JP2008521440A5 - - Google Patents
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- Publication number
- JP2008521440A5 JP2008521440A5 JP2007544479A JP2007544479A JP2008521440A5 JP 2008521440 A5 JP2008521440 A5 JP 2008521440A5 JP 2007544479 A JP2007544479 A JP 2007544479A JP 2007544479 A JP2007544479 A JP 2007544479A JP 2008521440 A5 JP2008521440 A5 JP 2008521440A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- xaa
- acid sequence
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 39
- 238000009472 formulation Methods 0.000 claims 14
- 239000000203 mixture Substances 0.000 claims 14
- 102000008230 Toll-like receptor 3 Human genes 0.000 claims 12
- 108010060885 Toll-like receptor 3 Proteins 0.000 claims 12
- 239000005557 antagonist Substances 0.000 claims 9
- 210000004027 cell Anatomy 0.000 claims 9
- 230000004968 inflammatory condition Effects 0.000 claims 9
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 8
- 102000040430 polynucleotide Human genes 0.000 claims 7
- 108091033319 polynucleotide Proteins 0.000 claims 7
- 239000002157 polynucleotide Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 4
- 102000036639 antigens Human genes 0.000 claims 4
- 108091007433 antigens Proteins 0.000 claims 4
- 239000012634 fragment Substances 0.000 claims 4
- 102100031092 C-C motif chemokine 3 Human genes 0.000 claims 3
- 101710155856 C-C motif chemokine 3 Proteins 0.000 claims 3
- 108010055166 Chemokine CCL5 Proteins 0.000 claims 3
- 102000004889 Interleukin-6 Human genes 0.000 claims 3
- 108090001005 Interleukin-6 Proteins 0.000 claims 3
- 102000004890 Interleukin-8 Human genes 0.000 claims 3
- 108090001007 Interleukin-8 Proteins 0.000 claims 3
- ZOKVLMBYDSIDKG-CSMHCCOUSA-N Lys-Thr Chemical compound C[C@@H](O)[C@@H](C(O)=O)NC(=O)[C@@H](N)CCCCN ZOKVLMBYDSIDKG-CSMHCCOUSA-N 0.000 claims 3
- ODGNUUUDJONJSC-UFYCRDLUSA-N Phe-Pro-Tyr Chemical compound C1C[C@H](N(C1)C(=O)[C@H](CC2=CC=CC=C2)N)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)O ODGNUUUDJONJSC-UFYCRDLUSA-N 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 3
- 229940100601 interleukin-6 Drugs 0.000 claims 3
- 229940096397 interleukin-8 Drugs 0.000 claims 3
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 102100032367 C-C motif chemokine 5 Human genes 0.000 claims 1
- 208000032928 Dyslipidaemia Diseases 0.000 claims 1
- CXRWMMRLEMVSEH-PEFMBERDSA-N Glu-Ile-Asn Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(O)=O CXRWMMRLEMVSEH-PEFMBERDSA-N 0.000 claims 1
- BBBXWRGITSUJPB-YUMQZZPRSA-N Glu-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](N)CCC(O)=O BBBXWRGITSUJPB-YUMQZZPRSA-N 0.000 claims 1
- OCQUNKSFDYDXBG-QXEWZRGKSA-N Gly-Arg-Ile Chemical compound CC[C@H](C)[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CCCN=C(N)N OCQUNKSFDYDXBG-QXEWZRGKSA-N 0.000 claims 1
- NURNJECQNNCRBK-FLBSBUHZSA-N Ile-Thr-Thr Chemical compound CC[C@H](C)[C@H](N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O NURNJECQNNCRBK-FLBSBUHZSA-N 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 208000017170 Lipid metabolism disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108010047562 NGR peptide Proteins 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- WWAQEUOYCYMGHB-FXQIFTODSA-N Pro-Asn-Asn Chemical compound NC(=O)C[C@@H](C(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1 WWAQEUOYCYMGHB-FXQIFTODSA-N 0.000 claims 1
- 206010040047 Sepsis Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- GRIUMVXCJDKVPI-IZPVPAKOSA-N Thr-Thr-Tyr Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O GRIUMVXCJDKVPI-IZPVPAKOSA-N 0.000 claims 1
- XXROXFHCMVXETG-UWVGGRQHSA-N Val-Gly-Val Chemical compound CC(C)[C@H](N)C(=O)NCC(=O)N[C@@H](C(C)C)C(O)=O XXROXFHCMVXETG-UWVGGRQHSA-N 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 108010077245 asparaginyl-proline Proteins 0.000 claims 1
- 230000030833 cell death Effects 0.000 claims 1
- 210000001072 colon Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000004408 hybridoma Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 230000007170 pathology Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63181504P | 2004-11-30 | 2004-11-30 | |
| US60/631,815 | 2004-11-30 | ||
| US63639904P | 2004-12-15 | 2004-12-15 | |
| US60/636,399 | 2004-12-15 | ||
| US64187705P | 2005-01-06 | 2005-01-06 | |
| US60/641,877 | 2005-01-06 | ||
| US71319505P | 2005-08-31 | 2005-08-31 | |
| US60/713,195 | 2005-08-31 | ||
| US72761005P | 2005-10-18 | 2005-10-18 | |
| US60/727,610 | 2005-10-18 | ||
| PCT/US2005/043373 WO2006060513A2 (en) | 2004-11-30 | 2005-11-30 | Toll like receptor 3 antagonists, methods and uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012097822A Division JP2012149092A (ja) | 2004-11-30 | 2012-04-23 | Ｔｏｌｌ様受容体３アンタゴニスト、方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008521440A JP2008521440A (ja) | 2008-06-26 |
| JP2008521440A5 true JP2008521440A5 (enExample) | 2009-01-22 |
| JP5039560B2 JP5039560B2 (ja) | 2012-10-03 |
Family
ID=36565702
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007544479A Expired - Fee Related JP5039560B2 (ja) | 2004-11-30 | 2005-11-30 | Ｔｏｌｌ様受容体３アンタゴニスト、方法および使用 |
| JP2012097822A Pending JP2012149092A (ja) | 2004-11-30 | 2012-04-23 | Ｔｏｌｌ様受容体３アンタゴニスト、方法および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012097822A Pending JP2012149092A (ja) | 2004-11-30 | 2012-04-23 | Ｔｏｌｌ様受容体３アンタゴニスト、方法および使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8153583B2 (enExample) |
| EP (2) | EP1824514B1 (enExample) |
| JP (2) | JP5039560B2 (enExample) |
| KR (1) | KR101317264B1 (enExample) |
| AR (1) | AR051836A1 (enExample) |
| AU (1) | AU2005311894A1 (enExample) |
| BR (1) | BRPI0518664A2 (enExample) |
| CA (1) | CA2589636C (enExample) |
| EA (1) | EA200701192A1 (enExample) |
| IL (1) | IL183541A (enExample) |
| MX (1) | MX2007006442A (enExample) |
| NO (1) | NO20073293L (enExample) |
| NZ (1) | NZ555475A (enExample) |
| TW (1) | TWI487535B (enExample) |
| WO (1) | WO2006060513A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0121591D0 (en) | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| DK1945820T3 (da) * | 2005-10-27 | 2013-11-11 | Janssen Biotech Inc | Toll-lignende receptor-3-modulatorer, fremgangsmåder og anvendelser |
| US8066981B2 (en) * | 2006-11-14 | 2011-11-29 | The Texas A & M University System | Compositions and methods related to toll-like receptor-3 |
| JP2010527633A (ja) * | 2007-05-25 | 2010-08-19 | セントコア・オーソ・バイオテツク・インコーポレーテツド | Ｔｏｌｌ様受容体３モジュレーター及びその使用 |
| AU2008333131B2 (en) | 2007-12-07 | 2013-10-24 | Merck Serono S/A | Humanized antibody molecules specific for IL-31 |
| CN102083984A (zh) * | 2007-12-26 | 2011-06-01 | 森托科尔奥索生物科技公司 | 食蟹猴Toll样受体3 |
| CA2726512A1 (en) * | 2008-06-09 | 2009-12-17 | Novartis Ag | Antibodies against neisserial factor h binding protein |
| EP2138513B1 (en) * | 2008-06-27 | 2011-02-09 | Theranor SPRL | Pharmaceutical compositions of antibodies for diseases caused by viruses |
| WO2010040054A2 (en) * | 2008-10-02 | 2010-04-08 | Centocor Ortho Biotech Inc. | Methods for suppressing toll-like receptor activity |
| HUE031756T2 (en) | 2008-10-31 | 2017-07-28 | Janssen Biotech Inc | TLR3 antagonists |
| US8460659B2 (en) | 2008-10-31 | 2013-06-11 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists for the treatment of metabolic and cardiovascular diseases |
| US20100135983A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100137246A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100136095A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100136097A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100137247A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Anti-inflammatory compositions and methods |
| US20100136094A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| US20100136096A1 (en) * | 2008-12-02 | 2010-06-03 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Systems for modulating inflammation |
| UA112282C2 (uk) * | 2009-04-29 | 2016-08-25 | Янссен Байотек, Інк. | Антагоніст толл-подібного рецептора 3 |
| RU2562865C2 (ru) * | 2009-07-10 | 2015-09-10 | Иннэйт Фарма | Tlr3 связывающие агенты |
| US20120301463A1 (en) | 2009-09-30 | 2012-11-29 | President And Fellows Of Harvard College | Methods for Modulation of Autophagy Through the Modulation of Autophagy-Enhancing Gene Products |
| US20140065154A1 (en) | 2011-01-12 | 2014-03-06 | Innate Pharma | Tlr3 binding agents |
| PT2748201T (pt) * | 2011-08-23 | 2018-02-08 | Roche Glycart Ag | Moléculas de ligação ao antigénio biespecíficas que ativam as células t |
| WO2013026837A1 (en) * | 2011-08-23 | 2013-02-28 | Roche Glycart Ag | Bispecific t cell activating antigen binding molecules |
| CA2855955A1 (en) * | 2011-09-12 | 2013-03-21 | Janssen Biotech, Inc. | Toll-like receptor 3 antagonists |
| EP2855527B1 (en) * | 2012-05-31 | 2018-08-01 | Innate Pharma | Tlr3 binding agents |
| TWI635098B (zh) | 2013-02-01 | 2018-09-11 | 再生元醫藥公司 | 含嵌合恆定區之抗體 |
| EA201891502A1 (ru) * | 2013-02-26 | 2018-12-28 | Роше Гликарт Аг | Биспецифические антигенсвязывающие молекулы, активирующие т-клетки |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| TWI701042B (zh) | 2014-03-19 | 2020-08-11 | 美商再生元醫藥公司 | 用於腫瘤治療之方法及抗體組成物 |
| SI3221359T1 (sl) | 2014-11-17 | 2020-08-31 | Regeneron Pharmaceuticals, Inc. | Metode zravljenja tumorja z uporabo bispecifičnega protitelesa CD3XCD20 |
| EP3277725B1 (en) | 2015-03-30 | 2020-11-25 | Regeneron Pharmaceuticals, Inc. | Heavy chain constant regions with reduced binding to fc gamma receptors |
| CN107849137B (zh) | 2015-10-02 | 2021-11-26 | 豪夫迈·罗氏有限公司 | 双特异性抗ceaxcd3 t细胞活化性抗原结合分子 |
| IL257696B2 (en) | 2015-12-09 | 2024-11-01 | Hoffmann La Roche | Type ii anti-cd20 antibody for reducing formation of anti-drug antibodies |
| KR20180097615A (ko) | 2016-01-08 | 2018-08-31 | 에프. 호프만-라 로슈 아게 | Pd-1 축 결합 길항물질 및 항-cea/항-cd3 이중특이성 항체를 사용하는 cea-양성 암의 치료 방법 |
| WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| RS66543B1 (sr) | 2018-08-31 | 2025-03-31 | Regeneron Pharma | Strategija doziranja koja ublažava sindrom oslobađanja citokina za cd3/cd20 bispecifična antitela |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US20030032090A1 (en) * | 1997-05-07 | 2003-02-13 | Schering Corporation, A New Jersey Corporation | Human receptor proteins; related reagents and methods |
| EP1798288B1 (en) | 1997-05-07 | 2009-09-16 | Schering Corporation | Human Toll-like receptor proteins, related reagents and methods |
| WO2000053224A2 (en) | 1999-03-09 | 2000-09-14 | Max-Delbrück-Centrum für Molekulare Medizin | Use of inhibitors of endotoxin for the treatment of heart failure and of cachexia |
| GB9930616D0 (en) | 1999-12-24 | 2000-02-16 | Mathilda & Terence Kennedy Ins | Activation and inhibition of the immune system |
| CN1575184A (zh) * | 2001-09-07 | 2005-02-02 | 波士顿大学理事会 | 治疗免疫复合物相关疾病的方法和组合物 |
| CA2461315A1 (en) | 2001-10-05 | 2003-04-17 | Coley Pharmaceutical Gmbh | Toll-like receptor 3 signaling agonists and antagonists |
| US20060058288A1 (en) | 2002-04-08 | 2006-03-16 | Masayuki Ii | Severe sepsis preventive therapeutic agent |
| JP2004016021A (ja) * | 2002-06-12 | 2004-01-22 | Japan Science & Technology Corp | 抗体および阻害剤並びにそれを用いた形質転換方法および形質転換キット |
| MXPA05013922A (es) * | 2003-06-20 | 2006-02-24 | Coley Pharm Group Inc | Antagonistas de receptor tipo toll de molecula pequena. |
-
2005
- 2005-11-29 TW TW094141961A patent/TWI487535B/zh not_active IP Right Cessation
- 2005-11-29 AR ARP050104988A patent/AR051836A1/es not_active Application Discontinuation
- 2005-11-30 BR BRPI0518664-1A patent/BRPI0518664A2/pt not_active Application Discontinuation
- 2005-11-30 KR KR1020077014790A patent/KR101317264B1/ko not_active Expired - Fee Related
- 2005-11-30 NZ NZ555475A patent/NZ555475A/en not_active IP Right Cessation
- 2005-11-30 AU AU2005311894A patent/AU2005311894A1/en not_active Abandoned
- 2005-11-30 EA EA200701192A patent/EA200701192A1/ru unknown
- 2005-11-30 MX MX2007006442A patent/MX2007006442A/es not_active Application Discontinuation
- 2005-11-30 US US11/291,140 patent/US8153583B2/en not_active Expired - Fee Related
- 2005-11-30 CA CA2589636A patent/CA2589636C/en not_active Expired - Lifetime
- 2005-11-30 WO PCT/US2005/043373 patent/WO2006060513A2/en not_active Ceased
- 2005-11-30 EP EP05852564.3A patent/EP1824514B1/en not_active Expired - Lifetime
- 2005-11-30 EP EP12155464A patent/EP2481425A1/en not_active Withdrawn
- 2005-11-30 JP JP2007544479A patent/JP5039560B2/ja not_active Expired - Fee Related
-
2007
- 2007-05-29 IL IL183541A patent/IL183541A/en active IP Right Grant
- 2007-06-26 NO NO20073293A patent/NO20073293L/no not_active Application Discontinuation
-
2012
- 2012-04-23 JP JP2012097822A patent/JP2012149092A/ja active Pending
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