JP2011508592A5 - - Google Patents
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- JP2011508592A5 JP2011508592A5 JP2010538920A JP2010538920A JP2011508592A5 JP 2011508592 A5 JP2011508592 A5 JP 2011508592A5 JP 2010538920 A JP2010538920 A JP 2010538920A JP 2010538920 A JP2010538920 A JP 2010538920A JP 2011508592 A5 JP2011508592 A5 JP 2011508592A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- binding member
- isolated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1586907P | 2007-12-21 | 2007-12-21 | |
| US61/015,869 | 2007-12-21 | ||
| PCT/GB2008/051212 WO2009081201A2 (en) | 2007-12-21 | 2008-12-19 | BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Rα) - 173 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130983A Division JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011508592A JP2011508592A (ja) | 2011-03-17 |
| JP2011508592A5 true JP2011508592A5 (enExample) | 2012-02-09 |
| JP5571567B2 JP5571567B2 (ja) | 2014-08-13 |
Family
ID=40532664
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538920A Expired - Fee Related JP5571567B2 (ja) | 2007-12-21 | 2008-12-19 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
| JP2014130983A Expired - Fee Related JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
| JP2016244210A Pending JP2017095467A (ja) | 2007-12-21 | 2016-12-16 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
| JP2018107457A Pending JP2018148922A (ja) | 2007-12-21 | 2018-06-05 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130983A Expired - Fee Related JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
| JP2016244210A Pending JP2017095467A (ja) | 2007-12-21 | 2016-12-16 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
| JP2018107457A Pending JP2018148922A (ja) | 2007-12-21 | 2018-06-05 | インターロイキン−4受容体α(IL−4Rα)−173に対する結合メンバー |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP2245064B1 (enExample) |
| JP (4) | JP5571567B2 (enExample) |
| KR (2) | KR101620539B1 (enExample) |
| CN (2) | CN102046658B (enExample) |
| AU (2) | AU2008339576B2 (enExample) |
| BR (1) | BRPI0822099A2 (enExample) |
| CA (1) | CA2708871C (enExample) |
| DK (1) | DK2245064T3 (enExample) |
| ES (1) | ES2518415T3 (enExample) |
| HK (1) | HK1212364A1 (enExample) |
| MX (2) | MX2010006735A (enExample) |
| PL (1) | PL2245064T3 (enExample) |
| RU (2) | RU2490278C2 (enExample) |
| WO (1) | WO2009081201A2 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7608693B2 (en) | 2006-10-02 | 2009-10-27 | Regeneron Pharmaceuticals, Inc. | High affinity human antibodies to human IL-4 receptor |
| US8092804B2 (en) | 2007-12-21 | 2012-01-10 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4Rα)-173 |
| SG172789A1 (en) | 2009-02-11 | 2011-08-29 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
| AU2010311332B2 (en) | 2009-10-30 | 2015-04-23 | Albumedix Ltd. | Albumin variants |
| KR20130070576A (ko) * | 2010-04-09 | 2013-06-27 | 노보자임스 바이오파마 디케이 에이/에스 | 알부민 유도체 및 변이체 |
| BR112013015508B1 (pt) * | 2010-12-20 | 2022-04-05 | Medimmune Limited | Molécula de anticorpo para il-18 humana, domínio vh isolado e domínio vl isolado, composição, uso de uma molécula de anticorpo ou do domínio vh isolado e do domínio vl isolado, molécula de ácido nucleico isolada, célula hospedeira procariótica recombinante, método para produzir um anticorpo, e método in vitro para medir il-18 em uma amostra de um indivíduo |
| EP2535714A1 (en) * | 2011-06-16 | 2012-12-19 | Istituto Nazionale Di Genetica Molecolare-INGM | Biomarkers for autoimmune liver diseases and uses thereof |
| KR102276792B1 (ko) * | 2011-10-10 | 2021-07-15 | 시티 오브 호프 | 메디토프와 메디토프-결합 항체 및 이들의 용도 |
| HK1200842A1 (en) | 2011-11-18 | 2015-08-14 | Albumedix Ltd | Proteins with improved half-life and other properties |
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| EP3330283A3 (en) | 2012-03-16 | 2018-07-11 | Albumedix A/S | Albumin variants |
| EP2674168A1 (en) | 2012-06-14 | 2013-12-18 | PLS-Design GmbH | Modulation of effector T cell responses by local depletion of complement component C3 |
| KR102502640B1 (ko) | 2012-08-21 | 2023-02-23 | 사노피 바이오테크놀로지 | Il-4r 길항제의 투여에 의한 천식의 치료 또는 예방 방법 |
| CA2890766A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
| RS59354B1 (sr) * | 2013-06-21 | 2019-10-31 | Sanofi Biotechnology | Postupci lečenja nosne polipoze davanjem il-4r antagonista |
| US8980273B1 (en) | 2014-07-15 | 2015-03-17 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| DE202014010499U1 (de) | 2013-12-17 | 2015-10-20 | Kymab Limited | Targeting von humaner PCSK9 zur Cholesterinbehandlung |
| US8986691B1 (en) | 2014-07-15 | 2015-03-24 | Kymab Limited | Method of treating atopic dermatitis or asthma using antibody to IL4RA |
| IL315136A (en) * | 2014-02-21 | 2024-10-01 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an il-4rantagonist |
| US10647768B2 (en) * | 2014-05-29 | 2020-05-12 | Macrogenics, Inc. | Multi-chain polypeptide-containing tri-specific binding molecules |
| WO2016023916A1 (en) | 2014-08-12 | 2016-02-18 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| CA2959629C (en) | 2014-09-03 | 2023-10-31 | Boehringer Ingelheim International Gmbh | Compound targeting il-23a and tnf-alpha and uses thereof |
| CN106604744A (zh) * | 2014-09-03 | 2017-04-26 | 免疫医疗有限公司 | 稳定的抗IL‑4R‑α抗体配制品 |
| WO2016071701A1 (en) | 2014-11-07 | 2016-05-12 | Kymab Limited | Treatment of disease using ligand binding to targets of interest |
| CA3246946A1 (en) | 2014-11-14 | 2025-11-29 | Sanofi Biotechnology | Methods for treating chronic sinusitis with nasal polyps by administering an il-4r antagonist |
| EP3954710A3 (en) | 2015-04-02 | 2022-07-20 | Intervet International B.V. | Antibodies to canine interleukin-4 receptor alpha |
| PE20180774A1 (es) | 2015-07-23 | 2018-05-07 | Boehringer Ingelheim Int | Compuesto que se dirige a il-23a y al factor de activacion de linfocitos b (baff) y usos de estos |
| BR112018003179A2 (pt) | 2015-08-20 | 2018-09-25 | Albumedix As | conjugados e variantes de albumina |
| EP3416685B1 (en) | 2016-02-19 | 2024-06-26 | Regeneron Pharmaceuticals, Inc. | Methods for enhancing efficacy of a vaccine by administering an il-4r antagonist |
| US20190086392A1 (en) | 2016-03-21 | 2019-03-21 | Inserm (Institut National De La Sante Et De La Recherch Medicale) | Methods for diagnosis and treatment of solar lentigo |
| CN105753987A (zh) * | 2016-05-11 | 2016-07-13 | 贵阳中医学院 | 抗il-4r单链抗体的制备方法及其在抗肿瘤上的应用 |
| GB201610198D0 (en) | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
| EA037848B1 (ru) | 2016-07-14 | 2021-05-27 | Общество С Ограниченной Ответственностью "Биохимический Агент" | Гибридный белок, полинуклеотид, генетическая конструкция, продуцент, препарат для регенерации хряща (варианты) |
| US11034768B2 (en) | 2017-10-30 | 2021-06-15 | Sanofi Biotechnology | Methods for treating or preventing asthma by administering an IL-4R antagonist |
| WO2019148405A1 (zh) * | 2018-02-01 | 2019-08-08 | 北京凯因科技股份有限公司 | IL-4Rα抗体及其用途 |
| MX2021001143A (es) * | 2018-08-24 | 2021-04-12 | Jiangsu Hengrui Medicine Co | Anticuerpo de union a il-4r humana, fragmento de union a antigeno y uso medico del mismo. |
| CN109459372B (zh) * | 2018-10-29 | 2021-03-26 | 迪瑞医疗科技股份有限公司 | 有核红细胞模拟粒子及其制备方法与应用 |
| KR102330596B1 (ko) * | 2018-11-09 | 2021-11-26 | 아주대학교산학협력단 | 인간 il-4 수용체 알파에 대한 고친화도 인간 항체 및 이의 용도 |
| CN111494626B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
| SG11202107007VA (en) * | 2018-12-27 | 2021-07-29 | Akeso Biopharma Inc | Antibody against human il-4ra and use thereof |
| CN111592597B (zh) * | 2019-05-29 | 2022-04-26 | 山东博安生物技术股份有限公司 | 白介素4受体(il-4r)结合蛋白及其用途 |
| KR20220034878A (ko) | 2019-07-16 | 2022-03-18 | 사노피 바이오테크놀로지 | Il-4r 길항제를 투여하여 천식을 치료 또는 예방하는 방법 |
| CN113527485B (zh) * | 2020-04-17 | 2024-11-15 | 湖南麦济生物技术股份有限公司 | 抗人白细胞介素-4受体α抗体及其制备方法和应用 |
| CN113549151A (zh) * | 2020-04-24 | 2021-10-26 | 苏州康乃德生物医药有限公司 | 与人IL-4Rα中特定表位结合的抗体及其应用 |
| WO2022052974A1 (en) * | 2020-09-10 | 2022-03-17 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Antibodies specifically recognizing interleukin-4 receptor alpha and uses thereof |
| CN114605539B (zh) * | 2020-12-09 | 2024-01-02 | 南京融捷康生物科技有限公司 | 人源化的抗IL-4Rα单域抗体及其应用 |
| TWI876192B (zh) * | 2021-08-05 | 2025-03-11 | 美商美國禮來大藥廠 | 人類介白素-4受體α抗體 |
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2008
- 2008-12-19 MX MX2010006735A patent/MX2010006735A/es active IP Right Grant
- 2008-12-19 CN CN200880123045.0A patent/CN102046658B/zh not_active Expired - Fee Related
- 2008-12-19 RU RU2010129558/10A patent/RU2490278C2/ru not_active IP Right Cessation
- 2008-12-19 KR KR1020107016269A patent/KR101620539B1/ko not_active Expired - Fee Related
- 2008-12-19 MX MX2013005138A patent/MX343594B/es unknown
- 2008-12-19 CA CA2708871A patent/CA2708871C/en not_active Expired - Fee Related
- 2008-12-19 WO PCT/GB2008/051212 patent/WO2009081201A2/en not_active Ceased
- 2008-12-19 AU AU2008339576A patent/AU2008339576B2/en not_active Ceased
- 2008-12-19 ES ES08865613.7T patent/ES2518415T3/es active Active
- 2008-12-19 CN CN201410733833.9A patent/CN104788563A/zh active Pending
- 2008-12-19 DK DK08865613.7T patent/DK2245064T3/da active
- 2008-12-19 EP EP08865613.7A patent/EP2245064B1/en not_active Not-in-force
- 2008-12-19 BR BRPI0822099A patent/BRPI0822099A2/pt active Search and Examination
- 2008-12-19 PL PL08865613T patent/PL2245064T3/pl unknown
- 2008-12-19 EP EP16204833.4A patent/EP3211010A1/en not_active Withdrawn
- 2008-12-19 KR KR1020167011877A patent/KR101759457B1/ko not_active Expired - Fee Related
- 2008-12-19 EP EP13152097.5A patent/EP2604628A3/en not_active Withdrawn
- 2008-12-19 JP JP2010538920A patent/JP5571567B2/ja not_active Expired - Fee Related
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2013
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- 2014-06-26 JP JP2014130983A patent/JP6093734B2/ja not_active Expired - Fee Related
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2016
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- 2018-06-05 JP JP2018107457A patent/JP2018148922A/ja active Pending
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