JP2014503209A5 - - Google Patents
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- JP2014503209A5 JP2014503209A5 JP2013544971A JP2013544971A JP2014503209A5 JP 2014503209 A5 JP2014503209 A5 JP 2014503209A5 JP 2013544971 A JP2013544971 A JP 2013544971A JP 2013544971 A JP2013544971 A JP 2013544971A JP 2014503209 A5 JP2014503209 A5 JP 2014503209A5
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- Prior art keywords
- immunoglobulin
- antibody
- fusion protein
- construct
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000018358 Immunoglobulins Human genes 0.000 claims 37
- 108060003951 Immunoglobulins Proteins 0.000 claims 37
- 102000004965 antibodies Human genes 0.000 claims 29
- 108090001123 antibodies Proteins 0.000 claims 29
- 108020001507 fusion proteins Proteins 0.000 claims 17
- 102000037240 fusion proteins Human genes 0.000 claims 17
- 208000006673 Asthma Diseases 0.000 claims 5
- 102100014838 FCGRT Human genes 0.000 claims 4
- 101710003435 FCGRT Proteins 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 230000000875 corresponding Effects 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- NFGXHKASABOEEW-UHFFFAOYSA-N (+)-methoprene Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 2
- 230000036499 Half live Effects 0.000 claims 2
- 102000015696 Interleukins Human genes 0.000 claims 2
- 108010063738 Interleukins Proteins 0.000 claims 2
- 206010039085 Rhinitis allergic Diseases 0.000 claims 2
- 201000010105 allergic rhinitis Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 230000002327 eosinophilic Effects 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 206010000880 Acute myeloid leukaemia Diseases 0.000 claims 1
- 208000006778 Allergic Bronchopulmonary Aspergillosis Diseases 0.000 claims 1
- 206010048594 Allergic granulomatous angiitis Diseases 0.000 claims 1
- 206010002425 Angioedemas Diseases 0.000 claims 1
- 206010006474 Bronchopulmonary aspergillosis allergic Diseases 0.000 claims 1
- 102100016493 CD33 Human genes 0.000 claims 1
- 101700017647 CD33 Proteins 0.000 claims 1
- 208000006344 Churg-Strauss Syndrome Diseases 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 206010012438 Dermatitis atopic Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 206010057271 Eosinophilic colitis Diseases 0.000 claims 1
- 208000009812 Eosinophilic enteropathy Diseases 0.000 claims 1
- 206010064212 Eosinophilic oesophagitis Diseases 0.000 claims 1
- 210000003979 Eosinophils Anatomy 0.000 claims 1
- 206010016654 Fibrosis Diseases 0.000 claims 1
- 208000005577 Gastroenteritis Diseases 0.000 claims 1
- 206010048643 Hypereosinophilic syndrome Diseases 0.000 claims 1
- 208000007046 Leukemia, Myeloid, Acute Diseases 0.000 claims 1
- 208000000112 Myalgia Diseases 0.000 claims 1
- 208000001797 Obstructive Sleep Apnea Diseases 0.000 claims 1
- 241000243981 Onchocerca Species 0.000 claims 1
- 206010039710 Scleroderma Diseases 0.000 claims 1
- 229960001138 acetylsalicylic acid Drugs 0.000 claims 1
- 201000009961 allergic asthma Diseases 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 claims 1
- 201000008937 atopic dermatitis Diseases 0.000 claims 1
- 210000004027 cells Anatomy 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 108091006028 chimera Proteins 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 201000009323 chronic eosinophilic pneumonia Diseases 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 claims 1
- 201000004624 dermatitis Diseases 0.000 claims 1
- 231100000406 dermatitis Toxicity 0.000 claims 1
- 230000002497 edematous Effects 0.000 claims 1
- 201000000708 eosinophilic esophagitis Diseases 0.000 claims 1
- 201000001561 eosinophilic gastritis Diseases 0.000 claims 1
- 230000004761 fibrosis Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000006011 modification reaction Methods 0.000 claims 1
- 201000001181 parasitic helminthiasis infectious disease Diseases 0.000 claims 1
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 238000005215 recombination Methods 0.000 claims 1
- 231100000240 steatosis hepatitis Toxicity 0.000 claims 1
Claims (16)
- 以下の：
（ｉ）ＫａｂａｔのＥＵインデックスに従って付番した第２５１−２５６アミノ酸残基の１もしくは複数における置換を含むように、対応する修飾されていないＩｇＧ４Ｆｃ領域またはそのＦｃＲｎ結合ドメインに対して修飾したヒトＩｇＧ４Ｆｃ領域またはそのＦｃＲｎ結合ドメイン；および
（ｉｉ）ＫａｂａｔのＥＵインデックスによるアミノ酸置換Ｓ２２８Ｐを含んでいるヒトＩｇＧ４コアヒンジ領域配列；
を含んでいる、単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質であって、
修飾された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質の生体内半減期が、対応する修飾されていない抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質と比べて延長される、
抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。 - 当該単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質が特異的にインターロイキン（IL）−５と結合する、請求項１に記載の単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。
- 当該単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質が特異的にＣＤ３３と結合する、請求項１に記載の単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。
- キメラ抗体、ヒト抗体、ヒト化抗体、ＣＤＲグラフト抗体、霊長類化抗体、脱免疫化抗体、または化粧張り抗体である、請求項１〜３のいずれか一項に記載の免疫グロブリン。
- 部分を含むように、化学的に結合したか、遺伝子組換えにより融合したか、または遺伝子操作した、請求項１〜４のいずれか１項に記載の抗体または免疫グロブリン構築物。
- 配列番号６に規定される重鎖定常領域配列および配列番号７に規定される重鎖可変領域配列を含んでいる、請求項２に記載の抗体。
- 配列番号８に規定される可変および定常領域配列を含んでいる軽鎖をさらに含んでいる、請求項６に記載の抗体。
- 配列番号１１に規定される重鎖配列および配列番号１２に規定される軽鎖配列を含んでいる、請求項３に記載の抗体。
- 以下の：
（ｉ）ＫａｂａｔのＥＵインデックスに従って付番したアミノ酸置換Ｍ２５２Ｙ、Ｓ２５４Ｔ、およびＴ２５６Ｅを含むように、対応する修飾されていないＩｇＧ４Ｆｃ領域またはそのＦｃＲｎ結合ドメインに対して修飾したヒトＩｇＧ４Ｆｃ領域またはそのＦｃＲｎ結合ドメイン；および
（ｉｉ）ＫａｂａｔのＥＵインデックスによるアミノ酸置換Ｓ２２８Ｐを含んでいるヒトＩｇＧ４コアヒンジ領域配列；
を含んでいる、延長された生体内半減期を有する単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質であって、
対象における疾患の処置または予防における使用のための、
抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。 - 余分な好酸球産生を特徴とする疾患の治療における使用のための、請求項２、６または７に記載の単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。
- 前記疾患が、アトピー性喘息、アトピー性皮膚炎、アレルギー性鼻炎、非アレルギー性鼻炎、喘息、重度の喘息、慢性好酸性肺炎、アレルギー性気管支肺アスペルギルス症、小児脂肪便症、チャーグ・ストラウス症候群、好酸球性筋肉痛症候群、特発性好酸球増加症候群、偶発性血管性浮腫を含めた浮腫性反応、蠕虫感染、オンコセルカ皮膚炎、好酸球性食道炎、好酸球性胃炎、好酸球性胃腸炎、好酸球性小腸炎、好酸球性結腸炎、鼻マイクロポリポーシス、鼻ポリポーシス、アスピリン不耐喘息、閉塞型睡眠時無呼吸、慢性喘息、クローン病、強皮症、および心内膜線維症から成る群から選択される、請求項９または１０に記載の単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。
- 癌の処置における使用のための、請求項３または８に記載された単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。
- 癌が急性骨髄性白血病である、請求項１２に記載された単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質。
- 請求項１から８のいずれか一項に記載された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質をコードする核酸。
- 請求項１４に記載された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質をコードする核酸を含む形質転換細胞。
- 医薬的に許容され得る賦形剤と一緒に請求項１から８のいずれか一項に記載された単離された抗体、免疫グロブリン構築物または免疫グロブリンＩｇＧ４融合タンパク質を含んでいる医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061425858P | 2010-12-22 | 2010-12-22 | |
| US61/425,858 | 2010-12-22 | ||
| PCT/AU2011/001662 WO2012083370A1 (en) | 2010-12-22 | 2011-12-22 | Modified antibody with improved half-life |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016255652A Division JP6334669B2 (ja) | 2010-12-22 | 2016-12-28 | 改善された半減期を有する修飾された抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014503209A JP2014503209A (ja) | 2014-02-13 |
| JP2014503209A5 true JP2014503209A5 (ja) | 2015-02-19 |
| JP6147670B2 JP6147670B2 (ja) | 2017-06-14 |
Family
ID=46312907
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013544971A Active JP6147670B2 (ja) | 2010-12-22 | 2011-12-22 | 改善された半減期を有する修飾された抗体 |
| JP2016255652A Active JP6334669B2 (ja) | 2010-12-22 | 2016-12-28 | 改善された半減期を有する修飾された抗体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016255652A Active JP6334669B2 (ja) | 2010-12-22 | 2016-12-28 | 改善された半減期を有する修飾された抗体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9505826B2 (ja) |
| EP (1) | EP2654790B1 (ja) |
| JP (2) | JP6147670B2 (ja) |
| KR (1) | KR101941514B1 (ja) |
| CN (1) | CN103429261A (ja) |
| AU (1) | AU2011349049B2 (ja) |
| BR (1) | BR112013016235B1 (ja) |
| CA (1) | CA2824279A1 (ja) |
| EA (1) | EA201390923A1 (ja) |
| ES (1) | ES2720136T3 (ja) |
| IL (1) | IL227081B (ja) |
| MX (1) | MX2013007392A (ja) |
| PT (1) | PT2654790T (ja) |
| WO (1) | WO2012083370A1 (ja) |
| ZA (1) | ZA201305123B (ja) |
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| KR101895634B1 (ko) * | 2013-05-31 | 2018-09-05 | 한미약품 주식회사 | 변이된 힌지 영역을 포함하는 IgG4 Fc 단편 |
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