JP2011508592A5 - - Google Patents
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- JP2011508592A5 JP2011508592A5 JP2010538920A JP2010538920A JP2011508592A5 JP 2011508592 A5 JP2011508592 A5 JP 2011508592A5 JP 2010538920 A JP2010538920 A JP 2010538920A JP 2010538920 A JP2010538920 A JP 2010538920A JP 2011508592 A5 JP2011508592 A5 JP 2011508592A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 102000004965 antibodies Human genes 0.000 claims 14
- 108090001123 antibodies Proteins 0.000 claims 14
- 206010020751 Hypersensitivity Diseases 0.000 claims 3
- 101000018983 IL4R Proteins 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 102000024888 human IL4R protein Human genes 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 201000005794 allergic hypersensitivity disease Diseases 0.000 claims 2
- 210000004602 germ cell Anatomy 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N (+)-methoprene Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 208000006673 Asthma Diseases 0.000 claims 1
- 206010006451 Bronchitis Diseases 0.000 claims 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 1
- 208000006313 Delayed Hypersensitivity Diseases 0.000 claims 1
- 102100014838 FCGRT Human genes 0.000 claims 1
- 101710003435 FCGRT Proteins 0.000 claims 1
- 102000009109 Fc receptors Human genes 0.000 claims 1
- 108010087819 Fc receptors Proteins 0.000 claims 1
- 101000018998 IL4 Proteins 0.000 claims 1
- 206010021972 Inflammatory bowel disease Diseases 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000010787 Interleukin-4 Receptors Human genes 0.000 claims 1
- 108010038486 Interleukin-4 Receptors Proteins 0.000 claims 1
- 241000282567 Macaca fascicularis Species 0.000 claims 1
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000001516 cell proliferation assay Methods 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 230000003176 fibrotic Effects 0.000 claims 1
- 102000026353 human IL4 protein Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
Claims (13)
- ヒトインターロイキン-4受容体α(hIL-4Rα)の配列番号460中の位置に従った位置92および93から選択される少なくとも１つのアミノ酸残基に結合することのできる単離された結合メンバーであって、該結合メンバーは、18pMの可溶性ヒトIL-4タンパク質を用いるTF-1増殖アッセイにおいて、ヒトIL-4(hIL-4)誘発細胞増殖の阻害についてのIC50幾何平均が50 pM未満であり、かつ該結合メンバーはカニクイザルインターロイキン-4受容体α(cyIL-4Rα)に結合することもできる、前記結合メンバー。
- 請求項１に記載のヒトインターロイキン-4受容体α(hIL-4Rα)に対する単離された結合メンバーであって、CDRのセット：HCDR1、HCDR2、HCDR3、LCDR1、LCDR2およびLCDR3を含み、
該CDRのセットが、抗体20由来の以下の参照CDRのセット：
HCDR1が配列番号193のアミノ酸配列を有し、
HCDR2が配列番号194のアミノ酸配列を有し、
HCDR3が配列番号195のアミノ酸配列を有し、
LCDR1が配列番号198のアミノ酸配列を有し、
LCDR2が配列番号199のアミノ酸配列を有し、かつ
LCDR3が配列番号200のアミノ酸配列を有するもの
を有し、さらに
該CDRのセットが、以下の図における該抗体20に対してアライメントされたときのアミノ酸が異なる箇所として示される、１以上のアミノ酸置換を有する前記結合メンバー。
上図は抗体20に対する抗体1-19および21-42のVHドメインのアラインメントを示す、
上図は抗体20に対する抗体1-19および21-42のVHドメインのアラインメントの続きを示す、
上図は抗体20に対する抗体1-19および21-42のVLドメインのアラインメントを示す、
上図は抗体20に対する抗体1-19および21-42のVLドメインのアラインメントの続きを示す - 前記アミノ酸置換が、Kabatの標準ナンバリングに従いCDR内の以下の残基、
HCDR2中の53、57、
HCDR3中の97、98、99、101、102、
LCDR1中の27、27A、27B、31、
LCDR2中の56、または
LCDR3中の92、93、94、95、95A、95B、95C、96、97
の１以上においてアミノ酸置換を有する、請求項２記載の単離された結合メンバー。 - 請求項１に記載のヒトインターロイキン-4受容体α(hIL-4Rα)に対する単離された結合メンバーであって、
HCDR1が配列番号363のアミノ酸配列を有し、
HCDR2が配列番号364のアミノ酸配列を有し、
HCDR3が配列番号365のアミノ酸配列を有し、
LCDR1が配列番号368のアミノ酸配列を有し、
LCDR2が配列番号369のアミノ酸配列を有し、かつ
LCDR3が配列番号370のアミノ酸配列を有するか、または
HCDR1が配列番号233のアミノ酸配列を有し、
HCDR2が配列番号234のアミノ酸配列を有し、
HCDR3が配列番号235のアミノ酸配列を有し、
LCDR1が配列番号238のアミノ酸配列を有し、
LCDR2が配列番号239のアミノ酸配列を有し、かつ
LCDR3が配列番号240のアミノ酸配列を有する
前記結合メンバー。 - 単離された結合メンバーが抗体Fc可変領域を含み、該領域がFc受容体FcRnへの強化された結合能を有する、請求項１記載の単離された結合メンバー。
- 単離された結合メンバーがIgG1、IgG2およびIgG4分子から選択される抗体分子である、請求項１〜５のいずれか１項記載の単離された結合メンバー。
- 単離された結合メンバーがVHドメインを有する単離されたヒト抗体であり、該VHドメインがヒト生殖細胞系列フレームワークVh1_DP-7_ (1-46)を含む、請求項１、および２〜４のいずれか１項記載の単離された結合メンバー。
- VLドメインがヒト生殖細胞系列フレームワークVλ1_DPL5を含む、請求項１記載の単離された結合メンバーまたはVLドメインを含む請求項２〜４のいずれか１項記載の単離された結合メンバー。
- 請求項1〜８のいずれか１項記載の単離された結合メンバーおよび製薬上許容される添加剤を含む組成物。
- IL-4Rαに関連する疾患の治療に使用するための、請求項９記載の組成物。
- 疾患がアレルギー、喘息、気管支炎、COPD、炎症性腸疾患、線維性疾患、アレルギー、移植拒絶反応、遅延型過敏症または接触過敏症反応の１以上である、請求項１０記載の組成物。
- 請求項1〜８のいずれか１項記載の結合メンバーまたは結合メンバーの単離されたVHもしくはVLドメインをコードするヌクレオチド配列を含む単離された核酸分子。
- 請求項１２記載の核酸により形質転換されたin vitroの宿主細胞。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1586907P | 2007-12-21 | 2007-12-21 | |
| US61/015,869 | 2007-12-21 | ||
| PCT/GB2008/051212 WO2009081201A2 (en) | 2007-12-21 | 2008-12-19 | BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Rα) - 173 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130983A Division JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011508592A JP2011508592A (ja) | 2011-03-17 |
| JP2011508592A5 true JP2011508592A5 (ja) | 2012-02-09 |
| JP5571567B2 JP5571567B2 (ja) | 2014-08-13 |
Family
ID=40532664
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538920A Expired - Fee Related JP5571567B2 (ja) | 2007-12-21 | 2008-12-19 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2014130983A Expired - Fee Related JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2016244210A Pending JP2017095467A (ja) | 2007-12-21 | 2016-12-16 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2018107457A Pending JP2018148922A (ja) | 2007-12-21 | 2018-06-05 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014130983A Expired - Fee Related JP6093734B2 (ja) | 2007-12-21 | 2014-06-26 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2016244210A Pending JP2017095467A (ja) | 2007-12-21 | 2016-12-16 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
| JP2018107457A Pending JP2018148922A (ja) | 2007-12-21 | 2018-06-05 | インターロイキン−４受容体α（ＩＬ−４Ｒα）−１７３に対する結合メンバー |
Country Status (14)
| Country | Link |
|---|---|
| EP (3) | EP3211010A1 (ja) |
| JP (4) | JP5571567B2 (ja) |
| KR (2) | KR101620539B1 (ja) |
| CN (2) | CN104788563A (ja) |
| AU (2) | AU2008339576B2 (ja) |
| BR (1) | BRPI0822099A2 (ja) |
| CA (1) | CA2708871C (ja) |
| DK (1) | DK2245064T3 (ja) |
| ES (1) | ES2518415T3 (ja) |
| HK (2) | HK1150275A1 (ja) |
| MX (2) | MX2010006735A (ja) |
| PL (1) | PL2245064T3 (ja) |
| RU (2) | RU2490278C2 (ja) |
| WO (1) | WO2009081201A2 (ja) |
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2008
- 2008-12-19 WO PCT/GB2008/051212 patent/WO2009081201A2/en active Application Filing
- 2008-12-19 BR BRPI0822099A patent/BRPI0822099A2/pt active Search and Examination
- 2008-12-19 PL PL08865613T patent/PL2245064T3/pl unknown
- 2008-12-19 EP EP16204833.4A patent/EP3211010A1/en not_active Withdrawn
- 2008-12-19 CA CA2708871A patent/CA2708871C/en not_active Expired - Fee Related
- 2008-12-19 EP EP13152097.5A patent/EP2604628A3/en not_active Withdrawn
- 2008-12-19 KR KR1020107016269A patent/KR101620539B1/ko not_active IP Right Cessation
- 2008-12-19 MX MX2010006735A patent/MX2010006735A/es active IP Right Grant
- 2008-12-19 RU RU2010129558/10A patent/RU2490278C2/ru not_active IP Right Cessation
- 2008-12-19 KR KR1020167011877A patent/KR101759457B1/ko active IP Right Grant
- 2008-12-19 EP EP08865613.7A patent/EP2245064B1/en not_active Not-in-force
- 2008-12-19 JP JP2010538920A patent/JP5571567B2/ja not_active Expired - Fee Related
- 2008-12-19 AU AU2008339576A patent/AU2008339576B2/en not_active Ceased
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- 2008-12-19 CN CN201410733833.9A patent/CN104788563A/zh active Pending
- 2008-12-19 CN CN200880123045.0A patent/CN102046658B/zh not_active Expired - Fee Related
- 2008-12-19 ES ES08865613.7T patent/ES2518415T3/es active Active
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- 2014-06-26 JP JP2014130983A patent/JP6093734B2/ja not_active Expired - Fee Related
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