JP2015504306A5 - - Google Patents
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- JP2015504306A5 JP2015504306A5 JP2014541658A JP2014541658A JP2015504306A5 JP 2015504306 A5 JP2015504306 A5 JP 2015504306A5 JP 2014541658 A JP2014541658 A JP 2014541658A JP 2014541658 A JP2014541658 A JP 2014541658A JP 2015504306 A5 JP2015504306 A5 JP 2015504306A5
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- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims description 24
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims description 24
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 16
- 150000007523 nucleic acids Chemical group 0.000 claims description 8
- 125000000539 amino acid group Chemical group 0.000 claims description 7
- 208000023275 Autoimmune disease Diseases 0.000 claims description 6
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 6
- 210000004027 cell Anatomy 0.000 claims description 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 5
- 102000005962 receptors Human genes 0.000 claims description 5
- 108020003175 receptors Proteins 0.000 claims description 5
- 208000037914 B-cell disorder Diseases 0.000 claims description 4
- 241000282553 Macaca Species 0.000 claims description 4
- 208000021161 Plasma cell disease Diseases 0.000 claims description 4
- 206010035226 Plasma cell myeloma Diseases 0.000 claims description 4
- 208000007452 Plasmacytoma Diseases 0.000 claims description 4
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 210000000988 bone and bone Anatomy 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 2
- 101000801255 Homo sapiens Tumor necrosis factor receptor superfamily member 17 Proteins 0.000 claims description 2
- 208000019758 Hypergammaglobulinemia Diseases 0.000 claims description 2
- 208000034578 Multiple myelomas Diseases 0.000 claims description 2
- 208000004346 Smoldering Multiple Myeloma Diseases 0.000 claims description 2
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims description 2
- 206010002022 amyloidosis Diseases 0.000 claims description 2
- 238000012258 culturing Methods 0.000 claims description 2
- 201000006569 extramedullary plasmacytoma Diseases 0.000 claims description 2
- 208000025750 heavy chain disease Diseases 0.000 claims description 2
- 102000046935 human TNFRSF17 Human genes 0.000 claims description 2
- 230000003053 immunization Effects 0.000 claims description 2
- 201000000564 macroglobulinemia Diseases 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 201000000050 myeloid neoplasm Diseases 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 208000031223 plasma cell leukemia Diseases 0.000 claims description 2
- 229920001184 polypeptide Polymers 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 2
- 208000010721 smoldering plasma cell myeloma Diseases 0.000 claims description 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 2
- 230000002596 correlated effect Effects 0.000 claims 2
- 230000000875 corresponding effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 241001465754 Metazoa Species 0.000 description 1
Applications Claiming Priority (15)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161560162P | 2011-11-15 | 2011-11-15 | |
| US201161560183P | 2011-11-15 | 2011-11-15 | |
| US201161560178P | 2011-11-15 | 2011-11-15 | |
| US201161560149P | 2011-11-15 | 2011-11-15 | |
| US201161560144P | 2011-11-15 | 2011-11-15 | |
| US61/560,144 | 2011-11-15 | ||
| US61/560,149 | 2011-11-15 | ||
| US61/560,178 | 2011-11-15 | ||
| US61/560,183 | 2011-11-15 | ||
| US61/560,162 | 2011-11-15 | ||
| US201261651486P | 2012-05-24 | 2012-05-24 | |
| US201261651474P | 2012-05-24 | 2012-05-24 | |
| US61/651,474 | 2012-05-24 | ||
| US61/651,486 | 2012-05-24 | ||
| PCT/EP2012/072699 WO2013072406A1 (en) | 2011-11-15 | 2012-11-15 | Binding molecules for bcma and cd3 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017212359A Division JP6738314B2 (ja) | 2011-11-15 | 2017-11-02 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015504306A JP2015504306A (ja) | 2015-02-12 |
| JP2015504306A5 true JP2015504306A5 (enExample) | 2015-11-26 |
| JP6378087B2 JP6378087B2 (ja) | 2018-08-22 |
Family
ID=47388493
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541658A Active JP6378087B2 (ja) | 2011-11-15 | 2012-11-15 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
| JP2014541660A Active JP6231007B2 (ja) | 2011-11-15 | 2012-11-15 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
| JP2017110658A Pending JP2017195889A (ja) | 2011-11-15 | 2017-06-05 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
| JP2017212359A Active JP6738314B2 (ja) | 2011-11-15 | 2017-11-02 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
| JP2020122548A Active JP7250736B2 (ja) | 2011-11-15 | 2020-07-17 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014541660A Active JP6231007B2 (ja) | 2011-11-15 | 2012-11-15 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
| JP2017110658A Pending JP2017195889A (ja) | 2011-11-15 | 2017-06-05 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
| JP2017212359A Active JP6738314B2 (ja) | 2011-11-15 | 2017-11-02 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
| JP2020122548A Active JP7250736B2 (ja) | 2011-11-15 | 2020-07-17 | Ｂｃｍａおよびｃｄ３に対する結合分子 |
Country Status (40)
Families Citing this family (193)
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| TWI679212B (zh) * | 2011-11-15 | 2019-12-11 | 美商安進股份有限公司 | 針對ｂｃｍａ之e3以及ｃｄ３的結合分子 |
| CN104520324A (zh) | 2012-02-24 | 2015-04-15 | 施特姆森特Rx股份有限公司 | Dll3调节剂及其使用方法 |
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| EP3262424B1 (en) * | 2015-02-24 | 2024-11-13 | The University of British Columbia | Continuous flow microfluidic system and method |
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