treating osteoarthritis with an antibody to NGF |
| MY161564A (en) * | 2007-08-10 | 2017-04-28 | Regeneron Pharma | High affinity human antibodies to human nerve growth factor |
| EP2231179A2 (en) * | 2007-12-20 | 2010-09-29 | Cytos Biotechnology AG | Ngf conjugates and uses thereof |
| TW201034684A (en) * | 2009-02-18 | 2010-10-01 | Genentech Inc | Method for inhibiting neurodegeneration |
| DK2448970T3 (da) | 2009-05-04 | 2014-10-06 | Abbvie Res B V | Antistoffer mod nervevækstfaktor (ngf) med forbedret in vivo-stabilitet |
| WO2010131704A1 (ja) * | 2009-05-13 | 2010-11-18 | 塩野義製薬株式会社 | 内臓脂肪型肥満の検査薬およびその利用 |
| RU2012144017A (ru) | 2010-03-17 | 2014-04-27 | Эбботт Рисерч Б.В. | Композиции антител против фактора роста нервов (ngf) |
| EP3333188B1 (en) | 2010-08-19 | 2022-02-09 | Zoetis Belgium S.A. | Anti-ngf antibodies and their use |
| EP3434691A1 (en) * | 2010-12-01 | 2019-01-30 | AlderBio Holdings LLC | Anti-ngf compositions and use thereof |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| JP5376095B2 (ja) | 2011-08-11 | 2013-12-25 | アステラス製薬株式会社 | 新規抗ヒトｎｇｆ抗体 |
| ES2894852T3 (es) | 2012-06-06 | 2022-02-16 | Zoetis Services Llc | Anticuerpos anti-NGF caninizados y métodos de los mismos |
| US9127055B2 (en) | 2013-02-08 | 2015-09-08 | Astellas Pharma Inc. | Method of treating pain with anti-human NGF antibody |
| EP3696193A1 (en) * | 2014-02-02 | 2020-08-19 | MedImmune Limited | Chimeric protein composed of ngf antagonist domain and a tnfa antagonist domain |
| MA42138A (fr) | 2015-05-22 | 2018-03-28 | Astellas Pharma Inc | NOUVEAU FRAGMENT Fab D'ANTICORPS CONTRE LE NGF HUMAIN |
| US9862760B2 (en) * | 2015-09-16 | 2018-01-09 | Novartis Ag | Polyomavirus neutralizing antibodies |
| EP3368039A1 (en) | 2015-10-26 | 2018-09-05 | The Regents of The University of Colorado, A Body Corporate | Point mutations in trk inhibitor-resistant cancer and methods relating to the same |
| MX2020009526A (es) | 2018-03-12 | 2020-10-28 | Zoetis Services Llc | Anticuerpos anti-ngf y metodos de estos. |
| EP3795176A4 (en) | 2018-05-15 | 2022-01-12 | Astellas Pharma Inc. | Pharmaceutical composition for suppressing atrial fibrillation having as active ingredient anti-human ngf antibody or antigen-binding fragment thereof |
| WO2020248942A1 (zh) * | 2019-06-10 | 2020-12-17 | 山东博安生物技术有限公司 | 抗β-NGF纳米抗体及其应用 |
| CN113527483B (zh) * | 2020-04-17 | 2023-09-22 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| CN113527482B (zh) * | 2020-04-17 | 2023-07-21 | 珠海泰诺麦博制药股份有限公司 | 抗人神经生长因子的抗体 |
| KR20230084199A (ko) | 2020-09-28 | 2023-06-12 | 메디뮨 리미티드 | 통증 치료를 위한 화합물 및 방법 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06503722A (ja) * | 1990-11-30 | 1994-04-28 | アボット・ラボラトリーズ | 末端欠失神経成長因子受容体の検出に有用なイムノアッセイおよびモノクローナル抗体 |
| IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| WO2001027279A1 (en) * | 1999-10-12 | 2001-04-19 | Cambridge Antibody Technology | Human anti-adipocyte monoclonal antibodies and their use |
| CA2393292A1 (en) * | 1999-12-13 | 2001-06-21 | Cambridge Antibody Technology Limited | Brain specific binding members |
| US6548062B2 (en) | 2000-02-29 | 2003-04-15 | Cephalon, Inc. | Method of treating cancer with anti-neurotrophin agents |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| WO2002096458A1 (en) * | 2001-05-30 | 2002-12-05 | Genentech, Inc. | Anti-ngf antibodies for the treatment of various disorders |
| US7521053B2 (en) * | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
| AU2003240822A1 (en) | 2002-05-30 | 2003-12-19 | Human Genome Sciences, Inc. | Antibodies that specifically bind to neurokinin b |
| US20060147450A1 (en) | 2002-10-04 | 2006-07-06 | Shelton David L | Methods for treating cardiac arrhythmia and preventing death due to cardiac arrhythmia using ngf antagonists |
| ES2357948T3 (es) | 2002-10-08 | 2011-05-04 | Rinat Neuroscience Corp. | Procedimientos para tratar dolor postquirúrgico mediante la administración de un anticuerpo frente al factor de crecimiento nervioso y composiciones que contienen el mismo. |
| CA2508375C (en) * | 2002-12-02 | 2014-05-27 | Abgenix, Inc. | Antibodies directed to tumor necrosis factor and uses thereof |
| CA2511598C (en) * | 2002-12-24 | 2016-09-13 | Rinat Neuroscience Corp. | Anti-ngf antibodies and methods using same |
| TWI503328B (zh) * | 2003-07-15 | 2015-10-11 | Amgen Inc | 作為選擇性神經生長因子（ｎｇｆ）通道抑制劑之人類抗-ｎｇｆ中和抗體 |
-
2006
- 2006-01-24 EP EP06701099.1A patent/EP1846451B1/en active Active
- 2006-01-24 EP EP10008629A patent/EP2298345A3/en not_active Withdrawn
- 2006-01-24 NZ NZ556157A patent/NZ556157A/en unknown
- 2006-01-24 CA CA2595800A patent/CA2595800C/en active Active
- 2006-01-24 ES ES06701099T patent/ES2435691T3/es active Active
- 2006-01-24 KR KR1020077017099A patent/KR101298383B1/ko active Active
- 2006-01-24 MX MX2007008722A patent/MX2007008722A/es active IP Right Grant
- 2006-01-24 WO PCT/GB2006/000238 patent/WO2006077441A1/en not_active Ceased
- 2006-01-24 JP JP2007551754A patent/JP5096167B2/ja not_active Expired - Fee Related
- 2006-01-24 US US11/814,668 patent/US9315571B2/en active Active
- 2006-01-24 PT PT67010991T patent/PT1846451E/pt unknown
- 2006-01-24 BR BRPI0606933A patent/BRPI0606933B8/pt active IP Right Grant
- 2006-01-24 RU RU2007132020/10A patent/RU2406728C2/ru active
- 2006-01-24 AU AU2006207338A patent/AU2006207338B2/en active Active
- 2006-01-24 CN CN2006800024090A patent/CN101107268B/zh active Active
-
2007
- 2007-06-07 IL IL183752A patent/IL183752A/en active IP Right Grant
- 2007-07-12 ZA ZA200705754A patent/ZA200705754B/xx unknown
- 2007-08-21 NO NO20074266A patent/NO343064B1/no unknown
-
2016
- 2016-04-18 US US15/131,825 patent/US9701746B2/en active Active
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